|
2022-11-29 |
2022-11-28 |
S
Sale
|
Non-Executive Director
|
25,548
-44.2%
365.06
US$1,977,461
|
25,548
-44.2%
|
365.06
|
US$1,977,461
|
|
|
2022-03-29 |
2022-03-28 |
S
Sale
|
Chief Scientific Officer
Officer
|
67,110
+19.5%
284.28
US$1,529,154
|
67,110
+19.5%
|
284.28
|
US$1,529,154
|
|
|
2022-03-29 |
2022-03-28 |
S
Sale
|
Ch. Financial & Business Offcr
Officer
|
51,193
-39.1%
267.89
US$3,696,211
|
51,193
-39.1%
|
267.89
|
US$3,696,211
|
|
|
2022-03-29 |
2022-03-28 |
S
Sale
|
Chief Technical Officer
Officer
|
3,325
-2.2%
2.41
US$8,023
|
3,325
-2.2%
|
2.41
|
US$8,023
|
|
|
2022-03-29 |
2022-03-28 |
S
Sale
|
President & CEO
Executive Director
|
11,243
-2.9%
2.41
US$27,129
|
11,243
-2.9%
|
2.41
|
US$27,129
|
|
|
2022-03-29 |
2022-03-25 |
S
Sale
|
Chief Scientific Officer
Officer
|
1,827
-1.0%
2.39
US$4,363
|
1,827
-1.0%
|
2.39
|
US$4,363
|
|
|
2022-03-29 |
2022-03-25 |
S
Sale
|
Ch. Financial & Business Offcr
Officer
|
4,015
-1.7%
2.39
US$9,588
|
4,015
-1.7%
|
2.39
|
US$9,588
|
|
|
2022-03-29 |
2022-03-25 |
S
Sale
|
Chief Technical Officer
Officer
|
2,374
-1.6%
2.39
US$5,669
|
2,374
-1.6%
|
2.39
|
US$5,669
|
|
|
2022-03-29 |
2022-03-25 |
S
Sale
|
President & CEO
Executive Director
|
8,026
-2.0%
2.39
US$19,166
|
8,026
-2.0%
|
2.39
|
US$19,166
|
|
|
2021-03-03 |
2021-03-03 |
S
Sale
|
Non-Executive Director
|
113,935
-100.0%
2.70
US$307,397
|
113,935
-100.0%
|
2.70
|
US$307,397
|
|
|
2021-03-03 |
2021-03-03 |
S
Sale
|
Non-Executive Director
|
207,245
-100.0%
2.70
US$559,147
|
207,245
-100.0%
|
2.70
|
US$559,147
|
|
|
2021-03-02 |
2021-03-02 |
S
Sale
|
Non-Executive Director
|
138,199
-54.8%
2.90
US$400,639
|
138,199
-54.8%
|
2.90
|
US$400,639
|
|
|
2021-03-02 |
2021-03-02 |
S
Sale
|
Non-Executive Director
|
251,375
-54.8%
2.90
US$728,736
|
251,375
-54.8%
|
2.90
|
US$728,736
|
|
|
2021-03-02 |
2021-03-01 |
S
Sale
|
Non-Executive Director
|
61,619
-19.6%
2.86
US$175,984
|
61,619
-19.6%
|
2.86
|
US$175,984
|
|
|
2021-03-02 |
2021-03-01 |
S
Sale
|
Non-Executive Director
|
112,081
-19.6%
2.86
US$320,103
|
112,081
-19.6%
|
2.86
|
US$320,103
|
|
|
2021-03-02 |
2021-02-26 |
S
Sale
|
Non-Executive Director
|
117,262
-27.2%
2.83
US$331,851
|
117,262
-27.2%
|
2.83
|
US$331,851
|
|
|
2021-03-02 |
2021-02-26 |
S
Sale
|
Non-Executive Director
|
213,292
-27.2%
2.83
US$603,616
|
213,292
-27.2%
|
2.83
|
US$603,616
|
|
|
2021-02-25 |
2021-02-25 |
S
Sale
|
Non-Executive Director
|
110,361
-20.4%
2.95
US$326,006
|
110,361
-20.4%
|
2.95
|
US$326,006
|
|
|
2021-02-25 |
2021-02-25 |
S
Sale
|
Non-Executive Director
|
200,739
-20.4%
2.95
US$592,983
|
200,739
-20.4%
|
2.95
|
US$592,983
|
|
|
2021-02-25 |
2021-02-24 |
S
Sale
|
Non-Executive Director
|
178,484
-24.8%
2.98
US$532,239
|
178,484
-24.8%
|
2.98
|
US$532,239
|
|
|
2021-02-25 |
2021-02-24 |
S
Sale
|
Non-Executive Director
|
324,651
-24.8%
2.98
US$968,109
|
324,651
-24.8%
|
2.98
|
US$968,109
|
|
|
2021-02-25 |
2021-02-23 |
S
Sale
|
Non-Executive Director
|
95,113
-11.7%
2.89
US$274,686
|
95,113
-11.7%
|
2.89
|
US$274,686
|
|
|
2021-02-25 |
2021-02-23 |
S
Sale
|
Non-Executive Director
|
173,005
-11.7%
2.89
US$499,638
|
173,005
-11.7%
|
2.89
|
US$499,638
|
|
|
2017-06-27 |
2017-06-26 |
PlS
Planned sale
|
LOUMEAU ERIC J
GC & Chief Compliance Officer
|
1,206
-100.0%
18.75
US$22,612
|
1,206
-100.0%
|
18.75
|
US$22,612
|
|
|
2017-06-27 |
2017-06-23 |
PlS
Planned sale
|
LOUMEAU ERIC J
GC & Chief Compliance Officer
|
2,316
-65.8%
18.50
US$42,846
|
2,316
-65.8%
|
18.50
|
US$42,846
|
|
|
2016-11-22 |
2016-11-21 |
PlS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
1,456
-13.3%
18.07
US$26,303
|
1,456
-13.3%
|
18.07
|
US$26,303
|
|
|
2016-11-22 |
2016-11-18 |
PlS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
9,169
-49.2%
18.07
US$165,703
|
9,169
-49.2%
|
18.07
|
US$165,703
|
|
|
2016-09-08 |
2016-09-06 |
PlS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
5,304
-35.9%
17.95
US$95,207
|
5,304
-35.9%
|
17.95
|
US$95,207
|
|
|
2016-09-08 |
2016-09-06 |
PlS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
3,813
-20.5%
17.95
US$68,443
|
3,813
-20.5%
|
17.95
|
US$68,443
|
|
|
2016-09-08 |
2016-09-06 |
PlS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
12,133
-39.5%
17.95
US$217,787
|
12,133
-39.5%
|
17.95
|
US$217,787
|
|
|
2015-12-22 |
2015-12-21 |
PlS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
8,061
-47.5%
28.38
US$228,753
|
8,061
-47.5%
|
28.38
|
US$228,753
|
|
|
2015-12-22 |
2015-12-21 |
PlS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
13,189
-43.7%
27.83
US$367,074
|
13,189
-43.7%
|
27.83
|
US$367,074
|
|
|
2015-12-18 |
2015-12-17 |
PlS
Planned sale
|
Cayer Paul E
Ch. Financial & Business Offcr
Officer
|
300
-3.0%
30.19
US$9,056
|
300
-3.0%
|
30.19
|
US$9,056
|
|
|
2015-12-18 |
2015-12-17 |
PlS
Planned sale
|
Cayer Paul E
Ch. Financial & Business Offcr
Officer
|
2,700
-21.4%
29.65
US$80,045
|
2,700
-21.4%
|
29.65
|
US$80,045
|
|
|
2015-12-16 |
2015-12-15 |
PlS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
5,208
-22.8%
27.25
US$141,917
|
5,208
-22.8%
|
27.25
|
US$141,917
|
|
|
2015-12-16 |
2015-12-14 |
S
Sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
100
-7.4%
27.70
US$2,770
|
100
-7.4%
|
27.70
|
US$2,770
|
|
|
2015-12-16 |
2015-12-14 |
S
Sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
1,289
-48.7%
27.26
US$35,136
|
1,289
-48.7%
|
27.26
|
US$35,136
|
|
|
2015-12-16 |
2015-12-14 |
S
Sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
1,289
-32.8%
26.15
US$33,706
|
1,289
-32.8%
|
26.15
|
US$33,706
|
|
|
2015-12-16 |
2015-12-14 |
PlS
Planned sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
2,322
-37.1%
25.14
US$58,363
|
2,322
-37.1%
|
25.14
|
US$58,363
|
|
|
2015-11-30 |
2015-11-30 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
590
-0.0%
29.22
US$17,240
|
590
-0.0%
|
29.22
|
US$17,240
|
|
|
2015-11-30 |
2015-11-30 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
2,716
-0.1%
28.64
US$77,786
|
2,716
-0.1%
|
28.64
|
US$77,786
|
|
|
2015-11-30 |
2015-11-30 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
590
-0.0%
29.22
US$17,240
|
590
-0.0%
|
29.22
|
US$17,240
|
|
|
2015-11-30 |
2015-11-30 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
2,716
-0.1%
28.64
US$77,786
|
2,716
-0.1%
|
28.64
|
US$77,786
|
|
|
2015-11-30 |
2015-11-27 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
29,000
-1.5%
28.97
US$840,130
|
29,000
-1.5%
|
28.97
|
US$840,130
|
|
|
2015-11-30 |
2015-11-27 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
29,000
-1.5%
28.97
US$840,130
|
29,000
-1.5%
|
28.97
|
US$840,130
|
|
|
2015-11-30 |
2015-11-25 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
34,800
-1.8%
28.91
US$1,006,068
|
34,800
-1.8%
|
28.91
|
US$1,006,068
|
|
|
2015-11-30 |
2015-11-25 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
34,800
-1.8%
28.91
US$1,006,068
|
34,800
-1.8%
|
28.91
|
US$1,006,068
|
|
|
2015-11-24 |
2015-11-24 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
36,100
-1.8%
28.75
US$1,037,875
|
36,100
-1.8%
|
28.75
|
US$1,037,875
|
|
|
2015-11-24 |
2015-11-24 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
36,100
-1.8%
28.75
US$1,037,875
|
36,100
-1.8%
|
28.75
|
US$1,037,875
|
|
|
2015-11-24 |
2015-11-23 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
80,800
-4.0%
28.45
US$2,298,760
|
80,800
-4.0%
|
28.45
|
US$2,298,760
|
|
|
2015-11-24 |
2015-11-23 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
80,800
-4.0%
28.45
US$2,298,760
|
80,800
-4.0%
|
28.45
|
US$2,298,760
|
|
|
2015-11-24 |
2015-11-20 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
83,900
-4.0%
28.59
US$2,398,701
|
83,900
-4.0%
|
28.59
|
US$2,398,701
|
|
|
2015-11-24 |
2015-11-20 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
83,900
-4.0%
28.59
US$2,398,701
|
83,900
-4.0%
|
28.59
|
US$2,398,701
|
|
|
2015-11-19 |
2015-11-19 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
127,300
-5.7%
28.60
US$3,640,780
|
127,300
-5.7%
|
28.60
|
US$3,640,780
|
|
|
2015-11-19 |
2015-11-19 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
127,300
-5.7%
28.60
US$3,640,780
|
127,300
-5.7%
|
28.60
|
US$3,640,780
|
|
|
2015-11-19 |
2015-11-17 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
200
-0.0%
29.09
US$5,818
|
200
-0.0%
|
29.09
|
US$5,818
|
|
|
2015-11-19 |
2015-11-17 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
200
-0.0%
29.09
US$5,818
|
200
-0.0%
|
29.09
|
US$5,818
|
|
|
2015-11-19 |
2015-11-17 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
10,898
-0.5%
28.80
US$313,862
|
10,898
-0.5%
|
28.80
|
US$313,862
|
|
|
2015-11-19 |
2015-11-17 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
10,898
-0.5%
28.80
US$313,862
|
10,898
-0.5%
|
28.80
|
US$313,862
|
|
|
2015-11-17 |
2015-11-17 |
PlS
Planned sale
|
Cayer Paul E
Ch. Financial & Business Offcr
Officer
|
3,000
-23.8%
28.69
US$86,057
|
3,000
-23.8%
|
28.69
|
US$86,057
|
|
|
2015-11-17 |
2015-11-16 |
S
Sale
|
Weber David Allen
President & CEO
Executive Director
|
100
-0.6%
29.25
US$2,925
|
100
-0.6%
|
29.25
|
US$2,925
|
|
|
2015-11-17 |
2015-11-16 |
PlS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
5,108
-22.4%
28.56
US$145,887
|
5,108
-22.4%
|
28.56
|
US$145,887
|
|
|
2015-11-13 |
2015-11-13 |
PlS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
10,416
-95.1%
30.95
US$322,375
|
10,416
-95.1%
|
30.95
|
US$322,375
|
|
|
2015-11-12 |
2015-11-11 |
PlS
Planned sale
|
Cayer Paul E
CFO/Ch. Business Offcr & Sec.
Officer
|
3,000
-23.8%
24.95
US$74,850
|
3,000
-23.8%
|
24.95
|
US$74,850
|
|
|
2015-11-12 |
2015-11-11 |
PlS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
5,208
-90.6%
24.95
US$129,940
|
5,208
-90.6%
|
24.95
|
US$129,940
|
|
|
2015-09-22 |
2015-09-21 |
PlS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
21,250
-70.4%
24.36
US$517,576
|
21,250
-70.4%
|
24.36
|
US$517,576
|
|
|
2015-09-18 |
2015-09-17 |
PlS
Planned sale
|
Cayer Paul E
CFO/Ch. Business Offcr & Sec.
Officer
|
3,000
-23.8%
24.95
US$74,850
|
3,000
-23.8%
|
24.95
|
US$74,850
|
|
|
2015-09-16 |
2015-09-15 |
PlS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
5,216
-90.6%
24.95
US$130,139
|
5,216
-90.6%
|
24.95
|
US$130,139
|
|
|
2015-09-15 |
2015-09-14 |
PlS
Planned sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
5,000
-79.9%
23.98
US$119,896
|
5,000
-79.9%
|
23.98
|
US$119,896
|
|
|
2015-06-17 |
2015-06-15 |
PlS
Planned sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
25,000
-95.2%
23.73
US$593,285
|
25,000
-95.2%
|
23.73
|
US$593,285
|
|
|
2015-05-27 |
2015-05-22 |
B
Purchase
|
CAPPS VICKIE L
Non-Executive Director
|
1,600
+inf%
24.35
US$38,960
|
1,600
+inf%
|
24.35
|
US$38,960
|
|
|
2015-05-27 |
2015-05-22 |
B
Purchase
|
CAPPS VICKIE L
Non-Executive Director
|
3,400
+inf%
24.36
US$82,808
|
3,400
+inf%
|
24.36
|
US$82,808
|
|
|
2014-08-21 |
2014-08-19 |
B
Purchase
|
Novo A/S
SEE REMARKS
Large shareholder
|
15,690
+0.7%
15.50
US$243,135
|
15,690
+0.7%
|
15.50
|
US$243,135
|
|
|
2014-08-19 |
2014-08-18 |
B
Purchase
|
Novo A/S
SEE REMARKS
Large shareholder
|
171,875
+8.6%
16.00
US$2,750,000
|
171,875
+8.6%
|
16.00
|
US$2,750,000
|
|
|
2014-08-19 |
2014-08-18 |
B
Purchase
|
Avalon Ventures VIII LP
Large shareholder
|
109,375
+15.5%
16.00
US$1,750,000
|
109,375
+15.5%
|
16.00
|
US$1,750,000
|
|