United States Pharmaceuticals

Amylyx Pharmaceuticals Inc (AMLX)

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Over the past 90 days, Amylyx Pharmaceuticals Inc. saw four insider transactions, resulting in a net negative value of approximately $1.02 million. While there was a purchase of $51,338 in May, recent activity has been dominated by planned sales from the Chief Legal Officer, totaling over $500,000 in July, following the company's April results financiers.
Ticker: AMLX Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Amylyx Pharmaceuticals Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Planned sale 10 Jul 2026
Value US$2,476,470.24 | Price 335.37 | Shares 31,651 (+32.6%)
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-07-13 2026-07-10 PlS Planned sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
31,651 +32.6%
335.37
US$2,476,470 		31,651 +32.6% 335.37 US$2,476,470
2026-07-13 2026-07-09 PlS Planned sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
37,284 +0.7%
100.27
US$4,545,397 		37,284 +0.7% 100.27 US$4,545,397
2026-07-09 2026-07-09 PrS Proposed sale
3.5
GINA MAZZARIELLO

Officer

Officer
60,056
197.11
US$3,928,342 		60,056 197.11 US$3,928,342
2026-05-26 2026-05-21 B Purchase
3.9
Firestone Karen
Non-Executive Director
3,800 +6.0%
13.51
US$51,338 		3,800 +6.0% 13.51 US$51,338
2026-03-04 2026-03-02 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
29,282 -0.9%
14.48
US$424,120 		29,282 -0.9% 14.48 US$424,120
2026-03-04 2026-03-02 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
29,282 -0.9%
14.47
US$423,760 		29,282 -0.9% 14.47 US$423,760
2026-03-04 2026-03-02 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
6,461 -3.7%
14.58
US$94,205 		6,461 -3.7% 14.58 US$94,205
2026-03-04 2026-03-02 S Sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
6,844 -4.8%
14.52
US$99,378 		6,844 -4.8% 14.52 US$99,378
2026-03-04 2026-03-02 S Sale
3.9
FRATES JAMES M

Chief Financial Officer

Officer
7,909 -4.6%
14.52
US$114,851 		7,909 -4.6% 14.52 US$114,851
2026-03-02 2026-03-02 PrS Proposed sale
3.7
Bedrosian Camille L

Officer

Officer
6,461
14.58
US$94,205 		6,461 14.58 US$94,205
2026-03-02 2026-03-02 PrS Proposed sale
3.9
Frates James M

Officer

Officer
7,909
14.52
US$114,852 		7,909 14.52 US$114,852
2026-03-02 2026-03-02 PrS Proposed sale
3.5
Mazzariello Gina

Officer

Officer
6,844
14.52
US$99,379 		6,844 14.52 US$99,379
2026-03-02 2026-03-02 PrS Proposed sale
2.8
Cohen Joshua B

Officer; Director

Executive Director
29,282
14.48
US$424,120 		29,282 14.48 US$424,120
2026-03-02 2026-03-02 PrS Proposed sale
2.8
Klee Justin B.

Officer; Director

Executive Director
29,282
14.47
US$423,760 		29,282 14.47 US$423,760
2026-02-25 2026-02-23 S Sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
3,419 -2.4%
14.14
US$48,352 		3,419 -2.4% 14.14 US$48,352
2026-02-23 2026-02-23 PrS Proposed sale
3.5
Mazzariello Gina

Officer

Officer
3,419
14.14
US$48,352 		3,419 14.14 US$48,352
2026-02-04 2026-02-02 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
15,500 -0.5%
14.68
US$227,593 		15,500 -0.5% 14.68 US$227,593
2026-02-04 2026-02-02 S Sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
3,448 -2.3%
14.65
US$50,516 		3,448 -2.3% 14.65 US$50,516
2026-02-04 2026-02-02 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
15,500 -0.5%
14.69
US$227,618 		15,500 -0.5% 14.69 US$227,618
2026-02-04 2026-02-02 S Sale
3.9
FRATES JAMES M

Chief Financial Officer

Officer
3,557 -2.0%
14.65
US$52,097 		3,557 -2.0% 14.65 US$52,097
2026-02-02 2026-02-02 PrS Proposed sale
2.8
Cohen Joshua B

Officer; Director

Executive Director
15,500
14.68
US$227,593 		15,500 14.68 US$227,593
2026-02-02 2026-02-02 PrS Proposed sale
2.8
Klee Justin B.

Officer; Director

Executive Director
15,500
14.68
US$227,617 		15,500 14.68 US$227,617
2026-02-02 2026-02-02 PrS Proposed sale
3.5
Mazzariello Gina

Officer

Officer
3,448
14.65
US$50,515 		3,448 14.65 US$50,515
2026-02-02 2026-02-02 PrS Proposed sale
3.9
Frates James M

Officer

Officer
3,557
14.65
US$52,097 		3,557 14.65 US$52,097
2026-01-20 2026-01-16 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
1,995 -0.1%
13.89
US$27,701 		1,995 -0.1% 13.89 US$27,701
2026-01-20 2026-01-16 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
1,974 -0.1%
13.83
US$27,299 		1,974 -0.1% 13.83 US$27,299
2026-01-16 2026-01-16 PrS Proposed sale
2.8
JUSTIN KLEE

Director; Officer

Executive Director
1,995
13.52
US$26,972 		1,995 13.52 US$26,972
2026-01-16 2026-01-16 PrS Proposed sale
2.8
JOSHUA COHEN

Director; Officer

Executive Director
1,974
13.52
US$26,688 		1,974 13.52 US$26,688
2026-01-20 2026-01-15 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
136,193 -3.9%
13.58
US$1,849,869 		136,193 -3.9% 13.58 US$1,849,869
2026-01-20 2026-01-15 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
136,193 -3.9%
13.59
US$1,850,795 		136,193 -3.9% 13.59 US$1,850,795
2026-01-15 2026-01-15 PrS Proposed sale
2.8
JOSHUA COHEN

Director; Officer

Executive Director
136,193
14.07
US$1,916,236 		136,193 14.07 US$1,916,236
2026-01-15 2026-01-15 PrS Proposed sale
2.8
JUSTIN KLEE

Director; Officer

Executive Director
136,193
14.07
US$1,916,236 		136,193 14.07 US$1,916,236
2026-01-08 2026-01-06 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
7,715 -0.2%
11.09
US$85,589 		7,715 -0.2% 11.09 US$85,589
2026-01-08 2026-01-06 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
7,715 -0.2%
11.09
US$85,596 		7,715 -0.2% 11.09 US$85,596
2026-01-08 2026-01-06 S Sale
3.9
FRATES JAMES M

Chief Financial Officer

Officer
3,326 -1.8%
11.11
US$36,954 		3,326 -1.8% 11.11 US$36,954
2026-01-06 2026-01-06 PrS Proposed sale
3.9
Frates James M

Officer

Officer
3,326
11.11
US$36,954 		3,326 11.11 US$36,954
2026-01-06 2026-01-06 PrS Proposed sale
2.8
Klee Justin B.

Officer; Director

Executive Director
7,715
11.09
US$85,590 		7,715 11.09 US$85,590
2026-01-06 2026-01-06 PrS Proposed sale
2.8
Cohen Joshua B

Officer; Director

Executive Director
7,715
11.09
US$85,597 		7,715 11.09 US$85,597
2025-12-23 2025-12-23 B Purchase
3.9
Firestone Karen
Non-Executive Director
8,100 +14.7%
12.45
US$100,845 		8,100 +14.7% 12.45 US$100,845
2025-12-03 2025-12-01 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
6,580 -3.6%
14.35
US$94,418 		6,580 -3.6% 14.35 US$94,418
2025-12-01 2025-12-01 PrS Proposed sale
3.7
Bedrosian Camille L

Officer

Officer
6,580
14.35
US$94,419 		6,580 14.35 US$94,419
2025-10-02 2025-09-30 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
12,039 -6.2%
14.58
US$175,518 		12,039 -6.2% 14.58 US$175,518
2025-10-02 2025-09-30 S Sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
8,828 -5.6%
14.58
US$128,669 		8,828 -5.6% 14.58 US$128,669
2025-10-02 2025-09-30 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
200 -0.0%
15.00
US$3,000 		200 -0.0% 15.00 US$3,000
2025-10-02 2025-09-30 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
29,733 -0.9%
14.34
US$426,469 		29,733 -0.9% 14.34 US$426,469
2025-10-02 2025-09-30 S Sale
3.9
FRATES JAMES M

Chief Financial Officer

Officer
10,558 -3.6%
14.65
US$154,650 		10,558 -3.6% 14.65 US$154,650
2025-10-02 2025-09-30 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
200 -0.0%
15.01
US$3,002 		200 -0.0% 15.01 US$3,002
2025-10-02 2025-09-30 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
29,775 -0.9%
14.37
US$427,950 		29,775 -0.9% 14.37 US$427,950
2025-08-14 2025-08-13 PlS Planned sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
15,000 -8.7%
8.34
US$125,046 		15,000 -8.7% 8.34 US$125,046
2025-08-14 2025-08-12 PlS Planned sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
15,000 -8.0%
8.07
US$121,102 		15,000 -8.0% 8.07 US$121,102
2025-08-12 2025-08-12 PrS Proposed sale
3.5
GINA MAZZARIELLO

Officer

Officer
30,000
7.82
US$234,600 		30,000 7.82 US$234,600
2025-04-02 2025-03-31 S Sale
3.9
FRATES JAMES M

Chief Financial Officer

Officer
10,896 -3.6%
3.47
US$37,806 		10,896 -3.6% 3.47 US$37,806
2025-04-02 2025-03-31 S Sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
9,192 -4.7%
3.48
US$31,954 		9,192 -4.7% 3.48 US$31,954
2025-04-02 2025-03-31 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
12,425 -6.0%
3.47
US$43,082 		12,425 -6.0% 3.47 US$43,082
2025-04-02 2025-03-31 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
21,490 -0.6%
3.46
US$74,454 		21,490 -0.6% 3.46 US$74,454
2025-04-02 2025-03-31 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
21,490 -0.6%
3.47
US$74,482 		21,490 -0.6% 3.47 US$74,482
2025-03-24 2025-03-20 B Purchase
3.5
Zeiher Bernhardt G
Non-Executive Director
10,000 +inf%
3.70
US$37,005 		10,000 +inf% 3.70 US$37,005
2025-03-05 2025-03-03 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
4,595 -0.1%
3.17
US$14,549 		4,595 -0.1% 3.17 US$14,549
2025-03-05 2025-03-03 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
4,595 -0.1%
3.15
US$14,483 		4,595 -0.1% 3.15 US$14,483
2025-03-05 2025-03-03 S Sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
1,611 -1.2%
3.12
US$5,022 		1,611 -1.2% 3.12 US$5,022
2025-02-26 2025-02-24 S Sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
4,169 -3.0%
3.15
US$13,145 		4,169 -3.0% 3.15 US$13,145
2025-02-05 2025-02-03 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
11,855 -0.4%
3.47
US$41,104 		11,855 -0.4% 3.47 US$41,104
2025-02-05 2025-02-03 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
11,851 -0.4%
3.47
US$41,108 		11,851 -0.4% 3.47 US$41,108
2025-02-05 2025-02-03 S Sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
3,678 -2.6%
3.49
US$12,839 		3,678 -2.6% 3.49 US$12,839
2025-01-08 2025-01-06 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
7,471 -0.2%
4.04
US$30,202 		7,471 -0.2% 4.04 US$30,202
2025-01-08 2025-01-06 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
7,471 -0.2%
4.05
US$30,232 		7,471 -0.2% 4.05 US$30,232
2024-12-03 2024-12-02 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
5,421 -3.8%
5.54
US$30,007 		5,421 -3.8% 5.54 US$30,007
2024-10-02 2024-09-30 S Sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
8,709 -5.7%
3.20
US$27,840 		8,709 -5.7% 3.20 US$27,840
2024-10-02 2024-09-30 S Sale
3.7
Bedrosian Camille L

Chief Medical Officer

Officer
11,442 -7.4%
3.20
US$36,559 		11,442 -7.4% 3.20 US$36,559
2024-10-02 2024-09-30 S Sale
2.8
Klee Justin B.

Co-Chief Executive Officer

Executive Director
18,589 -0.6%
3.20
US$59,429 		18,589 -0.6% 3.20 US$59,429
2024-10-02 2024-09-30 S Sale
2.8
Cohen Joshua B

Co-Chief Executive Officer

Executive Director
18,589 -0.6%
3.20
US$59,414 		18,589 -0.6% 3.20 US$59,414
2024-09-16 2024-09-12 B Purchase
3.9
FRATES JAMES M

Chief Financial Officer

Officer
40,000 +20.7%
2.53
US$101,368 		40,000 +20.7% 2.53 US$101,368
2024-09-09 2024-09-05 B Purchase
3.9
Firestone Karen
Non-Executive Director
50,000 +1000.0%
2.13
US$106,590 		50,000 +1000.0% 2.13 US$106,590
2024-09-05 2024-09-03 B Purchase
3.3
MILNE GEORGE M JR
Non-Executive Director
100,000 +13.2%
2.20
US$219,800 		100,000 +13.2% 2.20 US$219,800
2024-05-16 2024-05-15 PlS Planned sale
3.5
Mazzariello Gina

Chief Legal Officer

Officer
10,455 -6.5%
1.88
US$19,654 		10,455 -6.5% 1.88 US$19,654
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