Ros Matthew

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2021-02-05	2021-02-04	Epizyme Inc (EPZM)	PlS Planned sale	174 -0.3% 365.70 US$1,156,995	174 -0.3%	365.70	US$1,156,995
2021-01-27	2021-01-25	Epizyme Inc (EPZM)	PlS Planned sale	39,488 -21.7% 271.81 US$4,947,341	39,488 -21.7%	271.81	US$4,947,341
2020-06-22	2020-06-18	Epizyme Inc (EPZM)	PlS Planned sale	37,508 +47.0% 187.02 US$1,123,904	37,508 +47.0%	187.02	US$1,123,904
2020-06-22	2020-06-18	Epizyme Inc (EPZM)	PlS Planned sale	2,289 -4.2% 22.00 US$50,358	2,289 -4.2%	22.00	US$50,358
2020-06-22	2020-06-18	Epizyme Inc (EPZM)	PlS Planned sale	41,063 -44.2% 20.50 US$841,792	41,063 -44.2%	20.50	US$841,792
2020-03-26	2020-03-25	Epizyme Inc (EPZM)	PlS Planned sale	1,243 -2.3% 15.28 US$18,993	1,243 -2.3%	15.28	US$18,993
2020-01-27	2020-01-24	Epizyme Inc (EPZM)	PlS Planned sale	1,847 -4.2% 24.64 US$45,510	1,847 -4.2%	24.64	US$45,510
2019-06-14	2019-06-13	Epizyme Inc (EPZM)	PlS Planned sale	1,185 -2.9% 12.10 US$14,338	1,185 -2.9%	12.10	US$14,338