|
2017-10-05 |
2017-10-03 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
5,688
+37.5%
319.20
US$4,338,637
|
5,688
+37.5%
|
319.20
|
US$4,338,637
|
|
|
2017-10-05 |
2017-10-03 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
35,792
-14.2%
114.40
US$3,664,764
|
35,792
-14.2%
|
114.40
|
US$3,664,764
|
|
|
2017-10-02 |
2017-09-29 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
74,072
-13.6%
107.31
US$1,061,656
|
74,072
-13.6%
|
107.31
|
US$1,061,656
|
|
|
2017-10-02 |
2017-09-29 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
93,246
-31.8%
0.74
US$69,002
|
93,246
-31.8%
|
0.74
|
US$69,002
|
|
|
2017-10-02 |
2017-09-28 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
3,592
-56.3%
0.72
US$2,586
|
3,592
-56.3%
|
0.72
|
US$2,586
|
|
|
2017-10-02 |
2017-09-28 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
376,950
-56.3%
0.72
US$271,404
|
376,950
-56.3%
|
0.72
|
US$271,404
|
|
|
2017-09-28 |
2017-09-27 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
498
-7.2%
0.92
US$458
|
498
-7.2%
|
0.92
|
US$458
|
|
|
2017-09-28 |
2017-09-27 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
52,301
-7.2%
0.92
US$48,117
|
52,301
-7.2%
|
0.92
|
US$48,117
|
|
|
2017-09-28 |
2017-09-26 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
706
-9.3%
1.03
US$727
|
706
-9.3%
|
1.03
|
US$727
|
|
|
2017-09-28 |
2017-09-26 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
74,096
-9.3%
1.03
US$76,319
|
74,096
-9.3%
|
1.03
|
US$76,319
|
|
|
2017-08-25 |
2017-08-24 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
125
-1.6%
1.50
US$188
|
125
-1.6%
|
1.50
|
US$188
|
|
|
2017-08-25 |
2017-08-24 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
13,075
-1.6%
1.50
US$19,612
|
13,075
-1.6%
|
1.50
|
US$19,612
|
|
|
2017-08-25 |
2017-08-23 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
10
-0.1%
1.50
US$15
|
10
-0.1%
|
1.50
|
US$15
|
|
|
2017-08-25 |
2017-08-23 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
1,090
-0.1%
1.50
US$1,635
|
1,090
-0.1%
|
1.50
|
US$1,635
|
|
|
2017-08-22 |
2017-08-22 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
52
-0.7%
1.52
US$79
|
52
-0.7%
|
1.52
|
US$79
|
|
|
2017-08-22 |
2017-08-22 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
5,448
-0.7%
1.52
US$8,281
|
5,448
-0.7%
|
1.52
|
US$8,281
|
|
|
2017-08-22 |
2017-08-21 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
28
-0.4%
1.49
US$42
|
28
-0.4%
|
1.49
|
US$42
|
|
|
2017-08-22 |
2017-08-21 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
2,952
-0.4%
1.49
US$4,398
|
2,952
-0.4%
|
1.49
|
US$4,398
|
|
|
2017-08-22 |
2017-08-18 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
630
-7.5%
1.52
US$958
|
630
-7.5%
|
1.52
|
US$958
|
|
|
2017-08-22 |
2017-08-18 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
66,166
-7.5%
1.52
US$100,572
|
66,166
-7.5%
|
1.52
|
US$100,572
|
|
|
2014-11-17 |
2014-11-17 |
B
Purchase
|
MCGIRR DAVID W J
Non-Executive Director
|
20,994
+72.4%
3.65
US$76,697
|
20,994
+72.4%
|
3.65
|
US$76,697
|
|
|
2014-11-17 |
2014-11-14 |
B
Purchase
|
MCGIRR DAVID W J
Non-Executive Director
|
29,006
+inf%
3.57
US$103,424
|
29,006
+inf%
|
3.57
|
US$103,424
|
|
|
2014-07-24 |
2014-07-22 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
3,616
+13.5%
12.00
US$43,392
|
3,616
+13.5%
|
12.00
|
US$43,392
|
|
|
2014-07-24 |
2014-07-22 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
379,717
+13.5%
12.00
US$4,556,604
|
379,717
+13.5%
|
12.00
|
US$4,556,604
|
|
|
2014-07-24 |
2014-07-22 |
B
Purchase
|
SILVERSTEIN JONATHAN
Non-Executive Director
Large shareholder
|
3,616
+13.5%
12.00
US$43,392
|
3,616
+13.5%
|
12.00
|
US$43,392
|
|
|
2014-07-24 |
2014-07-22 |
B
Purchase
|
SILVERSTEIN JONATHAN
Non-Executive Director
Large shareholder
|
379,717
+13.5%
12.00
US$4,556,604
|
379,717
+13.5%
|
12.00
|
US$4,556,604
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
KOLLURI KRISHNA KITTU
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
BASKETT FOREST
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
BARRETT M JAMES
Non-Executive Director
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
Viswanathan Ravi
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
DRANT RYAN D
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
MOTT DAVID M
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
KERINS PATRICK J
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
Weller Harry R
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
NEW ENTERPRISE ASSOCIATES 13 LP
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
SANDELL SCOTT D
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|
|
2014-07-22 |
2014-07-22 |
B
Purchase
|
BARRIS PETER J
Large shareholder
|
383,333
+13.5%
12.00
US$4,599,996
|
383,333
+13.5%
|
12.00
|
US$4,599,996
|
|