|
2023-01-31 |
2023-01-27 |
S
Venta
|
Consejero no ejecutivo
|
14 344
-14.1%
173,18
2.322.813 US$
|
14 344
-14.1%
|
173,18
|
2.322.813 US$
|
|
|
2023-01-31 |
2023-01-27 |
S
Venta
|
Consejero no ejecutivo
|
21 878
+25.6%
383,51
3.945.611 US$
|
21 878
+25.6%
|
383,51
|
3.945.611 US$
|
|
|
2021-11-12 |
2021-11-11 |
S
Venta
|
Director
Oficial
|
17 863
-14.5%
430,53
2.668.115 US$
|
17 863
-14.5%
|
430,53
|
2.668.115 US$
|
|
|
2021-11-12 |
2021-11-10 |
S
Venta
|
Director
Oficial
|
30 000
-20.8%
0,86
25.695 US$
|
30 000
-20.8%
|
0,86
|
25.695 US$
|
|
|
2021-11-10 |
2021-11-10 |
B
Compra
|
Consejero no ejecutivo
|
200 000
+inf%
0,86
171.900 US$
|
200 000
+inf%
|
0,86
|
171.900 US$
|
|
|
2021-11-10 |
2021-11-10 |
B
Compra
|
SR. VP, DEVELOPMENT
Oficial
|
100 000
+21.9%
0,85
84.670 US$
|
100 000
+21.9%
|
0,85
|
84.670 US$
|
|
|
2021-11-10 |
2021-11-10 |
B
Compra
|
PRESIDENT & CEO
Consejero ejecutivo
|
100 000
+21.9%
0,85
84.670 US$
|
100 000
+21.9%
|
0,85
|
84.670 US$
|
|
|
2021-11-09 |
2021-11-09 |
S
Venta
|
Consejero no ejecutivo
|
51 810
-26.4%
0,84
43.520 US$
|
51 810
-26.4%
|
0,84
|
43.520 US$
|
|
|
2020-12-18 |
2020-12-16 |
Por favor
Venta prevista
|
Chief Medical Officer
Oficial
|
2 447
-18.1%
6,00
14.682 US$
|
2 447
-18.1%
|
6,00
|
14.682 US$
|
|
|
2020-05-26 |
2020-05-21 |
S
Venta
|
Gran accionista
|
192 250
-28.6%
6,00
1.153.500 US$
|
192 250
-28.6%
|
6,00
|
1.153.500 US$
|
|
|
2020-05-26 |
2020-05-21 |
S
Venta
|
Gran accionista
|
1 064 332
-27.8%
6,00
6.385.992 US$
|
1 064 332
-27.8%
|
6,00
|
6.385.992 US$
|
|
|
2020-05-26 |
2020-05-21 |
S
Venta
|
Gran accionista
|
1 027 016
-21.7%
6,00
6.162.096 US$
|
1 027 016
-21.7%
|
6,00
|
6.162.096 US$
|
|
|
2020-04-17 |
2020-04-15 |
Por favor
Venta prevista
|
SR. VP, FINANCE & SECRETARY
Oficial
|
5 000
-14.3%
8,00
40.000 US$
|
5 000
-14.3%
|
8,00
|
40.000 US$
|
|
|
2020-02-24 |
2020-02-20 |
Por favor
Venta prevista
|
Chief Medical Officer
Oficial
|
3 021
-26.1%
8,00
24.168 US$
|
3 021
-26.1%
|
8,00
|
24.168 US$
|
|
|
2019-12-26 |
2019-12-23 |
Por favor
Venta prevista
|
Orford Keith
Chief Medical Officer
Oficial
|
3 021
-20.7%
6,00
18.126 US$
|
3 021
-20.7%
|
6,00
|
18.126 US$
|
|
|
2019-11-22 |
2019-11-20 |
B
Compra
|
BVF PARTNERS L P/IL
Gran accionista
|
14 151
+2.1%
3,91
55.353 US$
|
14 151
+2.1%
|
3,91
|
55.353 US$
|
|
|
2019-11-22 |
2019-11-20 |
B
Compra
|
BVF PARTNERS L P/IL
Gran accionista
|
79 285
+2.1%
3,91
310.131 US$
|
79 285
+2.1%
|
3,91
|
310.131 US$
|
|
|
2019-11-22 |
2019-11-20 |
B
Compra
|
BVF PARTNERS L P/IL
Gran accionista
|
98 518
+2.1%
3,91
385.363 US$
|
98 518
+2.1%
|
3,91
|
385.363 US$
|
|
|
2019-11-18 |
2019-11-14 |
B
Compra
|
BVF PARTNERS L P/IL
Gran accionista
|
11 105
+1.7%
3,37
37.424 US$
|
11 105
+1.7%
|
3,37
|
37.424 US$
|
|
|
2019-11-18 |
2019-11-14 |
B
Compra
|
BVF PARTNERS L P/IL
Gran accionista
|
45 888
+1.2%
3,37
154.643 US$
|
45 888
+1.2%
|
3,37
|
154.643 US$
|
|
|
2019-11-18 |
2019-11-14 |
B
Compra
|
BVF PARTNERS L P/IL
Gran accionista
|
71 495
+1.6%
3,37
240.938 US$
|
71 495
+1.6%
|
3,37
|
240.938 US$
|
|
|
2019-10-31 |
2019-10-30 |
B
Compra
|
Gran accionista
|
57 868
+9.8%
2,70
156.244 US$
|
57 868
+9.8%
|
2,70
|
156.244 US$
|
|
|
2019-10-31 |
2019-10-30 |
B
Compra
|
Gran accionista
|
331 048
+9.8%
2,70
893.830 US$
|
331 048
+9.8%
|
2,70
|
893.830 US$
|
|
|
2019-10-31 |
2019-10-30 |
B
Compra
|
Gran accionista
|
408 592
+9.8%
2,70
1.103.198 US$
|
408 592
+9.8%
|
2,70
|
1.103.198 US$
|
|
|
2019-10-31 |
2019-10-29 |
B
Compra
|
Gran accionista
|
116 552
+24.6%
2,60
303.035 US$
|
116 552
+24.6%
|
2,60
|
303.035 US$
|
|
|
2019-10-31 |
2019-10-29 |
B
Compra
|
Gran accionista
|
610 052
+22.1%
2,60
1.586.135 US$
|
610 052
+22.1%
|
2,60
|
1.586.135 US$
|
|
|
2019-10-31 |
2019-10-29 |
B
Compra
|
Gran accionista
|
872 373
+26.5%
2,60
2.268.170 US$
|
872 373
+26.5%
|
2,60
|
2.268.170 US$
|
|
|
2019-06-27 |
2019-06-25 |
PÁGINAS
Compra planificada
|
SR. VP, DEVELOPMENT
|
51 600
+12.7%
3,88
200.208 US$
|
51 600
+12.7%
|
3,88
|
200.208 US$
|
|
|
2019-06-27 |
2019-06-25 |
PÁGINAS
Compra planificada
|
PRESIDENT AND CEO
Consejero ejecutivo
|
51 600
+12.7%
3,88
200.208 US$
|
51 600
+12.7%
|
3,88
|
200.208 US$
|
|
|
2019-06-19 |
2019-06-17 |
Por favor
Venta prevista
|
Chief Medical Officer
|
417
-3.3%
6,00
2.502 US$
|
417
-3.3%
|
6,00
|
2.502 US$
|
|
|
2019-05-24 |
2019-05-22 |
Por favor
Venta prevista
|
Chief Medical Officer
|
416
-4.0%
6,00
2.496 US$
|
416
-4.0%
|
6,00
|
2.496 US$
|
|
|
2019-04-17 |
2019-04-15 |
Por favor
Venta prevista
|
Chief Medical Officer
|
416
-3.8%
6,33
2.633 US$
|
416
-3.8%
|
6,33
|
2.633 US$
|
|
|
2019-03-19 |
2019-03-15 |
Por favor
Venta prevista
|
Chief Medical Officer
|
417
-3.7%
6,43
2.681 US$
|
417
-3.7%
|
6,43
|
2.681 US$
|
|
|
2019-03-13 |
2019-03-11 |
Por favor
Venta prevista
|
Chief Medical Officer
Oficial
|
1 565
-12.2%
6,00
9.390 US$
|
1 565
-12.2%
|
6,00
|
9.390 US$
|
|
|
2018-10-17 |
2018-10-15 |
Por favor
Venta prevista
|
Orford Keith
SR. VP, CLINICAL DEVELOPMENT
Oficial
|
313
-2.9%
6,05
1.894 US$
|
313
-2.9%
|
6,05
|
1.894 US$
|
|
|
2018-10-15 |
2018-10-11 |
Por favor
Venta prevista
|
Orford Keith
SR. VP, CLINICAL DEVELOPMENT
Oficial
|
1 252
-10.5%
6,00
7.512 US$
|
1 252
-10.5%
|
6,00
|
7.512 US$
|
|
|
2017-09-28 |
2017-09-28 |
S
Venta
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Gran accionista
|
38 000
-1.1%
15,50
589.000 US$
|
38 000
-1.1%
|
15,50
|
589.000 US$
|
|
|
2017-09-28 |
2017-09-27 |
S
Venta
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Gran accionista
|
186 000
-4.9%
15,59
2.899.740 US$
|
186 000
-4.9%
|
15,59
|
2.899.740 US$
|
|
|
2017-09-28 |
2017-09-26 |
S
Venta
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Gran accionista
|
352 000
-8.5%
15,68
5.519.360 US$
|
352 000
-8.5%
|
15,68
|
5.519.360 US$
|
|
|
2017-07-19 |
2017-07-17 |
Por favor
Venta prevista
|
Wong Stephanie
VP, FINANCE AND SECRETARY
Oficial
|
3 552
-25.2%
18,41
65.385 US$
|
3 552
-25.2%
|
18,41
|
65.385 US$
|
|
|
2017-07-19 |
2017-07-17 |
Por favor
Venta prevista
|
Orford Keith
SR. VP, CLINICAL DEVELOPMENT
Oficial
|
2 120
-23.6%
18,31
38.823 US$
|
2 120
-23.6%
|
18,31
|
38.823 US$
|
|
|
2017-07-07 |
2017-07-06 |
Por favor
Venta prevista
|
Hecht Curtis
SVP, BUS. & CORP. DEVELOPMENT
Oficial
|
700
-4.2%
18,00
12.600 US$
|
700
-4.2%
|
18,00
|
12.600 US$
|
|
|
2017-05-23 |
2017-05-19 |
Por favor
Venta prevista
|
Hecht Curtis
SVP, BUS. & CORP. DEVELOPMENT
Oficial
|
650
-4.2%
16,00
10.400 US$
|
650
-4.2%
|
16,00
|
10.400 US$
|
|
|
2017-03-24 |
2017-03-22 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Gran accionista
|
487 804
+13.4%
10,25
4.999.991 US$
|
487 804
+13.4%
|
10,25
|
4.999.991 US$
|
|
|
2017-03-15 |
2017-03-13 |
Por favor
Venta prevista
|
Hecht Curtis
SVP, BUS. & CORP. DEVELOPMENT
|
600
-3.7%
14,00
8.400 US$
|
600
-3.7%
|
14,00
|
8.400 US$
|
|
|
2017-03-06 |
2017-03-02 |
Por favor
Venta prevista
|
Hecht Curtis
See Remarks
|
550
-3.3%
12,00
6.600 US$
|
550
-3.3%
|
12,00
|
6.600 US$
|
|
|
2016-11-17 |
2016-11-16 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Gran accionista
|
500 000
+15.9%
3,15
1.575.000 US$
|
500 000
+15.9%
|
3,15
|
1.575.000 US$
|
|
|
2015-09-24 |
2015-09-23 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
40 168
+1.3%
6,07
243.768 US$
|
40 168
+1.3%
|
6,07
|
243.768 US$
|
|
|
2015-09-24 |
2015-09-22 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
41 800
+1.4%
6,00
250.938 US$
|
41 800
+1.4%
|
6,00
|
250.938 US$
|
|
|
2015-09-24 |
2015-09-22 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
25 000
+0.8%
6,00
149.942 US$
|
25 000
+0.8%
|
6,00
|
149.942 US$
|
|
|
2015-09-08 |
2015-09-04 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
2 300
+0.1%
5,95
13.685 US$
|
2 300
+0.1%
|
5,95
|
13.685 US$
|
|
|
2015-09-08 |
2015-09-03 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
88 000
+3.0%
5,93
521.840 US$
|
88 000
+3.0%
|
5,93
|
521.840 US$
|
|
|
2015-08-28 |
2015-08-28 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
22 000
+0.8%
5,58
122.760 US$
|
22 000
+0.8%
|
5,58
|
122.760 US$
|
|
|
2015-08-28 |
2015-08-28 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
20 700
+0.7%
5,55
114.885 US$
|
20 700
+0.7%
|
5,55
|
114.885 US$
|
|
|
2015-08-28 |
2015-08-27 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
32 400
+1.1%
5,35
173.340 US$
|
32 400
+1.1%
|
5,35
|
173.340 US$
|
|
|
2015-08-28 |
2015-08-27 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
29 089
+1.0%
5,17
150.390 US$
|
29 089
+1.0%
|
5,17
|
150.390 US$
|
|
|
2015-08-28 |
2015-08-27 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
19 578
+0.7%
5,58
109.245 US$
|
19 578
+0.7%
|
5,58
|
109.245 US$
|
|
|
2015-08-28 |
2015-08-27 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
6 253
+0.2%
5,43
33.954 US$
|
6 253
+0.2%
|
5,43
|
33.954 US$
|
|
|
2015-08-28 |
2015-08-27 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
9 848
+0.4%
5,41
53.278 US$
|
9 848
+0.4%
|
5,41
|
53.278 US$
|
|
|
2015-08-28 |
2015-08-26 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
32 058
+1.2%
4,65
149.070 US$
|
32 058
+1.2%
|
4,65
|
149.070 US$
|
|
|
2015-08-28 |
2015-08-26 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
200
+0.0%
4,70
940 US$
|
200
+0.0%
|
4,70
|
940 US$
|
|
|
2014-10-15 |
2014-10-15 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
25 000
+0.9%
6,80
170.000 US$
|
25 000
+0.9%
|
6,80
|
170.000 US$
|
|
|
2014-10-15 |
2014-10-15 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
13 000
+0.5%
7,25
94.250 US$
|
13 000
+0.5%
|
7,25
|
94.250 US$
|
|
|
2014-10-15 |
2014-10-14 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
25 000
+0.9%
6,99
174.750 US$
|
25 000
+0.9%
|
6,99
|
174.750 US$
|
|
|
2014-10-15 |
2014-10-14 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
30 000
+1.1%
7,00
210.000 US$
|
30 000
+1.1%
|
7,00
|
210.000 US$
|
|
|
2014-10-15 |
2014-10-13 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
88 700
+3.4%
6,94
615.578 US$
|
88 700
+3.4%
|
6,94
|
615.578 US$
|
|
|
2014-10-09 |
2014-10-07 |
B
Compra
|
Delphi Management Partners VIII, L.L.C.
Gran accionista
|
4 835
+26.0%
10,00
48.350 US$
|
4 835
+26.0%
|
10,00
|
48.350 US$
|
|
|
2014-10-09 |
2014-10-07 |
B
Compra
|
Delphi Management Partners VIII, L.L.C.
Gran accionista
|
495 165
+26.0%
10,00
4.951.650 US$
|
495 165
+26.0%
|
10,00
|
4.951.650 US$
|
|
|
2014-10-09 |
2014-10-07 |
B
Compra
|
George Jean
Consejero no ejecutivo
Gran accionista
|
300 000
+16.6%
10,00
3.000.000 US$
|
300 000
+16.6%
|
10,00
|
3.000.000 US$
|
|
|
2014-10-09 |
2014-10-07 |
B
Compra
|
MORGENTHALER VENTURE PARTNERS IX LP
Gran accionista
|
350 000
+19.3%
10,00
3.500.000 US$
|
350 000
+19.3%
|
10,00
|
3.500.000 US$
|
|
|
2014-10-09 |
2014-10-07 |
B
Compra
|
Christoffersen Ralph E
Consejero no ejecutivo
Gran accionista
|
350 000
+19.3%
10,00
3.500.000 US$
|
350 000
+19.3%
|
10,00
|
3.500.000 US$
|
|
|
2014-10-09 |
2014-10-07 |
B
Compra
|
Advanced Technology Ventures VIII LP
Gran accionista
|
300 000
+16.6%
10,00
3.000.000 US$
|
300 000
+16.6%
|
10,00
|
3.000.000 US$
|
|
|
2014-10-09 |
2014-10-07 |
B
Compra
|
PAKIANATHAN DEEPIKA
Consejero no ejecutivo
Gran accionista
|
4 835
+26.0%
10,00
48.350 US$
|
4 835
+26.0%
|
10,00
|
48.350 US$
|
|
|
2014-10-09 |
2014-10-07 |
B
Compra
|
PAKIANATHAN DEEPIKA
Consejero no ejecutivo
Gran accionista
|
495 165
+26.0%
10,00
4.951.650 US$
|
495 165
+26.0%
|
10,00
|
4.951.650 US$
|
|
|
2014-10-03 |
2014-10-01 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
800 000
+44.9%
10,00
8.000.000 US$
|
800 000
+44.9%
|
10,00
|
8.000.000 US$
|
|