Scadden David

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2025-11-14	2025-11-12	Agios Pharmaceuticals Inc (AGIO)	PlS Planned sale	88,535 +40.3% 414.69 US$692,952	88,535 +40.3%	414.69	US$692,952
2025-10-10	2025-10-08	Agios Pharmaceuticals Inc (AGIO)	PlS Planned sale	62,595 -7.8% 446.03 US$693,470	62,595 -7.8%	446.03	US$693,470
2025-10-08	2025-10-08	Agios Pharmaceuticals Inc (AGIO)	PrS Proposed sale	36,015 157.30 US$2,370,331	36,015	157.30	US$2,370,331
2025-10-02	2025-09-30	Agios Pharmaceuticals Inc (AGIO)	PlS Planned sale	200 -1.1% 40.00 US$8,000	200 -1.1%	40.00	US$8,000
2025-08-29	2025-08-27	Agios Pharmaceuticals Inc (AGIO)	PlS Planned sale	200 -1.1% 40.00 US$8,000	200 -1.1%	40.00	US$8,000
2025-08-27	2025-08-27	Agios Pharmaceuticals Inc (AGIO)	PrS Proposed sale	200 40.00 US$8,000	200	40.00	US$8,000
2025-07-15	2025-07-10	Agios Pharmaceuticals Inc (AGIO)	PlS Planned sale	1,400 -7.4% 40.00 US$56,000	1,400 -7.4%	40.00	US$56,000
2025-07-10	2025-07-10	Agios Pharmaceuticals Inc (AGIO)	PrS Proposed sale	1,400 40.00 US$56,000	1,400	40.00	US$56,000
2024-12-13	2024-12-11	Agios Pharmaceuticals Inc (AGIO)	PlS Planned sale	200 -1.3% 46.28 US$9,256	200 -1.3%	46.28	US$9,256