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United States Biotechnology & Medical Research

Annovis Bio Inc (ANVS)

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Over the last 90 days, Annovis Bio Inc. has seen significant insider buying, totaling $1.64 million, with a net buy value of $1.63 million. Michael B. Hoffman was the primary buyer, acquiring shares across multiple transactions. A single proposed sale by Director Mark K. White for $14,848 was also noted. The company's stock has declined 19.1% in the past 90 days.
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Ticker: ANVS Exchange: ASE
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
Hoffman Michael B
3 purchases — total 142,779 USD
Buy 20 May 2026
Value US$3,439,954.33 | Price 187.27 | Shares 952
Buy 20 May 2026
Value US$3,136,470.12 | Price 210.86 | Shares 84,690
Buy 20 May 2026
Value US$4,483.50 | Price 1.75 | Shares 2,562
Buy 2 Apr 2026
Value US$2,487,986.53 | Price 203.72 | Shares 90,657
Proposed sale 2 Apr 2026
Value US$14,848.00 | Price 2.08 | Shares 7,142
Buy 8 Dec 2025
Value US$63,600.00 | Price 4.24 | Shares 15,000
Buy 8 Dec 2025
Value US$130,194.00 | Price 4.34 | Shares 30,000
Buy 24 Nov 2025
Value US$116,598.40 | Price 4.15 | Shares 28,096
Buy 24 Nov 2025
Value US$1,718.10 | Price 4.14 | Shares 415
Buy 24 Nov 2025
Value US$35,420.00 | Price 3.85 | Shares 9,200
Buy 24 Nov 2025
Value US$6,149.57 | Price 4.13 | Shares 1,489
Buy 21 Nov 2025
Value US$35,000.00 | Price 3.50 | Shares 10,000
Buy 21 Nov 2025
Value US$34,900.00 | Price 3.49 | Shares 10,000
Buy 14 Nov 2025
Value US$31,650.00 | Price 2.11 | Shares 15,000
Buy 28 Oct 2025
Value US$2,000,000.50 | Price 2.05 | Shares 975,610
Buy 28 Oct 2025
Value US$200,000.05 | Price 2.05 | Shares 97,561
Buy 12 Oct 2021
Value US$137,000.00 | Price 27.40 | Shares 5,000
Buy 11 Oct 2021
Value US$5,006.46 | Price 27.66 | Shares 181
Buy 11 Oct 2021
Value US$496,980.00 | Price 27.61 | Shares 18,000
Buy 3 Feb 2020
Value US$1,175.88 | Price 7.17 | Shares 164
Buy 3 Feb 2020
Value US$138,252.40 | Price 7.15 | Shares 19,336
Buy 31 Jan 2020
Value US$150,000.00 | Price 6.00 | Shares 25,000
Buy 31 Jan 2020
Value US$10,404.00 | Price 6.00 | Shares 1,734
Buy 31 Jan 2020
Value US$199,998.00 | Price 6.00 | Shares 33,333
Buy 31 Jan 2020
Value US$199,998.00 | Price 6.00 | Shares 33,333
Buy 31 Jan 2020
Value US$9,600.00 | Price 6.00 | Shares 1,600
Buy 31 Jan 2020
Value US$4,800.00 | Price 6.00 | Shares 800
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-05-21 2026-05-20 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
952 +14.1%
187.27
US$3,439,954 		952 +14.1% 187.27 US$3,439,954
2026-05-21 2026-05-20 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
84,690 +23.0%
210.86
US$3,136,470 		84,690 +23.0% 210.86 US$3,136,470
2026-05-21 2026-05-20 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
68,036 -1.9%
281.26
US$1,204,767 		68,036 -1.9% 281.26 US$1,204,767
2026-04-03 2026-04-02 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
713,800 +27.7%
2.10
US$1,498,980 		713,800 +27.7% 2.10 US$1,498,980
2026-04-02 2026-04-02 PrS Proposed sale
1.9
White Mark K.

Director

Non-Executive Director
7,142
2.08
US$14,848 		7,142 2.08 US$14,848
2025-12-08 2025-12-08 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
15,000 +0.6%
4.24
US$63,600 		15,000 +0.6% 4.24 US$63,600
2025-12-08 2025-12-08 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
30,000 +1.2%
4.34
US$130,194 		30,000 +1.2% 4.34 US$130,194
2025-11-25 2025-11-24 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
28,096 +1.1%
4.15
US$116,598 		28,096 +1.1% 4.15 US$116,598
2025-11-25 2025-11-24 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
415 +0.0%
4.14
US$1,718 		415 +0.0% 4.14 US$1,718
2025-11-25 2025-11-24 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
9,200 +0.4%
3.85
US$35,420 		9,200 +0.4% 3.85 US$35,420
2025-11-25 2025-11-24 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
1,489 +0.1%
4.13
US$6,150 		1,489 +0.1% 4.13 US$6,150
2025-11-21 2025-11-21 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
10,000 +0.4%
3.50
US$35,000 		10,000 +0.4% 3.50 US$35,000
2025-11-21 2025-11-21 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
10,000 +0.4%
3.49
US$34,900 		10,000 +0.4% 3.49 US$34,900
2025-11-18 2025-11-14 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
15,000 +0.6%
2.11
US$31,650 		15,000 +0.6% 2.11 US$31,650
2025-11-12 2025-10-28 B Purchase
3.9
Hoffman Michael B
Non-Executive Director
975,610 +65.9%
2.05
US$2,000,000 		975,610 +65.9% 2.05 US$2,000,000
2025-11-12 2025-10-28 B Purchase
2.6
Maccecchini Maria-Luisa

President & CEO

Executive Director
97,561 +8.8%
2.05
US$200,000 		97,561 +8.8% 2.05 US$200,000
2021-10-13 2021-10-12 B Purchase
1.9
White Mark K.
Non-Executive Director
5,000 +9.8%
27.40
US$137,000 		5,000 +9.8% 27.40 US$137,000
2021-10-13 2021-10-11 B Purchase
1.4
Bruck Claudine
Non-Executive Director
181 +3.1%
27.66
US$5,006 		181 +3.1% 27.66 US$5,006
2021-10-13 2021-10-11 B Purchase
2.6
Maccecchini Maria-Luisa

PRESIDENT AND CEO

Executive Director Large shareholder
18,000 +1.9%
27.61
US$496,980 		18,000 +1.9% 27.61 US$496,980
2020-02-05 2020-02-03 B Purchase
0.8
McGroarty Jeffrey Brian

Chief Financial Officer
164 +0.3%
7.17
US$1,176 		164 +0.3% 7.17 US$1,176
2020-02-05 2020-02-03 B Purchase
0.8
McGroarty Jeffrey Brian

Chief Financial Officer
19,336 +58.0%
7.15
US$138,252 		19,336 +58.0% 7.15 US$138,252
2020-02-05 2020-01-31 B Purchase
2.5
Whelan, Jr. Robert M.
25,000 +inf%
6.00
US$150,000 		25,000 +inf% 6.00 US$150,000
2020-02-05 2020-01-31 B Purchase
1.9
White Mark K.
1,734 +inf%
6.00
US$10,404 		1,734 +inf% 6.00 US$10,404
2020-02-05 2020-01-31 B Purchase
0.8
McGroarty Jeffrey Brian

Chief Financial Officer
33,333 +inf%
6.00
US$199,998 		33,333 +inf% 6.00 US$199,998
2020-02-05 2020-01-31 B Purchase
3.9
Hoffman Michael B
Large shareholder
33,333 +233.3%
6.00
US$199,998 		33,333 +233.3% 6.00 US$199,998
2020-02-05 2020-01-31 B Purchase
2.6
Maccecchini Maria-Luisa

President and CEO

Executive Director Large shareholder
1,600 +0.8%
6.00
US$9,600 		1,600 +0.8% 6.00 US$9,600
2020-02-05 2020-01-31 B Purchase
1.4
Bruck Claudine
800 +inf%
6.00
US$4,800 		800 +inf% 6.00 US$4,800
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