|
2021-11-12 |
2021-11-10 |
S
Sale
|
Executive Chairman
Non-Executive Director
|
9,454
-33.6%
179.40
US$2,336,387
|
9,454
-33.6%
|
179.40
|
US$2,336,387
|
|
|
2021-11-12 |
2021-11-10 |
S
Sale
|
President and CEO
Executive Director
|
70,135
-35.8%
69.97
US$1,844,168
|
70,135
-35.8%
|
69.97
|
US$1,844,168
|
|
|
2021-10-07 |
2021-10-05 |
S
Sale
|
GC & Chief Compliance Officer
Officer
|
4,574
-47.9%
203.10
US$3,406,731
|
4,574
-47.9%
|
203.10
|
US$3,406,731
|
|
|
2021-08-12 |
2021-08-12 |
B
Purchase
|
Chief Financial Officer
Officer
|
1,449
+3.0%
6.89
US$9,976
|
1,449
+3.0%
|
6.89
|
US$9,976
|
|
|
2021-04-08 |
2021-04-06 |
S
Sale
|
VP, Controller and Interim CFO
Officer
|
1,508
-2.3%
7.13
US$10,751
|
1,508
-2.3%
|
7.13
|
US$10,751
|
|
|
2021-03-25 |
2021-03-12 |
S
Sale
|
VP, Controller and Interim CFO
Officer
|
1,582
-2.4%
7.49
US$11,849
|
1,582
-2.4%
|
7.49
|
US$11,849
|
|
|
2021-02-03 |
2021-02-02 |
S
Sale
|
Chief Financial Officer
Officer
|
4,123
-3.0%
4.91
US$20,256
|
4,123
-3.0%
|
4.91
|
US$20,256
|
|
|
2021-01-22 |
2021-01-20 |
S
Sale
|
GC & Chief Compliance Officer
Officer
|
4,399
-5.9%
4.49
US$19,752
|
4,399
-5.9%
|
4.49
|
US$19,752
|
|
|
2021-01-20 |
2021-01-13 |
S
Sale
|
Non-Executive Director
|
1,973
-1.4%
4.71
US$9,301
|
1,973
-1.4%
|
4.71
|
US$9,301
|
|
|
2020-02-20 |
2020-02-20 |
PlS
Planned sale
|
Chairman of the Board and CEO
Executive Director
|
63,557
-23.2%
5.91
US$375,368
|
63,557
-23.2%
|
5.91
|
US$375,368
|
|
|
2020-02-20 |
2020-02-19 |
PlS
Planned sale
|
Chairman of the Board and CEO
Executive Director
|
53,513
-16.4%
5.93
US$317,113
|
53,513
-16.4%
|
5.93
|
US$317,113
|
|
|
2020-02-20 |
2020-02-18 |
PlS
Planned sale
|
Chairman of the Board and CEO
Executive Director
|
16,506
-4.8%
6.00
US$98,960
|
16,506
-4.8%
|
6.00
|
US$98,960
|
|
|
2019-06-11 |
2019-06-07 |
B
Purchase
|
|
20,869
+11.4%
5.75
US$119,997
|
20,869
+11.4%
|
5.75
|
US$119,997
|
|
|
2019-06-11 |
2019-06-07 |
B
Purchase
|
Chief Financial Officer
|
17,391
+22.4%
5.75
US$99,998
|
17,391
+22.4%
|
5.75
|
US$99,998
|
|
|
2019-06-11 |
2019-06-07 |
B
Purchase
|
|
8,696
+19.3%
5.75
US$50,002
|
8,696
+19.3%
|
5.75
|
US$50,002
|
|
|
2018-11-08 |
2018-11-06 |
PlS
Planned sale
|
Haines Timothy
Non-Executive Director
|
81,137
-3.3%
21.60
US$1,752,559
|
81,137
-3.3%
|
21.60
|
US$1,752,559
|
|
|
2018-11-08 |
2018-11-06 |
PlS
Planned sale
|
Haines Timothy
Non-Executive Director
|
8,514
-0.3%
21.13
US$179,901
|
8,514
-0.3%
|
21.13
|
US$179,901
|
|
|
2018-09-05 |
2018-08-31 |
S
Sale
|
Nugent Jeffrey M
Chairman of the Board and CEO
Executive Director
|
1,852
-0.6%
24.90
US$46,115
|
1,852
-0.6%
|
24.90
|
US$46,115
|
|
|
2018-05-09 |
2018-05-07 |
B
Purchase
|
Haines Timothy
Non-Executive Director
|
281,482
+12.8%
13.50
US$3,800,007
|
281,482
+12.8%
|
13.50
|
US$3,800,007
|
|
|
2018-05-09 |
2018-05-07 |
B
Purchase
|
Abingworth LLP
|
281,482
+12.8%
13.50
US$3,800,007
|
281,482
+12.8%
|
13.50
|
US$3,800,007
|
|
|
2018-05-09 |
2018-05-07 |
B
Purchase
|
SCHAISON PHILIPPE
Non-Executive Director
|
7,407
+24.4%
13.50
US$99,994
|
7,407
+24.4%
|
13.50
|
US$99,994
|
|
|
2018-05-09 |
2018-05-07 |
B
Purchase
|
Williams Patrick F.
Chief Financial Officer & SVP
Officer
|
7,408
+14.8%
13.50
US$100,008
|
7,408
+14.8%
|
13.50
|
US$100,008
|
|
|
2018-05-09 |
2018-05-07 |
B
Purchase
|
Nugent Jeffrey M
Chairman of the Board and CEO
Executive Director
|
1,852
+0.6%
13.50
US$25,002
|
1,852
+0.6%
|
13.50
|
US$25,002
|
|
|
2018-05-09 |
2018-05-07 |
B
Purchase
|
Sullivan Keith J
Non-Executive Director
|
7,407
+6.5%
13.50
US$99,994
|
7,407
+6.5%
|
13.50
|
US$99,994
|
|
|
2018-05-09 |
2018-05-07 |
B
Purchase
|
GREER R SCOTT
Non-Executive Director
|
11,111
+26.7%
13.50
US$149,998
|
11,111
+26.7%
|
13.50
|
US$149,998
|
|
|
2018-05-09 |
2018-05-07 |
B
Purchase
|
OBOYLE KEVIN C
Non-Executive Director
|
7,407
+23.5%
13.50
US$99,994
|
7,407
+23.5%
|
13.50
|
US$99,994
|
|
|
2015-10-13 |
2015-10-12 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
2,785
-14.0%
5.98
US$16,654
|
2,785
-14.0%
|
5.98
|
US$16,654
|
|
|
2015-10-13 |
2015-10-12 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
285,106
-13.9%
5.98
US$1,704,934
|
285,106
-13.9%
|
5.98
|
US$1,704,934
|
|
|
2015-10-09 |
2015-10-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
2,041
-9.3%
7.03
US$14,348
|
2,041
-9.3%
|
7.03
|
US$14,348
|
|
|
2015-10-09 |
2015-10-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
210,668
-9.3%
7.03
US$1,480,996
|
210,668
-9.3%
|
7.03
|
US$1,480,996
|
|
|
2015-10-09 |
2015-10-08 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
3,837
-14.9%
7.24
US$27,780
|
3,837
-14.9%
|
7.24
|
US$27,780
|
|
|
2015-10-09 |
2015-10-08 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
396,163
-14.9%
7.24
US$2,868,220
|
396,163
-14.9%
|
7.24
|
US$2,868,220
|
|
|
2015-10-09 |
2015-10-07 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
454
-1.7%
7.36
US$3,341
|
454
-1.7%
|
7.36
|
US$3,341
|
|
|
2015-10-09 |
2015-10-07 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
53,446
-2.0%
7.36
US$393,363
|
53,446
-2.0%
|
7.36
|
US$393,363
|
|
|
2015-10-06 |
2015-10-06 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
59
-0.2%
7.80
US$460
|
59
-0.2%
|
7.80
|
US$460
|
|
|
2015-10-06 |
2015-10-06 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
6,941
-0.3%
7.80
US$54,140
|
6,941
-0.3%
|
7.80
|
US$54,140
|
|
|
2015-10-06 |
2015-10-05 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
1,163
-4.2%
8.19
US$9,525
|
1,163
-4.2%
|
8.19
|
US$9,525
|
|
|
2015-10-06 |
2015-10-05 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
136,937
-4.8%
8.19
US$1,121,514
|
136,937
-4.8%
|
8.19
|
US$1,121,514
|
|
|
2015-10-06 |
2015-10-02 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
403
-1.4%
10.34
US$4,167
|
403
-1.4%
|
10.34
|
US$4,167
|
|
|
2015-10-06 |
2015-10-02 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
47,497
-1.6%
10.34
US$491,119
|
47,497
-1.6%
|
10.34
|
US$491,119
|
|
|
2015-10-01 |
2015-10-01 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
400
-1.4%
10.34
US$4,136
|
400
-1.4%
|
10.34
|
US$4,136
|
|
|
2015-10-01 |
2015-10-01 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
47,100
-1.6%
10.34
US$487,014
|
47,100
-1.6%
|
10.34
|
US$487,014
|
|
|
2015-10-01 |
2015-09-30 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
369
-1.3%
10.17
US$3,753
|
369
-1.3%
|
10.17
|
US$3,753
|
|
|
2015-10-01 |
2015-09-30 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
43,471
-1.5%
10.17
US$442,100
|
43,471
-1.5%
|
10.17
|
US$442,100
|
|
|
2015-10-01 |
2015-09-29 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
89
-0.3%
10.08
US$897
|
89
-0.3%
|
10.08
|
US$897
|
|
|
2015-10-01 |
2015-09-29 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
10,469
-0.3%
10.08
US$105,528
|
10,469
-0.3%
|
10.08
|
US$105,528
|
|
|
2015-09-28 |
2015-09-28 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
89
-0.3%
10.30
US$917
|
89
-0.3%
|
10.30
|
US$917
|
|
|
2015-09-28 |
2015-09-28 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
10,513
-0.3%
10.30
US$108,284
|
10,513
-0.3%
|
10.30
|
US$108,284
|
|
|
2015-09-28 |
2015-09-25 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
311
-1.1%
11.07
US$3,443
|
311
-1.1%
|
11.07
|
US$3,443
|
|
|
2015-09-28 |
2015-09-25 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
66,489
-2.2%
11.07
US$736,033
|
66,489
-2.2%
|
11.07
|
US$736,033
|
|
|
2015-09-28 |
2015-09-25 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
800
-2.7%
10.07
US$8,056
|
800
-2.7%
|
10.07
|
US$8,056
|
|
|
2015-09-28 |
2015-09-25 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
64,400
-2.0%
10.07
US$648,508
|
64,400
-2.0%
|
10.07
|
US$648,508
|
|
|
2015-09-28 |
2015-09-24 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
8,152
-0.3%
11.00
US$89,672
|
8,152
-0.3%
|
11.00
|
US$89,672
|
|
|
2015-09-28 |
2015-09-24 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
148
-0.5%
11.00
US$1,628
|
148
-0.5%
|
11.00
|
US$1,628
|
|
|
2015-09-28 |
2015-09-24 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
6
-0.0%
9.78
US$59
|
6
-0.0%
|
9.78
|
US$59
|
|
|
2014-11-03 |
2014-10-29 |
B
Purchase
|
Haines Timothy
Non-Executive Director
Large shareholder
|
495,000
+29.0%
15.00
US$7,425,000
|
495,000
+29.0%
|
15.00
|
US$7,425,000
|
|
|
2014-10-31 |
2014-10-29 |
B
Purchase
|
Abingworth LLP
Large shareholder
|
495,000
+29.0%
15.00
US$7,425,000
|
495,000
+29.0%
|
15.00
|
US$7,425,000
|
|