|
Nov. 29, 2022 |
Nov. 28, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
200
+0.1%
4.68
936
USD
|
200
+0.1%
|
4.68
|
936
USD
|
|
|
Nov. 29, 2022 |
Nov. 28, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
100
+0.1%
4.70
470
USD
|
100
+0.1%
|
4.70
|
470
USD
|
|
|
Nov. 29, 2022 |
Nov. 28, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
8,638
+4.7%
4.68
40,426
USD
|
8,638
+4.7%
|
4.68
|
40,426
USD
|
|
|
Nov. 29, 2022 |
Nov. 28, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
2,531
+1.4%
4.70
11,896
USD
|
2,531
+1.4%
|
4.70
|
11,896
USD
|
|
|
Nov. 29, 2022 |
Nov. 28, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
1,665
+0.9%
4.69
7,809
USD
|
1,665
+0.9%
|
4.69
|
7,809
USD
|
|
|
Nov. 29, 2022 |
Nov. 28, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
500
+0.3%
4.68
2,340
USD
|
500
+0.3%
|
4.68
|
2,340
USD
|
|
|
Nov. 29, 2022 |
Nov. 28, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
11,366
+6.8%
4.71
53,534
USD
|
11,366
+6.8%
|
4.71
|
53,534
USD
|
|
|
May 20, 2022 |
May 20, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
20,000
+21.4%
2.93
58,518
USD
|
20,000
+21.4%
|
2.93
|
58,518
USD
|
|
|
May 20, 2022 |
May 19, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
10,000
+12.0%
2.89
28,898
USD
|
10,000
+12.0%
|
2.89
|
28,898
USD
|
|
|
May 19, 2022 |
May 18, 2022 |
B
Purchase
|
ROBERTS BRIAN K
Non-Executive Director
|
16,000
+12.1%
2.98
47,680
USD
|
16,000
+12.1%
|
2.98
|
47,680
USD
|
|
|
May 12, 2022 |
May 12, 2022 |
B
Purchase
|
JOHNSON B KRISTINE
Non-Executive Director
|
40,000
+21.9%
2.82
112,704
USD
|
40,000
+21.9%
|
2.82
|
112,704
USD
|
|
|
May 12, 2022 |
May 12, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
5,000
+6.4%
2.75
13,750
USD
|
5,000
+6.4%
|
2.75
|
13,750
USD
|
|
|
May 12, 2022 |
May 11, 2022 |
B
Purchase
|
Drake Scott William
President & CEO
Executive Director
|
117,012
+2.9%
2.53
295,514
USD
|
117,012
+2.9%
|
2.53
|
295,514
USD
|
|
|
May 12, 2022 |
May 11, 2022 |
B
Purchase
|
Castelein Caley
Non-Executive Director
|
1,065,000
+221.6%
2.54
2,701,479
USD
|
1,065,000
+221.6%
|
2.54
|
2,701,479
USD
|
|
|
May 12, 2022 |
May 11, 2022 |
B
Purchase
|
Stassen Zachary William
Chief Financial Officer
Officer
|
20,000
+3.1%
2.49
49,760
USD
|
20,000
+3.1%
|
2.49
|
49,760
USD
|
|
|
May 12, 2022 |
May 10, 2022 |
B
Purchase
|
Prange Karen
Non-Executive Director
|
26,300
+45.8%
2.66
69,958
USD
|
26,300
+45.8%
|
2.66
|
69,958
USD
|
|
|
May 12, 2022 |
May 10, 2022 |
B
Purchase
|
Prange Karen
Non-Executive Director
|
10,000
+21.1%
2.66
26,592
USD
|
10,000
+21.1%
|
2.66
|
26,592
USD
|
|
|
May 12, 2022 |
May 10, 2022 |
B
Purchase
|
Prange Karen
Non-Executive Director
|
1,300
+2.8%
2.66
3,452
USD
|
1,300
+2.8%
|
2.66
|
3,452
USD
|
|
|
May 12, 2022 |
May 10, 2022 |
B
Purchase
|
Drake Scott William
President & CEO
Executive Director
|
40,000
+1.0%
2.61
104,480
USD
|
40,000
+1.0%
|
2.61
|
104,480
USD
|
|
|
May 12, 2022 |
May 10, 2022 |
B
Purchase
|
Castelein Caley
Non-Executive Director
|
350,000
+268.0%
2.57
899,640
USD
|
350,000
+268.0%
|
2.57
|
899,640
USD
|
|
|
May 12, 2022 |
May 10, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
5,000
+6.8%
2.56
12,787
USD
|
5,000
+6.8%
|
2.56
|
12,787
USD
|
|
|
May 12, 2022 |
May 10, 2022 |
B
Purchase
|
Moore Daniel Jeffrey
Non-Executive Director
|
96,358
+54.6%
2.59
250,001
USD
|
96,358
+54.6%
|
2.59
|
250,001
USD
|
|
|
May 12, 2022 |
May 10, 2022 |
B
Purchase
|
Stassen Zachary William
Chief Financial Officer
Officer
|
100,000
+18.6%
2.68
268,490
USD
|
100,000
+18.6%
|
2.68
|
268,490
USD
|
|
|
May 11, 2022 |
May 9, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
5,000
+7.3%
2.40
12,024
USD
|
5,000
+7.3%
|
2.40
|
12,024
USD
|
|
|
May 11, 2022 |
May 9, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
5,000
+7.9%
2.42
12,124
USD
|
5,000
+7.9%
|
2.42
|
12,124
USD
|
|
|
March 14, 2022 |
March 11, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
5,000
+16.5%
3.90
19,500
USD
|
5,000
+16.5%
|
3.90
|
19,500
USD
|
|
|
March 14, 2022 |
March 11, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
5,000
+19.7%
3.90
19,487
USD
|
5,000
+19.7%
|
3.90
|
19,487
USD
|
|
|
March 14, 2022 |
March 11, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
5,000
+24.6%
3.84
19,194
USD
|
5,000
+24.6%
|
3.84
|
19,194
USD
|
|
|
March 14, 2022 |
March 10, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
5,000
+32.6%
3.90
19,495
USD
|
5,000
+32.6%
|
3.90
|
19,495
USD
|
|
|
March 14, 2022 |
March 10, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
4,900
+47.0%
3.71
18,179
USD
|
4,900
+47.0%
|
3.71
|
18,179
USD
|
|
|
March 14, 2022 |
March 10, 2022 |
B
Purchase
|
SCHNABEL SUSAN C
Non-Executive Director
|
100
+1.0%
3.71
371
USD
|
100
+1.0%
|
3.71
|
371
USD
|
|
|
Nov. 19, 2021 |
Nov. 19, 2021 |
B
Purchase
|
Stassen Zachary William
Chief Financial Officer
Officer
|
17,857
+4.0%
5.60
99,999
USD
|
17,857
+4.0%
|
5.60
|
99,999
USD
|
|
|
Nov. 19, 2021 |
Nov. 19, 2021 |
B
Purchase
|
Drake Scott William
President & CEO
Executive Director
|
89,285
+2.5%
5.60
499,996
USD
|
89,285
+2.5%
|
5.60
|
499,996
USD
|
|
|
Nov. 10, 2021 |
Nov. 8, 2021 |
S
Sale
|
Fosun International Ltd
Major owner
|
4,000,000
-26.5%
7.02
28,080,000
USD
|
4,000,000
-26.5%
|
7.02
|
28,080,000
USD
|
|
|
Nov. 10, 2021 |
Nov. 8, 2021 |
S
Sale
|
Strong Influence Ltd
Major owner
|
4,000,000
-26.5%
7.02
28,080,000
USD
|
4,000,000
-26.5%
|
7.02
|
28,080,000
USD
|
|
|
Aug. 25, 2021 |
Aug. 24, 2021 |
B
Purchase
|
Stassen Zachary William
Chief Financial Officer
Officer
|
40,000
+9.8%
5.32
212,800
USD
|
40,000
+9.8%
|
5.32
|
212,800
USD
|
|
|
June 10, 2021 |
June 8, 2021 |
S
Sale
|
Fosun International Ltd
Major owner
|
4,300,000
-22.2%
5.97
25,671,000
USD
|
4,300,000
-22.2%
|
5.97
|
25,671,000
USD
|
|
|
Nov. 12, 2020 |
Nov. 10, 2020 |
B
Purchase
|
Drake Scott William
President & CEO
Executive Director
|
155,000
+4.4%
3.23
499,906
USD
|
155,000
+4.4%
|
3.23
|
499,906
USD
|
|
|
Dec. 10, 2019 |
Dec. 6, 2019 |
B
Purchase
|
Strong Influence Ltd
Major owner
|
5,750,798
+42.1%
3.13
17,999,998
USD
|
5,750,798
+42.1%
|
3.13
|
17,999,998
USD
|
|
|
Dec. 10, 2019 |
Dec. 6, 2019 |
B
Purchase
|
Fosun International Ltd
Major owner
|
1,597,444
+inf%
3.13
5,000,000
USD
|
1,597,444
+inf%
|
3.13
|
5,000,000
USD
|
|
|
Dec. 10, 2019 |
Dec. 6, 2019 |
B
Purchase
|
Fosun International Ltd
Major owner
|
5,750,798
+42.1%
3.13
17,999,998
USD
|
5,750,798
+42.1%
|
3.13
|
17,999,998
USD
|
|
|
Sept. 4, 2019 |
Sept. 3, 2019 |
PS
Planned sale
|
Dempsey James F.
Chief Scientific Officer
Executive Director
|
63,257
-22.3%
3.57
225,574
USD
|
63,257
-22.3%
|
3.57
|
225,574
USD
|
|
|
Sept. 4, 2019 |
Sept. 3, 2019 |
PS
Planned sale
|
Dempsey James F.
Chief Scientific Officer
Executive Director
|
164,697
-42.7%
3.57
587,310
USD
|
164,697
-42.7%
|
3.57
|
587,310
USD
|
|
|
Sept. 4, 2019 |
Sept. 3, 2019 |
PS
Planned sale
|
Dempsey James F.
Chief Scientific Officer
Executive Director
|
51,460
-18.9%
3.57
183,506
USD
|
51,460
-18.9%
|
3.57
|
183,506
USD
|
|
|
Aug. 15, 2019 |
Aug. 14, 2019 |
B
Purchase
|
Matin Shahriar
Chief Operating Officer
Officer
|
60,000
+9.9%
4.02
241,200
USD
|
60,000
+9.9%
|
4.02
|
241,200
USD
|
|
|
Aug. 13, 2019 |
Aug. 13, 2019 |
B
Purchase
|
Drake Scott William
President & CEO
Executive Director
|
131,260
+10.7%
3.81
500,048
USD
|
131,260
+10.7%
|
3.81
|
500,048
USD
|
|
|
Aug. 2, 2019 |
Aug. 1, 2019 |
PS
Planned sale
|
Dempsey James F.
Chief Scientific Officer
Executive Director
|
16,469
-6.9%
8.97
147,791
USD
|
16,469
-6.9%
|
8.97
|
147,791
USD
|
|
|
Aug. 2, 2019 |
Aug. 1, 2019 |
PS
Planned sale
|
Dempsey James F.
Chief Scientific Officer
Executive Director
|
5,146
-2.3%
8.98
46,188
USD
|
5,146
-2.3%
|
8.98
|
46,188
USD
|
|
|
July 2, 2019 |
July 1, 2019 |
PS
Planned sale
|
Dempsey James F.
Chief Scientific Officer
Executive Director
|
5,146
-1.6%
8.63
44,431
USD
|
5,146
-1.6%
|
8.63
|
44,431
USD
|
|
|
Nov. 13, 2018 |
Nov. 13, 2018 |
B
Purchase
|
Drake Scott William
President & CEO
Executive Director
|
60,000
+5.2%
6.47
388,200
USD
|
60,000
+5.2%
|
6.47
|
388,200
USD
|
|
|
Nov. 13, 2018 |
Nov. 13, 2018 |
B
Purchase
|
Matin Shahriar
Chief Operating Officer
Officer
|
25,000
+4.3%
6.47
161,750
USD
|
25,000
+4.3%
|
6.47
|
161,750
USD
|
|
|
Aug. 31, 2018 |
Aug. 30, 2018 |
B
Purchase
|
Fosun International Ltd
Major owner
|
2,702,702
+2432.0%
9.25
24,999,994
USD
|
2,702,702
+2432.0%
|
9.25
|
24,999,994
USD
|
|
|
Aug. 20, 2018 |
Aug. 20, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
1,466
-2.1%
9.98
14,631
USD
|
1,466
-2.1%
|
9.98
|
14,631
USD
|
|
|
Aug. 20, 2018 |
Aug. 20, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
153,921
-2.1%
9.98
1,536,132
USD
|
153,921
-2.1%
|
9.98
|
1,536,132
USD
|
|
|
Aug. 20, 2018 |
Aug. 16, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
3,455
-4.6%
9.94
34,343
USD
|
3,455
-4.6%
|
9.94
|
34,343
USD
|
|
|
Aug. 20, 2018 |
Aug. 16, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
362,765
-4.6%
9.94
3,605,884
USD
|
362,765
-4.6%
|
9.94
|
3,605,884
USD
|
|
|
Aug. 15, 2018 |
Aug. 15, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
736
-1.0%
9.93
7,308
USD
|
736
-1.0%
|
9.93
|
7,308
USD
|
|
|
Aug. 15, 2018 |
Aug. 15, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
77,314
-1.0%
9.93
767,728
USD
|
77,314
-1.0%
|
9.93
|
767,728
USD
|
|
|
Aug. 15, 2018 |
Aug. 14, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
198
-0.3%
9.94
1,968
USD
|
198
-0.3%
|
9.94
|
1,968
USD
|
|
|
Aug. 15, 2018 |
Aug. 14, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
20,777
-0.3%
9.94
206,523
USD
|
20,777
-0.3%
|
9.94
|
206,523
USD
|
|
|
Aug. 15, 2018 |
Aug. 13, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
820
-1.1%
9.98
8,184
USD
|
820
-1.1%
|
9.98
|
8,184
USD
|
|
|
Aug. 15, 2018 |
Aug. 13, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
86,103
-1.1%
9.98
859,308
USD
|
86,103
-1.1%
|
9.98
|
859,308
USD
|
|
|
Aug. 10, 2018 |
Aug. 10, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
6,460
-7.9%
9.96
64,342
USD
|
6,460
-7.9%
|
9.96
|
64,342
USD
|
|
|
Aug. 10, 2018 |
Aug. 10, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
678,333
-7.9%
9.96
6,756,197
USD
|
678,333
-7.9%
|
9.96
|
6,756,197
USD
|
|
|
Aug. 10, 2018 |
Aug. 9, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
249
-0.3%
9.86
2,455
USD
|
249
-0.3%
|
9.86
|
2,455
USD
|
|
|
Aug. 10, 2018 |
Aug. 9, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
26,139
-0.3%
9.86
257,731
USD
|
26,139
-0.3%
|
9.86
|
257,731
USD
|
|
|
Aug. 10, 2018 |
Aug. 9, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
615
-0.7%
9.91
6,095
USD
|
615
-0.7%
|
9.91
|
6,095
USD
|
|
|
Aug. 10, 2018 |
Aug. 9, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
64,575
-0.7%
9.91
639,938
USD
|
64,575
-0.7%
|
9.91
|
639,938
USD
|
|
|
Aug. 10, 2018 |
Aug. 9, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
1,036
-1.2%
9.95
10,308
USD
|
1,036
-1.2%
|
9.95
|
10,308
USD
|
|
|
Aug. 10, 2018 |
Aug. 9, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
108,729
-1.2%
9.95
1,081,854
USD
|
108,729
-1.2%
|
9.95
|
1,081,854
USD
|
|
|
Aug. 10, 2018 |
Aug. 8, 2018 |
S
Sale
|
FMR LLC
See Remark 1
|
200,000
-24.9%
10.02
2,004,000
USD
|
200,000
-24.9%
|
10.02
|
2,004,000
USD
|
|
|
Aug. 10, 2018 |
Aug. 8, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
4,553
-5.2%
10.00
45,530
USD
|
4,553
-5.2%
|
10.00
|
45,530
USD
|
|
|
Aug. 10, 2018 |
Aug. 8, 2018 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
478,107
-5.2%
10.00
4,781,070
USD
|
478,107
-5.2%
|
10.00
|
4,781,070
USD
|
|
|
Aug. 8, 2018 |
Aug. 7, 2018 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
4,200
-0.5%
10.16
42,672
USD
|
4,200
-0.5%
|
10.16
|
42,672
USD
|
|
|
Aug. 8, 2018 |
Aug. 7, 2018 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
11,400
-1.4%
10.12
115,368
USD
|
11,400
-1.4%
|
10.12
|
115,368
USD
|
|
