United States Biotechnology & Medical Research

Lexicon Pharmaceuticals Inc (LXRX)

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Lexicon Pharmaceuticals Inc. experienced significant insider activity during February 2026, primarily driven by Raymond Debbane and Invus Global Management, LLC. These entities executed multiple purchase orders throughout the month. As the most recent transactions occurred over three months ago, no further analysis regarding current market performance or recent results is provided.
Ticker: LXRX Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Lexicon Pharmaceuticals Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Trades
Buy 25 Feb 2026
Value US$112,580.89 | Price 137.40 | Shares 77,521 (-38.4%)
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-02-27 2026-02-25 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
77,521 -38.4%
137.40
US$112,581 		77,521 -38.4% 137.40 US$112,581
2026-02-25 2026-02-23 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
43,859 +32.8%
380.36
US$3,842,613 		43,859 +32.8% 380.36 US$3,842,613
2026-02-23 2026-02-20 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
62,128 +45.6%
325.73
US$3,547,499 		62,128 +45.6% 325.73 US$3,547,499
2026-02-23 2026-02-19 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
50,000 +3.0%
1.44
US$71,965 		50,000 +3.0% 1.44 US$71,965
2026-02-18 2026-02-18 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
133,688 +8.8%
1.32
US$176,468 		133,688 +8.8% 1.32 US$176,468
2026-02-18 2026-02-17 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
76,857 +5.3%
1.31
US$100,544 		76,857 +5.3% 1.31 US$100,544
2026-02-18 2026-02-13 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
57,952 +4.2%
1.31
US$75,877 		57,952 +4.2% 1.31 US$75,877
2026-02-04 2026-02-02 B Purchase
3.3
Invus Global Management, LLC
Non-Executive Director Large shareholder
1,538,462 +inf%
1.30
US$2,000,001 		1,538,462 +inf% 1.30 US$2,000,001
2026-02-04 2026-02-02 B Purchase
3.3
Invus Global Management, LLC
Non-Executive Director Large shareholder
1,538,462 +inf%
1.30
US$2,000,001 		1,538,462 +inf% 1.30 US$2,000,001
2024-08-15 2024-08-15 PrS Proposed sale
3.5
COATS LONNEL

Former Affiliate
300,000
1.60
US$480,000 		300,000 1.60 US$480,000
2023-11-17 2023-11-16 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
90,000 +10.9%
1.05
US$94,797 		90,000 +10.9% 1.05 US$94,797
2023-11-14 2023-11-13 B Purchase
3.7
Amouyal Philippe
Non-Executive Director
200,000 +495.9%
1.01
US$201,520 		200,000 +495.9% 1.01 US$201,520
2023-11-13 2023-11-10 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
10,000 +1.2%
1.01
US$10,100 		10,000 +1.2% 1.01 US$10,100
2023-10-12 2023-10-12 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
148,820 +12.5%
1.03
US$153,805 		148,820 +12.5% 1.03 US$153,805
2023-10-12 2023-10-11 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
342,874 +40.4%
1.08
US$370,784 		342,874 +40.4% 1.08 US$370,784
2023-10-12 2023-10-10 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
508,306 +149.1%
1.14
US$579,367 		508,306 +149.1% 1.14 US$579,367
2023-09-14 2023-09-14 B Purchase
1.0
WADE JEFFREY L

President and CFO

Officer
10,000 +3.9%
1.38
US$13,800 		10,000 +3.9% 1.38 US$13,800
2023-08-07 2023-08-04 B Purchase
0.9
McDermott Wendy

VP, Human Resources

Officer
6,000 +26.7%
1.84
US$11,040 		6,000 +26.7% 1.84 US$11,040
2023-07-12 2023-07-12 PrS Proposed sale
Seth Kiernan

Former Affiliate
19,000
2.31
US$43,890 		19,000 2.31 US$43,890
2023-06-29 2023-06-29 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
10,000 +1.2%
2.16
US$21,600 		10,000 +1.2% 2.16 US$21,600
2023-06-26 2023-06-26 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
10,000 +1.3%
2.18
US$21,792 		10,000 +1.3% 2.18 US$21,792
2023-06-27 2023-06-23 B Purchase
0.9
McDermott Wendy

VP, Human Resources

Officer
10,000 +80.1%
2.43
US$24,300 		10,000 +80.1% 2.43 US$24,300
2023-06-26 2023-06-23 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
10,000 +1.3%
2.50
US$24,950 		10,000 +1.3% 2.50 US$24,950
2023-06-22 2023-06-22 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
40,000 +5.4%
2.31
US$92,400 		40,000 +5.4% 2.31 US$92,400
2023-06-20 2023-06-20 B Purchase
1.0
WADE JEFFREY L

President and CFO

Officer
2,000 +0.8%
2.33
US$4,650 		2,000 +0.8% 2.33 US$4,650
2023-06-20 2023-06-20 B Purchase
1.0
WADE JEFFREY L

President and CFO

Officer
10,000 +4.1%
2.34
US$23,350 		10,000 +4.1% 2.34 US$23,350
2023-06-05 2023-06-05 B Purchase
3.0
Artal International S.C.A.
Non-Executive Director Large shareholder
27,775,050 +54.6%
2.60
US$72,215,130 		27,775,050 +54.6% 2.60 US$72,215,130
2022-08-09 2022-08-05 B Purchase
1.9
Invus US Partners LLC
Non-Executive Director Large shareholder
147,390 +2.8%
2.50
US$368,475 		147,390 +2.8% 2.50 US$368,475
2022-08-09 2022-08-05 B Purchase
3.0
Artal International S.C.A.
Non-Executive Director Large shareholder
2,426,070 +5.0%
2.50
US$6,065,175 		2,426,070 +5.0% 2.50 US$6,065,175
2022-08-01 2022-08-01 B Purchase
1.9
Invus US Partners LLC
Non-Executive Director Large shareholder
982,600 +22.7%
2.50
US$2,456,500 		982,600 +22.7% 2.50 US$2,456,500
2022-08-01 2022-08-01 B Purchase
3.0
Artal International S.C.A.
Non-Executive Director Large shareholder
16,173,800 +50.1%
2.50
US$40,434,500 		16,173,800 +50.1% 2.50 US$40,434,500
2022-08-01 2022-08-01 B Purchase
3.7
DEBBANE RAYMOND
Non-Executive Director
982,600 +22.7%
2.50
US$2,456,500 		982,600 +22.7% 2.50 US$2,456,500
2021-03-16 2021-03-15 S Sale
3.3
Tessmer James F

VP, Finance & Accounting

Officer
12,000 -14.3%
6.93
US$83,100 		12,000 -14.3% 6.93 US$83,100
2021-03-16 2021-03-15 S Sale
3.3
Tessmer James F

VP, Finance & Accounting

Officer
10,912 -13.2%
6.90
US$75,340 		10,912 -13.2% 6.90 US$75,340
2020-12-17 2020-12-16 B Purchase
3.0
Artal International S.C.A.
Non-Executive Director Large shareholder
10,937,500 +51.3%
3.20
US$35,000,000 		10,937,500 +51.3% 3.20 US$35,000,000
2020-12-17 2020-12-16 B Purchase
3.8
Invus Public Equities, L.P.
Non-Executive Director Large shareholder
10,937,500 +51.3%
3.20
US$35,000,000 		10,937,500 +51.3% 3.20 US$35,000,000
2019-09-19 2019-09-18 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
50,000 +28.2%
3.10
US$155,000 		50,000 +28.2% 3.10 US$155,000
2019-09-19 2019-09-18 B Purchase
2.4
Santini Alexander A

EVP and CCO
2,000 +12.0%
3.52
US$7,040 		2,000 +12.0% 3.52 US$7,040
2019-09-19 2019-09-18 B Purchase
2.4
Santini Alexander A

EVP and CCO
2,500 +17.7%
3.23
US$8,075 		2,500 +17.7% 3.23 US$8,075
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
40,290 +29.4%
3.13
US$126,108 		40,290 +29.4% 3.13 US$126,108
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
277 +0.2%
3.13
US$867 		277 +0.2% 3.13 US$867
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
6,333 +4.8%
3.12
US$19,759 		6,333 +4.8% 3.12 US$19,759
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
3,000 +2.4%
3.12
US$9,357 		3,000 +2.4% 3.12 US$9,357
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
100 +0.1%
3.13
US$312 		100 +0.1% 3.13 US$312
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
3,400 +1.1%
2.80
US$9,520 		3,400 +1.1% 2.80 US$9,520
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
7,500 +2.5%
2.79
US$20,925 		7,500 +2.5% 2.79 US$20,925
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
3,900 +1.3%
2.78
US$10,842 		3,900 +1.3% 2.78 US$10,842
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
12,400 +4.3%
2.77
US$34,348 		12,400 +4.3% 2.77 US$34,348
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
4,500 +1.6%
2.76
US$12,420 		4,500 +1.6% 2.76 US$12,420
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
6,853 +2.5%
2.75
US$18,846 		6,853 +2.5% 2.75 US$18,846
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
1,900 +0.7%
2.74
US$5,206 		1,900 +0.7% 2.74 US$5,206
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
11,100 +4.2%
2.73
US$30,303 		11,100 +4.2% 2.73 US$30,303
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
8,082 +3.2%
2.72
US$21,983 		8,082 +3.2% 2.72 US$21,983
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
6,443 +2.6%
2.71
US$17,461 		6,443 +2.6% 2.71 US$17,461
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
400 +0.2%
2.70
US$1,080 		400 +0.2% 2.70 US$1,080
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
500 +0.2%
2.69
US$1,345 		500 +0.2% 2.69 US$1,345
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
1,300 +0.5%
2.68
US$3,484 		1,300 +0.5% 2.68 US$3,484
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
4,600 +1.9%
2.67
US$12,282 		4,600 +1.9% 2.67 US$12,282
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
1,100 +0.5%
2.66
US$2,926 		1,100 +0.5% 2.66 US$2,926
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
2,100 +0.9%
2.64
US$5,544 		2,100 +0.9% 2.64 US$5,544
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
4,800 +2.1%
2.63
US$12,624 		4,800 +2.1% 2.63 US$12,624
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
3,110 +1.4%
2.62
US$8,148 		3,110 +1.4% 2.62 US$8,148
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
5,795 +2.6%
2.61
US$15,125 		5,795 +2.6% 2.61 US$15,125
2019-09-17 2019-09-16 B Purchase
3.7
DEBBANE RAYMOND
3,990 +1.8%
2.60
US$10,374 		3,990 +1.8% 2.60 US$10,374
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
1,478 +1.1%
2.73
US$4,035 		1,478 +1.1% 2.73 US$4,035
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
3,700 +2.8%
2.75
US$10,175 		3,700 +2.8% 2.75 US$10,175
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
791 +0.6%
2.60
US$2,057 		791 +0.6% 2.60 US$2,057
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
200 +0.2%
2.59
US$518 		200 +0.2% 2.59 US$518
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
900 +0.7%
2.57
US$2,313 		900 +0.7% 2.57 US$2,313
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
100 +0.1%
2.58
US$258 		100 +0.1% 2.58 US$258
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
900 +0.7%
2.56
US$2,304 		900 +0.7% 2.56 US$2,304
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
800 +0.6%
2.54
US$2,032 		800 +0.6% 2.54 US$2,032
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
400 +0.3%
2.55
US$1,020 		400 +0.3% 2.55 US$1,020
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
820 +0.6%
2.53
US$2,075 		820 +0.6% 2.53 US$2,075
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
1,405 +1.1%
2.52
US$3,541 		1,405 +1.1% 2.52 US$3,541
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