Lexicon Pharmaceuticals Inc (LXRX)

Lexicon Pharmaceuticals Inc. has seen no insider trading activity within the last three months. The most recent transactions occurred in February 2026, featuring multiple buy orders from Raymond Debbane and Invus Global Management, LLC. These historical acquisitions represent the final recorded movements by company insiders prior to the current period.
Ticker: LXRX Exchange: NSM


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Insider trades have triggered activity signals for Lexicon Pharmaceuticals Inc. Upgrade to see score, net flow, insiders and the full signal context.

Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
137.40
Quantity 77,521 -38.4%
Value US$112,581
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
380.36
Quantity 43,859 +32.8%
Value US$3,842,613
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
325.73
Quantity 62,128 +45.6%
Value US$3,547,499
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
1.44
Quantity 50,000 +3.0%
Value US$71,965
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
1.32
Quantity 133,688 +8.8%
Value US$176,468
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
1.31
Quantity 76,857 +5.3%
Value US$100,544
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
1.31
Quantity 57,952 +4.2%
Value US$75,877
3.3
Invus Global Management, LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
1.30
Quantity 1,538,462 +inf%
Value US$2,000,001
3.3
Invus Global Management, LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
1.30
Quantity 1,538,462 +inf%
Value US$2,000,001
3.5
COATS LONNEL Former Affiliate
Transaction date
Proposed sale
Price
1.60
Quantity 300,000
Value US$480,000
3.5
COATS LONNEL Chief Executive Officer Executive Director
Transaction date
Purchase
Price
1.05
Quantity 90,000 +10.9%
Value US$94,797
3.7
Amouyal Philippe Non-Executive Director
Transaction date
Purchase
Price
1.01
Quantity 200,000 +495.9%
Value US$201,520
3.5
COATS LONNEL Chief Executive Officer Executive Director
Transaction date
Purchase
Price
1.01
Quantity 10,000 +1.2%
Value US$10,100
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
1.03
Quantity 148,820 +12.5%
Value US$153,805
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
1.08
Quantity 342,874 +40.4%
Value US$370,784
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
1.14
Quantity 508,306 +149.1%
Value US$579,367
1.0
WADE JEFFREY L President and CFO Officer
Transaction date
Purchase
Price
1.38
Quantity 10,000 +3.9%
Value US$13,800
0.9
McDermott Wendy VP, Human Resources Officer
Transaction date
Purchase
Price
1.84
Quantity 6,000 +26.7%
Value US$11,040
Seth Kiernan Former Affiliate
Transaction date
Proposed sale
Price
2.31
Quantity 19,000
Value US$43,890
3.5
COATS LONNEL Chief Executive Officer Executive Director
Transaction date
Purchase
Price
2.16
Quantity 10,000 +1.2%
Value US$21,600
3.5
COATS LONNEL Chief Executive Officer Executive Director
Transaction date
Purchase
Price
2.18
Quantity 10,000 +1.3%
Value US$21,792
0.9
McDermott Wendy VP, Human Resources Officer
Transaction date
Purchase
Price
2.43
Quantity 10,000 +80.1%
Value US$24,300
3.5
COATS LONNEL Chief Executive Officer Executive Director
Transaction date
Purchase
Price
2.50
Quantity 10,000 +1.3%
Value US$24,950
3.5
COATS LONNEL Chief Executive Officer Executive Director
Transaction date
Purchase
Price
2.31
Quantity 40,000 +5.4%
Value US$92,400
1.0
WADE JEFFREY L President and CFO Officer
Transaction date
Purchase
Price
2.33
Quantity 2,000 +0.8%
Value US$4,650
1.0
WADE JEFFREY L President and CFO Officer
Transaction date
Purchase
Price
2.34
Quantity 10,000 +4.1%
Value US$23,350
3.0
Artal International S.C.A. Non-Executive Director Large shareholder
Transaction date
Purchase
Price
2.60
Quantity 27,775,050 +54.6%
Value US$72,215,130
1.9
Invus US Partners LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
2.50
Quantity 147,390 +2.8%
Value US$368,475
3.0
Artal International S.C.A. Non-Executive Director Large shareholder
Transaction date
Purchase
Price
2.50
Quantity 2,426,070 +5.0%
Value US$6,065,175
1.9
Invus US Partners LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
2.50
Quantity 982,600 +22.7%
Value US$2,456,500
3.0
Artal International S.C.A. Non-Executive Director Large shareholder
Transaction date
Purchase
Price
2.50
Quantity 16,173,800 +50.1%
Value US$40,434,500
3.7
DEBBANE RAYMOND Non-Executive Director
Transaction date
Purchase
Price
2.50
Quantity 982,600 +22.7%
Value US$2,456,500
3.3
Tessmer James F VP, Finance & Accounting Officer
Transaction date
Sale
Price
6.93
Quantity 12,000 -14.3%
Value US$83,100
3.3
Tessmer James F VP, Finance & Accounting Officer
Transaction date
Sale
Price
6.90
Quantity 10,912 -13.2%
Value US$75,340
3.0
Artal International S.C.A. Non-Executive Director Large shareholder
Transaction date
Purchase
Price
3.20
Quantity 10,937,500 +51.3%
Value US$35,000,000
3.8
Invus Public Equities, L.P. Non-Executive Director Large shareholder
Transaction date
Purchase
Price
3.20
Quantity 10,937,500 +51.3%
Value US$35,000,000
3.5
COATS LONNEL President and CEO Executive Director
Transaction date
Purchase
Price
3.10
Quantity 50,000 +28.2%
Value US$155,000
2.4
Santini Alexander A EVP and CCO
Transaction date
Purchase
Price
3.52
Quantity 2,000 +12.0%
Value US$7,040
2.4
Santini Alexander A EVP and CCO
Transaction date
Purchase
Price
3.23
Quantity 2,500 +17.7%
Value US$8,075
3.5
COATS LONNEL President and CEO Executive Director
Transaction date
Purchase
Price
3.13
Quantity 40,290 +29.4%
Value US$126,108
3.5
COATS LONNEL President and CEO Executive Director
Transaction date
Purchase
Price
3.13
Quantity 277 +0.2%
Value US$867
3.5
COATS LONNEL President and CEO Executive Director
Transaction date
Purchase
Price
3.12
Quantity 6,333 +4.8%
Value US$19,759
3.5
COATS LONNEL President and CEO Executive Director
Transaction date
Purchase
Price
3.12
Quantity 3,000 +2.4%
Value US$9,357
3.5
COATS LONNEL President and CEO Executive Director
Transaction date
Purchase
Price
3.13
Quantity 100 +0.1%
Value US$312
Transaction date
Purchase
Price
2.80
Quantity 3,400 +1.1%
Value US$9,520
Transaction date
Purchase
Price
2.79
Quantity 7,500 +2.5%
Value US$20,925
Transaction date
Purchase
Price
2.78
Quantity 3,900 +1.3%
Value US$10,842
Transaction date
Purchase
Price
2.77
Quantity 12,400 +4.3%
Value US$34,348
Transaction date
Purchase
Price
2.76
Quantity 4,500 +1.6%
Value US$12,420
Transaction date
Purchase
Price
2.75
Quantity 6,853 +2.5%
Value US$18,846
Transaction date
Purchase
Price
2.74
Quantity 1,900 +0.7%
Value US$5,206
Transaction date
Purchase
Price
2.73
Quantity 11,100 +4.2%
Value US$30,303
Transaction date
Purchase
Price
2.72
Quantity 8,082 +3.2%
Value US$21,983
Transaction date
Purchase
Price
2.71
Quantity 6,443 +2.6%
Value US$17,461
Transaction date
Purchase
Price
2.70
Quantity 400 +0.2%
Value US$1,080
Transaction date
Purchase
Price
2.69
Quantity 500 +0.2%
Value US$1,345
Transaction date
Purchase
Price
2.68
Quantity 1,300 +0.5%
Value US$3,484
Transaction date
Purchase
Price
2.67
Quantity 4,600 +1.9%
Value US$12,282
Transaction date
Purchase
Price
2.66
Quantity 1,100 +0.5%
Value US$2,926
Transaction date
Purchase
Price
2.64
Quantity 2,100 +0.9%
Value US$5,544
Transaction date
Purchase
Price
2.63
Quantity 4,800 +2.1%
Value US$12,624
Transaction date
Purchase
Price
2.62
Quantity 3,110 +1.4%
Value US$8,148
Transaction date
Purchase
Price
2.61
Quantity 5,795 +2.6%
Value US$15,125
Transaction date
Purchase
Price
2.60
Quantity 3,990 +1.8%
Value US$10,374
Transaction date
Purchase
Price
2.73
Quantity 1,478 +1.1%
Value US$4,035
Transaction date
Purchase
Price
2.75
Quantity 3,700 +2.8%
Value US$10,175
Transaction date
Purchase
Price
2.60
Quantity 791 +0.6%
Value US$2,057
Transaction date
Purchase
Price
2.59
Quantity 200 +0.2%
Value US$518
Transaction date
Purchase
Price
2.57
Quantity 900 +0.7%
Value US$2,313
Transaction date
Purchase
Price
2.58
Quantity 100 +0.1%
Value US$258
Transaction date
Purchase
Price
2.56
Quantity 900 +0.7%
Value US$2,304
Transaction date
Purchase
Price
2.54
Quantity 800 +0.6%
Value US$2,032
Transaction date
Purchase
Price
2.55
Quantity 400 +0.3%
Value US$1,020
Transaction date
Purchase
Price
2.53
Quantity 820 +0.6%
Value US$2,075
Transaction date
Purchase
Price
2.52
Quantity 1,405 +1.1%
Value US$3,541
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value
Number of shares Price Value Details
2026-02-27 2026-02-25 B Purchase Non-Executive Director
77,521 -38.4%
137.40
US$112,581
77,521 -38.4% 137.40 US$112,581
2026-02-25 2026-02-23 B Purchase Non-Executive Director
43,859 +32.8%
380.36
US$3,842,613
43,859 +32.8% 380.36 US$3,842,613
2026-02-23 2026-02-20 B Purchase Non-Executive Director
62,128 +45.6%
325.73
US$3,547,499
62,128 +45.6% 325.73 US$3,547,499
2026-02-23 2026-02-19 B Purchase Non-Executive Director
50,000 +3.0%
1.44
US$71,965
50,000 +3.0% 1.44 US$71,965
2026-02-18 2026-02-18 B Purchase Non-Executive Director
133,688 +8.8%
1.32
US$176,468
133,688 +8.8% 1.32 US$176,468
2026-02-18 2026-02-17 B Purchase Non-Executive Director
76,857 +5.3%
1.31
US$100,544
76,857 +5.3% 1.31 US$100,544
2026-02-18 2026-02-13 B Purchase Non-Executive Director
57,952 +4.2%
1.31
US$75,877
57,952 +4.2% 1.31 US$75,877
2026-02-04 2026-02-02 B Purchase Non-Executive Director Large shareholder
1,538,462 +inf%
1.30
US$2,000,001
1,538,462 +inf% 1.30 US$2,000,001
2026-02-04 2026-02-02 B Purchase Non-Executive Director Large shareholder
1,538,462 +inf%
1.30
US$2,000,001
1,538,462 +inf% 1.30 US$2,000,001
2024-08-15 2024-08-15 PrS Proposed sale

Former Affiliate

300,000
1.60
US$480,000
300,000 1.60 US$480,000
2023-11-17 2023-11-16 B Purchase

Chief Executive Officer

Executive Director
90,000 +10.9%
1.05
US$94,797
90,000 +10.9% 1.05 US$94,797
2023-11-14 2023-11-13 B Purchase Non-Executive Director
200,000 +495.9%
1.01
US$201,520
200,000 +495.9% 1.01 US$201,520
2023-11-13 2023-11-10 B Purchase

Chief Executive Officer

Executive Director
10,000 +1.2%
1.01
US$10,100
10,000 +1.2% 1.01 US$10,100
2023-10-12 2023-10-12 B Purchase Non-Executive Director
148,820 +12.5%
1.03
US$153,805
148,820 +12.5% 1.03 US$153,805
2023-10-12 2023-10-11 B Purchase Non-Executive Director
342,874 +40.4%
1.08
US$370,784
342,874 +40.4% 1.08 US$370,784
2023-10-12 2023-10-10 B Purchase Non-Executive Director
508,306 +149.1%
1.14
US$579,367
508,306 +149.1% 1.14 US$579,367
2023-09-14 2023-09-14 B Purchase

President and CFO

Officer
10,000 +3.9%
1.38
US$13,800
10,000 +3.9% 1.38 US$13,800
2023-08-07 2023-08-04 B Purchase

VP, Human Resources

Officer
6,000 +26.7%
1.84
US$11,040
6,000 +26.7% 1.84 US$11,040
2023-07-12 2023-07-12 PrS Proposed sale

Former Affiliate

19,000
2.31
US$43,890
19,000 2.31 US$43,890
2023-06-29 2023-06-29 B Purchase

Chief Executive Officer

Executive Director
10,000 +1.2%
2.16
US$21,600
10,000 +1.2% 2.16 US$21,600
2023-06-26 2023-06-26 B Purchase

Chief Executive Officer

Executive Director
10,000 +1.3%
2.18
US$21,792
10,000 +1.3% 2.18 US$21,792
2023-06-27 2023-06-23 B Purchase

VP, Human Resources

Officer
10,000 +80.1%
2.43
US$24,300
10,000 +80.1% 2.43 US$24,300
2023-06-26 2023-06-23 B Purchase

Chief Executive Officer

Executive Director
10,000 +1.3%
2.50
US$24,950
10,000 +1.3% 2.50 US$24,950
2023-06-22 2023-06-22 B Purchase

Chief Executive Officer

Executive Director
40,000 +5.4%
2.31
US$92,400
40,000 +5.4% 2.31 US$92,400
2023-06-20 2023-06-20 B Purchase

President and CFO

Officer
2,000 +0.8%
2.33
US$4,650
2,000 +0.8% 2.33 US$4,650
2023-06-20 2023-06-20 B Purchase

President and CFO

Officer
10,000 +4.1%
2.34
US$23,350
10,000 +4.1% 2.34 US$23,350
2023-06-05 2023-06-05 B Purchase Non-Executive Director Large shareholder
27,775,050 +54.6%
2.60
US$72,215,130
27,775,050 +54.6% 2.60 US$72,215,130
2022-08-09 2022-08-05 B Purchase Non-Executive Director Large shareholder
147,390 +2.8%
2.50
US$368,475
147,390 +2.8% 2.50 US$368,475
2022-08-09 2022-08-05 B Purchase Non-Executive Director Large shareholder
2,426,070 +5.0%
2.50
US$6,065,175
2,426,070 +5.0% 2.50 US$6,065,175
2022-08-01 2022-08-01 B Purchase Non-Executive Director Large shareholder
982,600 +22.7%
2.50
US$2,456,500
982,600 +22.7% 2.50 US$2,456,500
2022-08-01 2022-08-01 B Purchase Non-Executive Director Large shareholder
16,173,800 +50.1%
2.50
US$40,434,500
16,173,800 +50.1% 2.50 US$40,434,500
2022-08-01 2022-08-01 B Purchase Non-Executive Director
982,600 +22.7%
2.50
US$2,456,500
982,600 +22.7% 2.50 US$2,456,500
2021-03-16 2021-03-15 S Sale

VP, Finance & Accounting

Officer
12,000 -14.3%
6.93
US$83,100
12,000 -14.3% 6.93 US$83,100
2021-03-16 2021-03-15 S Sale

VP, Finance & Accounting

Officer
10,912 -13.2%
6.90
US$75,340
10,912 -13.2% 6.90 US$75,340
2020-12-17 2020-12-16 B Purchase Non-Executive Director Large shareholder
10,937,500 +51.3%
3.20
US$35,000,000
10,937,500 +51.3% 3.20 US$35,000,000
2020-12-17 2020-12-16 B Purchase Non-Executive Director Large shareholder
10,937,500 +51.3%
3.20
US$35,000,000
10,937,500 +51.3% 3.20 US$35,000,000
2019-09-19 2019-09-18 B Purchase

President and CEO

Executive Director
50,000 +28.2%
3.10
US$155,000
50,000 +28.2% 3.10 US$155,000
2019-09-19 2019-09-18 B Purchase

EVP and CCO

2,000 +12.0%
3.52
US$7,040
2,000 +12.0% 3.52 US$7,040
2019-09-19 2019-09-18 B Purchase

EVP and CCO

2,500 +17.7%
3.23
US$8,075
2,500 +17.7% 3.23 US$8,075
2019-09-18 2019-09-17 B Purchase

President and CEO

Executive Director
40,290 +29.4%
3.13
US$126,108
40,290 +29.4% 3.13 US$126,108
2019-09-18 2019-09-17 B Purchase

President and CEO

Executive Director
277 +0.2%
3.13
US$867
277 +0.2% 3.13 US$867
2019-09-18 2019-09-17 B Purchase

President and CEO

Executive Director
6,333 +4.8%
3.12
US$19,759
6,333 +4.8% 3.12 US$19,759
2019-09-18 2019-09-17 B Purchase

President and CEO

Executive Director
3,000 +2.4%
3.12
US$9,357
3,000 +2.4% 3.12 US$9,357
2019-09-18 2019-09-17 B Purchase

President and CEO

Executive Director
100 +0.1%
3.13
US$312
100 +0.1% 3.13 US$312
2019-09-17 2019-09-16 B Purchase
3,400 +1.1%
2.80
US$9,520
3,400 +1.1% 2.80 US$9,520
2019-09-17 2019-09-16 B Purchase
7,500 +2.5%
2.79
US$20,925
7,500 +2.5% 2.79 US$20,925
2019-09-17 2019-09-16 B Purchase
3,900 +1.3%
2.78
US$10,842
3,900 +1.3% 2.78 US$10,842
2019-09-17 2019-09-16 B Purchase
12,400 +4.3%
2.77
US$34,348
12,400 +4.3% 2.77 US$34,348
2019-09-17 2019-09-16 B Purchase
4,500 +1.6%
2.76
US$12,420
4,500 +1.6% 2.76 US$12,420
2019-09-17 2019-09-16 B Purchase
6,853 +2.5%
2.75
US$18,846
6,853 +2.5% 2.75 US$18,846
2019-09-17 2019-09-16 B Purchase
1,900 +0.7%
2.74
US$5,206
1,900 +0.7% 2.74 US$5,206
2019-09-17 2019-09-16 B Purchase
11,100 +4.2%
2.73
US$30,303
11,100 +4.2% 2.73 US$30,303
2019-09-17 2019-09-16 B Purchase
8,082 +3.2%
2.72
US$21,983
8,082 +3.2% 2.72 US$21,983
2019-09-17 2019-09-16 B Purchase
6,443 +2.6%
2.71
US$17,461
6,443 +2.6% 2.71 US$17,461
2019-09-17 2019-09-16 B Purchase
400 +0.2%
2.70
US$1,080
400 +0.2% 2.70 US$1,080
2019-09-17 2019-09-16 B Purchase
500 +0.2%
2.69
US$1,345
500 +0.2% 2.69 US$1,345
2019-09-17 2019-09-16 B Purchase
1,300 +0.5%
2.68
US$3,484
1,300 +0.5% 2.68 US$3,484
2019-09-17 2019-09-16 B Purchase
4,600 +1.9%
2.67
US$12,282
4,600 +1.9% 2.67 US$12,282
2019-09-17 2019-09-16 B Purchase
1,100 +0.5%
2.66
US$2,926
1,100 +0.5% 2.66 US$2,926
2019-09-17 2019-09-16 B Purchase
2,100 +0.9%
2.64
US$5,544
2,100 +0.9% 2.64 US$5,544
2019-09-17 2019-09-16 B Purchase
4,800 +2.1%
2.63
US$12,624
4,800 +2.1% 2.63 US$12,624
2019-09-17 2019-09-16 B Purchase
3,110 +1.4%
2.62
US$8,148
3,110 +1.4% 2.62 US$8,148
2019-09-17 2019-09-16 B Purchase
5,795 +2.6%
2.61
US$15,125
5,795 +2.6% 2.61 US$15,125
2019-09-17 2019-09-16 B Purchase
3,990 +1.8%
2.60
US$10,374
3,990 +1.8% 2.60 US$10,374
2019-09-17 2019-09-16 B Purchase
1,478 +1.1%
2.73
US$4,035
1,478 +1.1% 2.73 US$4,035
2019-09-17 2019-09-16 B Purchase
3,700 +2.8%
2.75
US$10,175
3,700 +2.8% 2.75 US$10,175
2019-09-17 2019-09-16 B Purchase
791 +0.6%
2.60
US$2,057
791 +0.6% 2.60 US$2,057
2019-09-17 2019-09-16 B Purchase
200 +0.2%
2.59
US$518
200 +0.2% 2.59 US$518
2019-09-17 2019-09-16 B Purchase
900 +0.7%
2.57
US$2,313
900 +0.7% 2.57 US$2,313
2019-09-17 2019-09-16 B Purchase
100 +0.1%
2.58
US$258
100 +0.1% 2.58 US$258
2019-09-17 2019-09-16 B Purchase
900 +0.7%
2.56
US$2,304
900 +0.7% 2.56 US$2,304
2019-09-17 2019-09-16 B Purchase
800 +0.6%
2.54
US$2,032
800 +0.6% 2.54 US$2,032
2019-09-17 2019-09-16 B Purchase
400 +0.3%
2.55
US$1,020
400 +0.3% 2.55 US$1,020
2019-09-17 2019-09-16 B Purchase
820 +0.6%
2.53
US$2,075
820 +0.6% 2.53 US$2,075
2019-09-17 2019-09-16 B Purchase
1,405 +1.1%
2.52
US$3,541
1,405 +1.1% 2.52 US$3,541