James Frates

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2019-08-16	2019-08-15	SAGE Therapeutics Inc (SAGE)	PlS Planned sale	96,092 +15.1% 434.12 US$1,528,414	96,092 +15.1%	434.12	US$1,528,414
2018-05-08	2018-05-08	SAGE Therapeutics Inc (SAGE)	PlS Planned sale	32,427 +9.9% 288.41 US$846,171	32,427 +9.9%	288.41	US$846,171
2014-07-23	2014-07-23	SAGE Therapeutics Inc (SAGE)	B Purchase	70,450 -5.2% 450.18 US$376,209	70,450 -5.2%	450.18	US$376,209