|
2015-12-22 |
2015-12-21 |
B
Compra
|
Ticktin Robert
General Counsel
Oficial
|
42 706
-1.4%
244,38
76.591 US$
|
42 706
-1.4%
|
244,38
|
76.591 US$
|
|
|
2015-12-21 |
2015-12-17 |
B
Compra
|
Vincent Aurentz
Chief Business Officer
Oficial
|
71 230
+31.5%
328,36
2.543.053 US$
|
71 230
+31.5%
|
328,36
|
2.543.053 US$
|
|
|
2015-12-17 |
2015-12-16 |
B
Compra
|
Munshi Amit
Chief Executive Officer
Consejero ejecutivo
|
67 000
+17.7%
338,25
1.032.784 US$
|
67 000
+17.7%
|
338,25
|
1.032.784 US$
|
|
|
2015-12-16 |
2015-12-15 |
B
Compra
|
Munshi Amit
Chief Executive Officer
Consejero ejecutivo
|
8 069
+5.3%
2,87
23.158 US$
|
8 069
+5.3%
|
2,87
|
23.158 US$
|
|
|
2015-12-11 |
2015-12-09 |
B
Compra
|
Vincent Aurentz
Chief Business Officer
Oficial
|
2 800
+inf%
3,85
10.780 US$
|
2 800
+inf%
|
3,85
|
10.780 US$
|
|
|
2015-12-10 |
2015-12-09 |
B
Compra
|
Munshi Amit
Chief Executive Officer
Consejero ejecutivo
|
13 190
+9.4%
4,07
53.683 US$
|
13 190
+9.4%
|
4,07
|
53.683 US$
|
|
|
2015-09-22 |
2015-09-21 |
B
Compra
|
Munshi Amit
Chief Executive Officer
Consejero ejecutivo
|
10 000
+7.7%
6,19
61.900 US$
|
10 000
+7.7%
|
6,19
|
61.900 US$
|
|
|
2015-09-21 |
2015-09-18 |
B
Compra
|
Munshi Amit
Chief Executive Officer
Consejero ejecutivo
|
10 000
+8.3%
5,99
59.860 US$
|
10 000
+8.3%
|
5,99
|
59.860 US$
|
|
|
2015-02-09 |
2015-02-06 |
S
Venta
|
MONTREUX EQUITY PARTNERS IV LP
Gran accionista
|
100 000
-5.6%
5,01
500.930 US$
|
100 000
-5.6%
|
5,01
|
500.930 US$
|
|
|
2015-02-09 |
2015-02-05 |
S
Venta
|
MONTREUX EQUITY PARTNERS IV LP
Gran accionista
|
67 316
-3.7%
4,97
334.843 US$
|
67 316
-3.7%
|
4,97
|
334.843 US$
|
|
|
2015-02-06 |
2015-02-04 |
B
Compra
|
ROCKLAGE SCOTT M
Consejero no ejecutivo
Gran accionista
|
389 950
+18.1%
5,00
1.949.750 US$
|
389 950
+18.1%
|
5,00
|
1.949.750 US$
|
|
|
2015-02-06 |
2015-02-04 |
B
Compra
|
5AM Partners III, LLC
Gran accionista
|
389 950
+18.1%
5,00
1.949.750 US$
|
389 950
+18.1%
|
5,00
|
1.949.750 US$
|
|
|
2015-02-06 |
2015-02-04 |
B
Compra
|
ROCKLAGE SCOTT M
Consejero no ejecutivo
Gran accionista
|
10 050
+18.1%
5,00
50.250 US$
|
10 050
+18.1%
|
5,00
|
50.250 US$
|
|
|
2015-02-06 |
2015-02-04 |
B
Compra
|
5AM Partners III, LLC
Gran accionista
|
10 050
+18.1%
5,00
50.250 US$
|
10 050
+18.1%
|
5,00
|
50.250 US$
|
|
|
2015-02-05 |
2015-02-04 |
S
Venta
|
MONTREUX EQUITY PARTNERS IV LP
Gran accionista
|
5 684
-0.3%
4,95
28.139 US$
|
5 684
-0.3%
|
4,95
|
28.139 US$
|
|
|
2015-02-05 |
2015-02-03 |
S
Venta
|
MONTREUX EQUITY PARTNERS IV LP
Gran accionista
|
47 000
-2.5%
4,99
234.431 US$
|
47 000
-2.5%
|
4,99
|
234.431 US$
|
|
|
2015-01-28 |
2015-01-26 |
S
Venta
|
MONTREUX EQUITY PARTNERS IV LP
Gran accionista
|
38 516
-2.0%
6,47
249.102 US$
|
38 516
-2.0%
|
6,47
|
249.102 US$
|
|
|
2015-01-26 |
2015-01-23 |
S
Venta
|
MONTREUX EQUITY PARTNERS IV LP
Gran accionista
|
8 400
-0.4%
6,27
52.699 US$
|
8 400
-0.4%
|
6,27
|
52.699 US$
|
|
|
2015-01-26 |
2015-01-22 |
S
Venta
|
MONTREUX EQUITY PARTNERS IV LP
Gran accionista
|
14 130
-0.7%
6,30
88.979 US$
|
14 130
-0.7%
|
6,30
|
88.979 US$
|
|
|
2011-10-28 |
2011-10-27 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
738 807
-6.2%
1,03
760.971 US$
|
738 807
-6.2%
|
1,03
|
760.971 US$
|
|
|
2011-10-28 |
2011-10-27 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
738 807
-6.2%
1,03
760.971 US$
|
738 807
-6.2%
|
1,03
|
760.971 US$
|
|
|
2011-10-27 |
2011-10-26 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
78 000
-0.7%
1,02
79.560 US$
|
78 000
-0.7%
|
1,02
|
79.560 US$
|
|
|
2011-10-27 |
2011-10-26 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
78 000
-0.7%
1,02
79.560 US$
|
78 000
-0.7%
|
1,02
|
79.560 US$
|
|
|
2011-10-27 |
2011-10-25 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
203 200
-1.7%
1,02
207.264 US$
|
203 200
-1.7%
|
1,02
|
207.264 US$
|
|
|
2011-10-27 |
2011-10-25 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
203 200
-1.7%
1,02
207.264 US$
|
203 200
-1.7%
|
1,02
|
207.264 US$
|
|
|
2011-10-25 |
2011-10-24 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
252 000
-2.0%
1,03
259.560 US$
|
252 000
-2.0%
|
1,03
|
259.560 US$
|
|
|
2011-10-25 |
2011-10-24 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
252 000
-2.0%
1,03
259.560 US$
|
252 000
-2.0%
|
1,03
|
259.560 US$
|
|
|
2011-10-25 |
2011-10-21 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
70 100
-0.6%
1,02
71.502 US$
|
70 100
-0.6%
|
1,02
|
71.502 US$
|
|
|
2011-10-25 |
2011-10-21 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
70 100
-0.6%
1,02
71.502 US$
|
70 100
-0.6%
|
1,02
|
71.502 US$
|
|
|
2011-10-21 |
2011-10-20 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
425 000
-3.3%
1,03
437.750 US$
|
425 000
-3.3%
|
1,03
|
437.750 US$
|
|
|
2011-10-21 |
2011-10-20 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
425 000
-3.3%
1,03
437.750 US$
|
425 000
-3.3%
|
1,03
|
437.750 US$
|
|
|
2011-10-21 |
2011-10-19 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
34 817
-0.3%
1,02
35.513 US$
|
34 817
-0.3%
|
1,02
|
35.513 US$
|
|
|
2011-10-21 |
2011-10-19 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
34 817
-0.3%
1,02
35.513 US$
|
34 817
-0.3%
|
1,02
|
35.513 US$
|
|
|
2011-10-19 |
2011-10-17 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
19 644
-0.2%
1,02
20.037 US$
|
19 644
-0.2%
|
1,02
|
20.037 US$
|
|
|
2011-10-19 |
2011-10-17 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
19 644
-0.2%
1,02
20.037 US$
|
19 644
-0.2%
|
1,02
|
20.037 US$
|
|
|
2011-10-17 |
2011-10-14 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
39 700
-0.3%
1,02
40.494 US$
|
39 700
-0.3%
|
1,02
|
40.494 US$
|
|
|
2011-10-17 |
2011-10-14 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
39 700
-0.3%
1,02
40.494 US$
|
39 700
-0.3%
|
1,02
|
40.494 US$
|
|
|
2011-10-17 |
2011-10-13 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
5 000
-0.0%
1,02
5.100 US$
|
5 000
-0.0%
|
1,02
|
5.100 US$
|
|
|
2011-10-17 |
2011-10-13 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
5 000
-0.0%
1,02
5.100 US$
|
5 000
-0.0%
|
1,02
|
5.100 US$
|
|
|
2011-10-13 |
2011-10-12 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
131 800
-1.0%
102,00
13.443.600 US$
|
131 800
-1.0%
|
102,00
|
13.443.600 US$
|
|
|
2011-10-13 |
2011-10-12 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
131 800
-1.0%
102,00
13.443.600 US$
|
131 800
-1.0%
|
102,00
|
13.443.600 US$
|
|
|
2011-10-13 |
2011-10-11 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
206 500
-1.5%
1,02
210.630 US$
|
206 500
-1.5%
|
1,02
|
210.630 US$
|
|
|
2011-10-13 |
2011-10-11 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
206 500
-1.5%
1,02
210.630 US$
|
206 500
-1.5%
|
1,02
|
210.630 US$
|
|
|
2011-10-11 |
2011-10-10 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
230 000
-1.7%
1,04
239.200 US$
|
230 000
-1.7%
|
1,04
|
239.200 US$
|
|
|
2011-10-11 |
2011-10-10 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
230 000
-1.7%
1,04
239.200 US$
|
230 000
-1.7%
|
1,04
|
239.200 US$
|
|
|
2011-10-11 |
2011-10-07 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
275 200
-2.0%
1,03
283.456 US$
|
275 200
-2.0%
|
1,03
|
283.456 US$
|
|
|
2011-10-11 |
2011-10-07 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
275 200
-2.0%
1,03
283.456 US$
|
275 200
-2.0%
|
1,03
|
283.456 US$
|
|
|
2011-10-06 |
2011-10-06 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
170 000
-1.2%
1,02
173.400 US$
|
170 000
-1.2%
|
1,02
|
173.400 US$
|
|
|
2011-10-06 |
2011-10-06 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
170 000
-1.2%
1,02
173.400 US$
|
170 000
-1.2%
|
1,02
|
173.400 US$
|
|
|
2011-10-06 |
2011-10-05 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
33 124
-0.2%
1,02
33.786 US$
|
33 124
-0.2%
|
1,02
|
33.786 US$
|
|
|
2011-10-06 |
2011-10-05 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
33 124
-0.2%
1,02
33.786 US$
|
33 124
-0.2%
|
1,02
|
33.786 US$
|
|
|
2011-10-06 |
2011-09-30 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
23 308
-0.2%
1,02
23.774 US$
|
23 308
-0.2%
|
1,02
|
23.774 US$
|
|
|
2011-10-06 |
2011-09-30 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
23 308
-0.2%
1,02
23.774 US$
|
23 308
-0.2%
|
1,02
|
23.774 US$
|
|
|
2011-10-06 |
2011-09-29 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
53 800
-0.4%
1,02
54.876 US$
|
53 800
-0.4%
|
1,02
|
54.876 US$
|
|
|
2011-10-06 |
2011-09-29 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
53 800
-0.4%
1,02
54.876 US$
|
53 800
-0.4%
|
1,02
|
54.876 US$
|
|
|
2011-10-06 |
2011-09-28 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
100 000
-0.7%
1,02
102.000 US$
|
100 000
-0.7%
|
1,02
|
102.000 US$
|
|
|
2011-10-06 |
2011-09-28 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
100 000
-0.7%
1,02
102.000 US$
|
100 000
-0.7%
|
1,02
|
102.000 US$
|
|
|
2011-09-28 |
2011-09-27 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
200 000
-1.4%
1,09
218.000 US$
|
200 000
-1.4%
|
1,09
|
218.000 US$
|
|
|
2011-09-28 |
2011-09-27 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
200 000
-1.4%
1,09
218.000 US$
|
200 000
-1.4%
|
1,09
|
218.000 US$
|
|
|
2011-09-28 |
2011-09-26 |
S
Venta
|
MPM BIOVENTURES III LLC
Gran accionista
|
210 000
-1.4%
1,11
233.100 US$
|
210 000
-1.4%
|
1,11
|
233.100 US$
|
|
|
2011-09-28 |
2011-09-26 |
S
Venta
|
EVNIN LUKE
Gran accionista
|
210 000
-1.4%
1,11
233.100 US$
|
210 000
-1.4%
|
1,11
|
233.100 US$
|
|
|
2011-07-13 |
2011-07-12 |
S
Venta
|
Cole Jason
SVP & General Counsel
Oficial
|
54 687
-82.9%
2,70
147.655 US$
|
54 687
-82.9%
|
2,70
|
147.655 US$
|
|
|
2011-07-13 |
2011-07-12 |
S
Venta
|
Cole Jason
SVP & General Counsel
Oficial
|
70 947
-86.3%
2,70
191.557 US$
|
70 947
-86.3%
|
2,70
|
191.557 US$
|
|
|
2011-06-13 |
2011-06-09 |
S
Venta
|
Cole Jason
SVP & General Counsel
Oficial
|
54 687
-82.9%
2,33
127.421 US$
|
54 687
-82.9%
|
2,33
|
127.421 US$
|
|
|
2011-06-13 |
2011-06-09 |
S
Venta
|
Cole Jason
SVP & General Counsel
Oficial
|
70 948
-86.3%
2,33
165.309 US$
|
70 948
-86.3%
|
2,33
|
165.309 US$
|
|
|
2010-04-26 |
2010-04-22 |
B
Compra
|
Richardson Hartley T
Consejero no ejecutivo
|
343
+0.2%
1,36
466 US$
|
343
+0.2%
|
1,36
|
466 US$
|
|
|
2010-04-15 |
2010-04-13 |
B
Compra
|
Richardson Hartley T
Consejero no ejecutivo
|
161 200
+422.5%
1,24
199.888 US$
|
161 200
+422.5%
|
1,24
|
199.888 US$
|
|
|
2009-12-24 |
2009-12-22 |
S
Venta
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Gran accionista
|
1 863 000
-21.4%
0,80
1.490.400 US$
|
1 863 000
-21.4%
|
0,80
|
1.490.400 US$
|
|
|
2009-12-24 |
2009-12-22 |
S
Venta
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Gran accionista
|
538 000
-5.8%
0,80
430.400 US$
|
538 000
-5.8%
|
0,80
|
430.400 US$
|
|
|
2009-12-24 |
2009-12-22 |
S
Venta
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Gran accionista
|
776 899
-7.8%
0,80
621.519 US$
|
776 899
-7.8%
|
0,80
|
621.519 US$
|
|
|
2008-12-09 |
2008-12-05 |
B
Compra
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Gran accionista
|
28 000
+0.3%
0,57
15.960 US$
|
28 000
+0.3%
|
0,57
|
15.960 US$
|
|
|
2008-12-09 |
2008-12-05 |
B
Compra
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Gran accionista
|
8 000
+0.1%
0,57
4.560 US$
|
8 000
+0.1%
|
0,57
|
4.560 US$
|
|
|
2008-12-09 |
2008-12-05 |
B
Compra
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Gran accionista
|
11 000
+0.1%
0,57
6.270 US$
|
11 000
+0.1%
|
0,57
|
6.270 US$
|
|
|
2008-12-09 |
2008-12-05 |
B
Compra
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Gran accionista
|
3 000
+0.0%
0,57
1.709 US$
|
3 000
+0.0%
|
0,57
|
1.709 US$
|
|
|
2008-12-09 |
2008-12-05 |
B
Compra
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Gran accionista
|
1 000
+0.0%
0,57
570 US$
|
1 000
+0.0%
|
0,57
|
570 US$
|
|