|
2019-03-20 |
2019-03-20 |
S
Sale
|
Large shareholder
|
37,632
+2.1%
88.06
US$2,271,573
|
37,632
+2.1%
|
88.06
|
US$2,271,573
|
|
|
2019-03-20 |
2019-03-19 |
S
Sale
|
Large shareholder
|
71,163
-7.3%
349.54
US$714,008
|
71,163
-7.3%
|
349.54
|
US$714,008
|
|
|
2019-03-20 |
2019-03-18 |
S
Sale
|
Large shareholder
|
75,371
+13.5%
26.20
US$3,769,323
|
75,371
+13.5%
|
26.20
|
US$3,769,323
|
|
|
2019-03-13 |
2019-03-13 |
S
Sale
|
Large shareholder
|
1,199,930
-14.9%
0.59
US$707,959
|
1,199,930
-14.9%
|
0.59
|
US$707,959
|
|
|
2019-03-13 |
2019-03-12 |
S
Sale
|
Large shareholder
|
633,975
-7.3%
0.61
US$386,725
|
633,975
-7.3%
|
0.61
|
US$386,725
|
|
|
2019-03-13 |
2019-03-11 |
S
Sale
|
Large shareholder
|
520,102
-5.7%
0.63
US$327,664
|
520,102
-5.7%
|
0.63
|
US$327,664
|
|
|
2019-02-25 |
2019-02-21 |
S
Sale
|
Chief Operating Officer
Officer
|
971
-0.4%
0.89
US$864
|
971
-0.4%
|
0.89
|
US$864
|
|
|
2019-02-25 |
2019-02-21 |
S
Sale
|
Chief Commercial Officer
Officer
|
1,063
-0.4%
0.89
US$946
|
1,063
-0.4%
|
0.89
|
US$946
|
|
|
2019-02-25 |
2019-02-21 |
S
Sale
|
Chief Executive Officer
Officer
|
3,771
-0.7%
0.89
US$3,356
|
3,771
-0.7%
|
0.89
|
US$3,356
|
|
|
2019-02-25 |
2019-02-21 |
S
Sale
|
See Remarks
Officer
|
791
-0.3%
0.89
US$704
|
791
-0.3%
|
0.89
|
US$704
|
|
|
2019-02-25 |
2019-02-21 |
S
Sale
|
Chief Financial Officer
Officer
|
1,388
-0.6%
0.89
US$1,235
|
1,388
-0.6%
|
0.89
|
US$1,235
|
|
|
2019-02-07 |
2019-02-05 |
S
Sale
|
Chief Commercial Officer
Officer
|
818
-0.3%
1.35
US$1,104
|
818
-0.3%
|
1.35
|
US$1,104
|
|
|
2018-12-12 |
2018-12-11 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
306,848
+3.5%
1.65
US$505,010
|
306,848
+3.5%
|
1.65
|
US$505,010
|
|
|
2018-12-12 |
2018-12-10 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
436,500
+5.2%
1.60
US$697,789
|
436,500
+5.2%
|
1.60
|
US$697,789
|
|
|
2018-12-11 |
2018-12-07 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
22,431
+0.3%
1.40
US$31,394
|
22,431
+0.3%
|
1.40
|
US$31,394
|
|
|
2018-11-27 |
2018-11-27 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
77,585
+0.9%
1.68
US$129,963
|
77,585
+0.9%
|
1.68
|
US$129,963
|
|
|
2018-11-27 |
2018-11-23 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
80,175
+1.0%
1.89
US$151,643
|
80,175
+1.0%
|
1.89
|
US$151,643
|
|
|
2018-11-23 |
2018-11-20 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
231,495
+2.9%
1.93
US$446,947
|
231,495
+2.9%
|
1.93
|
US$446,947
|
|
|
2018-11-20 |
2018-11-19 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
4,648
+0.1%
1.62
US$7,525
|
4,648
+0.1%
|
1.62
|
US$7,525
|
|
|
2018-09-27 |
2018-09-25 |
S
Sale
|
General Counsel
Officer
|
1,038
-4.3%
4.15
US$4,308
|
1,038
-4.3%
|
4.15
|
US$4,308
|
|
|
2018-09-27 |
2018-09-25 |
S
Sale
|
Wise Blake
Chief Operating Officer
Officer
|
3,242
-3.4%
4.15
US$13,454
|
3,242
-3.4%
|
4.15
|
US$13,454
|
|
|
2018-06-28 |
2018-06-26 |
PlS
Planned sale
|
Chief Commercial Officer
|
450
-1.9%
9.59
US$4,316
|
450
-1.9%
|
9.59
|
US$4,316
|
|
|
2018-06-28 |
2018-06-26 |
PlS
Planned sale
|
Wise Blake
Chief Executive Officer
Executive Director
|
1,194
-1.2%
9.59
US$11,450
|
1,194
-1.2%
|
9.59
|
US$11,450
|
|
|
2018-06-28 |
2018-06-26 |
PlS
Planned sale
|
See Remarks
Executive Director
|
744
-0.6%
9.59
US$7,135
|
744
-0.6%
|
9.59
|
US$7,135
|
|
|
2018-06-28 |
2018-06-26 |
PlS
Planned sale
|
LOEB GARY
General Counsel
|
324
-1.3%
9.59
US$3,107
|
324
-1.3%
|
9.59
|
US$3,107
|
|
|
2018-06-28 |
2018-06-26 |
S
Sale
|
Schilke Tobin
Chief Financial Officer
|
298
-0.6%
9.59
US$2,858
|
298
-0.6%
|
9.59
|
US$2,858
|
|
|
2018-06-13 |
2018-06-11 |
PlS
Planned sale
|
Schilke Tobin
Chief Financial Officer
|
2,087
-4.2%
11.95
US$24,940
|
2,087
-4.2%
|
11.95
|
US$24,940
|
|
|
2018-05-07 |
2018-05-03 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
100,255
+inf%
11.43
US$1,146,316
|
100,255
+inf%
|
11.43
|
US$1,146,316
|
|
|
2018-05-07 |
2018-05-03 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
30,000
+inf%
11.54
US$346,338
|
30,000
+inf%
|
11.54
|
US$346,338
|
|
|
2018-05-07 |
2018-05-03 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
846,625
+11.8%
11.31
US$9,579,477
|
846,625
+11.8%
|
11.31
|
US$9,579,477
|
|
|
2018-04-27 |
2018-04-27 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
102,849
+1.5%
12.96
US$1,333,160
|
102,849
+1.5%
|
12.96
|
US$1,333,160
|
|
|
2018-04-27 |
2018-04-26 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
50,000
+0.7%
12.96
US$647,755
|
50,000
+0.7%
|
12.96
|
US$647,755
|
|
|
2018-04-27 |
2018-04-25 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
77,247
+1.1%
13.02
US$1,005,949
|
77,247
+1.1%
|
13.02
|
US$1,005,949
|
|
|
2018-04-23 |
2018-04-23 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
132,487
+1.9%
13.07
US$1,730,969
|
132,487
+1.9%
|
13.07
|
US$1,730,969
|
|
|
2018-04-23 |
2018-04-20 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
216,150
+3.3%
13.23
US$2,860,421
|
216,150
+3.3%
|
13.23
|
US$2,860,421
|
|
|
2018-04-23 |
2018-04-19 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
119,700
+1.8%
12.76
US$1,527,264
|
119,700
+1.8%
|
12.76
|
US$1,527,264
|
|
|
2018-04-04 |
2018-04-04 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
47,361
+0.7%
12.44
US$588,977
|
47,361
+0.7%
|
12.44
|
US$588,977
|
|
|
2018-04-04 |
2018-04-03 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
24,100
+0.4%
12.46
US$300,240
|
24,100
+0.4%
|
12.46
|
US$300,240
|
|
|
2018-04-04 |
2018-04-02 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
20,000
+0.3%
12.51
US$250,202
|
20,000
+0.3%
|
12.51
|
US$250,202
|
|
|
2018-03-30 |
2018-03-28 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
30,000
+0.5%
12.44
US$373,095
|
30,000
+0.5%
|
12.44
|
US$373,095
|
|
|
2018-03-21 |
2018-03-20 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
25,000
+0.4%
11.09
US$277,155
|
25,000
+0.4%
|
11.09
|
US$277,155
|
|
|
2018-03-21 |
2018-03-19 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
11,300
+0.2%
11.20
US$126,557
|
11,300
+0.2%
|
11.20
|
US$126,557
|
|
|
2018-03-16 |
2018-03-15 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
30,000
+0.5%
11.23
US$336,756
|
30,000
+0.5%
|
11.23
|
US$336,756
|
|
|
2018-03-16 |
2018-03-14 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
19,660
+0.3%
11.57
US$227,488
|
19,660
+0.3%
|
11.57
|
US$227,488
|
|
|
2018-03-15 |
2018-03-13 |
S
Sale
|
Hillan Kenneth J.
See Remarks
Executive Director
|
2,735
-2.8%
11.74
US$32,109
|
2,735
-2.8%
|
11.74
|
US$32,109
|
|
|
2018-03-13 |
2018-03-12 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
20,000
+0.3%
11.39
US$227,802
|
20,000
+0.3%
|
11.39
|
US$227,802
|
|
|
2018-03-13 |
2018-03-09 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
50,000
+0.8%
11.41
US$570,520
|
50,000
+0.8%
|
11.41
|
US$570,520
|
|
|
2018-03-02 |
2018-03-02 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
96,790
+1.6%
10.14
US$981,683
|
96,790
+1.6%
|
10.14
|
US$981,683
|
|
|
2018-03-02 |
2018-03-01 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
410,606
+7.2%
10.33
US$4,243,285
|
410,606
+7.2%
|
10.33
|
US$4,243,285
|
|
|
2018-03-02 |
2018-02-28 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
20,000
+0.4%
10.70
US$213,928
|
20,000
+0.4%
|
10.70
|
US$213,928
|
|
|
2018-02-23 |
2018-02-21 |
PlS
Planned sale
|
Chief Executive Officer
Executive Director
|
1,640
-2.4%
10.67
US$17,499
|
1,640
-2.4%
|
10.67
|
US$17,499
|
|
|
2018-02-23 |
2018-02-21 |
PlS
Planned sale
|
Chief Financial Officer
Officer
|
1,108
-2.7%
10.67
US$11,822
|
1,108
-2.7%
|
10.67
|
US$11,822
|
|
|
2018-02-23 |
2018-02-21 |
PlS
Planned sale
|
Swem Lee
Chief Scientific Officer
Officer
|
1,282
-3.4%
10.67
US$13,679
|
1,282
-3.4%
|
10.67
|
US$13,679
|
|
|
2018-02-23 |
2018-02-21 |
PlS
Planned sale
|
Hillan Kenneth J.
See Remarks
Executive Director
|
4,606
-4.5%
10.67
US$49,146
|
4,606
-4.5%
|
10.67
|
US$49,146
|
|
|
2018-02-15 |
2018-02-14 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
9,442
+0.2%
10.96
US$103,487
|
9,442
+0.2%
|
10.96
|
US$103,487
|
|
|
2018-02-15 |
2018-02-13 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
558
+0.0%
10.97
US$6,119
|
558
+0.0%
|
10.97
|
US$6,119
|
|
|
2018-01-05 |
2018-01-05 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
50,000
+0.9%
11.51
US$575,500
|
50,000
+0.9%
|
11.51
|
US$575,500
|
|
|
2018-01-05 |
2018-01-03 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
15,000
+0.3%
10.89
US$163,353
|
15,000
+0.3%
|
10.89
|
US$163,353
|
|
|
2017-12-20 |
2017-12-18 |
B
Purchase
|
DUGGAN ROBERT W
Large shareholder
|
95,012
+1.7%
11.13
US$1,057,493
|
95,012
+1.7%
|
11.13
|
US$1,057,493
|
|
|
2017-09-28 |
2017-09-26 |
S
Sale
|
General Counsel
|
1,146
-7.9%
15.99
US$18,325
|
1,146
-7.9%
|
15.99
|
US$18,325
|
|
|
2017-09-28 |
2017-09-26 |
S
Sale
|
President & COO
|
3,576
-5.1%
15.99
US$57,180
|
3,576
-5.1%
|
15.99
|
US$57,180
|
|
|
2018-05-15 |
2017-09-25 |
S
Sale
|
Swem Lee
Chief Scientific Officer
Officer
|
900
-2.4%
15.99
US$14,391
|
900
-2.4%
|
15.99
|
US$14,391
|
|
|
2017-06-14 |
2017-06-12 |
PlS
Planned sale
|
Chief Financial Officer
|
2,066
-4.9%
21.53
US$44,481
|
2,066
-4.9%
|
21.53
|
US$44,481
|
|
|
2017-03-16 |
2017-03-14 |
S
Sale
|
Chief Executive Officer
Executive Director
|
3,079
-3.0%
26.58
US$81,840
|
3,079
-3.0%
|
26.58
|
US$81,840
|
|
|
2017-02-23 |
2017-02-21 |
S
Sale
|
Sarpangal Zeryn
See Remarks
|
439
-2.6%
22.76
US$9,992
|
439
-2.6%
|
22.76
|
US$9,992
|
|
|
2017-02-23 |
2017-02-21 |
S
Sale
|
Friedland Ian
SVP, Chief Medical Officer
|
1,026
-2.7%
22.76
US$23,352
|
1,026
-2.7%
|
22.76
|
US$23,352
|
|
|
2017-02-23 |
2017-02-21 |
S
Sale
|
Chief Executive Officer
Executive Director
|
1,696
-2.7%
22.76
US$38,601
|
1,696
-2.7%
|
22.76
|
US$38,601
|
|
|
2017-01-30 |
2017-01-26 |
PlS
Planned sale
|
Chief Executive Officer
Executive Director
|
1,431
-2.2%
16.78
US$24,012
|
1,431
-2.2%
|
16.78
|
US$24,012
|
|
|
2017-01-30 |
2017-01-26 |
PlS
Planned sale
|
Friedland Ian
Chief Medical Officer
|
695
-1.8%
16.78
US$11,662
|
695
-1.8%
|
16.78
|
US$11,662
|
|
|
2017-01-30 |
2017-01-26 |
PlS
Planned sale
|
Chief Operating Officer
|
1,431
-3.0%
16.78
US$24,012
|
1,431
-3.0%
|
16.78
|
US$24,012
|
|
|
2017-01-30 |
2017-01-26 |
S
Sale
|
VP, HR and Corporate Affairs
|
781
-4.4%
16.78
US$13,105
|
781
-4.4%
|
16.78
|
US$13,105
|
|
|
2017-01-30 |
2017-01-26 |
S
Sale
|
General Counsel
|
521
-3.5%
16.78
US$8,742
|
521
-3.5%
|
16.78
|
US$8,742
|
|
|
2017-01-30 |
2017-01-26 |
S
Sale
|
Schilke Tobin
Chief Financial Officer
|
955
-3.5%
16.78
US$16,025
|
955
-3.5%
|
16.78
|
US$16,025
|
|
|
2016-12-19 |
2016-12-19 |
B
Purchase
|
MOTT DAVID M
Large shareholder
|
500,000
+10.6%
13.50
US$6,750,000
|
500,000
+10.6%
|
13.50
|
US$6,750,000
|
|
|
2016-12-19 |
2016-12-19 |
B
Purchase
|
Sonsini Peter W.
Large shareholder
|
500,000
+10.6%
13.50
US$6,750,000
|
500,000
+10.6%
|
13.50
|
US$6,750,000
|
|