ARCH Venture Partners VIII, LLC

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2019-02-26	2019-02-22	Sienna Biopharmaceuticals Inc (SNNAQ)	B Purchase	99,522 -12.6% 229.49 US$2,356,459	99,522 -12.6%	229.49	US$2,356,459
2019-02-26	2019-02-22	Sienna Biopharmaceuticals Inc (SNNAQ)	B Purchase	81,044 -44.3% 70.92 US$2,263,519	81,044 -44.3%	70.92	US$2,263,519
2019-02-26	2019-02-22	Sienna Biopharmaceuticals Inc (SNNAQ)	B Purchase	75,105 -12.2% 321.37 US$3,656,021	75,105 -12.2%	321.37	US$3,656,021