2020-11-13 |
2020-11-11 |
PS
Planned sale
|
RINGO WILLIAM R
Non-Executive Director
|
26,000
-72.2%
22.50
585,000
USD
|
26,000
-72.2%
|
22.50
|
585,000
USD
|
|
2020-11-13 |
2020-11-11 |
PS
Planned sale
|
RINGO WILLIAM R
Non-Executive Director
|
52,959
-84.1%
22.50
1,191,578
USD
|
52,959
-84.1%
|
22.50
|
1,191,578
USD
|
|
2020-11-13 |
2020-11-11 |
S
Sale
|
BVF PARTNERS L P/IL
|
502,649
-86.1%
20.19
10,146,825
USD
|
502,649
-86.1%
|
20.19
|
10,146,825
USD
|
|
2020-11-13 |
2020-11-11 |
S
Sale
|
BVF PARTNERS L P/IL
|
2,949,477
-85.9%
20.19
59,540,207
USD
|
2,949,477
-85.9%
|
20.19
|
59,540,207
USD
|
|
2020-11-13 |
2020-11-11 |
S
Sale
|
BVF PARTNERS L P/IL
|
3,941,214
-85.5%
20.19
79,560,105
USD
|
3,941,214
-85.5%
|
20.19
|
79,560,105
USD
|
|
2020-11-06 |
2020-11-06 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
2,334
+0.4%
4.98
11,633
USD
|
2,334
+0.4%
|
4.98
|
11,633
USD
|
|
2020-11-06 |
2020-11-06 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
10,436
+0.3%
4.98
52,013
USD
|
10,436
+0.3%
|
4.98
|
52,013
USD
|
|
2020-11-06 |
2020-11-06 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
17,230
+0.4%
4.98
85,874
USD
|
17,230
+0.4%
|
4.98
|
85,874
USD
|
|
2020-11-06 |
2020-11-04 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
15,355
+2.7%
4.88
74,997
USD
|
15,355
+2.7%
|
4.88
|
74,997
USD
|
|
2020-11-06 |
2020-11-04 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
143,403
+4.4%
4.88
700,409
USD
|
143,403
+4.4%
|
4.88
|
700,409
USD
|
|
2020-11-06 |
2020-11-04 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
257,804
+5.9%
4.88
1,259,166
USD
|
257,804
+5.9%
|
4.88
|
1,259,166
USD
|
|
2020-10-08 |
2020-10-06 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
25,107
+4.6%
5.04
126,414
USD
|
25,107
+4.6%
|
5.04
|
126,414
USD
|
|
2020-10-08 |
2020-10-06 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
162,352
+5.2%
5.04
817,442
USD
|
162,352
+5.2%
|
5.04
|
817,442
USD
|
|
2020-10-08 |
2020-10-06 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
157,782
+3.8%
5.04
794,432
USD
|
157,782
+3.8%
|
5.04
|
794,432
USD
|
|
2020-09-24 |
2020-09-22 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
32
+0.0%
3.80
122
USD
|
32
+0.0%
|
3.80
|
122
USD
|
|
2020-05-18 |
2020-05-14 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
4,476
+0.8%
4.10
18,352
USD
|
4,476
+0.8%
|
4.10
|
18,352
USD
|
|
2020-05-18 |
2020-05-14 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
39,810
+1.3%
4.10
163,221
USD
|
39,810
+1.3%
|
4.10
|
163,221
USD
|
|
2020-05-18 |
2020-05-14 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
249,301
+6.3%
4.10
1,022,134
USD
|
249,301
+6.3%
|
4.10
|
1,022,134
USD
|
|
2019-12-26 |
2019-12-20 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
32,606
+6.5%
4.05
132,054
USD
|
32,606
+6.5%
|
4.05
|
132,054
USD
|
|
2019-12-26 |
2019-12-20 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
201,096
+7.0%
4.05
814,439
USD
|
201,096
+7.0%
|
4.05
|
814,439
USD
|
|
2019-12-26 |
2019-12-20 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
281,318
+7.7%
4.05
1,139,338
USD
|
281,318
+7.7%
|
4.05
|
1,139,338
USD
|
|
2019-12-11 |
2019-12-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
2,397
+0.5%
4.02
9,630
USD
|
2,397
+0.5%
|
4.02
|
9,630
USD
|
|
2019-12-11 |
2019-12-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
18,729
+0.7%
4.02
75,244
USD
|
18,729
+0.7%
|
4.02
|
75,244
USD
|
|
2019-12-11 |
2019-12-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
113,874
+3.2%
4.02
457,489
USD
|
113,874
+3.2%
|
4.02
|
457,489
USD
|
|
2019-12-04 |
2019-12-03 |
S
Sale
|
BERGER FRANKLIN M
Non-Executive Director
|
47,890
-90.5%
4.00
191,560
USD
|
47,890
-90.5%
|
4.00
|
191,560
USD
|
|
2019-12-04 |
2019-12-02 |
S
Sale
|
BERGER FRANKLIN M
Non-Executive Director
|
32,090
-37.8%
3.92
125,793
USD
|
32,090
-37.8%
|
3.92
|
125,793
USD
|
|
2019-11-26 |
2019-11-22 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
81,857
+19.5%
3.40
278,322
USD
|
81,857
+19.5%
|
3.40
|
278,322
USD
|
|
2019-11-26 |
2019-11-22 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
462,056
+19.3%
3.40
1,571,037
USD
|
462,056
+19.3%
|
3.40
|
1,571,037
USD
|
|
2019-11-26 |
2019-11-22 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
576,097
+19.5%
3.40
1,958,787
USD
|
576,097
+19.5%
|
3.40
|
1,958,787
USD
|
|
2019-11-07 |
2019-11-05 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
70,921
+20.3%
4.00
283,684
USD
|
70,921
+20.3%
|
4.00
|
283,684
USD
|
|
2019-11-07 |
2019-11-05 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
400,470
+20.1%
4.00
1,601,880
USD
|
400,470
+20.1%
|
4.00
|
1,601,880
USD
|
|
2019-11-07 |
2019-11-05 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
496,721
+20.2%
4.00
1,986,884
USD
|
496,721
+20.2%
|
4.00
|
1,986,884
USD
|
|
2019-10-31 |
2019-10-31 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
504
+0.1%
3.85
1,940
USD
|
504
+0.1%
|
3.85
|
1,940
USD
|
|
2019-10-31 |
2019-10-31 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
2,913
+0.1%
3.85
11,214
USD
|
2,913
+0.1%
|
3.85
|
11,214
USD
|
|
2019-10-31 |
2019-10-31 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
3,416
+0.1%
3.85
13,150
USD
|
3,416
+0.1%
|
3.85
|
13,150
USD
|
|
2019-10-31 |
2019-10-30 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
1,456
+0.4%
3.89
5,667
USD
|
1,456
+0.4%
|
3.89
|
5,667
USD
|
|
2019-10-31 |
2019-10-30 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
8,236
+0.4%
3.89
32,055
USD
|
8,236
+0.4%
|
3.89
|
32,055
USD
|
|
2019-10-31 |
2019-10-30 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
10,389
+0.4%
3.89
40,435
USD
|
10,389
+0.4%
|
3.89
|
40,435
USD
|
|
2019-10-31 |
2019-10-29 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
240
+0.1%
3.90
935
USD
|
240
+0.1%
|
3.90
|
935
USD
|
|
2019-10-31 |
2019-10-29 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
1,133
+0.1%
3.90
4,415
USD
|
1,133
+0.1%
|
3.90
|
4,415
USD
|
|
2019-10-31 |
2019-10-29 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
1,027
+0.0%
3.90
4,002
USD
|
1,027
+0.0%
|
3.90
|
4,002
USD
|
|
2019-10-25 |
2019-10-25 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
2,155
+0.6%
3.75
8,075
USD
|
2,155
+0.6%
|
3.75
|
8,075
USD
|
|
2019-10-25 |
2019-10-25 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
12,899
+0.7%
3.75
48,336
USD
|
12,899
+0.7%
|
3.75
|
48,336
USD
|
|
2019-10-25 |
2019-10-25 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
15,728
+0.6%
3.75
58,938
USD
|
15,728
+0.6%
|
3.75
|
58,938
USD
|
|
2019-10-25 |
2019-10-24 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
1,629
+0.5%
3.74
6,100
USD
|
1,629
+0.5%
|
3.74
|
6,100
USD
|
|
2019-10-25 |
2019-10-24 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
57,723
+3.0%
3.74
216,155
USD
|
57,723
+3.0%
|
3.74
|
216,155
USD
|
|
2019-10-25 |
2019-10-24 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
76,036
+3.2%
3.74
284,732
USD
|
76,036
+3.2%
|
3.74
|
284,732
USD
|
|
2019-10-25 |
2019-10-23 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
3,200
+0.1%
3.75
11,986
USD
|
3,200
+0.1%
|
3.75
|
11,986
USD
|
|
2019-10-08 |
2019-10-08 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
4,689
+1.4%
3.68
17,270
USD
|
4,689
+1.4%
|
3.68
|
17,270
USD
|
|
2019-10-08 |
2019-10-08 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
24,716
+1.3%
3.68
91,029
USD
|
24,716
+1.3%
|
3.68
|
91,029
USD
|
|
2019-10-08 |
2019-10-08 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
31,007
+1.3%
3.68
114,199
USD
|
31,007
+1.3%
|
3.68
|
114,199
USD
|
|
2019-10-08 |
2019-10-07 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
24,425
+7.8%
3.75
91,594
USD
|
24,425
+7.8%
|
3.75
|
91,594
USD
|
|
2019-10-08 |
2019-10-07 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
14,242
+4.8%
3.75
53,382
USD
|
14,242
+4.8%
|
3.75
|
53,382
USD
|
|
2019-10-08 |
2019-10-07 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
138,609
+7.9%
3.75
519,784
USD
|
138,609
+7.9%
|
3.75
|
519,784
USD
|
|
2019-10-08 |
2019-10-07 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
80,821
+4.8%
3.75
302,933
USD
|
80,821
+4.8%
|
3.75
|
302,933
USD
|
|
2019-10-08 |
2019-10-07 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
168,640
+7.8%
3.75
632,400
USD
|
168,640
+7.8%
|
3.75
|
632,400
USD
|
|
2019-10-08 |
2019-10-07 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
98,333
+4.8%
3.75
368,572
USD
|
98,333
+4.8%
|
3.75
|
368,572
USD
|
|
2019-10-08 |
2019-10-04 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
991
+0.3%
3.74
3,704
USD
|
991
+0.3%
|
3.74
|
3,704
USD
|
|
2019-10-08 |
2019-10-04 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
7,314
+0.4%
3.74
27,336
USD
|
7,314
+0.4%
|
3.74
|
27,336
USD
|
|
2019-10-08 |
2019-10-04 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
7,695
+0.4%
3.74
28,760
USD
|
7,695
+0.4%
|
3.74
|
28,760
USD
|
|
2017-11-02 |
2017-11-01 |
PS
Planned sale
|
RINGO WILLIAM R
|
600
-100.0%
45.33
27,198
USD
|
600
-100.0%
|
45.33
|
27,198
USD
|
|
2017-10-03 |
2017-10-02 |
PS
Planned sale
|
RINGO WILLIAM R
|
600
-100.0%
40.78
24,468
USD
|
600
-100.0%
|
40.78
|
24,468
USD
|
|
2017-10-03 |
2017-09-29 |
PS
Planned sale
|
RINGO WILLIAM R
|
1,200
-100.0%
40.00
48,000
USD
|
1,200
-100.0%
|
40.00
|
48,000
USD
|
|
2017-10-02 |
2017-09-28 |
PS
Planned sale
|
RINGO WILLIAM R
Non-Executive Director
|
2,000
-100.0%
38.00
76,000
USD
|
2,000
-100.0%
|
38.00
|
76,000
USD
|
|
2017-03-01 |
2017-03-01 |
PS
Planned sale
|
RINGO WILLIAM R
Non-Executive Director
|
500
-100.0%
46.73
23,365
USD
|
500
-100.0%
|
46.73
|
23,365
USD
|
|
2017-02-01 |
2017-02-01 |
PS
Planned sale
|
RINGO WILLIAM R
Non-Executive Director
|
500
-100.0%
46.17
23,085
USD
|
500
-100.0%
|
46.17
|
23,085
USD
|
|
2017-01-18 |
2017-01-18 |
PS
Planned sale
|
Sarena Francis Willard
Chief Strategy Officer
Officer
|
3,636
-4.4%
47.39
172,310
USD
|
3,636
-4.4%
|
47.39
|
172,310
USD
|
|
2017-01-03 |
2017-01-03 |
PS
Planned sale
|
RINGO WILLIAM R
Non-Executive Director
|
500
-100.0%
51.07
25,535
USD
|
500
-100.0%
|
51.07
|
25,535
USD
|
|
2016-12-23 |
2016-12-23 |
PS
Planned sale
|
Williams Lewis T
President, CEO and Chairman
Executive Director
|
300
-0.1%
51.02
15,306
USD
|
300
-0.1%
|
51.02
|
15,306
USD
|
|
2016-12-23 |
2016-12-23 |
PS
Planned sale
|
Williams Lewis T
President, CEO and Chairman
Executive Director
|
29,700
-6.4%
50.49
1,499,553
USD
|
29,700
-6.4%
|
50.49
|
1,499,553
USD
|
|
2016-12-02 |
2016-12-01 |
PS
Planned sale
|
RINGO WILLIAM R
Non-Executive Director
|
500
-100.0%
57.72
28,860
USD
|
500
-100.0%
|
57.72
|
28,860
USD
|
|
2016-11-30 |
2016-11-28 |
PS
Planned sale
|
Sarena Francis Willard
Chief Strategy Officer
Officer
|
1,710
-2.1%
60.14
102,839
USD
|
1,710
-2.1%
|
60.14
|
102,839
USD
|
|
2016-11-28 |
2016-11-25 |
PS
Planned sale
|
Sarena Francis Willard
Chief Strategy Officer
Officer
|
21,189
-20.7%
60.48
1,281,511
USD
|
21,189
-20.7%
|
60.48
|
1,281,511
USD
|
|
2016-11-28 |
2016-11-23 |
PS
Planned sale
|
Sarena Francis Willard
Chief Strategy Officer
Officer
|
13,465
-14.2%
60.23
810,997
USD
|
13,465
-14.2%
|
60.23
|
810,997
USD
|
|
2016-11-10 |
2016-11-09 |
PS
Planned sale
|
Jensen Peder
Non-Executive Director
|
8,130
-100.0%
55.30
449,589
USD
|
8,130
-100.0%
|
55.30
|
449,589
USD
|
|