TOMBESI PAOLO

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2022-07-29	2022-07-27	Turning Point Therapeutics Inc (TPTX)	S Sale	96,237 -16.1% 423.71 US$2,469,758	96,237 -16.1%	423.71	US$2,469,758
2021-02-05	2021-02-04	Epizyme Inc (EPZM)	PlS Planned sale	34,213 -17.4% 307.47 US$4,594,617	34,213 -17.4%	307.47	US$4,594,617
2020-03-26	2020-03-25	Epizyme Inc (EPZM)	PlS Planned sale	12,709 -46.6% 39.98 US$4,720,764	12,709 -46.6%	39.98	US$4,720,764