|
2015-12-22 |
2015-12-21 |
B
Purchase
|
Ticktin Robert
General Counsel
Officer
|
42,706
-1.4%
244.38
US$76,591
|
42,706
-1.4%
|
244.38
|
US$76,591
|
|
|
2015-12-21 |
2015-12-17 |
B
Purchase
|
Vincent Aurentz
Chief Business Officer
Officer
|
71,230
+31.5%
328.36
US$2,543,053
|
71,230
+31.5%
|
328.36
|
US$2,543,053
|
|
|
2015-12-17 |
2015-12-16 |
B
Purchase
|
Munshi Amit
Chief Executive Officer
Executive Director
|
67,000
+17.7%
338.25
US$1,032,784
|
67,000
+17.7%
|
338.25
|
US$1,032,784
|
|
|
2015-12-16 |
2015-12-15 |
B
Purchase
|
Munshi Amit
Chief Executive Officer
Executive Director
|
8,069
+5.3%
2.87
US$23,158
|
8,069
+5.3%
|
2.87
|
US$23,158
|
|
|
2015-12-11 |
2015-12-09 |
B
Purchase
|
Vincent Aurentz
Chief Business Officer
Officer
|
2,800
+inf%
3.85
US$10,780
|
2,800
+inf%
|
3.85
|
US$10,780
|
|
|
2015-12-10 |
2015-12-09 |
B
Purchase
|
Munshi Amit
Chief Executive Officer
Executive Director
|
13,190
+9.4%
4.07
US$53,683
|
13,190
+9.4%
|
4.07
|
US$53,683
|
|
|
2015-09-22 |
2015-09-21 |
B
Purchase
|
Munshi Amit
Chief Executive Officer
Executive Director
|
10,000
+7.7%
6.19
US$61,900
|
10,000
+7.7%
|
6.19
|
US$61,900
|
|
|
2015-09-21 |
2015-09-18 |
B
Purchase
|
Munshi Amit
Chief Executive Officer
Executive Director
|
10,000
+8.3%
5.99
US$59,860
|
10,000
+8.3%
|
5.99
|
US$59,860
|
|
|
2015-02-09 |
2015-02-06 |
S
Sale
|
MONTREUX EQUITY PARTNERS IV LP
Large shareholder
|
100,000
-5.6%
5.01
US$500,930
|
100,000
-5.6%
|
5.01
|
US$500,930
|
|
|
2015-02-09 |
2015-02-05 |
S
Sale
|
MONTREUX EQUITY PARTNERS IV LP
Large shareholder
|
67,316
-3.7%
4.97
US$334,843
|
67,316
-3.7%
|
4.97
|
US$334,843
|
|
|
2015-02-06 |
2015-02-04 |
B
Purchase
|
ROCKLAGE SCOTT M
Non-Executive Director
Large shareholder
|
389,950
+18.1%
5.00
US$1,949,750
|
389,950
+18.1%
|
5.00
|
US$1,949,750
|
|
|
2015-02-06 |
2015-02-04 |
B
Purchase
|
5AM Partners III, LLC
Large shareholder
|
389,950
+18.1%
5.00
US$1,949,750
|
389,950
+18.1%
|
5.00
|
US$1,949,750
|
|
|
2015-02-06 |
2015-02-04 |
B
Purchase
|
ROCKLAGE SCOTT M
Non-Executive Director
Large shareholder
|
10,050
+18.1%
5.00
US$50,250
|
10,050
+18.1%
|
5.00
|
US$50,250
|
|
|
2015-02-06 |
2015-02-04 |
B
Purchase
|
5AM Partners III, LLC
Large shareholder
|
10,050
+18.1%
5.00
US$50,250
|
10,050
+18.1%
|
5.00
|
US$50,250
|
|
|
2015-02-05 |
2015-02-04 |
S
Sale
|
MONTREUX EQUITY PARTNERS IV LP
Large shareholder
|
5,684
-0.3%
4.95
US$28,139
|
5,684
-0.3%
|
4.95
|
US$28,139
|
|
|
2015-02-05 |
2015-02-03 |
S
Sale
|
MONTREUX EQUITY PARTNERS IV LP
Large shareholder
|
47,000
-2.5%
4.99
US$234,431
|
47,000
-2.5%
|
4.99
|
US$234,431
|
|
|
2015-01-28 |
2015-01-26 |
S
Sale
|
MONTREUX EQUITY PARTNERS IV LP
Large shareholder
|
38,516
-2.0%
6.47
US$249,102
|
38,516
-2.0%
|
6.47
|
US$249,102
|
|
|
2015-01-26 |
2015-01-23 |
S
Sale
|
MONTREUX EQUITY PARTNERS IV LP
Large shareholder
|
8,400
-0.4%
6.27
US$52,699
|
8,400
-0.4%
|
6.27
|
US$52,699
|
|
|
2015-01-26 |
2015-01-22 |
S
Sale
|
MONTREUX EQUITY PARTNERS IV LP
Large shareholder
|
14,130
-0.7%
6.30
US$88,979
|
14,130
-0.7%
|
6.30
|
US$88,979
|
|
|
2011-10-28 |
2011-10-27 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
738,807
-6.2%
1.03
US$760,971
|
738,807
-6.2%
|
1.03
|
US$760,971
|
|
|
2011-10-28 |
2011-10-27 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
738,807
-6.2%
1.03
US$760,971
|
738,807
-6.2%
|
1.03
|
US$760,971
|
|
|
2011-10-27 |
2011-10-26 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
78,000
-0.7%
1.02
US$79,560
|
78,000
-0.7%
|
1.02
|
US$79,560
|
|
|
2011-10-27 |
2011-10-26 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
78,000
-0.7%
1.02
US$79,560
|
78,000
-0.7%
|
1.02
|
US$79,560
|
|
|
2011-10-27 |
2011-10-25 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
203,200
-1.7%
1.02
US$207,264
|
203,200
-1.7%
|
1.02
|
US$207,264
|
|
|
2011-10-27 |
2011-10-25 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
203,200
-1.7%
1.02
US$207,264
|
203,200
-1.7%
|
1.02
|
US$207,264
|
|
|
2011-10-25 |
2011-10-24 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
252,000
-2.0%
1.03
US$259,560
|
252,000
-2.0%
|
1.03
|
US$259,560
|
|
|
2011-10-25 |
2011-10-24 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
252,000
-2.0%
1.03
US$259,560
|
252,000
-2.0%
|
1.03
|
US$259,560
|
|
|
2011-10-25 |
2011-10-21 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
70,100
-0.6%
1.02
US$71,502
|
70,100
-0.6%
|
1.02
|
US$71,502
|
|
|
2011-10-25 |
2011-10-21 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
70,100
-0.6%
1.02
US$71,502
|
70,100
-0.6%
|
1.02
|
US$71,502
|
|
|
2011-10-21 |
2011-10-20 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
425,000
-3.3%
1.03
US$437,750
|
425,000
-3.3%
|
1.03
|
US$437,750
|
|
|
2011-10-21 |
2011-10-20 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
425,000
-3.3%
1.03
US$437,750
|
425,000
-3.3%
|
1.03
|
US$437,750
|
|
|
2011-10-21 |
2011-10-19 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
34,817
-0.3%
1.02
US$35,513
|
34,817
-0.3%
|
1.02
|
US$35,513
|
|
|
2011-10-21 |
2011-10-19 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
34,817
-0.3%
1.02
US$35,513
|
34,817
-0.3%
|
1.02
|
US$35,513
|
|
|
2011-10-19 |
2011-10-17 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
19,644
-0.2%
1.02
US$20,037
|
19,644
-0.2%
|
1.02
|
US$20,037
|
|
|
2011-10-19 |
2011-10-17 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
19,644
-0.2%
1.02
US$20,037
|
19,644
-0.2%
|
1.02
|
US$20,037
|
|
|
2011-10-17 |
2011-10-14 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
39,700
-0.3%
1.02
US$40,494
|
39,700
-0.3%
|
1.02
|
US$40,494
|
|
|
2011-10-17 |
2011-10-14 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
39,700
-0.3%
1.02
US$40,494
|
39,700
-0.3%
|
1.02
|
US$40,494
|
|
|
2011-10-17 |
2011-10-13 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
5,000
-0.0%
1.02
US$5,100
|
5,000
-0.0%
|
1.02
|
US$5,100
|
|
|
2011-10-17 |
2011-10-13 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
5,000
-0.0%
1.02
US$5,100
|
5,000
-0.0%
|
1.02
|
US$5,100
|
|
|
2011-10-13 |
2011-10-12 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
131,800
-1.0%
102.00
US$13,443,600
|
131,800
-1.0%
|
102.00
|
US$13,443,600
|
|
|
2011-10-13 |
2011-10-12 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
131,800
-1.0%
102.00
US$13,443,600
|
131,800
-1.0%
|
102.00
|
US$13,443,600
|
|
|
2011-10-13 |
2011-10-11 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
206,500
-1.5%
1.02
US$210,630
|
206,500
-1.5%
|
1.02
|
US$210,630
|
|
|
2011-10-13 |
2011-10-11 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
206,500
-1.5%
1.02
US$210,630
|
206,500
-1.5%
|
1.02
|
US$210,630
|
|
|
2011-10-11 |
2011-10-10 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
230,000
-1.7%
1.04
US$239,200
|
230,000
-1.7%
|
1.04
|
US$239,200
|
|
|
2011-10-11 |
2011-10-10 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
230,000
-1.7%
1.04
US$239,200
|
230,000
-1.7%
|
1.04
|
US$239,200
|
|
|
2011-10-11 |
2011-10-07 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
275,200
-2.0%
1.03
US$283,456
|
275,200
-2.0%
|
1.03
|
US$283,456
|
|
|
2011-10-11 |
2011-10-07 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
275,200
-2.0%
1.03
US$283,456
|
275,200
-2.0%
|
1.03
|
US$283,456
|
|
|
2011-10-06 |
2011-10-06 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
170,000
-1.2%
1.02
US$173,400
|
170,000
-1.2%
|
1.02
|
US$173,400
|
|
|
2011-10-06 |
2011-10-06 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
170,000
-1.2%
1.02
US$173,400
|
170,000
-1.2%
|
1.02
|
US$173,400
|
|
|
2011-10-06 |
2011-10-05 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
33,124
-0.2%
1.02
US$33,786
|
33,124
-0.2%
|
1.02
|
US$33,786
|
|
|
2011-10-06 |
2011-10-05 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
33,124
-0.2%
1.02
US$33,786
|
33,124
-0.2%
|
1.02
|
US$33,786
|
|
|
2011-10-06 |
2011-09-30 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
23,308
-0.2%
1.02
US$23,774
|
23,308
-0.2%
|
1.02
|
US$23,774
|
|
|
2011-10-06 |
2011-09-30 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
23,308
-0.2%
1.02
US$23,774
|
23,308
-0.2%
|
1.02
|
US$23,774
|
|
|
2011-10-06 |
2011-09-29 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
53,800
-0.4%
1.02
US$54,876
|
53,800
-0.4%
|
1.02
|
US$54,876
|
|
|
2011-10-06 |
2011-09-29 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
53,800
-0.4%
1.02
US$54,876
|
53,800
-0.4%
|
1.02
|
US$54,876
|
|
|
2011-10-06 |
2011-09-28 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
100,000
-0.7%
1.02
US$102,000
|
100,000
-0.7%
|
1.02
|
US$102,000
|
|
|
2011-10-06 |
2011-09-28 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
100,000
-0.7%
1.02
US$102,000
|
100,000
-0.7%
|
1.02
|
US$102,000
|
|
|
2011-09-28 |
2011-09-27 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
200,000
-1.4%
1.09
US$218,000
|
200,000
-1.4%
|
1.09
|
US$218,000
|
|
|
2011-09-28 |
2011-09-27 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
200,000
-1.4%
1.09
US$218,000
|
200,000
-1.4%
|
1.09
|
US$218,000
|
|
|
2011-09-28 |
2011-09-26 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
210,000
-1.4%
1.11
US$233,100
|
210,000
-1.4%
|
1.11
|
US$233,100
|
|
|
2011-09-28 |
2011-09-26 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
210,000
-1.4%
1.11
US$233,100
|
210,000
-1.4%
|
1.11
|
US$233,100
|
|
|
2011-07-13 |
2011-07-12 |
S
Sale
|
Cole Jason
SVP & General Counsel
Officer
|
54,687
-82.9%
2.70
US$147,655
|
54,687
-82.9%
|
2.70
|
US$147,655
|
|
|
2011-07-13 |
2011-07-12 |
S
Sale
|
Cole Jason
SVP & General Counsel
Officer
|
70,947
-86.3%
2.70
US$191,557
|
70,947
-86.3%
|
2.70
|
US$191,557
|
|
|
2011-06-13 |
2011-06-09 |
S
Sale
|
Cole Jason
SVP & General Counsel
Officer
|
54,687
-82.9%
2.33
US$127,421
|
54,687
-82.9%
|
2.33
|
US$127,421
|
|
|
2011-06-13 |
2011-06-09 |
S
Sale
|
Cole Jason
SVP & General Counsel
Officer
|
70,948
-86.3%
2.33
US$165,309
|
70,948
-86.3%
|
2.33
|
US$165,309
|
|
|
2010-04-26 |
2010-04-22 |
B
Purchase
|
Richardson Hartley T
Non-Executive Director
|
343
+0.2%
1.36
US$466
|
343
+0.2%
|
1.36
|
US$466
|
|
|
2010-04-15 |
2010-04-13 |
B
Purchase
|
Richardson Hartley T
Non-Executive Director
|
161,200
+422.5%
1.24
US$199,888
|
161,200
+422.5%
|
1.24
|
US$199,888
|
|
|
2009-12-24 |
2009-12-22 |
S
Sale
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Large shareholder
|
1,863,000
-21.4%
0.80
US$1,490,400
|
1,863,000
-21.4%
|
0.80
|
US$1,490,400
|
|
|
2009-12-24 |
2009-12-22 |
S
Sale
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Large shareholder
|
538,000
-5.8%
0.80
US$430,400
|
538,000
-5.8%
|
0.80
|
US$430,400
|
|
|
2009-12-24 |
2009-12-22 |
S
Sale
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Large shareholder
|
776,899
-7.8%
0.80
US$621,519
|
776,899
-7.8%
|
0.80
|
US$621,519
|
|
|
2008-12-09 |
2008-12-05 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
28,000
+0.3%
0.57
US$15,960
|
28,000
+0.3%
|
0.57
|
US$15,960
|
|
|
2008-12-09 |
2008-12-05 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
8,000
+0.1%
0.57
US$4,560
|
8,000
+0.1%
|
0.57
|
US$4,560
|
|
|
2008-12-09 |
2008-12-05 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
11,000
+0.1%
0.57
US$6,270
|
11,000
+0.1%
|
0.57
|
US$6,270
|
|
|
2008-12-09 |
2008-12-05 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
3,000
+0.0%
0.57
US$1,709
|
3,000
+0.0%
|
0.57
|
US$1,709
|
|
|
2008-12-09 |
2008-12-05 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
1,000
+0.0%
0.57
US$570
|
1,000
+0.0%
|
0.57
|
US$570
|
|
