United States Biotechnology & Medical Research

Annovis Bio Inc (ANVS)

Annovis Bio Inc. witnessed significant insider trading activity recently, highlighted by a five million dollar purchase from Michael B. Hoffman on November 6, 2026. This acquisition occurred amidst a challenging period for the stock, which has declined over fifty-five percent in ninety days, following the company's latest quarterly results financiers.
Ticker: ANVS Exchange: ASE
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Annovis Bio Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
327.43
Quantity 79,868 -4.3%
Value US$3,854,267
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
187.27
Quantity 952 +14.1%
Value US$3,439,954
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
210.86
Quantity 84,690 +23.0%
Value US$3,136,470
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
1.75
Quantity 2,562 +0.1%
Value US$4,484
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
2.10
Quantity 713,800 +27.7%
Value US$1,498,980
1.9
White Mark K. Director Non-Executive Director
Transaction date
Proposed sale
Price
2.08
Quantity 7,142
Value US$14,848
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.24
Quantity 15,000 +0.6%
Value US$63,600
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.34
Quantity 30,000 +1.2%
Value US$130,194
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.15
Quantity 28,096 +1.1%
Value US$116,598
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.14
Quantity 415 +0.0%
Value US$1,718
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
3.85
Quantity 9,200 +0.4%
Value US$35,420
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
4.13
Quantity 1,489 +0.1%
Value US$6,150
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
3.50
Quantity 10,000 +0.4%
Value US$35,000
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
3.49
Quantity 10,000 +0.4%
Value US$34,900
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
2.11
Quantity 15,000 +0.6%
Value US$31,650
3.6
Hoffman Michael B Non-Executive Director
Transaction date
Purchase
Price
2.05
Quantity 975,610 +65.9%
Value US$2,000,000
2.6
Maccecchini Maria-Luisa President & CEO Executive Director
Transaction date
Purchase
Price
2.05
Quantity 97,561 +8.8%
Value US$200,000
1.9
White Mark K. Non-Executive Director
Transaction date
Purchase
Price
27.40
Quantity 5,000 +9.8%
Value US$137,000
1.4
Bruck Claudine Non-Executive Director
Transaction date
Purchase
Price
27.66
Quantity 181 +3.1%
Value US$5,006
2.6
Maccecchini Maria-Luisa PRESIDENT AND CEO Executive Director Large shareholder
Transaction date
Purchase
Price
27.61
Quantity 18,000 +1.9%
Value US$496,980
0.8
McGroarty Jeffrey Brian Chief Financial Officer
Transaction date
Purchase
Price
7.17
Quantity 164 +0.3%
Value US$1,176
0.8
McGroarty Jeffrey Brian Chief Financial Officer
Transaction date
Purchase
Price
7.15
Quantity 19,336 +58.0%
Value US$138,252
1.9
White Mark K.
Transaction date
Purchase
Price
6.00
Quantity 1,734 New position
Value US$10,404
0.8
McGroarty Jeffrey Brian Chief Financial Officer
Transaction date
Purchase
Price
6.00
Quantity 33,333 New position
Value US$199,998
3.6
Hoffman Michael B Large shareholder
Transaction date
Purchase
Price
6.00
Quantity 33,333 +233.3%
Value US$199,998
2.6
Maccecchini Maria-Luisa President and CEO Executive Director Large shareholder
Transaction date
Purchase
Price
6.00
Quantity 1,600 +0.8%
Value US$9,600
1.4
Bruck Claudine
Transaction date
Purchase
Price
6.00
Quantity 800 New position
Value US$4,800
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-11-06 2026-11-06 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
79,868 -4.3%
327.43
US$3,854,267 		79,868 -4.3% 327.43 US$3,854,267
2026-05-21 2026-05-20 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
952 +14.1%
187.27
US$3,439,954 		952 +14.1% 187.27 US$3,439,954
2026-05-21 2026-05-20 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
84,690 +23.0%
210.86
US$3,136,470 		84,690 +23.0% 210.86 US$3,136,470
2026-05-21 2026-05-20 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
2,562 +0.1%
1.75
US$4,484 		2,562 +0.1% 1.75 US$4,484
2026-04-03 2026-04-02 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
713,800 +27.7%
2.10
US$1,498,980 		713,800 +27.7% 2.10 US$1,498,980
2026-04-02 2026-04-02 PrS Proposed sale
1.9
White Mark K.

Director

Non-Executive Director
7,142
2.08
US$14,848 		7,142 2.08 US$14,848
2025-12-08 2025-12-08 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
15,000 +0.6%
4.24
US$63,600 		15,000 +0.6% 4.24 US$63,600
2025-12-08 2025-12-08 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
30,000 +1.2%
4.34
US$130,194 		30,000 +1.2% 4.34 US$130,194
2025-11-25 2025-11-24 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
28,096 +1.1%
4.15
US$116,598 		28,096 +1.1% 4.15 US$116,598
2025-11-25 2025-11-24 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
415 +0.0%
4.14
US$1,718 		415 +0.0% 4.14 US$1,718
2025-11-25 2025-11-24 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
9,200 +0.4%
3.85
US$35,420 		9,200 +0.4% 3.85 US$35,420
2025-11-25 2025-11-24 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
1,489 +0.1%
4.13
US$6,150 		1,489 +0.1% 4.13 US$6,150
2025-11-21 2025-11-21 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
10,000 +0.4%
3.50
US$35,000 		10,000 +0.4% 3.50 US$35,000
2025-11-21 2025-11-21 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
10,000 +0.4%
3.49
US$34,900 		10,000 +0.4% 3.49 US$34,900
2025-11-18 2025-11-14 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
15,000 +0.6%
2.11
US$31,650 		15,000 +0.6% 2.11 US$31,650
2025-11-12 2025-10-28 B Purchase
3.6
Hoffman Michael B
Non-Executive Director
975,610 +65.9%
2.05
US$2,000,000 		975,610 +65.9% 2.05 US$2,000,000
2025-11-12 2025-10-28 B Purchase
2.6
Maccecchini Maria-Luisa

President & CEO

Executive Director
97,561 +8.8%
2.05
US$200,000 		97,561 +8.8% 2.05 US$200,000
2021-10-13 2021-10-12 B Purchase
1.9
White Mark K.
Non-Executive Director
5,000 +9.8%
27.40
US$137,000 		5,000 +9.8% 27.40 US$137,000
2021-10-13 2021-10-11 B Purchase
1.4
Bruck Claudine
Non-Executive Director
181 +3.1%
27.66
US$5,006 		181 +3.1% 27.66 US$5,006
2021-10-13 2021-10-11 B Purchase
2.6
Maccecchini Maria-Luisa

PRESIDENT AND CEO

Executive Director Large shareholder
18,000 +1.9%
27.61
US$496,980 		18,000 +1.9% 27.61 US$496,980
2020-02-05 2020-02-03 B Purchase
0.8
McGroarty Jeffrey Brian

Chief Financial Officer
164 +0.3%
7.17
US$1,176 		164 +0.3% 7.17 US$1,176
2020-02-05 2020-02-03 B Purchase
0.8
McGroarty Jeffrey Brian

Chief Financial Officer
19,336 +58.0%
7.15
US$138,252 		19,336 +58.0% 7.15 US$138,252
2020-02-05 2020-01-31 B Purchase
2.5
Whelan, Jr. Robert M.
25,000 New position
6.00
US$150,000 		25,000 New position 6.00 US$150,000
2020-02-05 2020-01-31 B Purchase
1.9
White Mark K.
1,734 New position
6.00
US$10,404 		1,734 New position 6.00 US$10,404
2020-02-05 2020-01-31 B Purchase
0.8
McGroarty Jeffrey Brian

Chief Financial Officer
33,333 New position
6.00
US$199,998 		33,333 New position 6.00 US$199,998
2020-02-05 2020-01-31 B Purchase
3.6
Hoffman Michael B
Large shareholder
33,333 +233.3%
6.00
US$199,998 		33,333 +233.3% 6.00 US$199,998
2020-02-05 2020-01-31 B Purchase
2.6
Maccecchini Maria-Luisa

President and CEO

Executive Director Large shareholder
1,600 +0.8%
6.00
US$9,600 		1,600 +0.8% 6.00 US$9,600
2020-02-05 2020-01-31 B Purchase
1.4
Bruck Claudine
800 New position
6.00
US$4,800 		800 New position 6.00 US$4,800
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