United States Biotechnology & Medical Research

Annovis Bio Inc (ANVS)

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Annovis Bio Inc has seen no insider trading transactions within the last ninety days. The most recent activity occurred on May 20, 2026, involving multiple share purchases by Michael B. Hoffman. Prior to this period, historical data indicates significant accumulation by this individual alongside a single proposed sale by director Mark K. White.
Ticker: ANVS Exchange: ASE
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Annovis Bio Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
187.27
Quantity 952 +14.1%
Value US$3,439,954
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
210.86
Quantity 84,690 +23.0%
Value US$3,136,470
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
281.26
Quantity 68,036 -1.9%
Value US$1,204,767
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
2.10
Quantity 713,800 +27.7%
Value US$1,498,980
1.9
White Mark K. Director Non-Executive Director
Transaction date
Proposed sale
Price
2.08
Quantity 7,142
Value US$14,848
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.24
Quantity 15,000 +0.6%
Value US$63,600
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.34
Quantity 30,000 +1.2%
Value US$130,194
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.15
Quantity 28,096 +1.1%
Value US$116,598
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.14
Quantity 415 +0.0%
Value US$1,718
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
3.85
Quantity 9,200 +0.4%
Value US$35,420
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.13
Quantity 1,489 +0.1%
Value US$6,150
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
3.50
Quantity 10,000 +0.4%
Value US$35,000
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
3.49
Quantity 10,000 +0.4%
Value US$34,900
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
2.11
Quantity 15,000 +0.6%
Value US$31,650
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
2.05
Quantity 975,610 +65.9%
Value US$2,000,000
2.6
Maccecchini Maria-Luisa President & CEO Executive Director
Transaction date
Purchase
Price
2.05
Quantity 97,561 +8.8%
Value US$200,000
1.9
White Mark K. Non-Executive Director
Transaction date
Purchase
Price
27.40
Quantity 5,000 +9.8%
Value US$137,000
1.4
Bruck Claudine Non-Executive Director
Transaction date
Purchase
Price
27.66
Quantity 181 +3.1%
Value US$5,006
2.6
Maccecchini Maria-Luisa PRESIDENT AND CEO Executive Director Large shareholder
Transaction date
Purchase
Price
27.61
Quantity 18,000 +1.9%
Value US$496,980
0.8
McGroarty Jeffrey Brian Chief Financial Officer
Transaction date
Purchase
Price
7.17
Quantity 164 +0.3%
Value US$1,176
0.8
McGroarty Jeffrey Brian Chief Financial Officer
Transaction date
Purchase
Price
7.15
Quantity 19,336 +58.0%
Value US$138,252
1.9
White Mark K.
Transaction date
Purchase
Price
6.00
Quantity 1,734 +inf%
Value US$10,404
0.8
McGroarty Jeffrey Brian Chief Financial Officer
Transaction date
Purchase
Price
6.00
Quantity 33,333 +inf%
Value US$199,998
3.6
Hoffman Michael B Large shareholder
Transaction date
Purchase
Price
6.00
Quantity 33,333 +233.3%
Value US$199,998
2.6
Maccecchini Maria-Luisa President and CEO Executive Director Large shareholder
Transaction date
Purchase
Price
6.00
Quantity 1,600 +0.8%
Value US$9,600
1.4
Bruck Claudine
Transaction date
Purchase
Price
6.00
Quantity 800 +inf%
Value US$4,800
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-05-21 2026-05-20 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
952 +14.1%
187.27
US$3,439,954 		952 +14.1% 187.27 US$3,439,954
2026-05-21 2026-05-20 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
84,690 +23.0%
210.86
US$3,136,470 		84,690 +23.0% 210.86 US$3,136,470
2026-05-21 2026-05-20 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
68,036 -1.9%
281.26
US$1,204,767 		68,036 -1.9% 281.26 US$1,204,767
2026-04-03 2026-04-02 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
713,800 +27.7%
2.10
US$1,498,980 		713,800 +27.7% 2.10 US$1,498,980
2026-04-02 2026-04-02 PrS Proposed sale
1.9
White Mark K.

Director

Non-Executive Director
7,142
2.08
US$14,848 		7,142 2.08 US$14,848
2025-12-08 2025-12-08 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
15,000 +0.6%
4.24
US$63,600 		15,000 +0.6% 4.24 US$63,600
2025-12-08 2025-12-08 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
30,000 +1.2%
4.34
US$130,194 		30,000 +1.2% 4.34 US$130,194
2025-11-25 2025-11-24 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
28,096 +1.1%
4.15
US$116,598 		28,096 +1.1% 4.15 US$116,598
2025-11-25 2025-11-24 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
415 +0.0%
4.14
US$1,718 		415 +0.0% 4.14 US$1,718
2025-11-25 2025-11-24 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
9,200 +0.4%
3.85
US$35,420 		9,200 +0.4% 3.85 US$35,420
2025-11-25 2025-11-24 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
1,489 +0.1%
4.13
US$6,150 		1,489 +0.1% 4.13 US$6,150
2025-11-21 2025-11-21 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
10,000 +0.4%
3.50
US$35,000 		10,000 +0.4% 3.50 US$35,000
2025-11-21 2025-11-21 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
10,000 +0.4%
3.49
US$34,900 		10,000 +0.4% 3.49 US$34,900
2025-11-18 2025-11-14 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
15,000 +0.6%
2.11
US$31,650 		15,000 +0.6% 2.11 US$31,650
2025-11-12 2025-10-28 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
975,610 +65.9%
2.05
US$2,000,000 		975,610 +65.9% 2.05 US$2,000,000
2025-11-12 2025-10-28 B Purchase
2.6
Maccecchini Maria-Luisa

President & CEO

Executive Director
97,561 +8.8%
2.05
US$200,000 		97,561 +8.8% 2.05 US$200,000
2021-10-13 2021-10-12 B Purchase
1.9
White Mark K.
Non-Executive Director
5,000 +9.8%
27.40
US$137,000 		5,000 +9.8% 27.40 US$137,000
2021-10-13 2021-10-11 B Purchase
1.4
Bruck Claudine
Non-Executive Director
181 +3.1%
27.66
US$5,006 		181 +3.1% 27.66 US$5,006
2021-10-13 2021-10-11 B Purchase
2.6
Maccecchini Maria-Luisa

PRESIDENT AND CEO

Executive Director Large shareholder
18,000 +1.9%
27.61
US$496,980 		18,000 +1.9% 27.61 US$496,980
2020-02-05 2020-02-03 B Purchase
0.8
McGroarty Jeffrey Brian

Chief Financial Officer
164 +0.3%
7.17
US$1,176 		164 +0.3% 7.17 US$1,176
2020-02-05 2020-02-03 B Purchase
0.8
McGroarty Jeffrey Brian

Chief Financial Officer
19,336 +58.0%
7.15
US$138,252 		19,336 +58.0% 7.15 US$138,252
2020-02-05 2020-01-31 B Purchase
2.5
Whelan, Jr. Robert M.
25,000 +inf%
6.00
US$150,000 		25,000 +inf% 6.00 US$150,000
2020-02-05 2020-01-31 B Purchase
1.9
White Mark K.
1,734 +inf%
6.00
US$10,404 		1,734 +inf% 6.00 US$10,404
2020-02-05 2020-01-31 B Purchase
0.8
McGroarty Jeffrey Brian

Chief Financial Officer
33,333 +inf%
6.00
US$199,998 		33,333 +inf% 6.00 US$199,998
2020-02-05 2020-01-31 B Purchase
3.6
Hoffman Michael B
Large shareholder
33,333 +233.3%
6.00
US$199,998 		33,333 +233.3% 6.00 US$199,998
2020-02-05 2020-01-31 B Purchase
2.6
Maccecchini Maria-Luisa

President and CEO

Executive Director Large shareholder
1,600 +0.8%
6.00
US$9,600 		1,600 +0.8% 6.00 US$9,600
2020-02-05 2020-01-31 B Purchase
1.4
Bruck Claudine
800 +inf%
6.00
US$4,800 		800 +inf% 6.00 US$4,800
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