|
2024-01-12 |
2024-01-12 |
S
Sale
|
CFO
Officer
|
24,012
+24.8%
494.43
US$4,187,880
|
24,012
+24.8%
|
494.43
|
US$4,187,880
|
|
|
2023-12-22 |
2023-12-21 |
S
Sale
|
Non-Executive Director
|
90,291
-6.0%
108.29
US$3,674,013
|
90,291
-6.0%
|
108.29
|
US$3,674,013
|
|
|
2022-05-31 |
2022-05-27 |
B
Purchase
|
Chief Executive Officer
Executive Director
|
99,540
-21.3%
319.27
US$2,961,456
|
99,540
-21.3%
|
319.27
|
US$2,961,456
|
|
|
2021-12-20 |
2021-12-20 |
B
Purchase
|
Chief Executive Officer
Executive Director
|
135,000
+15.9%
0.38
US$50,625
|
135,000
+15.9%
|
0.38
|
US$50,625
|
|
|
2021-12-20 |
2021-12-20 |
B
Purchase
|
General Counsel and Secretary
Officer
|
25,000
+8.0%
0.39
US$9,725
|
25,000
+8.0%
|
0.39
|
US$9,725
|
|
|
2021-12-20 |
2021-12-20 |
B
Purchase
|
Chief Financial Officer
Officer
|
40,594
+9.2%
0.37
US$15,020
|
40,594
+9.2%
|
0.37
|
US$15,020
|
|
|
2021-06-21 |
2021-06-18 |
B
Purchase
|
Non-Executive Director
|
10,000
+107.7%
1.17
US$11,650
|
10,000
+107.7%
|
1.17
|
US$11,650
|
|
|
2021-06-14 |
2021-06-14 |
B
Purchase
|
Non-Executive Director
|
8,140
+inf%
1.31
US$10,663
|
8,140
+inf%
|
1.31
|
US$10,663
|
|
|
2021-06-14 |
2021-06-11 |
B
Purchase
|
Non-Executive Director
|
5,000
+95.2%
1.20
US$5,990
|
5,000
+95.2%
|
1.20
|
US$5,990
|
|
|
2021-06-11 |
2021-06-11 |
B
Purchase
|
Chief Commercial Officer
Officer
|
18,180
+4.0%
1.14
US$20,725
|
18,180
+4.0%
|
1.14
|
US$20,725
|
|
|
2021-06-10 |
2021-06-10 |
B
Purchase
|
General Counsel and Secretary
Officer
|
10,000
+3.3%
1.03
US$10,250
|
10,000
+3.3%
|
1.03
|
US$10,250
|
|
|
2021-06-10 |
2021-06-10 |
B
Purchase
|
Chief Executive Officer
Executive Director
|
50,000
+6.2%
1.03
US$51,500
|
50,000
+6.2%
|
1.03
|
US$51,500
|
|
|
2021-06-10 |
2021-06-10 |
B
Purchase
|
Chief Financial Officer
Officer
|
24,500
+5.9%
1.03
US$25,235
|
24,500
+5.9%
|
1.03
|
US$25,235
|
|
|
2021-03-09 |
2021-03-09 |
PP
Planned purchase
|
Chief Executive Officer
Executive Director
|
45,249
+5.3%
2.28
US$103,168
|
45,249
+5.3%
|
2.28
|
US$103,168
|
|
|
2020-11-18 |
2020-11-17 |
B
Purchase
|
Chief Financial Officer
Officer
|
7,760
+3.1%
2.17
US$16,839
|
7,760
+3.1%
|
2.17
|
US$16,839
|
|
|
2020-11-18 |
2020-11-17 |
B
Purchase
|
General Counsel and Secretary
Officer
|
9,090
+6.8%
2.20
US$19,998
|
9,090
+6.8%
|
2.20
|
US$19,998
|
|
|
2020-09-11 |
2020-09-11 |
B
Purchase
|
Chief Commercial Officer
Officer
|
3,000
+1.1%
2.08
US$6,240
|
3,000
+1.1%
|
2.08
|
US$6,240
|
|
|
2020-09-11 |
2020-09-10 |
B
Purchase
|
Chief Commercial Officer
Officer
|
1,000
+0.4%
2.71
US$2,710
|
1,000
+0.4%
|
2.71
|
US$2,710
|
|
|
2020-09-10 |
2020-09-08 |
S
Sale
|
Chief Executive Officer
Executive Director
|
122,500
-25.3%
3.26
US$399,350
|
122,500
-25.3%
|
3.26
|
US$399,350
|
|
|
2020-06-18 |
2020-06-17 |
B
Purchase
|
Non-Executive Director
|
5,250
+inf%
2.99
US$15,698
|
5,250
+inf%
|
2.99
|
US$15,698
|
|
|
2020-06-17 |
2020-06-15 |
B
Purchase
|
Non-Executive Director
|
5,000
+inf%
2.85
US$14,250
|
5,000
+inf%
|
2.85
|
US$14,250
|
|
|
2020-06-16 |
2020-06-12 |
B
Purchase
|
Non-Executive Director
Large shareholder
|
5,000
+116.6%
2.94
US$14,700
|
5,000
+116.6%
|
2.94
|
US$14,700
|
|
|
2020-06-15 |
2020-06-12 |
B
Purchase
|
Chief Financial Officer
Officer
|
8,500
+3.5%
3.14
US$26,690
|
8,500
+3.5%
|
3.14
|
US$26,690
|
|
|
2020-06-09 |
2020-06-05 |
B
Purchase
|
Large shareholder
|
857,143
+6.9%
3.50
US$3,000,000
|
857,143
+6.9%
|
3.50
|
US$3,000,000
|
|
|
2020-07-17 |
2020-06-04 |
S
Sale
|
Large shareholder
|
9,138,504
-100.0%
0.23
US$2,101,856
|
9,138,504
-100.0%
|
0.23
|
US$2,101,856
|
|
|
2020-06-09 |
2020-06-04 |
S
Sale
|
Large shareholder
|
9,138,504
-100.0%
3.21
US$29,325,459
|
9,138,504
-100.0%
|
3.21
|
US$29,325,459
|
|
|
2020-06-09 |
2020-05-26 |
S
Sale
|
Large shareholder
|
65
-0.0%
5.98
US$389
|
65
-0.0%
|
5.98
|
US$389
|
|
|
2020-06-09 |
2020-05-26 |
S
Sale
|
Large shareholder
|
73,814
-0.6%
5.79
US$427,383
|
73,814
-0.6%
|
5.79
|
US$427,383
|
|
|
2020-06-09 |
2020-05-15 |
S
Sale
|
Large shareholder
|
3,211
-0.0%
5.04
US$16,183
|
3,211
-0.0%
|
5.04
|
US$16,183
|
|
|
2020-05-01 |
2020-05-01 |
PlS
Planned sale
|
Chief Medical Officer
Officer
|
1,000
-0.5%
4.75
US$4,750
|
1,000
-0.5%
|
4.75
|
US$4,750
|
|
|
2020-05-01 |
2020-04-30 |
PlS
Planned sale
|
Chief Medical Officer
Officer
|
1,000
-0.5%
4.66
US$4,660
|
1,000
-0.5%
|
4.66
|
US$4,660
|
|
|
2020-02-21 |
2020-02-19 |
PlS
Planned sale
|
Chief Medical Officer
Officer
|
1,000
-0.5%
7.00
US$7,000
|
1,000
-0.5%
|
7.00
|
US$7,000
|
|
|
2020-02-21 |
2020-02-19 |
PlS
Planned sale
|
Chief Commercial Officer
Officer
|
14,957
-4.3%
6.50
US$97,220
|
14,957
-4.3%
|
6.50
|
US$97,220
|
|
|
2020-01-21 |
2020-01-16 |
PlS
Planned sale
|
Chief Commercial Officer
|
1,578
-0.8%
6.50
US$10,257
|
1,578
-0.8%
|
6.50
|
US$10,257
|
|
|
2020-01-15 |
2020-01-13 |
PlS
Planned sale
|
Chief Executive Officer
Executive Director
|
3,295
-0.9%
6.00
US$19,770
|
3,295
-0.9%
|
6.00
|
US$19,770
|
|
|
2020-01-15 |
2020-01-13 |
PlS
Planned sale
|
Chief Financial Officer
|
1,648
-0.9%
6.00
US$9,888
|
1,648
-0.9%
|
6.00
|
US$9,888
|
|
|
2020-01-06 |
2020-01-02 |
PlS
Planned sale
|
Chief Executive Officer
Executive Director
|
6,705
-1.8%
6.05
US$40,565
|
6,705
-1.8%
|
6.05
|
US$40,565
|
|
|
2020-01-06 |
2020-01-02 |
PlS
Planned sale
|
Chief Financial Officer
|
3,352
-1.8%
6.05
US$20,280
|
3,352
-1.8%
|
6.05
|
US$20,280
|
|
|
2019-12-04 |
2019-12-02 |
PlS
Planned sale
|
Chief Executive Officer
Executive Director
|
20,000
-5.1%
7.30
US$146,000
|
20,000
-5.1%
|
7.30
|
US$146,000
|
|
|
2019-12-04 |
2019-12-02 |
PlS
Planned sale
|
Culwell Kelly
Chief Medical Officer
Officer
|
1,000
-2.2%
7.35
US$7,350
|
1,000
-2.2%
|
7.35
|
US$7,350
|
|
|
2019-12-04 |
2019-12-02 |
PlS
Planned sale
|
Chief Financial Officer
Officer
|
10,000
-5.2%
7.16
US$71,600
|
10,000
-5.2%
|
7.16
|
US$71,600
|
|
|
2019-11-21 |
2019-11-21 |
PlS
Planned sale
|
Chief Financial Officer
Officer
|
4,900
-2.4%
6.00
US$29,400
|
4,900
-2.4%
|
6.00
|
US$29,400
|
|
|
2019-11-21 |
2019-11-21 |
PlS
Planned sale
|
PELLETIER SAUNDRA L
Chief Executive Officer
Executive Director
|
10,000
-2.4%
6.01
US$60,100
|
10,000
-2.4%
|
6.01
|
US$60,100
|
|
|
2019-11-21 |
2019-11-20 |
PlS
Planned sale
|
Chief Financial Officer
Officer
|
100
-0.0%
6.00
US$600
|
100
-0.0%
|
6.00
|
US$600
|
|
|
2019-06-12 |
2019-06-10 |
B
Purchase
|
Large shareholder
|
2,222,222
+23.2%
4.50
US$9,999,999
|
2,222,222
+23.2%
|
4.50
|
US$9,999,999
|
|
|
2019-06-10 |
2019-06-10 |
B
Purchase
|
Large shareholder
|
6,666,667
+100.0%
4.50
US$30,000,002
|
6,666,667
+100.0%
|
4.50
|
US$30,000,002
|
|
|
2019-05-23 |
2019-05-21 |
S
Sale
|
|
655
-100.0%
5.07
US$3,321
|
655
-100.0%
|
5.07
|
US$3,321
|
|
|
2019-02-12 |
2019-02-08 |
B
Purchase
|
Large shareholder
|
425,531
+4.6%
2.64
US$1,123,402
|
425,531
+4.6%
|
2.64
|
US$1,123,402
|
|
|
2018-11-26 |
2018-11-21 |
B
Purchase
|
Barrans Russell
Chief Commercial Officer
Officer
|
279
+2.2%
3.55
US$990
|
279
+2.2%
|
3.55
|
US$990
|
|
|
2018-08-21 |
2018-08-21 |
B
Purchase
|
General Counsel and Secretary
Officer
|
500
+0.7%
2.27
US$1,135
|
500
+0.7%
|
2.27
|
US$1,135
|
|
|
2018-08-21 |
2018-08-20 |
B
Purchase
|
General Counsel and Secretary
Officer
|
4,500
+6.4%
2.20
US$9,900
|
4,500
+6.4%
|
2.20
|
US$9,900
|
|
|
2018-08-20 |
2018-08-16 |
B
Purchase
|
Chief Medical Officer
Officer
|
3,000
+33.4%
2.24
US$6,720
|
3,000
+33.4%
|
2.24
|
US$6,720
|
|
|
2018-08-15 |
2018-08-15 |
B
Purchase
|
Lynch Thomas G
Non-Executive Director
|
68,929
+65.0%
2.33
US$160,605
|
68,929
+65.0%
|
2.33
|
US$160,605
|
|
|
2018-08-15 |
2018-08-14 |
B
Purchase
|
Lynch Thomas G
Non-Executive Director
|
31,071
+41.4%
2.10
US$65,249
|
31,071
+41.4%
|
2.10
|
US$65,249
|
|
|
2018-08-13 |
2018-08-10 |
B
Purchase
|
Chief Commercial Officer
Officer
|
3,715
+42.1%
1.98
US$7,356
|
3,715
+42.1%
|
1.98
|
US$7,356
|
|
|
2018-08-13 |
2018-08-10 |
B
Purchase
|
Chief Executive Officer
Executive Director
|
10,000
+3.0%
2.11
US$21,100
|
10,000
+3.0%
|
2.11
|
US$21,100
|
|
|
2018-05-24 |
2018-05-22 |
B
Purchase
|
Invesco Ltd.
Large shareholder
|
2,127,659
+30.2%
4.69
US$9,978,721
|
2,127,659
+30.2%
|
4.69
|
US$9,978,721
|
|
|
2015-12-30 |
2015-12-30 |
S
Sale
|
Alta Partners VIII, L.P.
Former 10% Owner
|
250,000
-15.7%
1.44
US$360,000
|
250,000
-15.7%
|
1.44
|
US$360,000
|
|
|
2015-12-30 |
2015-12-29 |
S
Sale
|
Alta Partners VIII, L.P.
Former 10% Owner
|
493,654
-23.7%
1.53
US$755,291
|
493,654
-23.7%
|
1.53
|
US$755,291
|
|
|
2015-12-30 |
2015-12-28 |
S
Sale
|
Alta Partners VIII, L.P.
Former 10% Owner
|
54,333
-2.5%
1.59
US$86,389
|
54,333
-2.5%
|
1.59
|
US$86,389
|
|
|
2015-12-17 |
2015-12-15 |
S
Sale
|
Alta Partners VIII, L.P.
Large shareholder
|
529,261
-19.8%
1.44
US$762,136
|
529,261
-19.8%
|
1.44
|
US$762,136
|
|
|
2015-11-19 |
2015-11-18 |
PlS
Planned sale
|
Chief Scientific Officer
Officer
|
6,098
-95.4%
8.30
US$50,619
|
6,098
-95.4%
|
8.30
|
US$50,619
|
|
|
2015-09-22 |
2015-09-18 |
PlS
Planned sale
|
VP, Pharma Dev & Manufacturing
Officer
|
1,000
-8.4%
12.20
US$12,195
|
1,000
-8.4%
|
12.20
|
US$12,195
|
|
|
2015-09-03 |
2015-09-01 |
PlS
Planned sale
|
Knudson Susan A.
Chief Financial Officer
Officer
|
3,000
-85.9%
11.33
US$33,990
|
3,000
-85.9%
|
11.33
|
US$33,990
|
|
|
2015-08-10 |
2015-08-07 |
PlS
Planned sale
|
VP, Pharma Dev & Manufacturing
Officer
|
1,000
-8.4%
12.88
US$12,880
|
1,000
-8.4%
|
12.88
|
US$12,880
|
|
|
2015-03-20 |
2015-03-19 |
B
Purchase
|
President and CEO
Executive Director
|
1,000
+0.5%
7.76
US$7,757
|
1,000
+0.5%
|
7.76
|
US$7,757
|
|
|
2014-11-26 |
2014-11-25 |
B
Purchase
|
DOMAIN PARTERS VII L P
Large shareholder
|
70,000
+2.3%
14.00
US$980,000
|
70,000
+2.3%
|
14.00
|
US$980,000
|
|
|
2014-11-25 |
2014-11-25 |
B
Purchase
|
Gorbachev Maxim
Non-Executive Director
Large shareholder
|
70,000
+4.6%
14.00
US$980,000
|
70,000
+4.6%
|
14.00
|
US$980,000
|
|
|
2014-11-25 |
2014-11-25 |
B
Purchase
|
RMI Investments S.a.r.l.
Large shareholder
|
70,000
+4.6%
14.00
US$980,000
|
70,000
+4.6%
|
14.00
|
US$980,000
|
|
|
2014-11-25 |
2014-11-25 |
B
Purchase
|
Non-Executive Director
Large shareholder
|
70,000
+2.7%
14.00
US$980,000
|
70,000
+2.7%
|
14.00
|
US$980,000
|
|
|
2014-11-25 |
2014-11-25 |
S
Sale
|
Non-Executive Director
Large shareholder
|
21,429
-0.8%
14.00
US$300,006
|
21,429
-0.8%
|
14.00
|
US$300,006
|
|
|
2014-11-25 |
2014-11-25 |
S
Sale
|
Non-Executive Director
Large shareholder
|
70,714
-2.7%
14.00
US$989,996
|
70,714
-2.7%
|
14.00
|
US$989,996
|
|
|
2014-11-25 |
2014-11-25 |
S
Sale
|
JANNEY DANIEL
Non-Executive Director
Large shareholder
|
57,143
-2.2%
14.00
US$800,002
|
57,143
-2.2%
|
14.00
|
US$800,002
|
|