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United States Biotechnology & Medical Research

Milestone Pharmaceuticals Inc (MIST)

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Over the last 90 days, Milestone Pharmaceuticals Inc. has seen significant insider selling, with a net value of -$824,366.40. A total of 7 transactions were recorded, all of which were sales. The company's stock has experienced a 24.9% decrease in price over the same period. The last earnings report indicated a significant miss.
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Ticker: MIST Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
Oliveto, Joseph Gerard
Director of Issuer, Senior Officer of Issuer
5 sales — total 82,437 USD
Sale 16 Apr 2026
Value US$520,932.28 | Price 40.06 | Shares 42,079
Sale 16 Apr 2026
Value US$2,755,093.53 | Price 345.29 | Shares 61,649
Sale 16 Apr 2026
Value US$37,479.84 | Price 2.26 | Shares 16,584
Sale 16 Apr 2026
Value US$5,321.80 | Price 2.26 | Shares 2,360
Sale 16 Apr 2026
Value US$26,001.00 | Price 2.25 | Shares 11,556
Planned sale 16 Apr 2026
Value US$3,998,385.81 | Price 224.24 | Shares 62,275
Proposed sale 16 Apr 2026
Value US$80,300.00 | Price 2.20 | Shares 36,500
Sale 26 Jan 2026
Value US$23,632.85 | Price 1.93 | Shares 12,245
Sale 26 Jan 2026
Value US$23,632.85 | Price 1.93 | Shares 12,245
Sale 26 Jan 2026
Value US$23,632.85 | Price 1.93 | Shares 12,245
Sale 26 Jan 2026
Value US$66,629.39 | Price 1.93 | Shares 34,523
Sale 26 Jan 2026
Value US$21,577.40 | Price 1.93 | Shares 11,180
Sale 8 Jan 2026
Value CA$1,014.72 | Price 2.27 | Shares 448
Sale 8 Jan 2026
Value CA$30,175.52 | Price 2.26 | Shares 13,352
Sale 8 Jan 2026
Value CA$3,267.50 | Price 2.26 | Shares 1,449
Sale 8 Jan 2026
Value CA$62,439.75 | Price 2.25 | Shares 27,751
Planned sale 8 Jan 2026
Value US$96,750.00 | Price 2.25 | Shares 43,000
Proposed sale 8 Jan 2026
Value US$170,925.00 | Price 2.15 | Shares 79,500
Planned sale 7 Jan 2026
Value US$1,125.00 | Price 2.25 | Shares 500
Proposed sale 7 Jan 2026
Value US$1,025.00 | Price 2.05 | Shares 500
Sale 15 Dec 2025
Value US$134,576.24 | Price 2.32 | Shares 58,007
Sale 15 Dec 2025
Value US$134,576.24 | Price 2.32 | Shares 58,007
Sale 15 Dec 2025
Value US$134,576.24 | Price 2.32 | Shares 58,007
Sale 15 Dec 2025
Value US$308,685.28 | Price 2.32 | Shares 133,054
Sale 15 Dec 2025
Value US$124,273.12 | Price 2.32 | Shares 53,566
Buy 11 Jul 2025
Value US$75,000.00 | Price 1.50 | Shares 50,000
Buy 11 Jul 2025
Value US$150,000.00 | Price 1.50 | Shares 100,000
Buy 11 Jul 2025
Value US$99,999.00 | Price 1.50 | Shares 66,666
Buy 11 Jul 2025
Value US$99,999.00 | Price 1.50 | Shares 66,666
Buy 11 Jul 2025
Value US$75,000.00 | Price 1.50 | Shares 50,000
Buy 11 Jul 2025
Value US$79,999.50 | Price 1.50 | Shares 53,333
Buy 27 Apr 2023
Value US$20,891.75 | Price 3.80 | Shares 5,500
Buy 27 Apr 2023
Value US$26,498.50 | Price 3.79 | Shares 7,000
Buy 27 Apr 2023
Value US$20,514.45 | Price 3.73 | Shares 5,500
Buy 27 Apr 2023
Value US$26,023.90 | Price 3.72 | Shares 7,000
Buy 5 Dec 2022
Value US$32,830.00 | Price 4.69 | Shares 7,000
Buy 1 Dec 2022
Value US$14,580.00 | Price 4.86 | Shares 3,000
Buy 21 Oct 2022
Value US$21,040.00 | Price 5.26 | Shares 4,000
Buy 21 Oct 2022
Value US$21,040.00 | Price 5.26 | Shares 4,000
Buy 20 Oct 2022
Value US$1,013.00 | Price 5.07 | Shares 200
Buy 20 Oct 2022
Value US$1,551.00 | Price 5.17 | Shares 300
Buy 20 Oct 2022
Value US$1,876.80 | Price 5.10 | Shares 368
Buy 20 Oct 2022
Value US$1,536.00 | Price 5.12 | Shares 300
Buy 20 Oct 2022
Value US$516.00 | Price 5.16 | Shares 100
Buy 20 Oct 2022
Value US$3,577.00 | Price 5.11 | Shares 700
Buy 20 Oct 2022
Value US$9,006.40 | Price 5.20 | Shares 1,732
Buy 20 Oct 2022
Value US$3,626.00 | Price 5.18 | Shares 700
Buy 20 Oct 2022
Value US$29,344.00 | Price 5.24 | Shares 5,600
Buy 20 Oct 2022
Value US$3,144.00 | Price 5.24 | Shares 600
Buy 20 Oct 2022
Value US$2,108.00 | Price 5.27 | Shares 400
Buy 20 Oct 2022
Value US$236.70 | Price 5.26 | Shares 45
Buy 20 Oct 2022
Value US$14,018.40 | Price 5.28 | Shares 2,655
Buy 20 Oct 2022
Value US$555.45 | Price 5.29 | Shares 105
Buy 20 Oct 2022
Value US$32,833.50 | Price 5.30 | Shares 6,195
Buy 20 Oct 2022
Value US$52,000.00 | Price 5.20 | Shares 10,000
Buy 20 Oct 2022
Value US$52,900.00 | Price 5.29 | Shares 10,000
Buy 19 Oct 2022
Value US$79,857.00 | Price 5.32 | Shares 15,000
Buy 19 Oct 2022
Value US$79,800.00 | Price 5.32 | Shares 15,000
Buy 19 Oct 2022
Value US$73,950.00 | Price 4.93 | Shares 15,000
Buy 19 Oct 2022
Value US$73,918.50 | Price 4.93 | Shares 15,000
Sale 7 Sep 2022
Value US$13,564,483.66 | Price 8.71 | Shares 1,557,346
Buy 7 Sep 2022
Value US$13,564,483.66 | Price 8.71 | Shares 1,557,346
Buy 31 May 2022
Value US$28,000.00 | Price 5.60 | Shares 5,000
Sale 29 Jul 2020
Value US$4,160,000.00 | Price 8.32 | Shares 500,000
Sale 28 Jul 2020
Value US$160,890.30 | Price 8.10 | Shares 19,863
Buy 19 Mar 2020
Value US$63,803.96 | Price 10.87 | Shares 5,870
Buy 18 Mar 2020
Value US$28,028.67 | Price 10.36 | Shares 2,705
Buy 2 Mar 2020
Value US$1,483,083.85 | Price 18.95 | Shares 78,263
Buy 13 Jan 2020
Value US$4,387,500.00 | Price 16.25 | Shares 270,000
Buy 31 Dec 2019
Value US$332,340.45 | Price 15.50 | Shares 21,438
Buy 30 Dec 2019
Value US$20,637.77 | Price 15.48 | Shares 1,333
Sale 25 Nov 2019
Value US$3,840,000.00 | Price 16.00 | Shares 240,000
Buy 20 Nov 2019
Value US$6,400,000.00 | Price 16.00 | Shares 400,000
Buy 15 Oct 2019
Value US$19,800.00 | Price 18.00 | Shares 1,100
Buy 11 Oct 2019
Value US$72,790.83 | Price 17.30 | Shares 4,208
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-04-20 2026-04-16 S Sale
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
42,079 +1.3%
40.06
US$520,932 		42,079 +1.3% 40.06 US$520,932
2026-04-20 2026-04-16 S Sale
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
61,649 +32.3%
345.29
US$2,755,094 		61,649 +32.3% 345.29 US$2,755,094
2026-04-20 2026-04-16 S Sale
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
40,988 +19.4%
239.94
US$3,715,194 		40,988 +19.4% 239.94 US$3,715,194
2026-04-20 2026-04-16 S Sale
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
2,360 -0.8%
2.26
US$5,322 		2,360 -0.8% 2.26 US$5,322
2026-04-20 2026-04-16 S Sale
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
11,556 -3.8%
2.25
US$26,001 		11,556 -3.8% 2.25 US$26,001
2026-04-20 2026-04-16 PlS Planned sale
3.5
Oliveto Joseph

President and CEO

Executive Director
36,500 -7.6%
2.26
US$82,490 		36,500 -7.6% 2.26 US$82,490
2026-04-16 2026-04-16 PrS Proposed sale
3.5
JOSEPH OLIVETO

Director; Officer

Executive Director
36,500
2.20
US$80,300 		36,500 2.20 US$80,300
2026-01-28 2026-01-26 S Sale
3.5
Nelson Jeffrey Edward

Chief Operating Officer

Officer
12,245 -19.7%
1.93
US$23,633 		12,245 -19.7% 1.93 US$23,633
2026-01-28 2026-01-26 S Sale
2.0
Bharucha David

Chief Medical Officer

Officer
12,245 -9.8%
1.93
US$23,633 		12,245 -9.8% 1.93 US$23,633
2026-01-28 2026-01-26 S Sale
3.5
Hasija Amit

CFO & EVP of Corp. Development

Officer
12,245 -10.9%
1.93
US$23,633 		12,245 -10.9% 1.93 US$23,633
2026-01-28 2026-01-26 S Sale
3.5
Oliveto Joseph

President and CEO

Executive Director
34,523 -6.7%
1.93
US$66,629 		34,523 -6.7% 1.93 US$66,629
2026-01-28 2026-01-26 S Sale
3.5
Muller Lorenz

Chief Commercial Officer

Officer
11,180 -5.2%
1.93
US$21,577 		11,180 -5.2% 1.93 US$21,577
2026-01-09 2026-01-08 S Sale
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
448 -0.1%
2.27
CA$1,015 		448 -0.1% 2.27 CA$1,015
2026-01-09 2026-01-08 S Sale
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
13,352 -4.2%
2.26
CA$30,176 		13,352 -4.2% 2.26 CA$30,176
2026-01-09 2026-01-08 S Sale
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
1,449 -0.5%
2.26
CA$3,267 		1,449 -0.5% 2.26 CA$3,267
2026-01-09 2026-01-08 S Sale
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
27,751 -8.0%
2.25
CA$62,440 		27,751 -8.0% 2.25 CA$62,440
2026-01-09 2026-01-08 PlS Planned sale
3.5
Oliveto Joseph

President and CEO

Executive Director
43,000 -12.4%
2.25
US$96,750 		43,000 -12.4% 2.25 US$96,750
2026-01-08 2026-01-08 PrS Proposed sale
3.5
JOSEPH OLIVETO

Director; Officer

Executive Director
79,500
2.15
US$170,925 		79,500 2.15 US$170,925
2026-01-09 2026-01-07 PlS Planned sale
3.5
Oliveto Joseph

President and CEO

Executive Director
500 -0.1%
2.25
US$1,125 		500 -0.1% 2.25 US$1,125
2026-01-07 2026-01-07 PrS Proposed sale
3.5
JOSEPH OLIVETO

Officer

Officer
500
2.05
US$1,025 		500 2.05 US$1,025
2026-01-28 2025-12-15 S Sale
3.5
Nelson Jeffrey Edward

Chief Operating Officer

Officer
58,007 -58.0%
2.32
US$134,576 		58,007 -58.0% 2.32 US$134,576
2026-01-28 2025-12-15 S Sale
2.0
Bharucha David

Chief Medical Officer

Officer
58,007 -35.5%
2.32
US$134,576 		58,007 -35.5% 2.32 US$134,576
2026-01-28 2025-12-15 S Sale
3.5
Hasija Amit

CFO & EVP of Corp. Development

Officer
58,007 -38.7%
2.32
US$134,576 		58,007 -38.7% 2.32 US$134,576
2026-01-28 2025-12-15 S Sale
3.5
Oliveto Joseph

President and CEO

Executive Director
133,054 -22.8%
2.32
US$308,685 		133,054 -22.8% 2.32 US$308,685
2026-01-28 2025-12-15 S Sale
3.5
Muller Lorenz

Chief Commercial Officer

Officer
53,566 -21.4%
2.32
US$124,273 		53,566 -21.4% 2.32 US$124,273
2025-07-15 2025-07-11 B Purchase
2.5
Wills, Robert James

Director of Issuer

Non-Executive Director
50,000 +333.3%
1.50
US$75,000 		50,000 +333.3% 1.50 US$75,000
2025-07-15 2025-07-11 B Purchase
3.1
Papa, Joseph

Director of Issuer

Non-Executive Director
100,000
1.50
US$150,000 		100,000 1.50 US$150,000
2025-07-15 2025-07-11 B Purchase
3.4
Oliveto, Joseph Gerard

Director of Issuer, Senior Officer of Issuer

Executive Director
66,666 +23.8%
1.50
US$99,999 		66,666 +23.8% 1.50 US$99,999
2025-07-15 2025-07-11 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
66,666 +50.0%
1.50
US$99,999 		66,666 +50.0% 1.50 US$99,999
2025-07-15 2025-07-11 B Purchase
3.1
Hasija, Amit

Senior Officer of Issuer

Officer
50,000
1.50
US$75,000 		50,000 1.50 US$75,000
2025-07-15 2025-07-11 B Purchase
3.1
Bharucha, David

Senior Officer of Issuer

Officer
53,333 +533.3%
1.50
US$80,000 		53,333 +533.3% 1.50 US$80,000
2023-04-28 2023-04-27 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
5,500 +4.3%
3.80
US$20,892 		5,500 +4.3% 3.80 US$20,892
2023-04-28 2023-04-27 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
7,000 +5.8%
3.79
US$26,498 		7,000 +5.8% 3.79 US$26,498
2023-04-28 2023-04-27 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
5,500 +4.8%
3.73
US$20,514 		5,500 +4.8% 3.73 US$20,514
2023-04-28 2023-04-27 B Purchase
3.0
Muller, Lorenz Andrew

Senior Officer of Issuer

Officer
7,000 +6.5%
3.72
US$26,024 		7,000 +6.5% 3.72 US$26,024
2022-12-05 2022-12-05 B Purchase
2.0
Bharucha David

Chief Medical Officer

Officer
7,000 +233.3%
4.69
US$32,830 		7,000 +233.3% 4.69 US$32,830
2022-12-05 2022-12-01 B Purchase
2.0
Bharucha David

Chief Medical Officer

Officer
3,000 +inf%
4.86
US$14,580 		3,000 +inf% 4.86 US$14,580
2022-10-21 2022-10-21 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
4,000
5.26
US$21,040 		4,000 5.26 US$21,040
2022-10-21 2022-10-21 B Purchase
0.9
Liebert Debra K.
Non-Executive Director
4,000 +inf%
5.26
US$21,040 		4,000 +inf% 5.26 US$21,040
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
200 +2.0%
5.07
US$1,013 		200 +2.0% 5.07 US$1,013
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
300 +3.2%
5.17
US$1,551 		300 +3.2% 5.17 US$1,551
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
368 +4.0%
5.10
US$1,877 		368 +4.0% 5.10 US$1,877
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
300 +3.4%
5.12
US$1,536 		300 +3.4% 5.12 US$1,536
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
100 +1.1%
5.16
US$516 		100 +1.1% 5.16 US$516
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
700 +8.7%
5.11
US$3,577 		700 +8.7% 5.11 US$3,577
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
1,732 +27.5%
5.20
US$9,006 		1,732 +27.5% 5.20 US$9,006
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
700 +12.5%
5.18
US$3,626 		700 +12.5% 5.18 US$3,626
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak, Richard C.

Director of Issuer

Non-Executive Director
5,600
5.24
US$29,344 		5,600 5.24 US$29,344
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
600 +6.4%
5.24
US$3,144 		600 +6.4% 5.24 US$3,144
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
400 +4.4%
5.27
US$2,108 		400 +4.4% 5.27 US$2,108
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
45 +0.5%
5.26
US$237 		45 +0.5% 5.26 US$237
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
2,655 +42.1%
5.28
US$14,018 		2,655 +42.1% 5.28 US$14,018
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
105 +1.7%
5.29
US$555 		105 +1.7% 5.29 US$555
2022-10-21 2022-10-20 B Purchase
0.9
Liebert, Debra Kay

Director of Issuer

Non-Executive Director
6,195
5.30
US$32,834 		6,195 5.30 US$32,834
2022-10-21 2022-10-20 B Purchase
0.6
Pasternak Richard C
Non-Executive Director
10,000 +inf%
5.20
US$52,000 		10,000 +inf% 5.20 US$52,000
2022-10-21 2022-10-20 B Purchase
0.9
Liebert Debra K.
Non-Executive Director
10,000 +inf%
5.29
US$52,900 		10,000 +inf% 5.29 US$52,900
2022-10-21 2022-10-19 B Purchase
0.6
Tomsicek, Michael John

Director of Issuer

Non-Executive Director
15,000
5.32
US$79,857 		15,000 5.32 US$79,857
2022-10-21 2022-10-19 B Purchase
0.6
TOMSICEK MICHAEL JOHN
Non-Executive Director
15,000 +inf%
5.32
US$79,800 		15,000 +inf% 5.32 US$79,800
2022-10-21 2022-10-19 B Purchase
1.8
Wills Robert James
Non-Executive Director
15,000 +inf%
4.93
US$73,950 		15,000 +inf% 4.93 US$73,950
2022-10-19 2022-10-19 B Purchase
2.5
Wills, Robert James

Director of Issuer

Non-Executive Director
15,000
4.93
US$73,918 		15,000 4.93 US$73,918
2022-09-09 2022-09-07 S Sale
2.7
RTW INVESTMENTS, LP
Large shareholder
1,557,346 -26.5%
8.71
US$13,564,484 		1,557,346 -26.5% 8.71 US$13,564,484
2022-09-09 2022-09-07 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
1,557,346 +56.5%
8.71
US$13,564,484 		1,557,346 +56.5% 8.71 US$13,564,484
2022-06-01 2022-05-31 B Purchase
3.2
TRUEX PAUL F
Non-Executive Director
5,000 +6.5%
5.60
US$28,000 		5,000 +6.5% 5.60 US$28,000
2020-07-30 2020-07-29 S Sale
3.8
FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC
Large shareholder
500,000 -18.1%
8.32
US$4,160,000 		500,000 -18.1% 8.32 US$4,160,000
2020-07-30 2020-07-28 S Sale
3.8
FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC
Large shareholder
19,863 -0.7%
8.10
US$160,890 		19,863 -0.7% 8.10 US$160,890
2020-03-19 2020-03-19 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
5,870 +0.1%
10.87
US$63,804 		5,870 +0.1% 10.87 US$63,804
2020-03-19 2020-03-18 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
2,705 +0.1%
10.36
US$28,029 		2,705 +0.1% 10.36 US$28,029
2020-03-19 2020-03-02 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
78,263 +1.9%
18.95
US$1,483,084 		78,263 +1.9% 18.95 US$1,483,084
2020-01-13 2020-01-13 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
270,000 +6.8%
16.25
US$4,387,500 		270,000 +6.8% 16.25 US$4,387,500
2020-01-02 2019-12-31 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
21,438 +0.5%
15.50
US$332,340 		21,438 +0.5% 15.50 US$332,340
2020-01-02 2019-12-30 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
1,333 +0.0%
15.48
US$20,638 		1,333 +0.0% 15.48 US$20,638
2019-11-27 2019-11-25 S Sale
2.3
Novo Holdings A/S

SEE REMARKS

Large shareholder
240,000 -9.0%
16.00
US$3,840,000 		240,000 -9.0% 16.00 US$3,840,000
2019-11-22 2019-11-20 B Purchase RTW INVESTMENTS, LP Large shareholder
400,000 +11.3%
16.00
US$6,400,000 		400,000 +11.3% 16.00 US$6,400,000
2019-10-15 2019-10-15 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
1,100 +0.0%
18.00
US$19,800 		1,100 +0.0% 18.00 US$19,800
2019-10-15 2019-10-11 B Purchase
2.7
RTW INVESTMENTS, LP
Large shareholder
4,208 +0.1%
17.30
US$72,791 		4,208 +0.1% 17.30 US$72,791
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