|
2019-07-01 |
2019-06-27 |
B
Compra
|
|
77 544
-17.4%
243,34
4.943.461 US$
|
77 544
-17.4%
|
243,34
|
4.943.461 US$
|
|
|
2019-07-01 |
2019-06-27 |
B
Compra
|
|
56 858
-13.9%
305,99
373.669 US$
|
56 858
-13.9%
|
305,99
|
373.669 US$
|
|
|
2019-07-01 |
2019-06-27 |
B
Compra
|
|
51 514
+7.4%
132,91
1.300.231 US$
|
51 514
+7.4%
|
132,91
|
1.300.231 US$
|
|
|
2019-07-01 |
2019-06-27 |
B
Compra
|
|
133 548
+4.0%
9,75
1.302.093 US$
|
133 548
+4.0%
|
9,75
|
1.302.093 US$
|
|
|
2018-10-22 |
2018-07-13 |
B
Compra
|
Nussbaum Ran
Consejero no ejecutivo
|
43 657
+2.8%
5,50
240.114 US$
|
43 657
+2.8%
|
5,50
|
240.114 US$
|
|
|
2018-10-22 |
2018-07-13 |
B
Compra
|
Nussbaum Ran
Consejero no ejecutivo
|
89 676
+2.8%
5,50
493.218 US$
|
89 676
+2.8%
|
5,50
|
493.218 US$
|
|
|
2018-10-22 |
2018-07-13 |
B
Compra
|
Nussbaum Ran
Consejero no ejecutivo
|
48 485
+2.8%
5,50
266.668 US$
|
48 485
+2.8%
|
5,50
|
266.668 US$
|
|
|
2018-06-01 |
2018-05-30 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
175 813
-18.6%
5,00
879.083 US$
|
175 813
-18.6%
|
5,00
|
879.083 US$
|
|
|
2018-06-01 |
2018-05-30 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
312 266
-8.9%
5,00
1.561.361 US$
|
312 266
-8.9%
|
5,00
|
1.561.361 US$
|
|
|
2018-06-01 |
2018-05-30 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
547 860
-10.5%
5,00
2.739.355 US$
|
547 860
-10.5%
|
5,00
|
2.739.355 US$
|
|
|
2018-05-18 |
2018-05-18 |
B
Compra
|
Nussbaum Ran
Consejero no ejecutivo
|
8 611
+inf%
3,29
28.330 US$
|
8 611
+inf%
|
3,29
|
28.330 US$
|
|
|
2018-05-18 |
2018-05-18 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
15 000
+3.7%
3,39
50.848 US$
|
15 000
+3.7%
|
3,39
|
50.848 US$
|
|
|
2018-05-15 |
2018-05-14 |
B
Compra
|
ZENNER PATRICK J
Consejero no ejecutivo
|
8 446
+11.4%
2,96
24.987 US$
|
8 446
+11.4%
|
2,96
|
24.987 US$
|
|
|
2018-05-15 |
2018-05-11 |
B
Compra
|
LINDSAY RONALD M
Consejero no ejecutivo
|
6 900
+15.7%
2,69
18.589 US$
|
6 900
+15.7%
|
2,69
|
18.589 US$
|
|
|
2018-05-11 |
2018-05-10 |
B
Compra
|
LINDSAY RONALD M
Consejero no ejecutivo
|
23 900
+119.5%
2,67
63.837 US$
|
23 900
+119.5%
|
2,67
|
63.837 US$
|
|
|
2018-05-11 |
2018-05-10 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
1 300
+0.3%
2,64
3.427 US$
|
1 300
+0.3%
|
2,64
|
3.427 US$
|
|
|
2018-04-20 |
2018-04-18 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
217 256
-18.7%
3,10
673.494 US$
|
217 256
-18.7%
|
3,10
|
673.494 US$
|
|
|
2018-04-20 |
2018-04-18 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
808 449
-18.8%
3,10
2.506.192 US$
|
808 449
-18.8%
|
3,10
|
2.506.192 US$
|
|
|
2018-04-20 |
2018-04-18 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
1 204 668
-18.7%
3,10
3.734.471 US$
|
1 204 668
-18.7%
|
3,10
|
3.734.471 US$
|
|
|
2018-04-06 |
2018-04-04 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
214 336
-15.5%
2,90
621.574 US$
|
214 336
-15.5%
|
2,90
|
621.574 US$
|
|
|
2018-04-06 |
2018-04-04 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
817 611
-16.0%
2,90
2.371.072 US$
|
817 611
-16.0%
|
2,90
|
2.371.072 US$
|
|
|
2018-04-06 |
2018-04-04 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
1 269 634
-16.5%
2,90
3.681.939 US$
|
1 269 634
-16.5%
|
2,90
|
3.681.939 US$
|
|
|
2017-09-08 |
2017-09-07 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
|
1 101
+0.3%
1,15
1.261 US$
|
1 101
+0.3%
|
1,15
|
1.261 US$
|
|
|
2017-09-07 |
2017-09-06 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
|
16 397
+4.2%
1,15
18.840 US$
|
16 397
+4.2%
|
1,15
|
18.840 US$
|
|
|
2017-09-06 |
2017-09-05 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
|
19 156
+5.2%
1,14
21.844 US$
|
19 156
+5.2%
|
1,14
|
21.844 US$
|
|
|
2017-08-31 |
2017-08-29 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
|
300
+0.1%
1,05
315 US$
|
300
+0.1%
|
1,05
|
315 US$
|
|
|
2017-08-29 |
2017-08-28 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
|
2 970
+0.8%
1,05
3.115 US$
|
2 970
+0.8%
|
1,05
|
3.115 US$
|
|
|
2017-08-28 |
2017-08-25 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
|
701
+0.2%
1,05
736 US$
|
701
+0.2%
|
1,05
|
736 US$
|
|
|
2017-08-28 |
2017-08-24 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
|
8 791
+2.5%
1,05
9.212 US$
|
8 791
+2.5%
|
1,05
|
9.212 US$
|
|
|
2015-12-18 |
2015-12-17 |
B
Compra
|
LOBERG MICHAEL D
Consejero no ejecutivo
|
3 719
+2.9%
2,16
8.030 US$
|
3 719
+2.9%
|
2,16
|
8.030 US$
|
|
|
2015-12-17 |
2015-12-16 |
B
Compra
|
LOBERG MICHAEL D
Consejero no ejecutivo
|
1 231
+1.0%
2,14
2.633 US$
|
1 231
+1.0%
|
2,14
|
2.633 US$
|
|
|
2015-12-16 |
2015-12-15 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
1 283
+0.5%
2,16
2.771 US$
|
1 283
+0.5%
|
2,16
|
2.771 US$
|
|
|
2015-12-14 |
2015-12-11 |
B
Compra
|
ZENNER PATRICK J
Consejero no ejecutivo
|
2 300
+3.2%
2,15
4.947 US$
|
2 300
+3.2%
|
2,15
|
4.947 US$
|
|
|
2015-12-14 |
2015-12-11 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
1 108
+0.4%
2,10
2.324 US$
|
1 108
+0.4%
|
2,10
|
2.324 US$
|
|
|
2015-12-11 |
2015-12-10 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
6 600
+2.7%
2,10
13.844 US$
|
6 600
+2.7%
|
2,10
|
13.844 US$
|
|
|
2015-12-11 |
2015-12-09 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
1 009
+0.4%
2,10
2.119 US$
|
1 009
+0.4%
|
2,10
|
2.119 US$
|
|
|
2015-03-12 |
2015-03-11 |
B
Compra
|
ZENNER PATRICK J
Consejero no ejecutivo
|
10 625
+17.5%
2,32
24.647 US$
|
10 625
+17.5%
|
2,32
|
24.647 US$
|
|
|
2014-11-20 |
2014-11-20 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
5 000
+2.1%
1,26
6.298 US$
|
5 000
+2.1%
|
1,26
|
6.298 US$
|
|
|
2014-11-18 |
2014-11-14 |
B
Compra
|
Messenger William G
Consejero no ejecutivo
|
8 500
+566.7%
1,21
10.284 US$
|
8 500
+566.7%
|
1,21
|
10.284 US$
|
|
|
2014-11-17 |
2014-11-14 |
B
Compra
|
ZENNER PATRICK J
Consejero no ejecutivo
|
20 830
+52.1%
1,20
24.952 US$
|
20 830
+52.1%
|
1,20
|
24.952 US$
|
|
|
2014-11-17 |
2014-11-13 |
B
Compra
|
Kelley Susan L.
Consejero no ejecutivo
|
50 000
+inf%
1,20
60.160 US$
|
50 000
+inf%
|
1,20
|
60.160 US$
|
|
|
2014-09-05 |
2014-09-04 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
5 000
+2.1%
1,31
6.525 US$
|
5 000
+2.1%
|
1,31
|
6.525 US$
|
|
|
2014-05-27 |
2014-05-23 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
5 000
+2.2%
1,40
7.010 US$
|
5 000
+2.2%
|
1,40
|
7.010 US$
|
|
|
2014-05-21 |
2014-05-20 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
5 000
+2.2%
1,42
7.124 US$
|
5 000
+2.2%
|
1,42
|
7.124 US$
|
|
|
2014-03-19 |
2014-03-17 |
B
Compra
|
ZENNER PATRICK J
Consejero no ejecutivo
|
4 715
+13.4%
2,12
10.009 US$
|
4 715
+13.4%
|
2,12
|
10.009 US$
|
|
|
2014-03-14 |
2014-03-13 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
10 000
+4.6%
2,10
20.990 US$
|
10 000
+4.6%
|
2,10
|
20.990 US$
|
|
|
2012-06-14 |
2012-06-12 |
B
Compra
|
ZENNER PATRICK J
Consejero no ejecutivo
|
4 000
+12.8%
6,47
25.871 US$
|
4 000
+12.8%
|
6,47
|
25.871 US$
|
|
|
2012-06-07 |
2012-06-06 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Oficial
|
4 754
+2.2%
6,24
29.684 US$
|
4 754
+2.2%
|
6,24
|
29.684 US$
|
|
|
2012-06-07 |
2012-06-06 |
B
Compra
|
Lawrence Peter S
President & COO
Oficial
|
1 000
+1.4%
6,25
6.254 US$
|
1 000
+1.4%
|
6,25
|
6.254 US$
|
|
|
2012-06-07 |
2012-06-06 |
B
Compra
|
SCHWARTZ BRIAN
Chief Medical Officer
Oficial
|
4 700
+20.0%
6,26
29.412 US$
|
4 700
+20.0%
|
6,26
|
29.412 US$
|
|
|
2011-12-05 |
2011-12-02 |
B
Compra
|
ZENNER PATRICK J
Consejero no ejecutivo
|
4 400
+16.4%
5,53
24.321 US$
|
4 400
+16.4%
|
5,53
|
24.321 US$
|
|
|
2011-09-01 |
2011-08-31 |
B
Compra
|
SCHWARTZ BRIAN
Chief Medical Officer
Oficial
|
4 000
+19.4%
4,41
17.621 US$
|
4 000
+19.4%
|
4,41
|
17.621 US$
|
|
|
2011-08-24 |
2011-08-24 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Consejero ejecutivo
|
6 600
+3.2%
4,45
29.376 US$
|
6 600
+3.2%
|
4,45
|
29.376 US$
|
|
|
2011-06-09 |
2011-06-07 |
B
Compra
|
LOBERG MICHAEL D
Consejero no ejecutivo
|
27 676
+68.0%
6,40
177.063 US$
|
27 676
+68.0%
|
6,40
|
177.063 US$
|
|
|
2011-05-26 |
2011-05-25 |
B
Compra
|
LOBERG MICHAEL D
Consejero no ejecutivo
|
1 398
+3.6%
6,32
8.838 US$
|
1 398
+3.6%
|
6,32
|
8.838 US$
|
|
|
2010-04-07 |
2010-04-05 |
S
Venta
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Gran accionista
|
354 000
-7.8%
6,13
2.170.303 US$
|
354 000
-7.8%
|
6,13
|
2.170.303 US$
|
|
|
2010-04-07 |
2010-04-05 |
S
Venta
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Gran accionista
|
102 000
-2.2%
6,13
625.342 US$
|
102 000
-2.2%
|
6,13
|
625.342 US$
|
|
|
2010-04-07 |
2010-04-05 |
S
Venta
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Gran accionista
|
147 000
-3.1%
6,13
901.228 US$
|
147 000
-3.1%
|
6,13
|
901.228 US$
|
|
|
2010-04-02 |
2010-04-01 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
653 000
-12.0%
5,81
3.794.779 US$
|
653 000
-12.0%
|
5,81
|
3.794.779 US$
|
|
|
2010-04-02 |
2010-04-01 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
188 000
-3.3%
5,81
1.092.524 US$
|
188 000
-3.3%
|
5,81
|
1.092.524 US$
|
|
|
2010-04-02 |
2010-04-01 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
272 000
-4.6%
5,81
1.580.674 US$
|
272 000
-4.6%
|
5,81
|
1.580.674 US$
|
|
|
2010-04-02 |
2010-03-31 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
1 548 000
-20.7%
6,24
9.660.758 US$
|
1 548 000
-20.7%
|
6,24
|
9.660.758 US$
|
|
|
2010-04-02 |
2010-03-31 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
447 000
-5.6%
6,24
2.789.638 US$
|
447 000
-5.6%
|
6,24
|
2.789.638 US$
|
|
|
2010-04-02 |
2010-03-31 |
S
Venta
|
BVF PARTNERS L P/IL
Gran accionista
|
645 000
-7.5%
6,24
4.025.316 US$
|
645 000
-7.5%
|
6,24
|
4.025.316 US$
|
|
|
2009-11-30 |
2009-11-25 |
B
Compra
|
ZENNER PATRICK J
Consejero no ejecutivo
|
6 900
+34.5%
3,58
24.734 US$
|
6 900
+34.5%
|
3,58
|
24.734 US$
|
|
|
2009-11-13 |
2009-11-12 |
B
Compra
|
Pucci Paolo
Chief Executive Officer
Consejero ejecutivo
|
5 000
+2.4%
3,48
17.420 US$
|
5 000
+2.4%
|
3,48
|
17.420 US$
|
|
|
2009-09-21 |
2009-09-17 |
S
Venta
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Gran accionista
|
2 100 000
-19.7%
5,25
11.025.000 US$
|
2 100 000
-19.7%
|
5,25
|
11.025.000 US$
|
|
|
2009-09-21 |
2009-09-17 |
S
Venta
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Gran accionista
|
660 000
-5.8%
5,25
3.465.000 US$
|
660 000
-5.8%
|
5,25
|
3.465.000 US$
|
|
|
2009-09-21 |
2009-09-17 |
S
Venta
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Gran accionista
|
920 000
-7.5%
5,25
4.830.000 US$
|
920 000
-7.5%
|
5,25
|
4.830.000 US$
|
|
|
2009-08-19 |
2009-08-18 |
B
Compra
|
BARABE TIMOTHY C
Consejero no ejecutivo
|
784
+3.1%
5,26
4.124 US$
|
784
+3.1%
|
5,26
|
4.124 US$
|
|
|
2009-08-19 |
2009-08-18 |
B
Compra
|
LOBERG MICHAEL D
Consejero no ejecutivo
|
356
+0.6%
5,26
1.873 US$
|
356
+0.6%
|
5,26
|
1.873 US$
|
|
|
2009-08-17 |
2009-08-13 |
B
Compra
|
LOBERG MICHAEL D
Consejero no ejecutivo
|
88
+0.1%
5,65
497 US$
|
88
+0.1%
|
5,65
|
497 US$
|
|
|
2009-08-06 |
2009-08-05 |
B
Compra
|
BARABE TIMOTHY C
Consejero no ejecutivo
|
104
+0.4%
5,73
596 US$
|
104
+0.4%
|
5,73
|
596 US$
|
|
|
2009-07-28 |
2009-07-24 |
B
Compra
|
BARABE TIMOTHY C
Consejero no ejecutivo
|
206
+0.8%
5,82
1.199 US$
|
206
+0.8%
|
5,82
|
1.199 US$
|
|
|
2009-07-28 |
2009-07-24 |
B
Compra
|
LOBERG MICHAEL D
Consejero no ejecutivo
|
171
+0.3%
5,82
995 US$
|
171
+0.3%
|
5,82
|
995 US$
|
|