|
2023-01-31 |
2023-01-27 |
V
Vente
|
PAKIANATHAN DEEPIKA
Administrateur non-exécutif
|
1 172
-100.0%
0,39
452 USD
|
1 172
-100.0%
|
0,39
|
452 USD
|
|
|
2023-01-31 |
2023-01-27 |
V
Vente
|
PAKIANATHAN DEEPIKA
Administrateur non-exécutif
|
120 161
-100.0%
0,39
46 358 USD
|
120 161
-100.0%
|
0,39
|
46 358 USD
|
|
|
2021-11-12 |
2021-11-11 |
V
Vente
|
Orford Keith
Director
Dirigeant
|
48 190
-42.2%
0,88
42 407 USD
|
48 190
-42.2%
|
0,88
|
42 407 USD
|
|
|
2021-11-12 |
2021-11-10 |
V
Vente
|
Orford Keith
Director
Dirigeant
|
30 000
-20.8%
0,86
25 695 USD
|
30 000
-20.8%
|
0,86
|
25 695 USD
|
|
|
2021-11-10 |
2021-11-10 |
A
Achat
|
DRACHMAN JONATHAN G
Administrateur non-exécutif
|
200 000
+inf%
0,86
171 900 USD
|
200 000
+inf%
|
0,86
|
171 900 USD
|
|
|
2021-11-10 |
2021-11-10 |
A
Achat
|
Molineaux Christopher
SR. VP, DEVELOPMENT
Dirigeant
|
100 000
+21.9%
0,85
84 670 USD
|
100 000
+21.9%
|
0,85
|
84 670 USD
|
|
|
2021-11-10 |
2021-11-10 |
A
Achat
|
Molineaux Susan
PRESIDENT & CEO
Administrateur exécutif
|
100 000
+21.9%
0,85
84 670 USD
|
100 000
+21.9%
|
0,85
|
84 670 USD
|
|
|
2021-11-09 |
2021-11-09 |
V
Vente
|
Orford Keith
Administrateur non-exécutif
|
51 810
-26.4%
0,84
43 520 USD
|
51 810
-26.4%
|
0,84
|
43 520 USD
|
|
|
2020-12-18 |
2020-12-16 |
VP
Vente planifiée
|
Orford Keith
Chief Medical Officer
Dirigeant
|
2 447
-18.1%
6,00
14 682 USD
|
2 447
-18.1%
|
6,00
|
14 682 USD
|
|
|
2020-05-26 |
2020-05-21 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
192 250
-28.6%
6,00
1 153 500 USD
|
192 250
-28.6%
|
6,00
|
1 153 500 USD
|
|
|
2020-05-26 |
2020-05-21 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 064 332
-27.8%
6,00
6 385 992 USD
|
1 064 332
-27.8%
|
6,00
|
6 385 992 USD
|
|
|
2020-05-26 |
2020-05-21 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 027 016
-21.7%
6,00
6 162 096 USD
|
1 027 016
-21.7%
|
6,00
|
6 162 096 USD
|
|
|
2020-04-17 |
2020-04-15 |
VP
Vente planifiée
|
Wong Stephanie
SR. VP, FINANCE & SECRETARY
Dirigeant
|
5 000
-14.3%
8,00
40 000 USD
|
5 000
-14.3%
|
8,00
|
40 000 USD
|
|
|
2020-02-24 |
2020-02-20 |
VP
Vente planifiée
|
Orford Keith
Chief Medical Officer
Dirigeant
|
3 021
-26.1%
8,00
24 168 USD
|
3 021
-26.1%
|
8,00
|
24 168 USD
|
|
|
2019-12-26 |
2019-12-23 |
VP
Vente planifiée
|
Orford Keith
Chief Medical Officer
Dirigeant
|
3 021
-20.7%
6,00
18 126 USD
|
3 021
-20.7%
|
6,00
|
18 126 USD
|
|
|
2019-11-22 |
2019-11-20 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
14 151
+2.1%
3,91
55 353 USD
|
14 151
+2.1%
|
3,91
|
55 353 USD
|
|
|
2019-11-22 |
2019-11-20 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
79 285
+2.1%
3,91
310 131 USD
|
79 285
+2.1%
|
3,91
|
310 131 USD
|
|
|
2019-11-22 |
2019-11-20 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
98 518
+2.1%
3,91
385 363 USD
|
98 518
+2.1%
|
3,91
|
385 363 USD
|
|
|
2019-11-18 |
2019-11-14 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
11 105
+1.7%
3,37
37 424 USD
|
11 105
+1.7%
|
3,37
|
37 424 USD
|
|
|
2019-11-18 |
2019-11-14 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
45 888
+1.2%
3,37
154 643 USD
|
45 888
+1.2%
|
3,37
|
154 643 USD
|
|
|
2019-11-18 |
2019-11-14 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
71 495
+1.6%
3,37
240 938 USD
|
71 495
+1.6%
|
3,37
|
240 938 USD
|
|
|
2019-10-31 |
2019-10-30 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
57 868
+9.8%
2,70
156 244 USD
|
57 868
+9.8%
|
2,70
|
156 244 USD
|
|
|
2019-10-31 |
2019-10-30 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
331 048
+9.8%
2,70
893 830 USD
|
331 048
+9.8%
|
2,70
|
893 830 USD
|
|
|
2019-10-31 |
2019-10-30 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
408 592
+9.8%
2,70
1 103 198 USD
|
408 592
+9.8%
|
2,70
|
1 103 198 USD
|
|
|
2019-10-31 |
2019-10-29 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
116 552
+24.6%
2,60
303 035 USD
|
116 552
+24.6%
|
2,60
|
303 035 USD
|
|
|
2019-10-31 |
2019-10-29 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
610 052
+22.1%
2,60
1 586 135 USD
|
610 052
+22.1%
|
2,60
|
1 586 135 USD
|
|
|
2019-10-31 |
2019-10-29 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
872 373
+26.5%
2,60
2 268 170 USD
|
872 373
+26.5%
|
2,60
|
2 268 170 USD
|
|
|
2019-06-27 |
2019-06-25 |
AP
Achat planifié
|
Molineaux Christopher
SR. VP, DEVELOPMENT
|
51 600
+12.7%
3,88
200 208 USD
|
51 600
+12.7%
|
3,88
|
200 208 USD
|
|
|
2019-06-27 |
2019-06-25 |
AP
Achat planifié
|
Molineaux Susan
PRESIDENT AND CEO
Administrateur exécutif
|
51 600
+12.7%
3,88
200 208 USD
|
51 600
+12.7%
|
3,88
|
200 208 USD
|
|
|
2019-06-19 |
2019-06-17 |
VP
Vente planifiée
|
Orford Keith
Chief Medical Officer
|
417
-3.3%
6,00
2 502 USD
|
417
-3.3%
|
6,00
|
2 502 USD
|
|
|
2019-05-24 |
2019-05-22 |
VP
Vente planifiée
|
Orford Keith
Chief Medical Officer
|
416
-4.0%
6,00
2 496 USD
|
416
-4.0%
|
6,00
|
2 496 USD
|
|
|
2019-04-17 |
2019-04-15 |
VP
Vente planifiée
|
Orford Keith
Chief Medical Officer
|
416
-3.8%
6,33
2 633 USD
|
416
-3.8%
|
6,33
|
2 633 USD
|
|
|
2019-03-19 |
2019-03-15 |
VP
Vente planifiée
|
Orford Keith
Chief Medical Officer
|
417
-3.7%
6,43
2 681 USD
|
417
-3.7%
|
6,43
|
2 681 USD
|
|
|
2019-03-13 |
2019-03-11 |
VP
Vente planifiée
|
Orford Keith
Chief Medical Officer
Dirigeant
|
1 565
-12.2%
6,00
9 390 USD
|
1 565
-12.2%
|
6,00
|
9 390 USD
|
|
|
2018-10-17 |
2018-10-15 |
VP
Vente planifiée
|
Orford Keith
SR. VP, CLINICAL DEVELOPMENT
Dirigeant
|
313
-2.9%
6,05
1 894 USD
|
313
-2.9%
|
6,05
|
1 894 USD
|
|
|
2018-10-15 |
2018-10-11 |
VP
Vente planifiée
|
Orford Keith
SR. VP, CLINICAL DEVELOPMENT
Dirigeant
|
1 252
-10.5%
6,00
7 512 USD
|
1 252
-10.5%
|
6,00
|
7 512 USD
|
|
|
2017-09-28 |
2017-09-28 |
V
Vente
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Actionnaire important
|
38 000
-1.1%
15,50
589 000 USD
|
38 000
-1.1%
|
15,50
|
589 000 USD
|
|
|
2017-09-28 |
2017-09-27 |
V
Vente
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Actionnaire important
|
186 000
-4.9%
15,59
2 899 740 USD
|
186 000
-4.9%
|
15,59
|
2 899 740 USD
|
|
|
2017-09-28 |
2017-09-26 |
V
Vente
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Actionnaire important
|
352 000
-8.5%
15,68
5 519 360 USD
|
352 000
-8.5%
|
15,68
|
5 519 360 USD
|
|
|
2017-07-19 |
2017-07-17 |
VP
Vente planifiée
|
Wong Stephanie
VP, FINANCE AND SECRETARY
Dirigeant
|
3 552
-25.2%
18,41
65 385 USD
|
3 552
-25.2%
|
18,41
|
65 385 USD
|
|
|
2017-07-19 |
2017-07-17 |
VP
Vente planifiée
|
Orford Keith
SR. VP, CLINICAL DEVELOPMENT
Dirigeant
|
2 120
-23.6%
18,31
38 823 USD
|
2 120
-23.6%
|
18,31
|
38 823 USD
|
|
|
2017-07-07 |
2017-07-06 |
VP
Vente planifiée
|
Hecht Curtis
SVP, BUS. & CORP. DEVELOPMENT
Dirigeant
|
700
-4.2%
18,00
12 600 USD
|
700
-4.2%
|
18,00
|
12 600 USD
|
|
|
2017-05-23 |
2017-05-19 |
VP
Vente planifiée
|
Hecht Curtis
SVP, BUS. & CORP. DEVELOPMENT
Dirigeant
|
650
-4.2%
16,00
10 400 USD
|
650
-4.2%
|
16,00
|
10 400 USD
|
|
|
2017-03-24 |
2017-03-22 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Actionnaire important
|
487 804
+13.4%
10,25
4 999 991 USD
|
487 804
+13.4%
|
10,25
|
4 999 991 USD
|
|
|
2017-03-15 |
2017-03-13 |
VP
Vente planifiée
|
Hecht Curtis
SVP, BUS. & CORP. DEVELOPMENT
|
600
-3.7%
14,00
8 400 USD
|
600
-3.7%
|
14,00
|
8 400 USD
|
|
|
2017-03-06 |
2017-03-02 |
VP
Vente planifiée
|
Hecht Curtis
See Remarks
|
550
-3.3%
12,00
6 600 USD
|
550
-3.3%
|
12,00
|
6 600 USD
|
|
|
2016-11-17 |
2016-11-16 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Actionnaire important
|
500 000
+15.9%
3,15
1 575 000 USD
|
500 000
+15.9%
|
3,15
|
1 575 000 USD
|
|
|
2015-09-24 |
2015-09-23 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
40 168
+1.3%
6,07
243 768 USD
|
40 168
+1.3%
|
6,07
|
243 768 USD
|
|
|
2015-09-24 |
2015-09-22 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
41 800
+1.4%
6,00
250 938 USD
|
41 800
+1.4%
|
6,00
|
250 938 USD
|
|
|
2015-09-24 |
2015-09-22 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
25 000
+0.8%
6,00
149 943 USD
|
25 000
+0.8%
|
6,00
|
149 943 USD
|
|
|
2015-09-08 |
2015-09-04 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
2 300
+0.1%
5,95
13 685 USD
|
2 300
+0.1%
|
5,95
|
13 685 USD
|
|
|
2015-09-08 |
2015-09-03 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
88 000
+3.0%
5,93
521 840 USD
|
88 000
+3.0%
|
5,93
|
521 840 USD
|
|
|
2015-08-28 |
2015-08-28 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
22 000
+0.8%
5,58
122 760 USD
|
22 000
+0.8%
|
5,58
|
122 760 USD
|
|
|
2015-08-28 |
2015-08-28 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
20 700
+0.7%
5,55
114 885 USD
|
20 700
+0.7%
|
5,55
|
114 885 USD
|
|
|
2015-08-28 |
2015-08-27 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
32 400
+1.1%
5,35
173 340 USD
|
32 400
+1.1%
|
5,35
|
173 340 USD
|
|
|
2015-08-28 |
2015-08-27 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
29 089
+1.0%
5,17
150 390 USD
|
29 089
+1.0%
|
5,17
|
150 390 USD
|
|
|
2015-08-28 |
2015-08-27 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
19 578
+0.7%
5,58
109 245 USD
|
19 578
+0.7%
|
5,58
|
109 245 USD
|
|
|
2015-08-28 |
2015-08-27 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
6 253
+0.2%
5,43
33 954 USD
|
6 253
+0.2%
|
5,43
|
33 954 USD
|
|
|
2015-08-28 |
2015-08-27 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
9 848
+0.4%
5,41
53 278 USD
|
9 848
+0.4%
|
5,41
|
53 278 USD
|
|
|
2015-08-28 |
2015-08-26 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
32 058
+1.2%
4,65
149 070 USD
|
32 058
+1.2%
|
4,65
|
149 070 USD
|
|
|
2015-08-28 |
2015-08-26 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
200
+0.0%
4,70
940 USD
|
200
+0.0%
|
4,70
|
940 USD
|
|
|
2014-10-15 |
2014-10-15 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
25 000
+0.9%
6,80
170 000 USD
|
25 000
+0.9%
|
6,80
|
170 000 USD
|
|
|
2014-10-15 |
2014-10-15 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
13 000
+0.5%
7,25
94 250 USD
|
13 000
+0.5%
|
7,25
|
94 250 USD
|
|
|
2014-10-15 |
2014-10-14 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
25 000
+0.9%
6,99
174 750 USD
|
25 000
+0.9%
|
6,99
|
174 750 USD
|
|
|
2014-10-15 |
2014-10-14 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
30 000
+1.1%
7,00
210 000 USD
|
30 000
+1.1%
|
7,00
|
210 000 USD
|
|
|
2014-10-15 |
2014-10-13 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
88 700
+3.4%
6,94
615 578 USD
|
88 700
+3.4%
|
6,94
|
615 578 USD
|
|
|
2014-10-09 |
2014-10-07 |
A
Achat
|
Delphi Management Partners VIII, L.L.C.
Actionnaire important
|
4 835
+26.0%
10,00
48 350 USD
|
4 835
+26.0%
|
10,00
|
48 350 USD
|
|
|
2014-10-09 |
2014-10-07 |
A
Achat
|
Delphi Management Partners VIII, L.L.C.
Actionnaire important
|
495 165
+26.0%
10,00
4 951 650 USD
|
495 165
+26.0%
|
10,00
|
4 951 650 USD
|
|
|
2014-10-09 |
2014-10-07 |
A
Achat
|
George Jean
Administrateur non-exécutif
Actionnaire important
|
300 000
+16.6%
10,00
3 000 000 USD
|
300 000
+16.6%
|
10,00
|
3 000 000 USD
|
|
|
2014-10-09 |
2014-10-07 |
A
Achat
|
MORGENTHALER VENTURE PARTNERS IX LP
Actionnaire important
|
350 000
+19.3%
10,00
3 500 000 USD
|
350 000
+19.3%
|
10,00
|
3 500 000 USD
|
|
|
2014-10-09 |
2014-10-07 |
A
Achat
|
Christoffersen Ralph E
Administrateur non-exécutif
Actionnaire important
|
350 000
+19.3%
10,00
3 500 000 USD
|
350 000
+19.3%
|
10,00
|
3 500 000 USD
|
|
|
2014-10-09 |
2014-10-07 |
A
Achat
|
Advanced Technology Ventures VIII LP
Actionnaire important
|
300 000
+16.6%
10,00
3 000 000 USD
|
300 000
+16.6%
|
10,00
|
3 000 000 USD
|
|
|
2014-10-09 |
2014-10-07 |
A
Achat
|
PAKIANATHAN DEEPIKA
Administrateur non-exécutif
Actionnaire important
|
4 835
+26.0%
10,00
48 350 USD
|
4 835
+26.0%
|
10,00
|
48 350 USD
|
|
|
2014-10-09 |
2014-10-07 |
A
Achat
|
PAKIANATHAN DEEPIKA
Administrateur non-exécutif
Actionnaire important
|
495 165
+26.0%
10,00
4 951 650 USD
|
495 165
+26.0%
|
10,00
|
4 951 650 USD
|
|
|
2014-10-03 |
2014-10-01 |
A
Achat
|
ADAGE CAPITAL PARTNERS GP LLC
Actionnaire important
|
800 000
+44.9%
10,00
8 000 000 USD
|
800 000
+44.9%
|
10,00
|
8 000 000 USD
|
|
