United States Biotechnology & Medical Research

Zymeworks Inc (ZYME)

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Recent insider activity at Zymeworks Inc. primarily consists of proposed sales and actual sales by officers and former officers. The most recent transactions occurred on March 6, 2026, involving significant proposed sales by Jeffrey T L Smith. Overall, the pattern indicates a notable volume of selling activity by key personnel.

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Ticker: ZYME Exchange: NYS

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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Trades

Jeffrey T L Smith

Former Officer

1 sale — total 6,133,858 USD

Proposed sale 6 Mar 2026

Value US$3,409,629.26 | Price 491.89 | Shares 77,907

Leone D Patterson

Former officer

1 sale — total 715,087 USD

Proposed sale 17 Feb 2026

Value US$3,111,964.01 | Price 335.30 | Shares 26,121

Leone D Patterson

Former officer

1 sale — total 2,978,457 USD

Proposed sale 13 Feb 2026

Value US$2,978,457.16 | Price 23.17 | Shares 128,548

Hollywood Mark

EVP & Chief Operating Officer

1 sale — total 138,762 USD

Sale 12 Jan 2026

Value US$138,761.82 | Price 22.67 | Shares 6,120

Leone D Patterson

Former officer

1 sale — total 158,297 USD

Proposed sale 12 Jan 2026

Value US$158,297.44 | Price 23.17 | Shares 6,832

Jeffrey T L Smith

Officer

1 sale — total 215,713 USD

Proposed sale 12 Jan 2026

Value US$215,712.70 | Price 23.17 | Shares 9,310

Paul Andrew Moore

Officer

1 sale — total 221,505 USD

Proposed sale 12 Jan 2026

Value US$221,505.20 | Price 23.17 | Shares 9,560

Mark Hollywood

Officer

1 sale — total 141,800 USD

Proposed sale 12 Jan 2026

Value US$141,800.40 | Price 23.17 | Shares 6,120

Kenneth Galbraith

Officer; Director

1 sale — total 704,924 USD

Proposed sale 12 Jan 2026

Value US$704,924.08 | Price 23.17 | Shares 30,424

Smith Jeffrey T L

EVP & Chief Medical Officer

1 sale — total 211,090 USD

Sale 12 Jan 2026

Value US$211,090.28 | Price 22.67 | Shares 9,310

Moore Paul Andrew

Chief Scientific Officer

1 sale — total 216,759 USD

Sale 12 Jan 2026

Value US$216,758.66 | Price 22.67 | Shares 9,560

Galbraith Kenneth

Chair & CEO

1 sale — total 689,819 USD

Sale 12 Jan 2026

Value US$689,818.56 | Price 22.67 | Shares 30,424

Smith Jeffrey T L

Officer

2 sales — total 544,993 USD

Proposed sale 5 Jan 2026

Value US$280,521.56 | Price 26.62 | Shares 10,538

Sale 5 Jan 2026

Value US$264,471.13 | Price 25.10 | Shares 10,538

Kenneth Galbraith

Officer; Director

1 sale — total 1,446,611 USD

Proposed sale 5 Jan 2026

Value US$1,446,610.66 | Price 26.62 | Shares 54,343

Paul Andrew Moore

Officer

1 sale — total 535,328 USD

Proposed sale 5 Jan 2026

Value US$535,328.20 | Price 26.62 | Shares 20,110

Galbraith Kenneth

Chair & CEO

2 sales — total 1,363,841 USD

Sale 5 Jan 2026

Value US$795,220.37 | Price 25.10 | Shares 31,686

Sale 5 Jan 2026

Value US$568,620.46 | Price 25.10 | Shares 22,657

Moore Paul Andrew

Chief Scientific Officer

2 sales — total 504,699 USD

Sale 5 Jan 2026

Value US$271,573.55 | Price 25.10 | Shares 10,821

Sale 5 Jan 2026

Value US$233,125.10 | Price 25.10 | Shares 9,289

Galbraith, Kenneth

Officer; Director

1 sale — total 1,294,187 USD

Proposed sale 22 Dec 2025

Value US$1,294,187.44 | Price 27.23 | Shares 47,528

Galbraith Kenneth

Chair & CEO

1 sale — total 1,284,311 USD

Sale 22 Dec 2025

Value US$1,284,311.12 | Price 27.02 | Shares 47,528

Derek John Michael Miller

Former Director

1 sale — total 2,810,760 USD

Proposed sale 24 Nov 2025

Value US$2,810,760.00 | Price 23.82 | Shares 118,000

Neil Gallagher

Former Director

1 sale — total 2,501,100 USD

Proposed sale 21 Nov 2025

Value US$2,501,100.00 | Price 23.82 | Shares 105,000

EcoR1 Capital, LLC

1 purchase — total 69,738 USD

Buy 19 May 2025

Value US$69,738.25 | Price 11.78 | Shares 5,919

EcoR1 Capital, LLC

1 purchase — total 565,847 USD

Buy 15 May 2025

Value US$565,847.46 | Price 11.43 | Shares 49,502

EcoR1 Capital, LLC

1 purchase — total 630,819 USD

Buy 17 Apr 2025

Value US$630,818.77 | Price 11.52 | Shares 54,760

EcoR1 Capital, LLC

1 purchase — total 825,589 USD

Buy 16 Apr 2025

Value US$825,589.11 | Price 11.16 | Shares 73,953

EcoR1 Capital, LLC

1 purchase — total 2,193,800 USD

Buy 4 Apr 2025

Value US$2,193,799.94 | Price 11.17 | Shares 196,438

EcoR1 Capital, LLC

1 purchase — total 1,430,170 USD

Buy 3 Apr 2025

Value US$1,430,170.42 | Price 11.84 | Shares 120,770

EcoR1 Capital, LLC

1 purchase — total 881,017 USD

Buy 2 Apr 2025

Value US$881,017.28 | Price 11.85 | Shares 74,360

EcoR1 Capital, LLC

1 purchase — total 564,647 USD

Buy 1 Apr 2025

Value US$564,646.90 | Price 11.60 | Shares 48,658

EcoR1 Capital, LLC

1 purchase — total 51,658 USD

Buy 31 Mar 2025

Value US$51,658.15 | Price 11.75 | Shares 4,397

EcoR1 Capital, LLC

1 purchase — total 536,857 USD

Buy 26 Mar 2025

Value US$536,857.37 | Price 12.24 | Shares 43,848

EcoR1 Capital, LLC

1 purchase — total 690,452 USD

Buy 25 Mar 2025

Value US$690,451.81 | Price 12.91 | Shares 53,501

EcoR1 Capital, LLC

1 purchase — total 296,847 USD

Buy 24 Mar 2025

Value US$296,846.99 | Price 13.08 | Shares 22,689

EcoR1 Capital, LLC

1 purchase — total 396,518 USD

Buy 21 Mar 2025

Value US$396,517.95 | Price 12.78 | Shares 31,033

EcoR1 Capital, LLC

1 purchase — total 949,883 USD

Buy 20 Mar 2025

Value US$949,883.03 | Price 12.93 | Shares 73,476

EcoR1 Capital, LLC

1 purchase — total 737,233 USD

Buy 19 Mar 2025

Value US$737,232.73 | Price 12.64 | Shares 58,306

EcoR1 Capital, LLC

1 purchase — total 1,440,855 USD

Buy 18 Mar 2025

Value US$1,440,855.31 | Price 12.65 | Shares 113,880

EcoR1 Capital, LLC

1 purchase — total 688,465 USD

Buy 17 Mar 2025

Value US$688,464.68 | Price 12.23 | Shares 56,277

EcoR1 Capital, LLC

1 purchase — total 5,847,237 USD

Buy 13 Mar 2025

Value US$5,847,237.32 | Price 12.48 | Shares 468,356

EcoR1 Capital, LLC

1 purchase — total 3,587,826 USD

Buy 12 Mar 2025

Value US$3,587,826.34 | Price 12.25 | Shares 292,934

EcoR1 Capital, LLC

1 purchase — total 3,685,851 USD

Buy 11 Mar 2025

Value US$3,685,850.52 | Price 11.49 | Shares 320,690

EcoR1 Capital, LLC

1 purchase — total 273,998 USD

Buy 17 Jan 2025

Value US$273,997.58 | Price 13.87 | Shares 19,748

EcoR1 Capital, LLC

1 purchase — total 1,689,541 USD

Buy 16 Jan 2025

Value US$1,689,540.68 | Price 13.89 | Shares 121,681

EcoR1 Capital, LLC

1 purchase — total 546,671 USD

Buy 15 Jan 2025

Value US$546,671.40 | Price 14.01 | Shares 39,029

EcoR1 Capital, LLC

1 purchase — total 739,265 USD

Buy 14 Jan 2025

Value US$739,265.25 | Price 13.56 | Shares 54,500

EcoR1 Capital, LLC

1 purchase — total 992,875 USD

Buy 13 Jan 2025

Value US$992,874.72 | Price 13.39 | Shares 74,125

EcoR1 Capital, LLC

1 purchase — total 2,678,990 USD

Buy 10 Jan 2025

Value US$2,678,990.35 | Price 13.13 | Shares 204,098

EcoR1 Capital, LLC

1 purchase — total 295,829 USD

Buy 8 Jan 2025

Value US$295,828.53 | Price 14.07 | Shares 21,021

Smith Jeffrey T L

Officer

2 sales — total 326,458 USD

Proposed sale 6 Jan 2025

Value US$160,651.00 | Price 14.46 | Shares 11,110

Sale 6 Jan 2025

Value US$165,806.75 | Price 14.92 | Shares 11,110

Moore Paul Andrew

Officer

3 sales — total 622,943 USD

Proposed sale 6 Jan 2025

Value US$306,552.00 | Price 14.46 | Shares 21,200

Sale 6 Jan 2025

Value US$170,254.13 | Price 14.92 | Shares 11,408

Sale 6 Jan 2025

Value US$146,136.79 | Price 14.92 | Shares 9,792

Galbraith, Kenneth

Officer; Director

1 sale — total 828,428 USD

Proposed sale 6 Jan 2025

Value US$828,428.00 | Price 14.46 | Shares 57,291

Galbraith Kenneth

Chair & CEO

2 sales — total 855,017 USD

Sale 6 Jan 2025

Value US$498,554.48 | Price 14.92 | Shares 33,406

Sale 6 Jan 2025

Value US$356,462.13 | Price 14.92 | Shares 23,885

EcoR1 Capital, LLC

1 purchase — total 2,333,403 USD

Buy 2 Jan 2025

Value US$2,333,403.25 | Price 14.78 | Shares 157,880

EcoR1 Capital, LLC

1 purchase — total 2,134,446 USD

Buy 31 Dec 2024

Value US$2,134,446.32 | Price 14.57 | Shares 146,501

EcoR1 Capital, LLC

1 purchase — total 853,326 USD

Buy 30 Dec 2024

Value US$853,326.31 | Price 14.47 | Shares 58,988

EcoR1 Capital, LLC

1 purchase — total 1,473,181 USD

Buy 27 Dec 2024

Value US$1,473,181.23 | Price 14.49 | Shares 101,659

EcoR1 Capital, LLC

1 purchase — total 240,038 USD

Buy 26 Dec 2024

Value US$240,037.64 | Price 14.38 | Shares 16,692

EcoR1 Capital, LLC

1 purchase — total 168,896 USD

Buy 24 Dec 2024

Value US$168,895.99 | Price 14.12 | Shares 11,958

Christopher Astle

Former Officer

1 sale — total 774,057 USD

Proposed sale 11 Jun 2024

Value US$774,057.18 | Price 8.97 | Shares 86,294

Astle Christopher

SVP & Chief Financial Officer

1 sale — total 16,050 USD

Sale 8 Jan 2024

Value US$16,049.52 | Price 11.22 | Shares 1,431

Galbraith Kenneth

Chair & CEO

1 sale — total 63,996 USD

Sale 8 Jan 2024

Value US$63,996.21 | Price 11.22 | Shares 5,706

Moore Paul Andrew

Chief Scientific Officer

1 sale — total 26,233 USD

Sale 8 Jan 2024

Value US$26,233.29 | Price 11.22 | Shares 2,339

Astle Christopher

SVP & Chief Financial Officer

2 sales — total 111,903 USD

Sale 5 Jan 2024

Value US$48,605.99 | Price 10.65 | Shares 4,563

Proposed sale 5 Jan 2024

Value US$63,297.00 | Price 10.56 | Shares 5,994

Galbraith Kenneth

Chair & CEO

1 sale — total 193,849 USD

Sale 5 Jan 2024

Value US$193,848.74 | Price 10.65 | Shares 18,198

Moore Paul Andrew

Chief Scientific Officer

2 sales — total 182,943 USD

Sale 5 Jan 2024

Value US$79,465.41 | Price 10.65 | Shares 7,460

Proposed sale 5 Jan 2024

Value US$103,478.00 | Price 10.56 | Shares 9,799

Galbraith, Kenneth

Officer; Director

1 sale — total 252,427 USD

Proposed sale 5 Jan 2024

Value US$252,427.00 | Price 10.56 | Shares 23,904

Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Insider and/or position	Nb. shares Price Value	Number of shares	Price	Value
2026-03-06	2026-03-06	PrS Proposed sale	2.5 Jeffrey T L Smith Former Officer Officer	77,907 491.89 US$3,409,629	77,907	491.89	US$3,409,629
2026-02-17	2026-02-17	PrS Proposed sale	3.8 Leone D Patterson Former officer Officer	26,121 335.30 US$3,111,964	26,121	335.30	US$3,111,964
2026-02-13	2026-02-13	PrS Proposed sale	3.8 Leone D Patterson Former officer Officer	42,861 98.52 US$2,777,784	42,861	98.52	US$2,777,784
2026-01-13	2026-01-12	S Sale	1.0 Hollywood Mark EVP & Chief Operating Officer Officer	6,120 -4.4% 22.67 US$138,762	6,120 -4.4%	22.67	US$138,762
2026-01-12	2026-01-12	PrS Proposed sale	3.8 Leone D Patterson Former officer Officer	6,832 23.17 US$158,297	6,832	23.17	US$158,297
2026-01-12	2026-01-12	PrS Proposed sale	2.5 Jeffrey T L Smith Officer Officer	9,310 23.17 US$215,713	9,310	23.17	US$215,713
2026-01-12	2026-01-12	PrS Proposed sale	2.9 Paul Andrew Moore Officer Officer	9,560 23.17 US$221,505	9,560	23.17	US$221,505
2026-01-12	2026-01-12	PrS Proposed sale	1.0 Mark Hollywood Officer Officer	6,120 23.17 US$141,800	6,120	23.17	US$141,800
2026-01-12	2026-01-12	PrS Proposed sale	3.2 Kenneth Galbraith Officer; Director Executive Director	30,424 23.17 US$704,924	30,424	23.17	US$704,924
2026-01-12	2026-01-12	S Sale	2.5 Smith Jeffrey T L EVP & Chief Medical Officer Officer	9,310 -25.8% 22.67 US$211,090	9,310 -25.8%	22.67	US$211,090
2026-01-12	2026-01-12	S Sale	2.9 Moore Paul Andrew Chief Scientific Officer Officer	9,560 -16.5% 22.67 US$216,759	9,560 -16.5%	22.67	US$216,759
2026-01-12	2026-01-12	S Sale	3.2 Galbraith Kenneth Chair & CEO Executive Director	30,424 -11.8% 22.67 US$689,819	30,424 -11.8%	22.67	US$689,819
2026-01-05	2026-01-05	PrS Proposed sale	2.5 Smith Jeffrey T L Officer Officer	10,538 26.62 US$280,522	10,538	26.62	US$280,522
2026-01-05	2026-01-05	PrS Proposed sale	3.2 Kenneth Galbraith Officer; Director Executive Director	54,343 26.62 US$1,446,611	54,343	26.62	US$1,446,611
2026-01-05	2026-01-05	PrS Proposed sale	2.9 Paul Andrew Moore Officer Officer	20,110 26.62 US$535,328	20,110	26.62	US$535,328
2026-01-05	2026-01-05	S Sale	2.5 Smith Jeffrey T L EVP & Chief Medical Officer Officer	10,538 -36.5% 25.10 US$264,471	10,538 -36.5%	25.10	US$264,471
2026-01-05	2026-01-05	S Sale	3.2 Galbraith Kenneth Chair & CEO Executive Director	31,686 -14.1% 25.10 US$795,220	31,686 -14.1%	25.10	US$795,220
2026-01-05	2026-01-05	S Sale	3.2 Galbraith Kenneth Chair & CEO Executive Director	22,657 -12.5% 25.10 US$568,620	22,657 -12.5%	25.10	US$568,620
2026-01-05	2026-01-05	S Sale	2.9 Moore Paul Andrew Chief Scientific Officer Officer	10,821 -21.1% 25.10 US$271,574	10,821 -21.1%	25.10	US$271,574
2026-01-05	2026-01-05	S Sale	2.9 Moore Paul Andrew Chief Scientific Officer Officer	9,289 -22.9% 25.10 US$233,125	9,289 -22.9%	25.10	US$233,125
2025-12-22	2025-12-22	PrS Proposed sale	3.2 Galbraith, Kenneth Officer; Director Executive Director	47,528 27.23 US$1,294,187	47,528	27.23	US$1,294,187
2025-12-22	2025-12-22	S Sale	3.2 Galbraith Kenneth Chair & CEO Executive Director	47,528 -26.3% 27.02 US$1,284,311	47,528 -26.3%	27.02	US$1,284,311
2025-11-24	2025-11-24	PrS Proposed sale	Derek John Michael Miller Former Director Non-Executive Director	118,000 23.82 US$2,810,760	118,000	23.82	US$2,810,760
2025-11-21	2025-11-21	PrS Proposed sale	3.2 Neil Gallagher Former Director Non-Executive Director	105,000 23.82 US$2,501,100	105,000	23.82	US$2,501,100
2025-05-19	2025-05-19	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	5,919 +0.0% 11.78 US$69,738	5,919 +0.0%	11.78	US$69,738
2025-05-19	2025-05-15	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	49,502 +0.3% 11.43 US$565,847	49,502 +0.3%	11.43	US$565,847
2025-04-18	2025-04-17	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	54,760 +0.3% 11.52 US$630,819	54,760 +0.3%	11.52	US$630,819
2025-04-18	2025-04-16	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	73,953 +0.4% 11.16 US$825,589	73,953 +0.4%	11.16	US$825,589
2025-04-07	2025-04-04	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	196,438 +1.1% 11.17 US$2,193,800	196,438 +1.1%	11.17	US$2,193,800
2025-04-07	2025-04-03	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	120,770 +0.7% 11.84 US$1,430,170	120,770 +0.7%	11.84	US$1,430,170
2025-04-02	2025-04-02	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	74,360 +0.4% 11.85 US$881,017	74,360 +0.4%	11.85	US$881,017
2025-04-02	2025-04-01	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	48,658 +0.3% 11.60 US$564,647	48,658 +0.3%	11.60	US$564,647
2025-04-02	2025-03-31	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	4,397 +0.0% 11.75 US$51,658	4,397 +0.0%	11.75	US$51,658
2025-03-27	2025-03-26	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	43,848 +0.3% 12.24 US$536,857	43,848 +0.3%	12.24	US$536,857
2025-03-27	2025-03-25	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	53,501 +0.3% 12.91 US$690,452	53,501 +0.3%	12.91	US$690,452
2025-03-24	2025-03-24	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	22,689 +0.1% 13.08 US$296,847	22,689 +0.1%	13.08	US$296,847
2025-03-24	2025-03-21	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	31,033 +0.2% 12.78 US$396,518	31,033 +0.2%	12.78	US$396,518
2025-03-24	2025-03-20	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	73,476 +0.4% 12.93 US$949,883	73,476 +0.4%	12.93	US$949,883
2025-03-19	2025-03-19	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	58,306 +0.3% 12.64 US$737,233	58,306 +0.3%	12.64	US$737,233
2025-03-19	2025-03-18	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	113,880 +0.7% 12.65 US$1,440,855	113,880 +0.7%	12.65	US$1,440,855
2025-03-19	2025-03-17	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	56,277 +0.3% 12.23 US$688,465	56,277 +0.3%	12.23	US$688,465
2025-03-13	2025-03-13	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	468,356 +2.9% 12.48 US$5,847,237	468,356 +2.9%	12.48	US$5,847,237
2025-03-13	2025-03-12	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	292,934 +1.8% 12.25 US$3,587,826	292,934 +1.8%	12.25	US$3,587,826
2025-03-13	2025-03-11	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	320,690 +2.0% 11.49 US$3,685,851	320,690 +2.0%	11.49	US$3,685,851
2025-01-21	2025-01-17	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	19,748 +0.1% 13.87 US$273,998	19,748 +0.1%	13.87	US$273,998
2025-01-21	2025-01-16	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	121,681 +0.8% 13.89 US$1,689,541	121,681 +0.8%	13.89	US$1,689,541
2025-01-15	2025-01-15	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	39,029 +0.3% 14.01 US$546,671	39,029 +0.3%	14.01	US$546,671
2025-01-15	2025-01-14	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	54,500 +0.4% 13.56 US$739,265	54,500 +0.4%	13.56	US$739,265
2025-01-15	2025-01-13	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	74,125 +0.5% 13.39 US$992,875	74,125 +0.5%	13.39	US$992,875
2025-01-10	2025-01-10	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	204,098 +1.3% 13.13 US$2,678,990	204,098 +1.3%	13.13	US$2,678,990
2025-01-10	2025-01-08	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	21,021 +0.1% 14.07 US$295,829	21,021 +0.1%	14.07	US$295,829
2025-01-06	2025-01-06	PrS Proposed sale	2.5 Smith Jeffrey T L Officer Officer	11,110 14.46 US$160,651	11,110	14.46	US$160,651
2025-01-06	2025-01-06	PrS Proposed sale	2.9 Moore Paul Andrew Officer Officer	21,200 14.46 US$306,552	21,200	14.46	US$306,552
2025-01-06	2025-01-06	PrS Proposed sale	3.2 Galbraith, Kenneth Officer; Director Executive Director	57,291 14.46 US$828,428	57,291	14.46	US$828,428
2025-01-06	2025-01-06	S Sale	2.9 Moore Paul Andrew Chief Scientific Officer Officer	11,408 -32.8% 14.92 US$170,254	11,408 -32.8%	14.92	US$170,254
2025-01-06	2025-01-06	S Sale	2.9 Moore Paul Andrew Chief Scientific Officer Officer	9,792 -39.9% 14.92 US$146,137	9,792 -39.9%	14.92	US$146,137
2025-01-06	2025-01-06	S Sale	3.2 Galbraith Kenneth Chair & CEO Executive Director	33,406 -29.2% 14.92 US$498,554	33,406 -29.2%	14.92	US$498,554
2025-01-06	2025-01-06	S Sale	3.2 Galbraith Kenneth Chair & CEO Executive Director	23,885 -33.4% 14.92 US$356,462	23,885 -33.4%	14.92	US$356,462
2025-01-06	2025-01-06	S Sale	2.5 Smith Jeffrey T L EVP & Chief Medical Officer Officer	11,110 -55.5% 14.92 US$165,807	11,110 -55.5%	14.92	US$165,807
2025-01-02	2025-01-02	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	157,880 +1.1% 14.78 US$2,333,403	157,880 +1.1%	14.78	US$2,333,403
2025-01-02	2024-12-31	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	146,501 +1.0% 14.57 US$2,134,446	146,501 +1.0%	14.57	US$2,134,446
2025-01-02	2024-12-30	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	58,988 +0.4% 14.47 US$853,326	58,988 +0.4%	14.47	US$853,326
2024-12-27	2024-12-27	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	101,659 +0.7% 14.49 US$1,473,181	101,659 +0.7%	14.49	US$1,473,181
2024-12-27	2024-12-26	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	16,692 +0.1% 14.38 US$240,038	16,692 +0.1%	14.38	US$240,038
2024-12-27	2024-12-24	B Purchase	3.1 EcoR1 Capital, LLC Non-Executive Director Large shareholder	11,958 +0.1% 14.12 US$168,896	11,958 +0.1%	14.12	US$168,896
2024-06-11	2024-06-11	PrS Proposed sale	2.4 Christopher Astle Former Officer Officer	86,294 8.97 US$774,057	86,294	8.97	US$774,057
2024-01-08	2024-01-08	S Sale	2.4 Astle Christopher SVP & Chief Financial Officer Officer	1,431 -18.0% 11.22 US$16,050	1,431 -18.0%	11.22	US$16,050
2024-01-08	2024-01-08	S Sale	3.2 Galbraith Kenneth Chair & CEO Executive Director	5,706 -19.4% 11.22 US$63,996	5,706 -19.4%	11.22	US$63,996
2024-01-08	2024-01-08	S Sale	2.9 Moore Paul Andrew Chief Scientific Officer Officer	2,339 -24.1% 11.22 US$26,233	2,339 -24.1%	11.22	US$26,233
2024-01-08	2024-01-05	S Sale	2.4 Astle Christopher SVP & Chief Financial Officer Officer	4,563 -36.5% 10.65 US$48,606	4,563 -36.5%	10.65	US$48,606
2024-01-08	2024-01-05	S Sale	3.2 Galbraith Kenneth Chair & CEO Executive Director	18,198 -38.2% 10.65 US$193,849	18,198 -38.2%	10.65	US$193,849
2024-01-08	2024-01-05	S Sale	2.9 Moore Paul Andrew Chief Scientific Officer Officer	7,460 -43.5% 10.65 US$79,465	7,460 -43.5%	10.65	US$79,465
2024-01-05	2024-01-05	PrS Proposed sale	2.4 Astle Christopher Officer Officer	5,994 10.56 US$63,297	5,994	10.56	US$63,297
2024-01-05	2024-01-05	PrS Proposed sale	3.2 Galbraith, Kenneth Officer; Director Executive Director	23,904 10.56 US$252,427	23,904	10.56	US$252,427
2024-01-05	2024-01-05	PrS Proposed sale	2.9 Moore Paul Andrew Officer Officer	9,799 10.56 US$103,478	9,799	10.56	US$103,478