ANDREA DIFABIO

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2026-03-13	2026-03-13	Xenon Pharmaceuticals Inc (XENE)	PlS Planned sale	52,006 -43.9% 477.56 US$4,404,917	52,006 -43.9%	477.56	US$4,404,917
2026-03-13	2026-03-13	Xenon Pharmaceuticals Inc (XENE)	PrS Proposed sale	604 343.45 US$3,472,291	604	343.45	US$3,472,291
2026-03-11	2026-03-10	Xenon Pharmaceuticals Inc (XENE)	PlS Planned sale	16,058 +9.8% 422.12 US$4,637,832	16,058 +9.8%	422.12	US$4,637,832
2026-03-10	2026-03-10	Xenon Pharmaceuticals Inc (XENE)	PrS Proposed sale	2,607 60.11 US$156,702	2,607	60.11	US$156,702