|
2023-09-12 |
2023-09-12 |
PlS
Planned sale
|
Non-Executive Director
|
6,749
-10.7%
285.02
US$3,038,717
|
6,749
-10.7%
|
285.02
|
US$3,038,717
|
|
|
2021-02-16 |
2021-02-11 |
S
Sale
|
Large shareholder
|
76,050
-42.2%
339.09
US$496,783
|
76,050
-42.2%
|
339.09
|
US$496,783
|
|
|
2021-02-16 |
2021-02-11 |
S
Sale
|
Large shareholder
|
31,349
-3.5%
293.52
US$4,114,151
|
31,349
-3.5%
|
293.52
|
US$4,114,151
|
|
|
2021-02-16 |
2021-02-11 |
S
Sale
|
Large shareholder
|
1,215,491
-21.5%
5.37
US$6,525,485
|
1,215,491
-21.5%
|
5.37
|
US$6,525,485
|
|
|
2021-01-26 |
2021-01-22 |
S
Sale
|
Large shareholder
|
568,019
-45.3%
4.14
US$2,350,917
|
568,019
-45.3%
|
4.14
|
US$2,350,917
|
|
|
2021-01-26 |
2021-01-22 |
S
Sale
|
Large shareholder
|
2,458,838
-37.1%
4.14
US$10,176,639
|
2,458,838
-37.1%
|
4.14
|
US$10,176,639
|
|
|
2021-01-26 |
2021-01-22 |
S
Sale
|
Large shareholder
|
2,821,663
-33.3%
4.14
US$11,678,299
|
2,821,663
-33.3%
|
4.14
|
US$11,678,299
|
|
|
2018-12-17 |
2018-12-13 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
120,539
+1.9%
1.20
US$144,587
|
120,539
+1.9%
|
1.20
|
US$144,587
|
|
|
2018-12-17 |
2018-12-13 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
54,461
+0.6%
1.20
US$65,326
|
54,461
+0.6%
|
1.20
|
US$65,326
|
|
|
2018-11-30 |
2018-11-28 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
100,000
+1.6%
1.30
US$130,000
|
100,000
+1.6%
|
1.30
|
US$130,000
|
|
|
2018-11-21 |
2018-11-21 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
581
+0.0%
1.35
US$784
|
581
+0.0%
|
1.35
|
US$784
|
|
|
2018-11-21 |
2018-11-21 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
4,119
+0.0%
1.35
US$5,561
|
4,119
+0.0%
|
1.35
|
US$5,561
|
|
|
2018-11-21 |
2018-11-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
5,573
+0.4%
1.35
US$7,524
|
5,573
+0.4%
|
1.35
|
US$7,524
|
|
|
2018-11-21 |
2018-11-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
38,001
+0.6%
1.35
US$51,301
|
38,001
+0.6%
|
1.35
|
US$51,301
|
|
|
2018-11-21 |
2018-11-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
50,044
+0.6%
1.35
US$67,559
|
50,044
+0.6%
|
1.35
|
US$67,559
|
|
|
2018-11-21 |
2018-11-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
81,648
+7.0%
1.37
US$111,841
|
81,648
+7.0%
|
1.37
|
US$111,841
|
|
|
2018-11-21 |
2018-11-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
556,709
+9.6%
1.37
US$762,580
|
556,709
+9.6%
|
1.37
|
US$762,580
|
|
|
2018-11-21 |
2018-11-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
733,151
+9.6%
1.37
US$1,004,270
|
733,151
+9.6%
|
1.37
|
US$1,004,270
|
|
|
2018-11-15 |
2018-11-15 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
39,074
+0.7%
1.35
US$52,750
|
39,074
+0.7%
|
1.35
|
US$52,750
|
|
|
2018-11-15 |
2018-11-15 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
52,400
+0.7%
1.35
US$70,740
|
52,400
+0.7%
|
1.35
|
US$70,740
|
|
|
2018-11-15 |
2018-11-14 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
92,960
+1.6%
1.34
US$124,566
|
92,960
+1.6%
|
1.34
|
US$124,566
|
|
|
2018-11-15 |
2018-11-14 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
117,290
+1.6%
1.34
US$157,169
|
117,290
+1.6%
|
1.34
|
US$157,169
|
|
|
2018-11-15 |
2018-11-13 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
562,754
+11.0%
1.35
US$759,718
|
562,754
+11.0%
|
1.35
|
US$759,718
|
|
|
2018-11-15 |
2018-11-13 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
41,454
+0.6%
1.35
US$55,963
|
41,454
+0.6%
|
1.35
|
US$55,963
|
|
|
2018-10-02 |
2018-10-01 |
PlS
Planned sale
|
Perkins Adelene Q
Chief Executive Officer
Executive Director
|
5,000
-0.8%
2.82
US$14,100
|
5,000
-0.8%
|
2.82
|
US$14,100
|
|
|
2018-08-17 |
2018-08-16 |
PlS
Planned sale
|
Kutok Jeffery
Chief Scientific Officer
Officer
|
6,133
-100.0%
2.00
US$12,266
|
6,133
-100.0%
|
2.00
|
US$12,266
|
|
|
2018-08-17 |
2018-08-15 |
PlS
Planned sale
|
Kutok Jeffery
Chief Scientific Officer
Officer
|
8,180
-57.2%
2.01
US$16,421
|
8,180
-57.2%
|
2.01
|
US$16,421
|
|
|
2018-06-25 |
2018-06-22 |
PlS
Planned sale
|
Kutok Jeffery
Chief Scientific Officer
|
14,313
-50.0%
2.00
US$28,695
|
14,313
-50.0%
|
2.00
|
US$28,695
|
|
|
2018-06-21 |
2018-06-21 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
36,825
+3.3%
1.65
US$60,761
|
36,825
+3.3%
|
1.65
|
US$60,761
|
|
|
2018-06-21 |
2018-06-21 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
158,151
+3.2%
1.65
US$260,949
|
158,151
+3.2%
|
1.65
|
US$260,949
|
|
|
2018-06-21 |
2018-06-21 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
230,555
+3.2%
1.65
US$380,416
|
230,555
+3.2%
|
1.65
|
US$380,416
|
|
|
2018-06-21 |
2018-06-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
179,893
+18.9%
1.65
US$296,823
|
179,893
+18.9%
|
1.65
|
US$296,823
|
|
|
2018-06-21 |
2018-06-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
1,419,907
+40.1%
1.65
US$2,342,847
|
1,419,907
+40.1%
|
1.65
|
US$2,342,847
|
|
|
2018-06-21 |
2018-06-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
1,916,760
+36.3%
1.65
US$3,162,654
|
1,916,760
+36.3%
|
1.65
|
US$3,162,654
|
|
|
2018-04-11 |
2018-04-10 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
97,453
+11.4%
2.00
US$194,906
|
97,453
+11.4%
|
2.00
|
US$194,906
|
|
|
2018-04-11 |
2018-04-10 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
365,682
+11.5%
2.00
US$731,364
|
365,682
+11.5%
|
2.00
|
US$731,364
|
|
|
2018-04-11 |
2018-04-10 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
546,865
+11.5%
2.00
US$1,093,730
|
546,865
+11.5%
|
2.00
|
US$1,093,730
|
|
|
2018-04-11 |
2018-04-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
62,437
+7.9%
1.90
US$118,630
|
62,437
+7.9%
|
1.90
|
US$118,630
|
|
|
2018-04-11 |
2018-04-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
208,872
+7.0%
1.90
US$396,857
|
208,872
+7.0%
|
1.90
|
US$396,857
|
|
|
2018-04-11 |
2018-04-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
228,691
+5.1%
1.90
US$434,513
|
228,691
+5.1%
|
1.90
|
US$434,513
|
|
|
2018-03-07 |
2018-03-05 |
PlS
Planned sale
|
Perkins Adelene Q
Chief Executive Officer
Executive Director
|
5,000
-0.8%
2.78
US$13,890
|
5,000
-0.8%
|
2.78
|
US$13,890
|
|
|
2017-12-07 |
2017-12-06 |
B
Purchase
|
BLOCH LAWRENCE E
President
|
500,000
+617.7%
1.81
US$905,000
|
500,000
+617.7%
|
1.81
|
US$905,000
|
|
|
2017-10-05 |
2017-10-04 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
63,042
+8.7%
1.28
US$80,946
|
63,042
+8.7%
|
1.28
|
US$80,946
|
|
|
2017-10-05 |
2017-10-04 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
235,326
+8.6%
1.28
US$302,159
|
235,326
+8.6%
|
1.28
|
US$302,159
|
|
|
2017-10-05 |
2017-10-04 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
355,081
+8.5%
1.28
US$455,924
|
355,081
+8.5%
|
1.28
|
US$455,924
|
|
|
2017-10-05 |
2017-10-03 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
28,918
+4.1%
1.24
US$35,714
|
28,918
+4.1%
|
1.24
|
US$35,714
|
|
|
2017-10-05 |
2017-10-03 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
394,078
+16.8%
1.24
US$486,686
|
394,078
+16.8%
|
1.24
|
US$486,686
|
|
|
2017-10-05 |
2017-10-03 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
523,601
+14.4%
1.24
US$646,647
|
523,601
+14.4%
|
1.24
|
US$646,647
|
|
|
2017-03-20 |
2017-03-17 |
S
Sale
|
VENUTI MICHAEL C
Non-Executive Director
|
6,250
-11.1%
3.48
US$21,750
|
6,250
-11.1%
|
3.48
|
US$21,750
|
|
|
2017-01-05 |
2017-01-03 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
3,234
+0.1%
1.34
US$4,333
|
3,234
+0.1%
|
1.34
|
US$4,333
|
|
|
2017-01-05 |
2017-01-03 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
1,145
+0.0%
1.34
US$1,534
|
1,145
+0.0%
|
1.34
|
US$1,534
|
|
|
2016-12-30 |
2016-12-30 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
1,205
+0.1%
1.34
US$1,614
|
1,205
+0.1%
|
1.34
|
US$1,614
|
|
|
2016-12-30 |
2016-12-30 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
2,348
+0.1%
1.34
US$3,145
|
2,348
+0.1%
|
1.34
|
US$3,145
|
|
|
2016-12-30 |
2016-12-28 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
77,076
+12.4%
1.34
US$102,943
|
77,076
+12.4%
|
1.34
|
US$102,943
|
|
|
2016-12-30 |
2016-12-28 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
260,046
+12.5%
1.34
US$347,317
|
260,046
+12.5%
|
1.34
|
US$347,317
|
|
|
2016-12-30 |
2016-12-28 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
401,726
+12.5%
1.34
US$536,545
|
401,726
+12.5%
|
1.34
|
US$536,545
|
|
|
2016-12-20 |
2016-12-20 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
2,244
+0.4%
1.35
US$3,040
|
2,244
+0.4%
|
1.35
|
US$3,040
|
|
|
2016-12-20 |
2016-12-20 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
8,111
+0.4%
1.35
US$10,990
|
8,111
+0.4%
|
1.35
|
US$10,990
|
|
|
2016-12-20 |
2016-12-20 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
11,646
+0.4%
1.35
US$15,779
|
11,646
+0.4%
|
1.35
|
US$15,779
|
|
|
2016-12-20 |
2016-12-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
21,021
+3.5%
1.36
US$28,555
|
21,021
+3.5%
|
1.36
|
US$28,555
|
|
|
2016-12-20 |
2016-12-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
69,041
+3.5%
1.36
US$93,785
|
69,041
+3.5%
|
1.36
|
US$93,785
|
|
|
2016-12-20 |
2016-12-19 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
108,202
+3.5%
1.36
US$146,982
|
108,202
+3.5%
|
1.36
|
US$146,982
|
|
|
2016-12-20 |
2016-12-16 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
47,812
+8.7%
1.28
US$61,199
|
47,812
+8.7%
|
1.28
|
US$61,199
|
|
|
2016-12-20 |
2016-12-16 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
150,451
+8.1%
1.28
US$192,577
|
150,451
+8.1%
|
1.28
|
US$192,577
|
|
|
2016-12-20 |
2016-12-16 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
236,393
+8.2%
1.28
US$302,583
|
236,393
+8.2%
|
1.28
|
US$302,583
|
|
|
2016-12-14 |
2016-12-13 |
S
Sale
|
KANGO SUJAY
Chief Commercial Officer
Officer
|
7,676
-92.8%
1.25
US$9,623
|
7,676
-92.8%
|
1.25
|
US$9,623
|
|
|
2016-12-14 |
2016-12-13 |
S
Sale
|
KANGO SUJAY
Chief Commercial Officer
Officer
|
42,017
-83.5%
1.27
US$53,248
|
42,017
-83.5%
|
1.27
|
US$53,248
|
|
|
2016-12-14 |
2016-12-13 |
S
Sale
|
KANGO SUJAY
Chief Commercial Officer
Officer
|
298
-0.6%
1.30
US$387
|
298
-0.6%
|
1.30
|
US$387
|
|
|
2016-12-14 |
2016-12-12 |
S
Sale
|
KANGO SUJAY
Chief Commercial Officer
Officer
|
25,009
-33.1%
1.30
US$32,612
|
25,009
-33.1%
|
1.30
|
US$32,612
|
|
|
2016-12-02 |
2016-12-02 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
2,916
+0.5%
1.19
US$3,470
|
2,916
+0.5%
|
1.19
|
US$3,470
|
|
|
2016-12-02 |
2016-12-02 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
18,586
+1.0%
1.19
US$22,119
|
18,586
+1.0%
|
1.19
|
US$22,119
|
|
|
2016-12-02 |
2016-12-02 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
30,998
+1.1%
1.19
US$36,891
|
30,998
+1.1%
|
1.19
|
US$36,891
|
|
|
2016-12-02 |
2016-12-01 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
15,161
+2.8%
1.18
US$17,958
|
15,161
+2.8%
|
1.18
|
US$17,958
|
|
|
2016-12-02 |
2016-12-01 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
52,457
+3.0%
1.18
US$62,135
|
52,457
+3.0%
|
1.18
|
US$62,135
|
|
|
2016-12-02 |
2016-12-01 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
81,276
+2.9%
1.18
US$96,271
|
81,276
+2.9%
|
1.18
|
US$96,271
|
|