McKechnie Duncan

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2026-03-13	2026-03-11	Vertex Pharmaceuticals Inc (VRTX)	PlS Planned sale	66,076 -21.7% 323.15 US$2,342,144	66,076 -21.7%	323.15	US$2,342,144
2026-03-11	2026-03-11	Vertex Pharmaceuticals Inc (VRTX)	PrS Proposed sale	91,818 228.03 US$210,296	91,818	228.03	US$210,296
2026-03-06	2026-03-04	Vertex Pharmaceuticals Inc (VRTX)	PlS Planned sale	97,361 -30.8% 297.26 US$4,416,558	97,361 -30.8%	297.26	US$4,416,558
2026-03-04	2026-03-04	Vertex Pharmaceuticals Inc (VRTX)	PrS Proposed sale	2,437 475.30 US$1,158,306	2,437	475.30	US$1,158,306
2026-02-26	2026-02-25	Vertex Pharmaceuticals Inc (VRTX)	PlS Planned sale	2,410 -12.1% 489.00 US$1,178,490	2,410 -12.1%	489.00	US$1,178,490
2026-02-26	2026-02-25	Vertex Pharmaceuticals Inc (VRTX)	PlS Planned sale	2,500 -11.1% 486.35 US$1,215,875	2,500 -11.1%	486.35	US$1,215,875
2026-02-25	2026-02-25	Vertex Pharmaceuticals Inc (VRTX)	PrS Proposed sale	4,910 487.65 US$2,394,365	4,910	487.65	US$2,394,365