Canada Biotechnology & Medical Research

Milestone Pharmaceuticals Inc (MIST)

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Milestone Pharmaceuticals Inc. experienced multiple divestments by key executives, including the CEO, throughout early 2026. The most recent insider trading activity occurred on April 16, 2026, involving significant share sales by Joseph Oliveto. These transactions represent a consistent pattern of equity liquidation by leadership personnel over the observed period.
Ticker: MIST Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Sale
Price
40.06
Quantity 42,079 +1.3%
Value US$520,932
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Sale
Price
345.29
Quantity 61,649 +32.3%
Value US$2,755,094
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Sale
Price
239.94
Quantity 40,988 +19.4%
Value US$3,715,194
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Sale
Price
2.26
Quantity 2,360 -0.8%
Value US$5,322
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Sale
Price
2.25
Quantity 11,556 -3.8%
Value US$26,001
3.5
Oliveto Joseph President and CEO Executive Director
Transaction date
Planned sale
Price
2.26
Quantity 36,500 -7.6%
Value US$82,490
3.5
JOSEPH OLIVETO Director; Officer Executive Director
Transaction date
Proposed sale
Price
2.20
Quantity 36,500
Value US$80,300
3.5
Nelson Jeffrey Edward Chief Operating Officer Officer
Transaction date
Sale
Price
1.93
Quantity 12,245 -19.7%
Value US$23,633
2.0
Bharucha David Chief Medical Officer Officer
Transaction date
Sale
Price
1.93
Quantity 12,245 -9.8%
Value US$23,633
3.5
Hasija Amit CFO & EVP of Corp. Development Officer
Transaction date
Sale
Price
1.93
Quantity 12,245 -10.9%
Value US$23,633
3.5
Oliveto Joseph President and CEO Executive Director
Transaction date
Sale
Price
1.93
Quantity 34,523 -6.7%
Value US$66,629
3.5
Muller Lorenz Chief Commercial Officer Officer
Transaction date
Sale
Price
1.93
Quantity 11,180 -5.2%
Value US$21,577
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Sale
Price
2.27
Quantity 448 -0.1%
Value CA$1,015
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Sale
Price
2.26
Quantity 13,352 -4.2%
Value CA$30,176
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Sale
Price
2.26
Quantity 1,449 -0.5%
Value CA$3,267
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Sale
Price
2.25
Quantity 27,751 -8.0%
Value CA$62,440
3.5
Oliveto Joseph President and CEO Executive Director
Transaction date
Planned sale
Price
2.25
Quantity 43,000 -12.4%
Value US$96,750
3.5
JOSEPH OLIVETO Director; Officer Executive Director
Transaction date
Proposed sale
Price
2.15
Quantity 79,500
Value US$170,925
3.5
Oliveto Joseph President and CEO Executive Director
Transaction date
Planned sale
Price
2.25
Quantity 500 -0.1%
Value US$1,125
3.5
JOSEPH OLIVETO Officer Officer
Transaction date
Proposed sale
Price
2.05
Quantity 500
Value US$1,025
3.5
Nelson Jeffrey Edward Chief Operating Officer Officer
Transaction date
Sale
Price
2.32
Quantity 58,007 -58.0%
Value US$134,576
2.0
Bharucha David Chief Medical Officer Officer
Transaction date
Sale
Price
2.32
Quantity 58,007 -35.5%
Value US$134,576
3.5
Hasija Amit CFO & EVP of Corp. Development Officer
Transaction date
Sale
Price
2.32
Quantity 58,007 -38.7%
Value US$134,576
3.5
Oliveto Joseph President and CEO Executive Director
Transaction date
Sale
Price
2.32
Quantity 133,054 -22.8%
Value US$308,685
3.5
Muller Lorenz Chief Commercial Officer Officer
Transaction date
Sale
Price
2.32
Quantity 53,566 -21.4%
Value US$124,273
2.5
Wills, Robert James Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
1.50
Quantity 50,000 +333.3%
Value US$75,000
3.1
Papa, Joseph Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
1.50
Quantity 100,000
Value US$150,000
3.8
Oliveto, Joseph Gerard Director of Issuer, Senior Officer of Issuer Executive Director
Transaction date
Purchase
Price
1.50
Quantity 66,666 +23.8%
Value US$99,999
3.0
Muller, Lorenz Andrew Senior Officer of Issuer Officer
Transaction date
Purchase
Price
1.50
Quantity 66,666 +50.0%
Value US$99,999
3.1
Hasija, Amit Senior Officer of Issuer Officer
Transaction date
Purchase
Price
1.50
Quantity 50,000
Value US$75,000
3.1
Bharucha, David Senior Officer of Issuer Officer
Transaction date
Purchase
Price
1.50
Quantity 53,333 +533.3%
Value US$80,000
3.0
Muller, Lorenz Andrew Senior Officer of Issuer Officer
Transaction date
Purchase
Price
3.80
Quantity 5,500 +4.3%
Value US$20,892
3.0
Muller, Lorenz Andrew Senior Officer of Issuer Officer
Transaction date
Purchase
Price
3.79
Quantity 7,000 +5.8%
Value US$26,498
3.0
Muller, Lorenz Andrew Senior Officer of Issuer Officer
Transaction date
Purchase
Price
3.73
Quantity 5,500 +4.8%
Value US$20,514
3.0
Muller, Lorenz Andrew Senior Officer of Issuer Officer
Transaction date
Purchase
Price
3.72
Quantity 7,000 +6.5%
Value US$26,024
2.0
Bharucha David Chief Medical Officer Officer
Transaction date
Purchase
Price
4.69
Quantity 7,000 +233.3%
Value US$32,830
2.0
Bharucha David Chief Medical Officer Officer
Transaction date
Purchase
Price
4.86
Quantity 3,000 +inf%
Value US$14,580
0.9
Liebert, Debra Kay Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.26
Quantity 4,000
Value US$21,040
0.9
Liebert Debra K. Non-Executive Director
Transaction date
Purchase
Price
5.26
Quantity 4,000 +inf%
Value US$21,040
0.6
Pasternak, Richard C. Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.07
Quantity 200 +2.0%
Value US$1,013
0.6
Pasternak, Richard C. Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.17
Quantity 300 +3.2%
Value US$1,551
0.6
Pasternak, Richard C. Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.10
Quantity 368 +4.0%
Value US$1,877
0.6
Pasternak, Richard C. Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.12
Quantity 300 +3.4%
Value US$1,536
0.6
Pasternak, Richard C. Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.16
Quantity 100 +1.1%
Value US$516
0.6
Pasternak, Richard C. Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.11
Quantity 700 +8.7%
Value US$3,577
0.6
Pasternak, Richard C. Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.20
Quantity 1,732 +27.5%
Value US$9,006
0.6
Pasternak, Richard C. Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.18
Quantity 700 +12.5%
Value US$3,626
0.6
Pasternak, Richard C. Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.24
Quantity 5,600
Value US$29,344
0.9
Liebert, Debra Kay Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.24
Quantity 600 +6.4%
Value US$3,144
0.9
Liebert, Debra Kay Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.27
Quantity 400 +4.4%
Value US$2,108
0.9
Liebert, Debra Kay Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.26
Quantity 45 +0.5%
Value US$237
0.9
Liebert, Debra Kay Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.28
Quantity 2,655 +42.1%
Value US$14,018
0.9
Liebert, Debra Kay Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.29
Quantity 105 +1.7%
Value US$555
0.9
Liebert, Debra Kay Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.30
Quantity 6,195
Value US$32,834
0.6
Pasternak Richard C Non-Executive Director
Transaction date
Purchase
Price
5.20
Quantity 10,000 +inf%
Value US$52,000
0.9
Liebert Debra K. Non-Executive Director
Transaction date
Purchase
Price
5.29
Quantity 10,000 +inf%
Value US$52,900
0.6
Tomsicek, Michael John Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.32
Quantity 15,000
Value US$79,857
0.6
TOMSICEK MICHAEL JOHN Non-Executive Director
Transaction date
Purchase
Price
5.32
Quantity 15,000 +inf%
Value US$79,800
1.8
Wills Robert James Non-Executive Director
Transaction date
Purchase
Price
4.93
Quantity 15,000 +inf%
Value US$73,950
2.5
Wills, Robert James Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
4.93
Quantity 15,000
Value US$73,918
2.7
RTW INVESTMENTS, LP Large shareholder
Transaction date
Sale
Price
8.71
Quantity 1,557,346 -26.5%
Value US$13,564,484
2.7
RTW INVESTMENTS, LP Large shareholder
Transaction date
Purchase
Price
8.71
Quantity 1,557,346 +56.5%
Value US$13,564,484
Truex, Paul Francis Director of Issuer Non-Executive Director
Transaction date
Purchase
Price
5.60
Quantity 5,000 +6.5%
Value US$28,000
3.2
TRUEX PAUL F Non-Executive Director
Transaction date
Purchase
Price
5.60
Quantity 5,000 +6.5%
Value US$28,000
2.7
RTW INVESTMENTS, LP Large shareholder
Transaction date
Purchase
Price
10.87
Quantity 5,870 +0.1%
Value US$63,804
2.7
RTW INVESTMENTS, LP Large shareholder
Transaction date
Purchase
Price
10.36
Quantity 2,705 +0.1%
Value US$28,029
2.7
RTW INVESTMENTS, LP Large shareholder
Transaction date
Purchase
Price
18.95
Quantity 78,263 +1.9%
Value US$1,483,084
2.7
RTW INVESTMENTS, LP Large shareholder
Transaction date
Purchase
Price
16.25
Quantity 270,000 +6.8%
Value US$4,387,500
2.7
RTW INVESTMENTS, LP Large shareholder
Transaction date
Purchase
Price
15.50
Quantity 21,438 +0.5%
Value US$332,340
2.7
RTW INVESTMENTS, LP Large shareholder
Transaction date
Purchase
Price
15.48
Quantity 1,333 +0.0%
Value US$20,638
2.3
Novo Holdings A/S SEE REMARKS Large shareholder
Transaction date
Sale
Price
16.00
Quantity 240,000 -9.0%
Value US$3,840,000
RTW INVESTMENTS, LP Large shareholder
Transaction date
Purchase
Price
16.00
Quantity 400,000 +11.3%
Value US$6,400,000
2.7
RTW INVESTMENTS, LP Large shareholder
Transaction date
Purchase
Price
18.00
Quantity 1,100 +0.0%
Value US$19,800
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-04-20 2026-04-16 S Sale
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
42,079 +1.3%
40.06
US$520,932 		42,079 +1.3% 40.06 US$520,932
2026-04-20 2026-04-16 S Sale
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
61,649 +32.3%
345.29
US$2,755,094 		61,649 +32.3% 345.29 US$2,755,094
2026-04-20 2026-04-16 S Sale
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
40,988 +19.4%
239.94
US$3,715,194 		40,988 +19.4% 239.94 US$3,715,194
2026-04-20 2026-04-16 S Sale
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
2,360 -0.8%
2.26
US$5,322 		2,360 -0.8% 2.26 US$5,322
2026-04-20 2026-04-16 S Sale
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
11,556 -3.8%
2.25
US$26,001 		11,556 -3.8% 2.25 US$26,001
2026-04-20 2026-04-16 PlS Planned sale
3.5
Oliveto Joseph

President and CEO

Executive Director
36,500 -7.6%
2.26
US$82,490 		36,500 -7.6% 2.26 US$82,490
2026-04-16 2026-04-16 PrS Proposed sale
3.5
JOSEPH OLIVETO

Director; Officer

Executive Director
36,500
2.20
US$80,300 		36,500 2.20 US$80,300
2026-01-28 2026-01-26 S Sale
3.5
Nelson Jeffrey Edward

Chief Operating Officer

Officer
12,245 -19.7%
1.93
US$23,633 		12,245 -19.7% 1.93 US$23,633
2026-01-28 2026-01-26 S Sale
2.0
Bharucha David

Chief Medical Officer

Officer
12,245 -9.8%
1.93
US$23,633 		12,245 -9.8% 1.93 US$23,633
2026-01-28 2026-01-26 S Sale
3.5
Hasija Amit

CFO & EVP of Corp. Development

Officer
12,245 -10.9%
1.93
US$23,633 		12,245 -10.9% 1.93 US$23,633
2026-01-28 2026-01-26 S Sale
3.5
Oliveto Joseph

President and CEO

Executive Director
34,523 -6.7%
1.93
US$66,629 		34,523 -6.7% 1.93 US$66,629
2026-01-28 2026-01-26 S Sale
3.5
Muller Lorenz

Chief Commercial Officer

Officer
11,180 -5.2%
1.93
US$21,577 		11,180 -5.2% 1.93 US$21,577
2026-01-09 2026-01-08 S Sale
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
448 -0.1%
2.27
CA$1,015 		448 -0.1% 2.27 CA$1,015
2026-01-09 2026-01-08 S Sale
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
13,352 -4.2%
2.26
CA$30,176 		13,352 -4.2% 2.26 CA$30,176
2026-01-09 2026-01-08 S Sale
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
1,449 -0.5%
2.26
CA$3,267 		1,449 -0.5% 2.26 CA$3,267
2026-01-09 2026-01-08 S Sale
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
27,751 -8.0%
2.25
CA$62,440 		27,751 -8.0% 2.25 CA$62,440
2026-01-09 2026-01-08 PlS Planned sale
3.5
Oliveto Joseph

President and CEO

Executive Director
43,000 -12.4%
2.25
US$96,750 		43,000 -12.4% 2.25 US$96,750
2026-01-08 2026-01-08 PrS Proposed sale
3.5
JOSEPH OLIVETO

Director; Officer

Executive Director
79,500
2.15
US$170,925 		79,500 2.15 US$170,925
2026-01-09 2026-01-07 PlS Planned sale
3.5
Oliveto Joseph

President and CEO

Executive Director
500 -0.1%
2.25
US$1,125 		500 -0.1% 2.25 US$1,125
2026-01-07 2026-01-07 PrS Proposed sale
3.5
JOSEPH OLIVETO

Officer

Officer
500
2.05
US$1,025 		500 2.05 US$1,025
2026-01-28 2025-12-15 S Sale
3.5
Nelson Jeffrey Edward

Chief Operating Officer

Officer
58,007 -58.0%
2.32
US$134,576 		58,007 -58.0% 2.32 US$134,576
2026-01-28 2025-12-15 S Sale
2.0
Bharucha David

Chief Medical Officer

Officer
58,007 -35.5%
2.32
US$134,576 		58,007 -35.5% 2.32 US$134,576
2026-01-28 2025-12-15 S Sale
3.5
Hasija Amit

CFO & EVP of Corp. Development

Officer
58,007 -38.7%
2.32
US$134,576 		58,007 -38.7% 2.32 US$134,576
2026-01-28 2025-12-15 S Sale
3.5
Oliveto Joseph

President and CEO

Executive Director
133,054 -22.8%
2.32
US$308,685 		133,054 -22.8% 2.32 US$308,685
2026-01-28 2025-12-15 S Sale
3.5
Muller Lorenz

Chief Commercial Officer

Officer
53,566 -21.4%
2.32
US$124,273 		53,566 -21.4% 2.32 US$124,273
2025-07-15 2025-07-11 B Purchase
2.5
Wills, Robert James

Director of Issuer

Non-Executive Director
50,000 +333.3%
1.50
US$75,000 		50,000 +333.3% 1.50 US$75,000
2025-07-15 2025-07-11 B Purchase
3.1
Papa, Joseph

Director of Issuer

Non-Executive Director
100,000
1.50
US$150,000 		100,000 1.50 US$150,000
2025-07-15 2025-07-11 B Purchase
3.8
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
66,666 +23.8%
1.50
US$99,999 		66,666 +23.8% 1.50 US$99,999
2025-07-15 2025-07-11 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
66,666 +50.0%
1.50
US$99,999 		66,666 +50.0% 1.50 US$99,999
2025-07-15 2025-07-11 B Purchase
3.1
Hasija, Amit

Senior Officer of Issuer

Officer
50,000
1.50
US$75,000 		50,000 1.50 US$75,000
2025-07-15 2025-07-11 B Purchase
3.1
Bharucha, David

Senior Officer of Issuer

Officer
53,333 +533.3%
1.50
US$80,000 		53,333 +533.3% 1.50 US$80,000
2023-04-28 2023-04-27 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
5,500 +4.3%
3.80
US$20,892 		5,500 +4.3% 3.80 US$20,892
2023-04-28 2023-04-27 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
7,000 +5.8%
3.79
US$26,498 		7,000 +5.8% 3.79 US$26,498
2023-04-28 2023-04-27 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
5,500 +4.8%
3.73
US$20,514 		5,500 +4.8% 3.73 US$20,514
2023-04-28 2023-04-27 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
7,000 +6.5%
3.72
US$26,024 		7,000 +6.5% 3.72 US$26,024
2022-12-05 2022-12-05 B Purchase
2.0
Bharucha David

Chief Medical Officer

Officer
7,000 +233.3%
4.69
US$32,830 		7,000 +233.3% 4.69 US$32,830
2022-12-05 2022-12-01 B Purchase
2.0
Bharucha David

Chief Medical Officer

Officer
3,000 +inf%
4.86
US$14,580 		3,000 +inf% 4.86 US$14,580
2022-10-21 2022-10-21 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
4,000
5.26
US$21,040 		4,000 5.26 US$21,040
2022-10-21 2022-10-21 B Purchase
0.9
Liebert Debra K.
Non-Executive Director
4,000 +inf%
5.26
US$21,040 		4,000 +inf% 5.26 US$21,040
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
200 +2.0%
5.07
US$1,013 		200 +2.0% 5.07 US$1,013
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
300 +3.2%
5.17
US$1,551 		300 +3.2% 5.17 US$1,551
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
368 +4.0%
5.10
US$1,877 		368 +4.0% 5.10 US$1,877
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
300 +3.4%
5.12
US$1,536 		300 +3.4% 5.12 US$1,536
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
100 +1.1%
5.16
US$516 		100 +1.1% 5.16 US$516
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
700 +8.7%
5.11
US$3,577 		700 +8.7% 5.11 US$3,577
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
1,732 +27.5%
5.20
US$9,006 		1,732 +27.5% 5.20 US$9,006
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
700 +12.5%
5.18
US$3,626 		700 +12.5% 5.18 US$3,626
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
5,600
5.24
US$29,344 		5,600 5.24 US$29,344
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
600 +6.4%
5.24
US$3,144 		600 +6.4% 5.24 US$3,144
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
400 +4.4%
5.27
US$2,108 		400 +4.4% 5.27 US$2,108
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
45 +0.5%
5.26
US$237 		45 +0.5% 5.26 US$237
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
2,655 +42.1%
5.28
US$14,018 		2,655 +42.1% 5.28 US$14,018
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
105 +1.7%
5.29
US$555 		105 +1.7% 5.29 US$555
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
6,195
5.30
US$32,834 		6,195 5.30 US$32,834
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak Richard C
Non-Executive Director
10,000 +inf%
5.20
US$52,000 		10,000 +inf% 5.20 US$52,000
2022-10-21 2022-10-20 B Purchase
0.9
Liebert Debra K.
Non-Executive Director
10,000 +inf%
5.29
US$52,900 		10,000 +inf% 5.29 US$52,900
2022-10-21 2022-10-19 B Purchase
0.6
Tomsicek, Michael John

Director of Issuer

Non-Executive Director
15,000
5.32
US$79,857 		15,000 5.32 US$79,857
2022-10-21 2022-10-19 B Purchase
0.6
TOMSICEK MICHAEL JOHN
Non-Executive Director
15,000 +inf%
5.32
US$79,800 		15,000 +inf% 5.32 US$79,800
2022-10-21 2022-10-19 B Purchase
1.8
Wills Robert James
Non-Executive Director
15,000 +inf%
4.93
US$73,950 		15,000 +inf% 4.93 US$73,950
2022-10-19 2022-10-19 B Purchase
2.5
Wills, Robert James

Director of Issuer

Non-Executive Director
15,000
4.93
US$73,918 		15,000 4.93 US$73,918
2022-09-09 2022-09-07 S Sale
2.7
RTW INVESTMENTS, LP
Large shareholder
1,557,346 -26.5%
8.71
US$13,564,484 		1,557,346 -26.5% 8.71 US$13,564,484
2022-09-09 2022-09-07 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
1,557,346 +56.5%
8.71
US$13,564,484 		1,557,346 +56.5% 8.71 US$13,564,484
2022-06-01 2022-05-31 B Purchase
Truex, Paul Francis

Director of Issuer

Non-Executive Director
5,000 +6.5%
5.60
US$28,000 		5,000 +6.5% 5.60 US$28,000
2022-06-01 2022-05-31 B Purchase
3.2
TRUEX PAUL F
Non-Executive Director
5,000 +6.5%
5.60
US$28,000 		5,000 +6.5% 5.60 US$28,000
2020-07-30 2020-07-29 S Sale
3.8
FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC
Large shareholder
500,000 -18.1%
8.32
US$4,160,000 		500,000 -18.1% 8.32 US$4,160,000
2020-07-30 2020-07-28 S Sale
3.8
FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC
Large shareholder
19,863 -0.7%
8.10
US$160,890 		19,863 -0.7% 8.10 US$160,890
2020-03-19 2020-03-19 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
5,870 +0.1%
10.87
US$63,804 		5,870 +0.1% 10.87 US$63,804
2020-03-19 2020-03-18 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
2,705 +0.1%
10.36
US$28,029 		2,705 +0.1% 10.36 US$28,029
2020-03-19 2020-03-02 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
78,263 +1.9%
18.95
US$1,483,084 		78,263 +1.9% 18.95 US$1,483,084
2020-01-13 2020-01-13 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
270,000 +6.8%
16.25
US$4,387,500 		270,000 +6.8% 16.25 US$4,387,500
2020-01-02 2019-12-31 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
21,438 +0.5%
15.50
US$332,340 		21,438 +0.5% 15.50 US$332,340
2020-01-02 2019-12-30 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
1,333 +0.0%
15.48
US$20,638 		1,333 +0.0% 15.48 US$20,638
2019-11-27 2019-11-25 S Sale
2.3
Novo Holdings A/S

SEE REMARKS

Large shareholder
240,000 -9.0%
16.00
US$3,840,000 		240,000 -9.0% 16.00 US$3,840,000
2019-11-22 2019-11-20 B Purchase RTW INVESTMENTS, LP Large shareholder
400,000 +11.3%
16.00
US$6,400,000 		400,000 +11.3% 16.00 US$6,400,000
2019-10-15 2019-10-15 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
1,100 +0.0%
18.00
US$19,800 		1,100 +0.0% 18.00 US$19,800
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