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United States Pharmaceuticals

Amylyx Pharmaceuticals Inc (AMLX)

Track

Over the last 90 days, insider trading at Amylyx Pharmaceuticals Inc. shows a net buy of $51,338 from one insider. This contrasts with significant selling activity by multiple executives in early March, totaling over $1.1 million. The stock has seen a 11.1% decrease in the last 90 days.
Stock chart
Ticker: AMLX Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
Firestone Karen
1 purchase — total 51,338 USD
Buy 21 May 2026
Value US$4,073,471.57 | Price 388.00 | Shares 62,869
Sale 2 Mar 2026
Value US$353,094.35 | Price 449.64 | Shares 12,337
Proposed sale 2 Mar 2026
Value US$1,317,201.94 | Price 44.55 | Shares 71,454
Sale 2 Mar 2026
Value US$423,760.32 | Price 14.47 | Shares 29,282
Proposed sale 2 Mar 2026
Value US$423,760.00 | Price 14.47 | Shares 29,282
Sale 2 Mar 2026
Value US$94,205.26 | Price 14.58 | Shares 6,461
Proposed sale 2 Mar 2026
Value US$94,205.00 | Price 14.58 | Shares 6,461
Sale 2 Mar 2026
Value US$99,378.30 | Price 14.52 | Shares 6,844
Proposed sale 2 Mar 2026
Value US$99,379.00 | Price 14.52 | Shares 6,844
Sale 2 Mar 2026
Value US$114,851.33 | Price 14.52 | Shares 7,909
Proposed sale 2 Mar 2026
Value US$114,852.00 | Price 14.52 | Shares 7,909
Sale 23 Feb 2026
Value US$48,352.18 | Price 14.14 | Shares 3,419
Proposed sale 23 Feb 2026
Value US$48,352.00 | Price 14.14 | Shares 3,419
Sale 2 Feb 2026
Value US$227,592.70 | Price 14.68 | Shares 15,500
Proposed sale 2 Feb 2026
Value US$227,593.00 | Price 14.68 | Shares 15,500
Sale 2 Feb 2026
Value US$50,515.61 | Price 14.65 | Shares 3,448
Proposed sale 2 Feb 2026
Value US$50,515.00 | Price 14.65 | Shares 3,448
Sale 2 Feb 2026
Value US$227,617.50 | Price 14.69 | Shares 15,500
Proposed sale 2 Feb 2026
Value US$227,617.00 | Price 14.68 | Shares 15,500
Sale 2 Feb 2026
Value US$52,096.89 | Price 14.65 | Shares 3,557
Proposed sale 2 Feb 2026
Value US$52,097.00 | Price 14.65 | Shares 3,557
Sale 16 Jan 2026
Value US$27,701.17 | Price 13.89 | Shares 1,995
Sale 16 Jan 2026
Value US$27,299.04 | Price 13.83 | Shares 1,974
Proposed sale 16 Jan 2026
Value US$26,972.40 | Price 13.52 | Shares 1,995
Proposed sale 16 Jan 2026
Value US$26,688.48 | Price 13.52 | Shares 1,974
Sale 15 Jan 2026
Value US$1,849,868.66 | Price 13.58 | Shares 136,193
Sale 15 Jan 2026
Value US$1,850,794.77 | Price 13.59 | Shares 136,193
Proposed sale 15 Jan 2026
Value US$1,916,235.51 | Price 14.07 | Shares 136,193
Proposed sale 15 Jan 2026
Value US$1,916,235.51 | Price 14.07 | Shares 136,193
Sale 6 Jan 2026
Value US$85,589.44 | Price 11.09 | Shares 7,715
Proposed sale 6 Jan 2026
Value US$85,590.00 | Price 11.09 | Shares 7,715
Sale 6 Jan 2026
Value US$85,596.38 | Price 11.09 | Shares 7,715
Proposed sale 6 Jan 2026
Value US$85,597.00 | Price 11.09 | Shares 7,715
Sale 6 Jan 2026
Value US$36,953.86 | Price 11.11 | Shares 3,326
Proposed sale 6 Jan 2026
Value US$36,954.00 | Price 11.11 | Shares 3,326
Buy 23 Dec 2025
Value US$100,845.00 | Price 12.45 | Shares 8,100
Sale 1 Dec 2025
Value US$94,418.39 | Price 14.35 | Shares 6,580
Proposed sale 1 Dec 2025
Value US$94,419.00 | Price 14.35 | Shares 6,580
Sale 30 Sep 2025
Value US$175,517.78 | Price 14.58 | Shares 12,039
Sale 30 Sep 2025
Value US$128,668.98 | Price 14.58 | Shares 8,828
Sale 30 Sep 2025
Value US$2,999.50 | Price 15.00 | Shares 200
Sale 30 Sep 2025
Value US$426,469.34 | Price 14.34 | Shares 29,733
Sale 30 Sep 2025
Value US$154,650.42 | Price 14.65 | Shares 10,558
Sale 30 Sep 2025
Value US$3,002.00 | Price 15.01 | Shares 200
Sale 30 Sep 2025
Value US$427,950.12 | Price 14.37 | Shares 29,775
Planned sale 13 Aug 2025
Value US$125,046.00 | Price 8.34 | Shares 15,000
Planned sale 12 Aug 2025
Value US$121,102.50 | Price 8.07 | Shares 15,000
Proposed sale 12 Aug 2025
Value US$234,600.00 | Price 7.82 | Shares 30,000
Sale 31 Mar 2025
Value US$37,805.85 | Price 3.47 | Shares 10,896
Sale 31 Mar 2025
Value US$31,954.15 | Price 3.48 | Shares 9,192
Sale 31 Mar 2025
Value US$43,082.44 | Price 3.47 | Shares 12,425
Sale 31 Mar 2025
Value US$74,454.25 | Price 3.46 | Shares 21,490
Sale 31 Mar 2025
Value US$74,482.19 | Price 3.47 | Shares 21,490
Buy 20 Mar 2025
Value US$37,005.00 | Price 3.70 | Shares 10,000
Sale 3 Mar 2025
Value US$14,549.15 | Price 3.17 | Shares 4,595
Sale 3 Mar 2025
Value US$14,483.44 | Price 3.15 | Shares 4,595
Sale 3 Mar 2025
Value US$5,022.29 | Price 3.12 | Shares 1,611
Sale 24 Feb 2025
Value US$13,144.86 | Price 3.15 | Shares 4,169
Sale 3 Feb 2025
Value US$41,103.66 | Price 3.47 | Shares 11,855
Sale 3 Feb 2025
Value US$41,107.56 | Price 3.47 | Shares 11,851
Sale 3 Feb 2025
Value US$12,839.16 | Price 3.49 | Shares 3,678
Sale 6 Jan 2025
Value US$30,201.52 | Price 4.04 | Shares 7,471
Sale 6 Jan 2025
Value US$30,232.15 | Price 4.05 | Shares 7,471
Sale 2 Dec 2024
Value US$30,007.40 | Price 5.54 | Shares 5,421
Sale 30 Sep 2024
Value US$27,840.06 | Price 3.20 | Shares 8,709
Sale 30 Sep 2024
Value US$36,559.48 | Price 3.20 | Shares 11,442
Sale 30 Sep 2024
Value US$59,429.03 | Price 3.20 | Shares 18,589
Sale 30 Sep 2024
Value US$59,414.16 | Price 3.20 | Shares 18,589
Buy 12 Sep 2024
Value US$101,368.00 | Price 2.53 | Shares 40,000
Buy 5 Sep 2024
Value US$106,590.00 | Price 2.13 | Shares 50,000
Buy 3 Sep 2024
Value US$219,800.00 | Price 2.20 | Shares 100,000
Planned sale 15 May 2024
Value US$19,654.35 | Price 1.88 | Shares 10,455
Buy 15 May 2024
Value US$4,252.28 | Price 1.89 | Shares 2,250
Proposed sale 15 May 2024
Value US$19,550.85 | Price 1.87 | Shares 10,455
Buy 14 May 2024
Value US$5,183.75 | Price 1.89 | Shares 2,750
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-05-26 2026-05-21 B Purchase
3.8
Firestone Karen
Non-Executive Director
62,869 -30.6%
388.00
US$4,073,472 		62,869 -30.6% 388.00 US$4,073,472
2026-03-04 2026-03-02 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
12,337 -10.3%
449.64
US$353,094 		12,337 -10.3% 449.64 US$353,094
2026-03-04 2026-03-02 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
19,783 -43.8%
366.03
US$1,824,715 		19,783 -43.8% 366.03 US$1,824,715
2026-03-04 2026-03-02 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
6,461 -3.7%
14.58
US$94,205 		6,461 -3.7% 14.58 US$94,205
2026-03-04 2026-03-02 S Sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
6,844 -4.8%
14.52
US$99,378 		6,844 -4.8% 14.52 US$99,378
2026-03-04 2026-03-02 S Sale
4.0
FRATES JAMES M

Chief Financial Officer

Officer
7,909 -4.6%
14.52
US$114,851 		7,909 -4.6% 14.52 US$114,851
2026-03-02 2026-03-02 PrS Proposed sale
3.7
Bedrosian Camille L

Officer

Officer
6,461
14.58
US$94,205 		6,461 14.58 US$94,205
2026-03-02 2026-03-02 PrS Proposed sale
4.0
Frates James M

Officer

Officer
7,909
14.52
US$114,852 		7,909 14.52 US$114,852
2026-03-02 2026-03-02 PrS Proposed sale
3.7
Mazzariello Gina

Officer

Officer
6,844
14.52
US$99,379 		6,844 14.52 US$99,379
2026-03-02 2026-03-02 PrS Proposed sale
2.8
Cohen Joshua B

Officer; Director

Executive Director
29,282
14.48
US$424,120 		29,282 14.48 US$424,120
2026-03-02 2026-03-02 PrS Proposed sale
2.8
Klee Justin B.

Officer; Director

Executive Director
29,282
14.47
US$423,760 		29,282 14.47 US$423,760
2026-02-25 2026-02-23 S Sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
3,419 -2.4%
14.14
US$48,352 		3,419 -2.4% 14.14 US$48,352
2026-02-23 2026-02-23 PrS Proposed sale
3.7
Mazzariello Gina

Officer

Officer
3,419
14.14
US$48,352 		3,419 14.14 US$48,352
2026-02-04 2026-02-02 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
15,500 -0.5%
14.68
US$227,593 		15,500 -0.5% 14.68 US$227,593
2026-02-04 2026-02-02 S Sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
3,448 -2.3%
14.65
US$50,516 		3,448 -2.3% 14.65 US$50,516
2026-02-04 2026-02-02 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
15,500 -0.5%
14.69
US$227,618 		15,500 -0.5% 14.69 US$227,618
2026-02-04 2026-02-02 S Sale
4.0
FRATES JAMES M

Chief Financial Officer

Officer
3,557 -2.0%
14.65
US$52,097 		3,557 -2.0% 14.65 US$52,097
2026-02-02 2026-02-02 PrS Proposed sale
2.8
Cohen Joshua B

Officer; Director

Executive Director
15,500
14.68
US$227,593 		15,500 14.68 US$227,593
2026-02-02 2026-02-02 PrS Proposed sale
2.8
Klee Justin B.

Officer; Director

Executive Director
15,500
14.68
US$227,617 		15,500 14.68 US$227,617
2026-02-02 2026-02-02 PrS Proposed sale
3.7
Mazzariello Gina

Officer

Officer
3,448
14.65
US$50,515 		3,448 14.65 US$50,515
2026-02-02 2026-02-02 PrS Proposed sale
4.0
Frates James M

Officer

Officer
3,557
14.65
US$52,097 		3,557 14.65 US$52,097
2026-01-20 2026-01-16 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
1,995 -0.1%
13.89
US$27,701 		1,995 -0.1% 13.89 US$27,701
2026-01-20 2026-01-16 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
1,974 -0.1%
13.83
US$27,299 		1,974 -0.1% 13.83 US$27,299
2026-01-16 2026-01-16 PrS Proposed sale
2.8
JUSTIN KLEE

Director; Officer

Executive Director
1,995
13.52
US$26,972 		1,995 13.52 US$26,972
2026-01-16 2026-01-16 PrS Proposed sale
2.8
JOSHUA COHEN

Director; Officer

Executive Director
1,974
13.52
US$26,688 		1,974 13.52 US$26,688
2026-01-20 2026-01-15 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
136,193 -3.9%
13.58
US$1,849,869 		136,193 -3.9% 13.58 US$1,849,869
2026-01-20 2026-01-15 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
136,193 -3.9%
13.59
US$1,850,795 		136,193 -3.9% 13.59 US$1,850,795
2026-01-15 2026-01-15 PrS Proposed sale
2.8
JOSHUA COHEN

Director; Officer

Executive Director
136,193
14.07
US$1,916,236 		136,193 14.07 US$1,916,236
2026-01-15 2026-01-15 PrS Proposed sale
2.8
JUSTIN KLEE

Director; Officer

Executive Director
136,193
14.07
US$1,916,236 		136,193 14.07 US$1,916,236
2026-01-08 2026-01-06 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
7,715 -0.2%
11.09
US$85,589 		7,715 -0.2% 11.09 US$85,589
2026-01-08 2026-01-06 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
7,715 -0.2%
11.09
US$85,596 		7,715 -0.2% 11.09 US$85,596
2026-01-08 2026-01-06 S Sale
4.0
FRATES JAMES M

Chief Financial Officer

Officer
3,326 -1.8%
11.11
US$36,954 		3,326 -1.8% 11.11 US$36,954
2026-01-06 2026-01-06 PrS Proposed sale
4.0
Frates James M

Officer

Officer
3,326
11.11
US$36,954 		3,326 11.11 US$36,954
2026-01-06 2026-01-06 PrS Proposed sale
2.8
Klee Justin B.

Officer; Director

Executive Director
7,715
11.09
US$85,590 		7,715 11.09 US$85,590
2026-01-06 2026-01-06 PrS Proposed sale
2.8
Cohen Joshua B

Officer; Director

Executive Director
7,715
11.09
US$85,597 		7,715 11.09 US$85,597
2025-12-23 2025-12-23 B Purchase
3.8
Firestone Karen
Non-Executive Director
8,100 +14.7%
12.45
US$100,845 		8,100 +14.7% 12.45 US$100,845
2025-12-03 2025-12-01 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
6,580 -3.6%
14.35
US$94,418 		6,580 -3.6% 14.35 US$94,418
2025-12-01 2025-12-01 PrS Proposed sale
3.7
Bedrosian Camille L

Officer

Officer
6,580
14.35
US$94,419 		6,580 14.35 US$94,419
2025-10-02 2025-09-30 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
12,039 -6.2%
14.58
US$175,518 		12,039 -6.2% 14.58 US$175,518
2025-10-02 2025-09-30 S Sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
8,828 -5.6%
14.58
US$128,669 		8,828 -5.6% 14.58 US$128,669
2025-10-02 2025-09-30 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
200 -0.0%
15.00
US$3,000 		200 -0.0% 15.00 US$3,000
2025-10-02 2025-09-30 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
29,733 -0.9%
14.34
US$426,469 		29,733 -0.9% 14.34 US$426,469
2025-10-02 2025-09-30 S Sale
4.0
FRATES JAMES M

Chief Financial Officer

Officer
10,558 -3.6%
14.65
US$154,650 		10,558 -3.6% 14.65 US$154,650
2025-10-02 2025-09-30 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
200 -0.0%
15.01
US$3,002 		200 -0.0% 15.01 US$3,002
2025-10-02 2025-09-30 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
29,775 -0.9%
14.37
US$427,950 		29,775 -0.9% 14.37 US$427,950
2025-08-14 2025-08-13 PlS Planned sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
15,000 -8.7%
8.34
US$125,046 		15,000 -8.7% 8.34 US$125,046
2025-08-14 2025-08-12 PlS Planned sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
15,000 -8.0%
8.07
US$121,102 		15,000 -8.0% 8.07 US$121,102
2025-08-12 2025-08-12 PrS Proposed sale
3.7
GINA MAZZARIELLO

Officer

Officer
30,000
7.82
US$234,600 		30,000 7.82 US$234,600
2025-04-02 2025-03-31 S Sale
4.0
FRATES JAMES M

Chief Financial Officer

Officer
10,896 -3.6%
3.47
US$37,806 		10,896 -3.6% 3.47 US$37,806
2025-04-02 2025-03-31 S Sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
9,192 -4.7%
3.48
US$31,954 		9,192 -4.7% 3.48 US$31,954
2025-04-02 2025-03-31 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
12,425 -6.0%
3.47
US$43,082 		12,425 -6.0% 3.47 US$43,082
2025-04-02 2025-03-31 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
21,490 -0.6%
3.46
US$74,454 		21,490 -0.6% 3.46 US$74,454
2025-04-02 2025-03-31 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
21,490 -0.6%
3.47
US$74,482 		21,490 -0.6% 3.47 US$74,482
2025-03-24 2025-03-20 B Purchase
3.3
Zeiher Bernhardt G
Non-Executive Director
10,000 +inf%
3.70
US$37,005 		10,000 +inf% 3.70 US$37,005
2025-03-05 2025-03-03 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
4,595 -0.1%
3.17
US$14,549 		4,595 -0.1% 3.17 US$14,549
2025-03-05 2025-03-03 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
4,595 -0.1%
3.15
US$14,483 		4,595 -0.1% 3.15 US$14,483
2025-03-05 2025-03-03 S Sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
1,611 -1.2%
3.12
US$5,022 		1,611 -1.2% 3.12 US$5,022
2025-02-26 2025-02-24 S Sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
4,169 -3.0%
3.15
US$13,145 		4,169 -3.0% 3.15 US$13,145
2025-02-05 2025-02-03 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
11,855 -0.4%
3.47
US$41,104 		11,855 -0.4% 3.47 US$41,104
2025-02-05 2025-02-03 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
11,851 -0.4%
3.47
US$41,108 		11,851 -0.4% 3.47 US$41,108
2025-02-05 2025-02-03 S Sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
3,678 -2.6%
3.49
US$12,839 		3,678 -2.6% 3.49 US$12,839
2025-01-08 2025-01-06 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
7,471 -0.2%
4.04
US$30,202 		7,471 -0.2% 4.04 US$30,202
2025-01-08 2025-01-06 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
7,471 -0.2%
4.05
US$30,232 		7,471 -0.2% 4.05 US$30,232
2024-12-03 2024-12-02 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
5,421 -3.8%
5.54
US$30,007 		5,421 -3.8% 5.54 US$30,007
2024-10-02 2024-09-30 S Sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
8,709 -5.7%
3.20
US$27,840 		8,709 -5.7% 3.20 US$27,840
2024-10-02 2024-09-30 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
11,442 -7.4%
3.20
US$36,559 		11,442 -7.4% 3.20 US$36,559
2024-10-02 2024-09-30 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
18,589 -0.6%
3.20
US$59,429 		18,589 -0.6% 3.20 US$59,429
2024-10-02 2024-09-30 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
18,589 -0.6%
3.20
US$59,414 		18,589 -0.6% 3.20 US$59,414
2024-09-16 2024-09-12 B Purchase
4.0
FRATES JAMES M

Chief Financial Officer

Officer
40,000 +20.7%
2.53
US$101,368 		40,000 +20.7% 2.53 US$101,368
2024-09-09 2024-09-05 B Purchase
3.8
Firestone Karen
Non-Executive Director
50,000 +1000.0%
2.13
US$106,590 		50,000 +1000.0% 2.13 US$106,590
2024-09-05 2024-09-03 B Purchase
3.3
MILNE GEORGE M JR
Non-Executive Director
100,000 +13.2%
2.20
US$219,800 		100,000 +13.2% 2.20 US$219,800
2024-05-16 2024-05-15 PlS Planned sale
3.7
Mazzariello Gina

Chief Legal Officer

Officer
10,455 -6.5%
1.88
US$19,654 		10,455 -6.5% 1.88 US$19,654
2024-05-16 2024-05-15 B Purchase
2.1
Quimi Daphne
Non-Executive Director
2,250 +81.8%
1.89
US$4,252 		2,250 +81.8% 1.89 US$4,252
2024-05-15 2024-05-15 PrS Proposed sale
3.7
GINA MAZZARIELLO

Officer

Officer
10,455
1.87
US$19,551 		10,455 1.87 US$19,551
2024-05-16 2024-05-14 B Purchase
2.1
Quimi Daphne
Non-Executive Director
2,750 +inf%
1.89
US$5,184 		2,750 +inf% 1.89 US$5,184
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