|
2018-11-28 |
2018-11-27 |
B
Compra
|
Gurnet Holding Co
Gran accionista
|
75 154
-20.0%
167,69
3.570.804 US$
|
75 154
-20.0%
|
167,69
|
3.570.804 US$
|
|
|
2018-11-28 |
2018-11-27 |
B
Compra
|
Gurnet Holding Co
Gran accionista
|
43 181
-10.4%
93,11
1.212.741 US$
|
43 181
-10.4%
|
93,11
|
1.212.741 US$
|
|
|
2018-10-15 |
2018-10-12 |
S
Venta
|
PERCEPTIVE ADVISORS LLC
Gran accionista
|
22 220
-2.9%
427,78
3.322.340 US$
|
22 220
-2.9%
|
427,78
|
3.322.340 US$
|
|
|
2018-10-15 |
2018-10-12 |
S
Venta
|
PERCEPTIVE ADVISORS LLC
Gran accionista
|
500 000
-9.0%
12,51
6.255.000 US$
|
500 000
-9.0%
|
12,51
|
6.255.000 US$
|
|
|
2018-10-15 |
2018-10-11 |
S
Venta
|
PERCEPTIVE ADVISORS LLC
Gran accionista
|
500 000
-8.2%
12,50
6.250.000 US$
|
500 000
-8.2%
|
12,50
|
6.250.000 US$
|
|
|
2018-10-15 |
2018-10-11 |
S
Venta
|
PERCEPTIVE ADVISORS LLC
Gran accionista
|
282 447
-4.4%
12,51
3.533.412 US$
|
282 447
-4.4%
|
12,51
|
3.533.412 US$
|
|
|
2018-08-17 |
2018-08-17 |
S
Venta
|
Sweemer Timothy D
Chief Accounting Officer
Oficial
|
346
-1.0%
9,01
3.117 US$
|
346
-1.0%
|
9,01
|
3.117 US$
|
|
|
2018-08-17 |
2018-08-17 |
S
Venta
|
Singh Parminder
CTO & Vice President, R&D
Oficial
|
3 133
-16.5%
9,01
28.224 US$
|
3 133
-16.5%
|
9,01
|
28.224 US$
|
|
|
2018-08-17 |
2018-08-17 |
S
Venta
|
BREUIL ROBERT S
Chief Financial Officer
Oficial
|
972
-6.3%
9,01
8.756 US$
|
972
-6.3%
|
9,01
|
8.756 US$
|
|
|
2018-08-17 |
2018-08-17 |
S
Venta
|
Sarret Joseph J.
Chief Business Officer
Oficial
|
3 565
-18.0%
9,01
32.116 US$
|
3 565
-18.0%
|
9,01
|
32.116 US$
|
|
|
2018-08-17 |
2018-08-17 |
Por favor
Venta prevista
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
34 320
-12.2%
8,96
307.586 US$
|
34 320
-12.2%
|
8,96
|
307.586 US$
|
|
|
2018-08-17 |
2018-08-17 |
S
Venta
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
2 701
-0.9%
9,01
24.332 US$
|
2 701
-0.9%
|
9,01
|
24.332 US$
|
|
|
2018-08-17 |
2018-08-16 |
Por favor
Venta prevista
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
39 320
-12.4%
8,66
340.606 US$
|
39 320
-12.4%
|
8,66
|
340.606 US$
|
|
|
2018-08-17 |
2018-08-15 |
Por favor
Venta prevista
|
Thomas Robert
Consejero no ejecutivo
|
35 608
-100.0%
8,86
315.476 US$
|
35 608
-100.0%
|
8,86
|
315.476 US$
|
|
|
2018-01-18 |
2018-01-18 |
B
Compra
|
PERCEPTIVE ADVISORS LLC
Gran accionista
|
310 000
+5.1%
12,80
3.968.000 US$
|
310 000
+5.1%
|
12,80
|
3.968.000 US$
|
|
|
2018-01-18 |
2018-01-17 |
B
Compra
|
PERCEPTIVE ADVISORS LLC
Gran accionista
|
149 650
+2.5%
12,24
1.831.716 US$
|
149 650
+2.5%
|
12,24
|
1.831.716 US$
|
|
|
2018-01-18 |
2018-01-16 |
B
Compra
|
PERCEPTIVE ADVISORS LLC
Gran accionista
|
50 350
+0.9%
11,83
595.640 US$
|
50 350
+0.9%
|
11,83
|
595.640 US$
|
|
|
2017-11-17 |
2017-11-17 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
25 000
-0.7%
10,95
273.750 US$
|
25 000
-0.7%
|
10,95
|
273.750 US$
|
|
|
2017-11-17 |
2017-11-17 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
9 255
-0.3%
10,96
101.435 US$
|
9 255
-0.3%
|
10,96
|
101.435 US$
|
|
|
2017-11-17 |
2017-11-17 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
100 000
-2.7%
10,95
1.095.000 US$
|
100 000
-2.7%
|
10,95
|
1.095.000 US$
|
|
|
2017-11-17 |
2017-11-17 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
65 345
-1.7%
11,01
719.448 US$
|
65 345
-1.7%
|
11,01
|
719.448 US$
|
|
|
2017-11-17 |
2017-11-16 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
400
-0.0%
10,97
4.388 US$
|
400
-0.0%
|
10,97
|
4.388 US$
|
|
|
2017-11-17 |
2017-11-16 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
25 000
-0.7%
10,88
272.000 US$
|
25 000
-0.7%
|
10,88
|
272.000 US$
|
|
|
2017-11-17 |
2017-11-16 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
25 000
-0.7%
10,85
271.250 US$
|
25 000
-0.7%
|
10,85
|
271.250 US$
|
|
|
2017-11-17 |
2017-11-16 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
250 000
-6.1%
10,97
2.742.500 US$
|
250 000
-6.1%
|
10,97
|
2.742.500 US$
|
|
|
2017-11-03 |
2017-11-02 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
150 000
-3.6%
11,05
1.657.500 US$
|
150 000
-3.6%
|
11,05
|
1.657.500 US$
|
|
|
2017-10-06 |
2017-10-04 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
218 100
-4.9%
11,01
2.401.107 US$
|
218 100
-4.9%
|
11,01
|
2.401.107 US$
|
|
|
2017-08-23 |
2017-08-22 |
S
Venta
|
Singh Parminder
CTO & Vice President, R&D
|
22 822
-74.2%
7,61
173.561 US$
|
22 822
-74.2%
|
7,61
|
173.561 US$
|
|
|
2017-08-23 |
2017-08-21 |
S
Venta
|
Singh Parminder
CTO & Vice President, R&D
|
7 593
-19.8%
7,53
57.139 US$
|
7 593
-19.8%
|
7,53
|
57.139 US$
|
|
|
2017-08-18 |
2017-08-17 |
S
Venta
|
Sweemer Timothy D
Chief Accounting Officer
|
12 012
-27.1%
7,62
91.529 US$
|
12 012
-27.1%
|
7,62
|
91.529 US$
|
|
|
2017-08-18 |
2017-08-17 |
S
Venta
|
Singh Parminder
CTO & Vice President, R&D
|
32 000
-45.5%
7,61
243.619 US$
|
32 000
-45.5%
|
7,61
|
243.619 US$
|
|
|
2017-08-18 |
2017-08-16 |
S
Venta
|
Sweemer Timothy D
Chief Accounting Officer
|
15 488
-25.9%
7,82
121.156 US$
|
15 488
-25.9%
|
7,82
|
121.156 US$
|
|
|
2017-07-21 |
2017-07-20 |
Por favor
Venta prevista
|
Sarret Joseph J.
Chief Business Officer
Oficial
|
2 038
-21.5%
8,95
18.232 US$
|
2 038
-21.5%
|
8,95
|
18.232 US$
|
|
|
2017-07-05 |
2017-06-30 |
B
Compra
|
PERCEPTIVE ADVISORS LLC
Gran accionista
|
301 004
+5.4%
7,71
2.319.236 US$
|
301 004
+5.4%
|
7,71
|
2.319.236 US$
|
|
|
2017-05-25 |
2017-05-25 |
B
Compra
|
PERCEPTIVE ADVISORS LLC
Gran accionista
|
1 902 400
+52.2%
6,25
11.890.000 US$
|
1 902 400
+52.2%
|
6,25
|
11.890.000 US$
|
|
|
2016-05-20 |
2016-05-19 |
B
Compra
|
BJERKHOLT ERIC
Consejero no ejecutivo
|
6 341
+112.1%
3,70
23.453 US$
|
6 341
+112.1%
|
3,70
|
23.453 US$
|
|
|
2016-05-20 |
2016-05-19 |
B
Compra
|
BJERKHOLT ERIC
Consejero no ejecutivo
|
7 790
+165.4%
3,71
28.879 US$
|
7 790
+165.4%
|
3,71
|
28.879 US$
|
|
|
2016-05-20 |
2016-05-18 |
B
Compra
|
BJERKHOLT ERIC
Consejero no ejecutivo
|
5 659
+inf%
3,57
20.179 US$
|
5 659
+inf%
|
3,57
|
20.179 US$
|
|
|
2016-05-20 |
2016-05-18 |
B
Compra
|
BJERKHOLT ERIC
Consejero no ejecutivo
|
4 710
+inf%
3,54
16.688 US$
|
4 710
+inf%
|
3,54
|
16.688 US$
|
|
|
2016-05-17 |
2016-05-16 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
6 500
+22.9%
3,70
24.046 US$
|
6 500
+22.9%
|
3,70
|
24.046 US$
|
|
|
2016-05-17 |
2016-05-13 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
6 000
+26.8%
3,50
20.996 US$
|
6 000
+26.8%
|
3,50
|
20.996 US$
|
|
|
2016-05-16 |
2016-05-12 |
B
Compra
|
GREENWOOD DAVID
Consejero no ejecutivo
|
3 000
+inf%
3,58
10.742 US$
|
3 000
+inf%
|
3,58
|
10.742 US$
|
|
|
2015-02-26 |
2015-02-25 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
3 600
+19.2%
6,99
25.169 US$
|
3 600
+19.2%
|
6,99
|
25.169 US$
|
|
|
2014-11-24 |
2014-11-24 |
B
Compra
|
BREUIL ROBERT S
Chief Financial Officer
Oficial
|
1 600
+40.0%
5,40
8.640 US$
|
1 600
+40.0%
|
5,40
|
8.640 US$
|
|
|
2014-11-24 |
2014-11-21 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
9 000
+92.0%
5,34
48.055 US$
|
9 000
+92.0%
|
5,34
|
48.055 US$
|
|
|
2014-08-27 |
2014-08-27 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
300
+3.2%
6,20
1.860 US$
|
300
+3.2%
|
6,20
|
1.860 US$
|
|
|
2014-08-27 |
2014-08-26 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
1 000
+11.8%
6,14
6.144 US$
|
1 000
+11.8%
|
6,14
|
6.144 US$
|
|
|
2014-08-27 |
2014-08-25 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
1 278
+17.8%
6,05
7.726 US$
|
1 278
+17.8%
|
6,05
|
7.726 US$
|
|
|
2014-05-30 |
2014-05-30 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
2 400
+50.0%
7,08
16.982 US$
|
2 400
+50.0%
|
7,08
|
16.982 US$
|
|
|
2014-05-30 |
2014-05-29 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
2 900
+152.6%
7,08
20.518 US$
|
2 900
+152.6%
|
7,08
|
20.518 US$
|
|
|
2014-05-30 |
2014-05-28 |
B
Compra
|
STAPLE PETER D
President & CEO
Consejero ejecutivo
|
1 900
+inf%
6,95
13.206 US$
|
1 900
+inf%
|
6,95
|
13.206 US$
|
|
|
2014-04-08 |
2014-04-08 |
B
Compra
|
ESSEX WOODLANDS HEALTH VENTURES FUND VII LP
Gran accionista
|
400 000
+4.5%
8,00
3.200.000 US$
|
400 000
+4.5%
|
8,00
|
3.200.000 US$
|
|
|
2014-04-08 |
2014-04-08 |
B
Compra
|
Eastman Ronald W
Consejero no ejecutivo
Gran accionista
|
400 000
+4.5%
8,00
3.200.000 US$
|
400 000
+4.5%
|
8,00
|
3.200.000 US$
|
|