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United States Biotechnology & Medical Research

Lexicon Pharmaceuticals Inc (LXRX)

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The most recent insider trading activity occurred on February 25, 2026, with Raymond Debbane making a BUY transaction of 2,000 shares valued at $2,980. Prior to this, significant BUY activity was noted from Invus Global Management, LLC on February 2, 2026, and multiple BUY transactions from Raymond Debbane in late February 2026. The last reported PROPOSED_SALE was on August 15, 2024.
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Ticker: LXRX Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
DEBBANE RAYMOND
1 purchase — total 2,980 USD
Buy 25 Feb 2026
Value US$112,580.89 | Price 137.40 | Shares 77,521
Buy 23 Feb 2026
Value US$3,842,612.84 | Price 380.36 | Shares 43,859
Buy 20 Feb 2026
Value US$147,790.00 | Price 1.48 | Shares 100,000
Buy 19 Feb 2026
Value US$71,965.00 | Price 1.44 | Shares 50,000
Buy 18 Feb 2026
Value US$176,468.16 | Price 1.32 | Shares 133,688
Buy 17 Feb 2026
Value US$100,544.33 | Price 1.31 | Shares 76,857
Buy 13 Feb 2026
Value US$75,876.55 | Price 1.31 | Shares 57,952
Buy 2 Feb 2026
Value US$2,000,000.60 | Price 1.30 | Shares 1,538,462
Buy 2 Feb 2026
Value US$2,000,000.60 | Price 1.30 | Shares 1,538,462
Proposed sale 15 Aug 2024
Value US$480,000.00 | Price 1.60 | Shares 300,000
Buy 16 Nov 2023
Value US$94,797.00 | Price 1.05 | Shares 90,000
Buy 13 Nov 2023
Value US$201,520.00 | Price 1.01 | Shares 200,000
Buy 10 Nov 2023
Value US$10,100.00 | Price 1.01 | Shares 10,000
Buy 12 Oct 2023
Value US$153,805.47 | Price 1.03 | Shares 148,820
Buy 11 Oct 2023
Value US$370,783.94 | Price 1.08 | Shares 342,874
Buy 10 Oct 2023
Value US$579,367.18 | Price 1.14 | Shares 508,306
Buy 14 Sep 2023
Value US$13,800.00 | Price 1.38 | Shares 10,000
Buy 4 Aug 2023
Value US$11,040.00 | Price 1.84 | Shares 6,000
Proposed sale 12 Jul 2023
Value US$43,890.00 | Price 2.31 | Shares 19,000
Buy 29 Jun 2023
Value US$21,600.00 | Price 2.16 | Shares 10,000
Buy 26 Jun 2023
Value US$21,792.00 | Price 2.18 | Shares 10,000
Buy 23 Jun 2023
Value US$24,300.00 | Price 2.43 | Shares 10,000
Buy 23 Jun 2023
Value US$24,950.00 | Price 2.50 | Shares 10,000
Buy 22 Jun 2023
Value US$92,400.00 | Price 2.31 | Shares 40,000
Buy 20 Jun 2023
Value US$4,650.00 | Price 2.33 | Shares 2,000
Buy 20 Jun 2023
Value US$23,350.00 | Price 2.34 | Shares 10,000
Buy 5 Jun 2023
Value US$72,215,130.00 | Price 2.60 | Shares 27,775,050
Buy 5 Aug 2022
Value US$368,475.00 | Price 2.50 | Shares 147,390
Buy 5 Aug 2022
Value US$6,065,175.00 | Price 2.50 | Shares 2,426,070
Buy 1 Aug 2022
Value US$2,456,500.00 | Price 2.50 | Shares 982,600
Buy 1 Aug 2022
Value US$40,434,500.00 | Price 2.50 | Shares 16,173,800
Buy 1 Aug 2022
Value US$2,456,500.00 | Price 2.50 | Shares 982,600
Sale 15 Mar 2021
Value US$83,100.00 | Price 6.93 | Shares 12,000
Sale 15 Mar 2021
Value US$75,339.72 | Price 6.90 | Shares 10,912
Buy 16 Dec 2020
Value US$35,000,000.00 | Price 3.20 | Shares 10,937,500
Buy 16 Dec 2020
Value US$35,000,000.00 | Price 3.20 | Shares 10,937,500
Buy 18 Sep 2019
Value US$155,000.00 | Price 3.10 | Shares 50,000
Buy 18 Sep 2019
Value US$7,040.00 | Price 3.52 | Shares 2,000
Buy 18 Sep 2019
Value US$8,075.00 | Price 3.23 | Shares 2,500
Buy 17 Sep 2019
Value US$126,107.70 | Price 3.13 | Shares 40,290
Buy 17 Sep 2019
Value US$866.90 | Price 3.13 | Shares 277
Buy 17 Sep 2019
Value US$19,758.96 | Price 3.12 | Shares 6,333
Buy 17 Sep 2019
Value US$9,357.00 | Price 3.12 | Shares 3,000
Buy 17 Sep 2019
Value US$312.50 | Price 3.13 | Shares 100
Buy 16 Sep 2019
Value US$9,520.00 | Price 2.80 | Shares 3,400
Buy 16 Sep 2019
Value US$20,925.00 | Price 2.79 | Shares 7,500
Buy 16 Sep 2019
Value US$10,842.00 | Price 2.78 | Shares 3,900
Buy 16 Sep 2019
Value US$34,348.00 | Price 2.77 | Shares 12,400
Buy 16 Sep 2019
Value US$12,420.00 | Price 2.76 | Shares 4,500
Buy 16 Sep 2019
Value US$18,845.75 | Price 2.75 | Shares 6,853
Buy 16 Sep 2019
Value US$5,206.00 | Price 2.74 | Shares 1,900
Buy 16 Sep 2019
Value US$30,303.00 | Price 2.73 | Shares 11,100
Buy 16 Sep 2019
Value US$21,983.04 | Price 2.72 | Shares 8,082
Buy 16 Sep 2019
Value US$17,460.53 | Price 2.71 | Shares 6,443
Buy 16 Sep 2019
Value US$1,080.00 | Price 2.70 | Shares 400
Buy 16 Sep 2019
Value US$1,345.00 | Price 2.69 | Shares 500
Buy 16 Sep 2019
Value US$3,484.00 | Price 2.68 | Shares 1,300
Buy 16 Sep 2019
Value US$12,282.00 | Price 2.67 | Shares 4,600
Buy 16 Sep 2019
Value US$2,926.00 | Price 2.66 | Shares 1,100
Buy 16 Sep 2019
Value US$5,544.00 | Price 2.64 | Shares 2,100
Buy 16 Sep 2019
Value US$12,624.00 | Price 2.63 | Shares 4,800
Buy 16 Sep 2019
Value US$8,148.20 | Price 2.62 | Shares 3,110
Buy 16 Sep 2019
Value US$15,124.95 | Price 2.61 | Shares 5,795
Buy 16 Sep 2019
Value US$10,374.00 | Price 2.60 | Shares 3,990
Buy 16 Sep 2019
Value US$4,034.94 | Price 2.73 | Shares 1,478
Buy 16 Sep 2019
Value US$10,175.00 | Price 2.75 | Shares 3,700
Buy 16 Sep 2019
Value US$2,056.60 | Price 2.60 | Shares 791
Buy 16 Sep 2019
Value US$518.00 | Price 2.59 | Shares 200
Buy 16 Sep 2019
Value US$2,313.00 | Price 2.57 | Shares 900
Buy 16 Sep 2019
Value US$258.00 | Price 2.58 | Shares 100
Buy 16 Sep 2019
Value US$2,304.00 | Price 2.56 | Shares 900
Buy 16 Sep 2019
Value US$2,032.00 | Price 2.54 | Shares 800
Buy 16 Sep 2019
Value US$1,020.00 | Price 2.55 | Shares 400
Buy 16 Sep 2019
Value US$2,074.60 | Price 2.53 | Shares 820
Buy 16 Sep 2019
Value US$3,540.60 | Price 2.52 | Shares 1,405
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-02-27 2026-02-25 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
77,521 -38.4%
137.40
US$112,581 		77,521 -38.4% 137.40 US$112,581
2026-02-25 2026-02-23 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
43,859 +32.8%
380.36
US$3,842,613 		43,859 +32.8% 380.36 US$3,842,613
2026-02-23 2026-02-20 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
62,128 +45.6%
325.73
US$3,547,499 		62,128 +45.6% 325.73 US$3,547,499
2026-02-23 2026-02-19 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
50,000 +3.0%
1.44
US$71,965 		50,000 +3.0% 1.44 US$71,965
2026-02-18 2026-02-18 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
133,688 +8.8%
1.32
US$176,468 		133,688 +8.8% 1.32 US$176,468
2026-02-18 2026-02-17 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
76,857 +5.3%
1.31
US$100,544 		76,857 +5.3% 1.31 US$100,544
2026-02-18 2026-02-13 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
57,952 +4.2%
1.31
US$75,877 		57,952 +4.2% 1.31 US$75,877
2026-02-04 2026-02-02 B Purchase
3.3
Invus Global Management, LLC
Non-Executive Director Large shareholder
1,538,462 +inf%
1.30
US$2,000,001 		1,538,462 +inf% 1.30 US$2,000,001
2026-02-04 2026-02-02 B Purchase
3.3
Invus Global Management, LLC
Non-Executive Director Large shareholder
1,538,462 +inf%
1.30
US$2,000,001 		1,538,462 +inf% 1.30 US$2,000,001
2024-08-15 2024-08-15 PrS Proposed sale
3.5
COATS LONNEL

Former Affiliate
300,000
1.60
US$480,000 		300,000 1.60 US$480,000
2023-11-17 2023-11-16 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
90,000 +10.9%
1.05
US$94,797 		90,000 +10.9% 1.05 US$94,797
2023-11-14 2023-11-13 B Purchase
3.7
Amouyal Philippe
Non-Executive Director
200,000 +495.9%
1.01
US$201,520 		200,000 +495.9% 1.01 US$201,520
2023-11-13 2023-11-10 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
10,000 +1.2%
1.01
US$10,100 		10,000 +1.2% 1.01 US$10,100
2023-10-12 2023-10-12 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
148,820 +12.5%
1.03
US$153,805 		148,820 +12.5% 1.03 US$153,805
2023-10-12 2023-10-11 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
342,874 +40.4%
1.08
US$370,784 		342,874 +40.4% 1.08 US$370,784
2023-10-12 2023-10-10 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
508,306 +149.1%
1.14
US$579,367 		508,306 +149.1% 1.14 US$579,367
2023-09-14 2023-09-14 B Purchase
1.0
WADE JEFFREY L

President and CFO

Officer
10,000 +3.9%
1.38
US$13,800 		10,000 +3.9% 1.38 US$13,800
2023-08-07 2023-08-04 B Purchase
0.9
McDermott Wendy

VP, Human Resources

Officer
6,000 +26.7%
1.84
US$11,040 		6,000 +26.7% 1.84 US$11,040
2023-07-12 2023-07-12 PrS Proposed sale
Seth Kiernan

Former Affiliate
19,000
2.31
US$43,890 		19,000 2.31 US$43,890
2023-06-29 2023-06-29 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
10,000 +1.2%
2.16
US$21,600 		10,000 +1.2% 2.16 US$21,600
2023-06-26 2023-06-26 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
10,000 +1.3%
2.18
US$21,792 		10,000 +1.3% 2.18 US$21,792
2023-06-27 2023-06-23 B Purchase
0.9
McDermott Wendy

VP, Human Resources

Officer
10,000 +80.1%
2.43
US$24,300 		10,000 +80.1% 2.43 US$24,300
2023-06-26 2023-06-23 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
10,000 +1.3%
2.50
US$24,950 		10,000 +1.3% 2.50 US$24,950
2023-06-22 2023-06-22 B Purchase
3.5
COATS LONNEL

Chief Executive Officer

Executive Director
40,000 +5.4%
2.31
US$92,400 		40,000 +5.4% 2.31 US$92,400
2023-06-20 2023-06-20 B Purchase
1.0
WADE JEFFREY L

President and CFO

Officer
2,000 +0.8%
2.33
US$4,650 		2,000 +0.8% 2.33 US$4,650
2023-06-20 2023-06-20 B Purchase
1.0
WADE JEFFREY L

President and CFO

Officer
10,000 +4.1%
2.34
US$23,350 		10,000 +4.1% 2.34 US$23,350
2023-06-05 2023-06-05 B Purchase
3.0
Artal International S.C.A.
Non-Executive Director Large shareholder
27,775,050 +54.6%
2.60
US$72,215,130 		27,775,050 +54.6% 2.60 US$72,215,130
2022-08-09 2022-08-05 B Purchase
1.9
Invus US Partners LLC
Non-Executive Director Large shareholder
147,390 +2.8%
2.50
US$368,475 		147,390 +2.8% 2.50 US$368,475
2022-08-09 2022-08-05 B Purchase
3.0
Artal International S.C.A.
Non-Executive Director Large shareholder
2,426,070 +5.0%
2.50
US$6,065,175 		2,426,070 +5.0% 2.50 US$6,065,175
2022-08-01 2022-08-01 B Purchase
1.9
Invus US Partners LLC
Non-Executive Director Large shareholder
982,600 +22.7%
2.50
US$2,456,500 		982,600 +22.7% 2.50 US$2,456,500
2022-08-01 2022-08-01 B Purchase
3.0
Artal International S.C.A.
Non-Executive Director Large shareholder
16,173,800 +50.1%
2.50
US$40,434,500 		16,173,800 +50.1% 2.50 US$40,434,500
2022-08-01 2022-08-01 B Purchase
3.6
DEBBANE RAYMOND
Non-Executive Director
982,600 +22.7%
2.50
US$2,456,500 		982,600 +22.7% 2.50 US$2,456,500
2021-03-16 2021-03-15 S Sale
3.3
Tessmer James F

VP, Finance & Accounting

Officer
12,000 -14.3%
6.93
US$83,100 		12,000 -14.3% 6.93 US$83,100
2021-03-16 2021-03-15 S Sale
3.3
Tessmer James F

VP, Finance & Accounting

Officer
10,912 -13.2%
6.90
US$75,340 		10,912 -13.2% 6.90 US$75,340
2020-12-17 2020-12-16 B Purchase
3.0
Artal International S.C.A.
Non-Executive Director Large shareholder
10,937,500 +51.3%
3.20
US$35,000,000 		10,937,500 +51.3% 3.20 US$35,000,000
2020-12-17 2020-12-16 B Purchase
3.8
Invus Public Equities, L.P.
Non-Executive Director Large shareholder
10,937,500 +51.3%
3.20
US$35,000,000 		10,937,500 +51.3% 3.20 US$35,000,000
2019-09-19 2019-09-18 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
50,000 +28.2%
3.10
US$155,000 		50,000 +28.2% 3.10 US$155,000
2019-09-19 2019-09-18 B Purchase
2.4
Santini Alexander A

EVP and CCO
2,000 +12.0%
3.52
US$7,040 		2,000 +12.0% 3.52 US$7,040
2019-09-19 2019-09-18 B Purchase
2.4
Santini Alexander A

EVP and CCO
2,500 +17.7%
3.23
US$8,075 		2,500 +17.7% 3.23 US$8,075
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
40,290 +29.4%
3.13
US$126,108 		40,290 +29.4% 3.13 US$126,108
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
277 +0.2%
3.13
US$867 		277 +0.2% 3.13 US$867
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
6,333 +4.8%
3.12
US$19,759 		6,333 +4.8% 3.12 US$19,759
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
3,000 +2.4%
3.12
US$9,357 		3,000 +2.4% 3.12 US$9,357
2019-09-18 2019-09-17 B Purchase
3.5
COATS LONNEL

President and CEO

Executive Director
100 +0.1%
3.13
US$312 		100 +0.1% 3.13 US$312
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
3,400 +1.1%
2.80
US$9,520 		3,400 +1.1% 2.80 US$9,520
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
7,500 +2.5%
2.79
US$20,925 		7,500 +2.5% 2.79 US$20,925
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
3,900 +1.3%
2.78
US$10,842 		3,900 +1.3% 2.78 US$10,842
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
12,400 +4.3%
2.77
US$34,348 		12,400 +4.3% 2.77 US$34,348
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
4,500 +1.6%
2.76
US$12,420 		4,500 +1.6% 2.76 US$12,420
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
6,853 +2.5%
2.75
US$18,846 		6,853 +2.5% 2.75 US$18,846
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
1,900 +0.7%
2.74
US$5,206 		1,900 +0.7% 2.74 US$5,206
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
11,100 +4.2%
2.73
US$30,303 		11,100 +4.2% 2.73 US$30,303
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
8,082 +3.2%
2.72
US$21,983 		8,082 +3.2% 2.72 US$21,983
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
6,443 +2.6%
2.71
US$17,461 		6,443 +2.6% 2.71 US$17,461
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
400 +0.2%
2.70
US$1,080 		400 +0.2% 2.70 US$1,080
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
500 +0.2%
2.69
US$1,345 		500 +0.2% 2.69 US$1,345
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
1,300 +0.5%
2.68
US$3,484 		1,300 +0.5% 2.68 US$3,484
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
4,600 +1.9%
2.67
US$12,282 		4,600 +1.9% 2.67 US$12,282
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
1,100 +0.5%
2.66
US$2,926 		1,100 +0.5% 2.66 US$2,926
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
2,100 +0.9%
2.64
US$5,544 		2,100 +0.9% 2.64 US$5,544
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
4,800 +2.1%
2.63
US$12,624 		4,800 +2.1% 2.63 US$12,624
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
3,110 +1.4%
2.62
US$8,148 		3,110 +1.4% 2.62 US$8,148
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
5,795 +2.6%
2.61
US$15,125 		5,795 +2.6% 2.61 US$15,125
2019-09-17 2019-09-16 B Purchase
3.6
DEBBANE RAYMOND
3,990 +1.8%
2.60
US$10,374 		3,990 +1.8% 2.60 US$10,374
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
1,478 +1.1%
2.73
US$4,035 		1,478 +1.1% 2.73 US$4,035
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
3,700 +2.8%
2.75
US$10,175 		3,700 +2.8% 2.75 US$10,175
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
791 +0.6%
2.60
US$2,057 		791 +0.6% 2.60 US$2,057
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
200 +0.2%
2.59
US$518 		200 +0.2% 2.59 US$518
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
900 +0.7%
2.57
US$2,313 		900 +0.7% 2.57 US$2,313
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
100 +0.1%
2.58
US$258 		100 +0.1% 2.58 US$258
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
900 +0.7%
2.56
US$2,304 		900 +0.7% 2.56 US$2,304
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
800 +0.6%
2.54
US$2,032 		800 +0.6% 2.54 US$2,032
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
400 +0.3%
2.55
US$1,020 		400 +0.3% 2.55 US$1,020
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
820 +0.6%
2.53
US$2,075 		820 +0.6% 2.53 US$2,075
2019-09-17 2019-09-16 B Purchase
3.7
SOBECKI CHRISTOPHER J
1,405 +1.1%
2.52
US$3,541 		1,405 +1.1% 2.52 US$3,541
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