United States Biotechnology & Medical Research

Ardea Biosciences Inc (RDEA)

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Ticker: RDEA Exchange: NSQ
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
No insider activity signals detected

Insider trades have not triggered unusual activity signals for this company.

Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Sale
Price
153.26
Quantity 48,925 +43.5%
Value US$3,514,894
Beck John W SVP, Finance & Operations, CFO Officer
Transaction date
Sale
Price
48.35
Quantity 97,865 +31.6%
Value US$788,769
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
296.36
Quantity 89,747 -40.6%
Value US$2,051,941
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
31.82
Quantity 5,000 -33.9%
Value US$159,078
FUCHS HENRY J Non-Executive Director
Transaction date
Planned sale
Price
31.64
Quantity 10,000 -49.0%
Value US$316,432
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
22.65
Quantity 5,000 -33.9%
Value US$113,272
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
20.99
Quantity 5,000 -33.9%
Value US$104,970
Baker Brothers Life Sciences Capital (GP), LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 876,828 +21.7%
Value US$14,906,076
TANG KEVIN C Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 426,470 +12.9%
Value US$7,249,990
14159 capital (GP), LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 23,172 +24.8%
Value US$393,924
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
18.01
Quantity 5,000 -33.9%
Value US$90,030
DAVIS STEPHEN EVP & COO Officer
Transaction date
Planned sale
Price
15.91
Quantity 700 -4.1%
Value US$11,138
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
16.97
Quantity 5,000 -33.9%
Value US$84,862
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
17.67
Quantity 5,000 -33.9%
Value US$88,357
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
21.27
Quantity 5,000 -34.8%
Value US$106,374
DAVIS STEPHEN EVP & COO Officer
Transaction date
Planned sale
Price
15.43
Quantity 700 -3.9%
Value US$10,803
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
16.28
Quantity 5,000 -34.8%
Value US$81,423
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
15.13
Quantity 5,000 -34.8%
Value US$75,634
Johnson Craig A Non-Executive Director
Transaction date
Planned sale
Price
23.16
Quantity 1,000 -100.0%
Value US$23,163
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
23.56
Quantity 5,000 -34.8%
Value US$117,813
Beck John W SVP, Finance & Operations, CFO Officer
Transaction date
Planned sale
Price
24.46
Quantity 16,000 -78.4%
Value US$391,411
DAVIS STEPHEN EVP & COO Officer
Transaction date
Planned sale
Price
25.65
Quantity 700 -3.6%
Value US$17,957
Johnson Craig A Non-Executive Director
Transaction date
Planned sale
Price
26.60
Quantity 477 -100.0%
Value US$12,688
Johnson Craig A Non-Executive Director
Transaction date
Planned sale
Price
26.13
Quantity 1,523 -76.1%
Value US$39,801
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
25.37
Quantity 5,000 -34.8%
Value US$126,874
FUCHS HENRY J Non-Executive Director
Transaction date
Sale
Price
24.25
Quantity 3,000 -22.4%
Value US$72,746
POYHONEN JOHN Non-Executive Director
Transaction date
Sale
Price
24.50
Quantity 500 -100.0%
Value US$12,250
POYHONEN JOHN Non-Executive Director
Transaction date
Sale
Price
24.70
Quantity 5,000 -100.0%
Value US$123,478
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
24.83
Quantity 5,000 -34.8%
Value US$124,172
DAVIS STEPHEN EVP & COO Officer
Transaction date
Planned sale
Price
26.06
Quantity 100 -0.5%
Value US$2,606
Quart Barry D President and CEO Executive Director
Transaction date
Planned sale
Price
27.20
Quantity 20,000 -24.3%
Value US$544,076
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
27.80
Quantity 5,000 -35.6%
Value US$139,022
DAVIS STEPHEN EVP & COO Officer
Transaction date
Planned sale
Price
28.20
Quantity 3,000 -13.2%
Value US$84,594
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
27.76
Quantity 5,000 -35.6%
Value US$138,824
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
26.50
Quantity 5,000 -35.6%
Value US$132,483
Quart Barry D President and CEO Executive Director
Transaction date
Planned sale
Price
26.77
Quantity 20,000 -29.8%
Value US$535,352
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
27.38
Quantity 5,000 -35.6%
Value US$136,923
TANG KEVIN C Non-Executive Director Large shareholder
Transaction date
Purchase
Price
26.00
Quantity 212,000 +6.8%
Value US$5,512,000
14159 capital (GP), LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
26.00
Quantity 9,815 +11.8%
Value US$255,190
Baker Brothers Life Sciences Capital (GP), LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
26.00
Quantity 355,585 +9.7%
Value US$9,245,210
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
26.62
Quantity 5,000 -55.3%
Value US$133,076
Quart Barry D President and CEO Executive Director
Transaction date
Planned sale
Price
21.92
Quantity 20,000 -35.0%
Value US$438,392
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
22.24
Quantity 5,000 -55.3%
Value US$111,218
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
21.03
Quantity 5,000 -57.5%
Value US$105,144
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
23.03
Quantity 5,000 -57.5%
Value US$115,139
POYHONEN JOHN Non-Executive Director
Transaction date
Sale
Price
23.02
Quantity 4,000 -100.0%
Value US$92,066
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
20.00
Quantity 8,968 -70.8%
Value US$179,336
Quart Barry D President and CEO Executive Director
Transaction date
Planned sale
Price
20.21
Quantity 20,000 -32.3%
Value US$404,268
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
19.44
Quantity 2,500 -24.6%
Value US$48,600
Krueger Christopher W SVP & CBO Officer
Transaction date
Planned sale
Price
18.54
Quantity 3,000 -76.3%
Value US$55,612
FUCHS HENRY J Non-Executive Director
Transaction date
Planned sale
Price
19.95
Quantity 2,000 -16.1%
Value US$39,898
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
21.92
Quantity 2,500 -24.6%
Value US$54,809
Krueger Christopher W SVP & CBO Officer
Transaction date
Planned sale
Price
21.93
Quantity 3,000 -76.3%
Value US$65,798
FUCHS HENRY J Non-Executive Director
Transaction date
Planned sale
Price
20.98
Quantity 2,000 -16.1%
Value US$41,956
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
25.64
Quantity 200 -2.5%
Value US$5,127
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
24.91
Quantity 2,300 -22.6%
Value US$57,296
Krueger Christopher W SVP & CBO Officer
Transaction date
Planned sale
Price
22.97
Quantity 3,000 -76.3%
Value US$68,906
FUCHS HENRY J Non-Executive Director
Transaction date
Planned sale
Price
21.77
Quantity 2,000 -16.1%
Value US$43,541
Quart Barry D President and CEO Executive Director
Transaction date
Planned sale
Price
21.70
Quantity 2,404 -5.5%
Value US$52,170
Quart Barry D President and CEO Executive Director
Transaction date
Planned sale
Price
21.15
Quantity 22,596 -34.0%
Value US$477,892
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
25.16
Quantity 2,500 -25.4%
Value US$62,912
Krueger Christopher W SVP & CBO Officer
Transaction date
Planned sale
Price
26.24
Quantity 3,000 -76.3%
Value US$78,718
FUCHS HENRY J Non-Executive Director
Transaction date
Planned sale
Price
23.24
Quantity 2,000 -16.1%
Value US$46,476
14159 capital (GP), LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
20.00
Quantity 13,431 +19.2%
Value US$268,620
Baker Brothers Life Sciences Capital (GP), LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
20.00
Quantity 486,569 +15.2%
Value US$9,731,380
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
18.72
Quantity 2,500 -25.4%
Value US$46,790
Krueger Christopher W SVP & CBO Officer
Transaction date
Planned sale
Price
18.45
Quantity 9,000 -90.6%
Value US$166,084
FUCHS HENRY J Non-Executive Director
Transaction date
Planned sale
Price
16.12
Quantity 4,000 -27.7%
Value US$64,479
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
14.28
Quantity 2,500 -25.4%
Value US$35,708
Quart Barry D President and CEO Executive Director
Transaction date
Planned sale
Price
14.57
Quantity 25,000 -53.7%
Value US$364,268
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
14.54
Quantity 2,500 -25.4%
Value US$36,350
FUCHS HENRY J Non-Executive Director
Transaction date
Planned sale
Price
15.83
Quantity 6,000 -36.5%
Value US$94,954
MANHARD KIMBERLY SVP, Regulatory & Dev Ops Officer
Transaction date
Planned sale
Price
14.49
Quantity 2,500 -25.4%
Value US$36,225
Krueger Christopher W SVP & CBO Officer
Transaction date
Planned sale
Price
15.11
Quantity 6,000 -86.5%
Value US$90,682
Quart Barry D President and CEO Executive Director
Transaction date
Planned sale
Price
14.48
Quantity 25,000 -40.3%
Value US$361,992
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2012-06-20 2012-06-19 S Sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
48,925 +43.5%
153.26
US$3,514,894 		48,925 +43.5% 153.26 US$3,514,894
2012-06-12 2012-06-11 S Sale Beck John W

SVP, Finance & Operations, CFO

Officer
97,865 +31.6%
48.35
US$788,769 		97,865 +31.6% 48.35 US$788,769
2012-05-29 2012-05-29 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
89,747 -40.6%
296.36
US$2,051,941 		89,747 -40.6% 296.36 US$2,051,941
2012-04-30 2012-04-30 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -33.9%
31.82
US$159,078 		5,000 -33.9% 31.82 US$159,078
2012-04-26 2012-04-25 PlS Planned sale FUCHS HENRY J Non-Executive Director
10,000 -49.0%
31.64
US$316,432 		10,000 -49.0% 31.64 US$316,432
2012-03-29 2012-03-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -33.9%
22.65
US$113,272 		5,000 -33.9% 22.65 US$113,272
2012-02-29 2012-02-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -33.9%
20.99
US$104,970 		5,000 -33.9% 20.99 US$104,970
2012-02-03 2012-02-01 B Purchase Baker Brothers Life Sciences Capital (GP), LLC Non-Executive Director Large shareholder
876,828 +21.7%
17.00
US$14,906,076 		876,828 +21.7% 17.00 US$14,906,076
2012-02-03 2012-02-01 B Purchase TANG KEVIN C Non-Executive Director Large shareholder
426,470 +12.9%
17.00
US$7,249,990 		426,470 +12.9% 17.00 US$7,249,990
2012-02-03 2012-02-01 B Purchase 14159 capital (GP), LLC Non-Executive Director Large shareholder
23,172 +24.8%
17.00
US$393,924 		23,172 +24.8% 17.00 US$393,924
2012-01-31 2012-01-30 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -33.9%
18.01
US$90,030 		5,000 -33.9% 18.01 US$90,030
2012-01-06 2012-01-06 PlS Planned sale DAVIS STEPHEN

EVP & COO

Officer
700 -4.1%
15.91
US$11,138 		700 -4.1% 15.91 US$11,138
2011-12-29 2011-12-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -33.9%
16.97
US$84,862 		5,000 -33.9% 16.97 US$84,862
2011-11-29 2011-11-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -33.9%
17.67
US$88,357 		5,000 -33.9% 17.67 US$88,357
2011-10-28 2011-10-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -34.8%
21.27
US$106,374 		5,000 -34.8% 21.27 US$106,374
2011-10-07 2011-10-06 PlS Planned sale DAVIS STEPHEN

EVP & COO

Officer
700 -3.9%
15.43
US$10,803 		700 -3.9% 15.43 US$10,803
2011-09-30 2011-09-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -34.8%
16.28
US$81,423 		5,000 -34.8% 16.28 US$81,423
2011-08-30 2011-08-29 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -34.8%
15.13
US$75,634 		5,000 -34.8% 15.13 US$75,634
2011-08-02 2011-08-01 PlS Planned sale Johnson Craig A Non-Executive Director
1,000 -100.0%
23.16
US$23,163 		1,000 -100.0% 23.16 US$23,163
2011-07-29 2011-07-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -34.8%
23.56
US$117,813 		5,000 -34.8% 23.56 US$117,813
2011-07-26 2011-07-25 PlS Planned sale Beck John W

SVP, Finance & Operations, CFO

Officer
16,000 -78.4%
24.46
US$391,411 		16,000 -78.4% 24.46 US$391,411
2011-07-08 2011-07-06 PlS Planned sale DAVIS STEPHEN

EVP & COO

Officer
700 -3.6%
25.65
US$17,957 		700 -3.6% 25.65 US$17,957
2011-07-05 2011-07-01 PlS Planned sale Johnson Craig A Non-Executive Director
477 -100.0%
26.60
US$12,688 		477 -100.0% 26.60 US$12,688
2011-07-05 2011-07-01 PlS Planned sale Johnson Craig A Non-Executive Director
1,523 -76.1%
26.13
US$39,801 		1,523 -76.1% 26.13 US$39,801
2011-06-29 2011-06-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -34.8%
25.37
US$126,874 		5,000 -34.8% 25.37 US$126,874
2011-06-06 2011-06-03 S Sale FUCHS HENRY J Non-Executive Director
3,000 -22.4%
24.25
US$72,746 		3,000 -22.4% 24.25 US$72,746
2011-06-03 2011-06-03 S Sale POYHONEN JOHN Non-Executive Director
500 -100.0%
24.50
US$12,250 		500 -100.0% 24.50 US$12,250
2011-06-03 2011-06-02 S Sale POYHONEN JOHN Non-Executive Director
5,000 -100.0%
24.70
US$123,478 		5,000 -100.0% 24.70 US$123,478
2011-06-01 2011-05-31 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -34.8%
24.83
US$124,172 		5,000 -34.8% 24.83 US$124,172
2011-05-18 2011-05-16 PlS Planned sale DAVIS STEPHEN

EVP & COO

Officer
100 -0.5%
26.06
US$2,606 		100 -0.5% 26.06 US$2,606
2011-05-11 2011-05-09 PlS Planned sale Quart Barry D

President and CEO

Executive Director
20,000 -24.3%
27.20
US$544,076 		20,000 -24.3% 27.20 US$544,076
2011-04-29 2011-04-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -35.6%
27.80
US$139,022 		5,000 -35.6% 27.80 US$139,022
2011-04-08 2011-04-08 PlS Planned sale DAVIS STEPHEN

EVP & COO

Officer
3,000 -13.2%
28.20
US$84,594 		3,000 -13.2% 28.20 US$84,594
2011-03-29 2011-03-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -35.6%
27.76
US$138,824 		5,000 -35.6% 27.76 US$138,824
2011-03-01 2011-02-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -35.6%
26.50
US$132,483 		5,000 -35.6% 26.50 US$132,483
2011-02-09 2011-02-07 PlS Planned sale Quart Barry D

President and CEO

Executive Director
20,000 -29.8%
26.77
US$535,352 		20,000 -29.8% 26.77 US$535,352
2011-01-28 2011-01-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -35.6%
27.38
US$136,923 		5,000 -35.6% 27.38 US$136,923
2011-01-24 2011-01-20 B Purchase TANG KEVIN C Non-Executive Director Large shareholder
212,000 +6.8%
26.00
US$5,512,000 		212,000 +6.8% 26.00 US$5,512,000
2011-01-24 2011-01-20 B Purchase 14159 capital (GP), LLC Non-Executive Director Large shareholder
9,815 +11.8%
26.00
US$255,190 		9,815 +11.8% 26.00 US$255,190
2011-01-24 2011-01-20 B Purchase Baker Brothers Life Sciences Capital (GP), LLC Non-Executive Director Large shareholder
355,585 +9.7%
26.00
US$9,245,210 		355,585 +9.7% 26.00 US$9,245,210
2010-12-30 2010-12-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -55.3%
26.62
US$133,076 		5,000 -55.3% 26.62 US$133,076
2010-12-10 2010-12-08 PlS Planned sale Quart Barry D

President and CEO

Executive Director
20,000 -35.0%
21.92
US$438,392 		20,000 -35.0% 21.92 US$438,392
2010-11-30 2010-11-29 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -55.3%
22.24
US$111,218 		5,000 -55.3% 22.24 US$111,218
2010-11-01 2010-10-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -57.5%
21.03
US$105,144 		5,000 -57.5% 21.03 US$105,144
2010-09-30 2010-09-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
5,000 -57.5%
23.03
US$115,139 		5,000 -57.5% 23.03 US$115,139
2010-09-24 2010-09-23 S Sale POYHONEN JOHN Non-Executive Director
4,000 -100.0%
23.02
US$92,066 		4,000 -100.0% 23.02 US$92,066
2010-09-01 2010-08-30 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
8,968 -70.8%
20.00
US$179,336 		8,968 -70.8% 20.00 US$179,336
2010-08-10 2010-08-09 PlS Planned sale Quart Barry D

President and CEO

Executive Director
20,000 -32.3%
20.21
US$404,268 		20,000 -32.3% 20.21 US$404,268
2010-07-29 2010-07-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
2,500 -24.6%
19.44
US$48,600 		2,500 -24.6% 19.44 US$48,600
2010-07-26 2010-07-23 PlS Planned sale Krueger Christopher W

SVP & CBO

Officer
3,000 -76.3%
18.54
US$55,612 		3,000 -76.3% 18.54 US$55,612
2010-07-14 2010-07-12 PlS Planned sale FUCHS HENRY J Non-Executive Director
2,000 -16.1%
19.95
US$39,898 		2,000 -16.1% 19.95 US$39,898
2010-06-29 2010-06-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
2,500 -24.6%
21.92
US$54,809 		2,500 -24.6% 21.92 US$54,809
2010-06-24 2010-06-23 PlS Planned sale Krueger Christopher W

SVP & CBO

Officer
3,000 -76.3%
21.93
US$65,798 		3,000 -76.3% 21.93 US$65,798
2010-06-14 2010-06-10 PlS Planned sale FUCHS HENRY J Non-Executive Director
2,000 -16.1%
20.98
US$41,956 		2,000 -16.1% 20.98 US$41,956
2010-06-01 2010-05-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
200 -2.5%
25.64
US$5,127 		200 -2.5% 25.64 US$5,127
2010-06-01 2010-05-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
2,300 -22.6%
24.91
US$57,296 		2,300 -22.6% 24.91 US$57,296
2010-05-26 2010-05-24 PlS Planned sale Krueger Christopher W

SVP & CBO

Officer
3,000 -76.3%
22.97
US$68,906 		3,000 -76.3% 22.97 US$68,906
2010-05-11 2010-05-10 PlS Planned sale FUCHS HENRY J Non-Executive Director
2,000 -16.1%
21.77
US$43,541 		2,000 -16.1% 21.77 US$43,541
2010-05-07 2010-05-07 PlS Planned sale Quart Barry D

President and CEO

Executive Director
2,404 -5.5%
21.70
US$52,170 		2,404 -5.5% 21.70 US$52,170
2010-05-07 2010-05-07 PlS Planned sale Quart Barry D

President and CEO

Executive Director
22,596 -34.0%
21.15
US$477,892 		22,596 -34.0% 21.15 US$477,892
2010-04-29 2010-04-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
2,500 -25.4%
25.16
US$62,912 		2,500 -25.4% 25.16 US$62,912
2010-04-26 2010-04-23 PlS Planned sale Krueger Christopher W

SVP & CBO

Officer
3,000 -76.3%
26.24
US$78,718 		3,000 -76.3% 26.24 US$78,718
2010-04-13 2010-04-12 PlS Planned sale FUCHS HENRY J Non-Executive Director
2,000 -16.1%
23.24
US$46,476 		2,000 -16.1% 23.24 US$46,476
2010-04-08 2010-04-06 B Purchase 14159 capital (GP), LLC Non-Executive Director Large shareholder
13,431 +19.2%
20.00
US$268,620 		13,431 +19.2% 20.00 US$268,620
2010-04-08 2010-04-06 B Purchase Baker Brothers Life Sciences Capital (GP), LLC Non-Executive Director Large shareholder
486,569 +15.2%
20.00
US$9,731,380 		486,569 +15.2% 20.00 US$9,731,380
2010-03-30 2010-03-29 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
2,500 -25.4%
18.72
US$46,790 		2,500 -25.4% 18.72 US$46,790
2010-03-24 2010-03-23 PlS Planned sale Krueger Christopher W

SVP & CBO

Officer
9,000 -90.6%
18.45
US$166,084 		9,000 -90.6% 18.45 US$166,084
2010-03-12 2010-03-10 PlS Planned sale FUCHS HENRY J Non-Executive Director
4,000 -27.7%
16.12
US$64,479 		4,000 -27.7% 16.12 US$64,479
2010-03-01 2010-02-26 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
2,500 -25.4%
14.28
US$35,708 		2,500 -25.4% 14.28 US$35,708
2010-02-10 2010-02-08 PlS Planned sale Quart Barry D

President and CEO

Executive Director
25,000 -53.7%
14.57
US$364,268 		25,000 -53.7% 14.57 US$364,268
2010-01-29 2010-01-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
2,500 -25.4%
14.54
US$36,350 		2,500 -25.4% 14.54 US$36,350
2010-01-12 2010-01-11 PlS Planned sale FUCHS HENRY J Non-Executive Director
6,000 -36.5%
15.83
US$94,954 		6,000 -36.5% 15.83 US$94,954
2009-12-29 2009-12-28 PlS Planned sale MANHARD KIMBERLY

SVP, Regulatory & Dev Ops

Officer
2,500 -25.4%
14.49
US$36,225 		2,500 -25.4% 14.49 US$36,225
2009-12-24 2009-12-23 PlS Planned sale Krueger Christopher W

SVP & CBO

Officer
6,000 -86.5%
15.11
US$90,682 		6,000 -86.5% 15.11 US$90,682
2009-12-11 2009-12-09 PlS Planned sale Quart Barry D

President and CEO

Executive Director
25,000 -40.3%
14.48
US$361,992 		25,000 -40.3% 14.48 US$361,992
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