|
2017-09-20 |
2017-09-20 |
B
Purchase
|
THOMPSON JOHN CRAIG
President & CEO
|
98,633
+48.6%
424.26
US$1,842,586
|
98,633
+48.6%
|
424.26
|
US$1,842,586
|
|
|
2017-09-07 |
2017-09-07 |
B
Purchase
|
TRUEX PAUL F
|
13,416
+12.1%
351.45
US$3,455,945
|
13,416
+12.1%
|
351.45
|
US$3,455,945
|
|
|
2015-11-18 |
2015-11-13 |
PlS
Planned sale
|
Hislop Colin
Chief Medical Officer
Officer
|
87,810
-28.3%
376.35
US$3,798,842
|
87,810
-28.3%
|
376.35
|
US$3,798,842
|
|
|
2015-11-12 |
2015-11-11 |
S
Sale
|
Hislop Colin
Chief Medical Officer
Officer
|
5,000
-20.7%
5.38
US$26,900
|
5,000
-20.7%
|
5.38
|
US$26,900
|
|
|
2013-06-26 |
2013-06-24 |
B
Purchase
|
Thompson David E.
Non-Executive Director
|
100,000
+354.6%
0.53
US$53,000
|
100,000
+354.6%
|
0.53
|
US$53,000
|
|
|
2013-06-04 |
2013-05-31 |
B
Purchase
|
DZIURZYNSKI BOGDAN
Non-Executive Director
|
10,000
+inf%
0.59
US$5,900
|
10,000
+inf%
|
0.59
|
US$5,900
|
|
|
2013-02-01 |
2013-01-30 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
5,700,000
+323.5%
0.66
US$3,762,000
|
5,700,000
+323.5%
|
0.66
|
US$3,762,000
|
|
|
2013-01-29 |
2013-01-25 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
1,762,000
+inf%
0.65
US$1,142,481
|
1,762,000
+inf%
|
0.65
|
US$1,142,481
|
|
|
2012-07-03 |
2012-06-29 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
1,283,300
-100.0%
0.73
US$942,071
|
1,283,300
-100.0%
|
0.73
|
US$942,071
|
|
|
2012-07-02 |
2012-06-29 |
B
Purchase
|
HENNEY CHRISTOPHER S
Non-Executive Director
|
100,000
+inf%
0.75
US$74,930
|
100,000
+inf%
|
0.75
|
US$74,930
|
|
|
2012-07-02 |
2012-06-29 |
B
Purchase
|
HENNEY CHRISTOPHER S
Non-Executive Director
|
100,000
+97.6%
0.75
US$74,930
|
100,000
+97.6%
|
0.75
|
US$74,930
|
|
|
2012-07-02 |
2012-06-29 |
B
Purchase
|
TRUEX PAUL F
President and CEO
Executive Director
|
20,000
+3.2%
0.76
US$15,200
|
20,000
+3.2%
|
0.76
|
US$15,200
|
|
|
2012-03-22 |
2012-03-22 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
1,306,700
-50.5%
2.40
US$3,140,131
|
1,306,700
-50.5%
|
2.40
|
US$3,140,131
|
|
|
2012-03-22 |
2012-03-21 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
125,000
-4.6%
2.87
US$358,312
|
125,000
-4.6%
|
2.87
|
US$358,312
|
|
|
2012-03-22 |
2012-03-20 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
116,800
-4.1%
2.90
US$338,638
|
116,800
-4.1%
|
2.90
|
US$338,638
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
280
-0.6%
6.23
US$1,743
|
280
-0.6%
|
6.23
|
US$1,743
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
4,090
-0.6%
6.23
US$25,460
|
4,090
-0.6%
|
6.23
|
US$25,460
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
280
-0.6%
6.23
US$1,743
|
280
-0.6%
|
6.23
|
US$1,743
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
4,090
-0.6%
6.23
US$25,460
|
4,090
-0.6%
|
6.23
|
US$25,460
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
20,630
-0.6%
6.23
US$128,422
|
20,630
-0.6%
|
6.23
|
US$128,422
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
20,630
-0.6%
6.23
US$128,422
|
20,630
-0.6%
|
6.23
|
US$128,422
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
280
-0.6%
6.22
US$1,743
|
280
-0.6%
|
6.22
|
US$1,743
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
4,090
-0.6%
6.22
US$25,457
|
4,090
-0.6%
|
6.22
|
US$25,457
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
20,630
-0.6%
6.22
US$128,405
|
20,630
-0.6%
|
6.22
|
US$128,405
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
280
-0.6%
6.22
US$1,743
|
280
-0.6%
|
6.22
|
US$1,743
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
4,090
-0.6%
6.22
US$25,457
|
4,090
-0.6%
|
6.22
|
US$25,457
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
20,630
-0.6%
6.22
US$128,405
|
20,630
-0.6%
|
6.22
|
US$128,405
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
280
-0.6%
6.51
US$1,823
|
280
-0.6%
|
6.51
|
US$1,823
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
4,090
-0.6%
6.51
US$26,629
|
4,090
-0.6%
|
6.51
|
US$26,629
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
280
-0.6%
6.51
US$1,823
|
280
-0.6%
|
6.51
|
US$1,823
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
4,090
-0.6%
6.51
US$26,629
|
4,090
-0.6%
|
6.51
|
US$26,629
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
20,630
-0.6%
6.51
US$134,318
|
20,630
-0.6%
|
6.51
|
US$134,318
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
20,630
-0.6%
6.51
US$134,318
|
20,630
-0.6%
|
6.51
|
US$134,318
|
|
|
2011-12-13 |
2011-12-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
16,200
-0.6%
6.50
US$105,300
|
16,200
-0.6%
|
6.50
|
US$105,300
|
|
|
2011-12-13 |
2011-12-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
40,000
-1.4%
6.75
US$270,000
|
40,000
-1.4%
|
6.75
|
US$270,000
|
|
|
2011-11-18 |
2011-11-18 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
3,000
-0.1%
6.50
US$19,500
|
3,000
-0.1%
|
6.50
|
US$19,500
|
|
|
2011-11-18 |
2011-11-17 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
24,000
-0.8%
6.67
US$160,080
|
24,000
-0.8%
|
6.67
|
US$160,080
|
|
|
2011-11-18 |
2011-11-16 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
25,000
-0.9%
6.87
US$171,750
|
25,000
-0.9%
|
6.87
|
US$171,750
|
|
|
2011-11-17 |
2011-11-15 |
PlS
Planned sale
|
TRUEX PAUL F
President and CEO
Executive Director
|
15,000
-2.2%
6.96
US$104,352
|
15,000
-2.2%
|
6.96
|
US$104,352
|
|
|
2011-11-17 |
2011-11-15 |
PlS
Planned sale
|
TRUEX PAUL F
President and CEO
Executive Director
|
15,000
-2.2%
6.96
US$104,352
|
15,000
-2.2%
|
6.96
|
US$104,352
|
|
|
2011-11-15 |
2011-11-15 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
50,000
-1.7%
6.93
US$346,500
|
50,000
-1.7%
|
6.93
|
US$346,500
|
|
|
2011-11-15 |
2011-11-14 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
5,000
-0.2%
6.95
US$34,750
|
5,000
-0.2%
|
6.95
|
US$34,750
|
|
|
2011-11-15 |
2011-11-11 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
5,000
-0.2%
7.14
US$35,700
|
5,000
-0.2%
|
7.14
|
US$35,700
|
|
|
2011-11-10 |
2011-11-08 |
S
Sale
|
Hislop Colin
Chief Medical Officer
Officer
|
15,000
-20.6%
6.74
US$101,163
|
15,000
-20.6%
|
6.74
|
US$101,163
|
|
|
2011-10-25 |
2011-10-21 |
PlS
Planned sale
|
TRUEX PAUL F
President and CEO
Executive Director
|
11,879
-1.8%
6.25
US$74,244
|
11,879
-1.8%
|
6.25
|
US$74,244
|
|
|
2011-08-04 |
2011-08-02 |
PlS
Planned sale
|
LOWE CHRISTOPHER P.
Chief Financial Officer & CBO
Officer
|
300
-6.1%
7.93
US$2,378
|
300
-6.1%
|
7.93
|
US$2,378
|
|
|
2011-06-20 |
2011-06-16 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
10
-0.1%
8.67
US$87
|
10
-0.1%
|
8.67
|
US$87
|
|
|
2011-06-20 |
2011-06-16 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
281
-0.1%
8.67
US$2,436
|
281
-0.1%
|
8.67
|
US$2,436
|
|
|
2011-06-20 |
2011-06-16 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
2,809
-0.1%
8.67
US$24,354
|
2,809
-0.1%
|
8.67
|
US$24,354
|
|
|
2011-06-17 |
2011-06-15 |
PlS
Planned sale
|
TRUEX PAUL F
President and CEO
Executive Director
|
15,000
-2.2%
8.30
US$124,539
|
15,000
-2.2%
|
8.30
|
US$124,539
|
|
|
2011-06-15 |
2011-06-14 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
2
-0.0%
8.81
US$18
|
2
-0.0%
|
8.81
|
US$18
|
|
|
2011-06-15 |
2011-06-14 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
63
-0.0%
8.81
US$555
|
63
-0.0%
|
8.81
|
US$555
|
|
|
2011-06-15 |
2011-06-14 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
634
-0.0%
8.81
US$5,586
|
634
-0.0%
|
8.81
|
US$5,586
|
|
|
2011-06-15 |
2011-06-13 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
4
-0.0%
8.80
US$35
|
4
-0.0%
|
8.80
|
US$35
|
|
|
2011-06-15 |
2011-06-13 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
118
-0.0%
8.80
US$1,038
|
118
-0.0%
|
8.80
|
US$1,038
|
|
|
2011-06-15 |
2011-06-13 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
1,178
-0.0%
8.80
US$10,366
|
1,178
-0.0%
|
8.80
|
US$10,366
|
|
|
2011-06-10 |
2011-06-10 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
30,000
-1.0%
8.18
US$245,400
|
30,000
-1.0%
|
8.18
|
US$245,400
|
|
|
2011-06-10 |
2011-06-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
37,000
-1.2%
8.11
US$300,070
|
37,000
-1.2%
|
8.11
|
US$300,070
|
|
|
2011-06-10 |
2011-06-08 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
33,000
-1.1%
8.02
US$264,660
|
33,000
-1.1%
|
8.02
|
US$264,660
|
|
|
2011-05-31 |
2011-05-26 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
16
-0.1%
8.60
US$138
|
16
-0.1%
|
8.60
|
US$138
|
|
|
2011-05-31 |
2011-05-26 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
435
-0.1%
8.60
US$3,741
|
435
-0.1%
|
8.60
|
US$3,741
|
|
|
2011-05-31 |
2011-05-26 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
4,349
-0.1%
8.60
US$37,401
|
4,349
-0.1%
|
8.60
|
US$37,401
|
|
|
2011-05-27 |
2011-05-25 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
4,800
8.65
US$41,520
|
4,800
|
8.65
|
US$41,520
|
|
|
2011-05-25 |
2011-05-25 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
108
-0.6%
8.67
US$936
|
108
-0.6%
|
8.67
|
US$936
|
|
|
2011-05-25 |
2011-05-25 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
2,970
-0.6%
8.67
US$25,750
|
2,970
-0.6%
|
8.67
|
US$25,750
|
|
|
2011-05-25 |
2011-05-25 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
29,672
-0.6%
8.67
US$257,256
|
29,672
-0.6%
|
8.67
|
US$257,256
|
|
|
2011-05-25 |
2011-05-24 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
172
-1.0%
8.42
US$1,448
|
172
-1.0%
|
8.42
|
US$1,448
|
|
|
2011-05-25 |
2011-05-24 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
4,734
-1.0%
8.42
US$39,860
|
4,734
-1.0%
|
8.42
|
US$39,860
|
|
|
2011-05-25 |
2011-05-24 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
47,290
-1.0%
8.42
US$398,182
|
47,290
-1.0%
|
8.42
|
US$398,182
|
|
|
2011-05-25 |
2011-05-23 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
88
-0.5%
8.18
US$720
|
88
-0.5%
|
8.18
|
US$720
|
|
|
2011-05-25 |
2011-05-23 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
2,422
-0.5%
8.18
US$19,812
|
2,422
-0.5%
|
8.18
|
US$19,812
|
|
|
2011-05-25 |
2011-05-23 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
24,193
-0.5%
8.18
US$197,899
|
24,193
-0.5%
|
8.18
|
US$197,899
|
|
|
2011-05-19 |
2011-05-19 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
412
-2.2%
8.03
US$3,308
|
412
-2.2%
|
8.03
|
US$3,308
|
|
|
2011-05-19 |
2011-05-19 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
11,337
-2.2%
8.03
US$91,036
|
11,337
-2.2%
|
8.03
|
US$91,036
|
|
|
2011-05-19 |
2011-05-19 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
113,251
-2.2%
8.03
US$909,406
|
113,251
-2.2%
|
8.03
|
US$909,406
|
|