|
2019-02-01 |
2019-01-30 |
Por favor
Venta prevista
|
SEE REMARKS
Oficial
|
61 606
+20.3%
239,50
2.250.308 US$
|
61 606
+20.3%
|
239,50
|
2.250.308 US$
|
|
|
2018-12-17 |
2018-12-17 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
81 801
-2.3%
466,25
84.815 US$
|
81 801
-2.3%
|
466,25
|
84.815 US$
|
|
|
2018-11-09 |
2018-11-07 |
Por favor
Venta prevista
|
HEINEN ERNST
Chief Development Officer
Oficial
|
49 501
-30.4%
263,83
143.362 US$
|
49 501
-30.4%
|
263,83
|
143.362 US$
|
|
|
2018-11-06 |
2018-11-02 |
Por favor
Venta prevista
|
HEINEN ERNST
Chief Development Officer
Oficial
|
692
-0.4%
6,95
4.809 US$
|
692
-0.4%
|
6,95
|
4.809 US$
|
|
|
2018-10-31 |
2018-10-30 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
11 513
-2.0%
5,86
67.454 US$
|
11 513
-2.0%
|
5,86
|
67.454 US$
|
|
|
2018-09-21 |
2018-09-21 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
75 000
-11.6%
6,06
454.305 US$
|
75 000
-11.6%
|
6,06
|
454.305 US$
|
|
|
2018-08-14 |
2018-08-14 |
Por favor
Venta prevista
|
HEINEN ERNST
Chief Development Officer
Oficial
|
1 712
-1.1%
5,15
8.817 US$
|
1 712
-1.1%
|
5,15
|
8.817 US$
|
|
|
2018-08-14 |
2018-08-13 |
Por favor
Venta prevista
|
HEINEN ERNST
Chief Development Officer
Oficial
|
8 660
-5.2%
5,15
44.599 US$
|
8 660
-5.2%
|
5,15
|
44.599 US$
|
|
|
2018-08-10 |
2018-08-10 |
Por favor
Venta prevista
|
HEINEN ERNST
Chief Development Officer
Oficial
|
1 954
-1.2%
5,15
10.063 US$
|
1 954
-1.2%
|
5,15
|
10.063 US$
|
|
|
2018-08-10 |
2018-08-08 |
Por favor
Venta prevista
|
HEINEN ERNST
Chief Development Officer
Oficial
|
2 674
-1.6%
5,15
13.771 US$
|
2 674
-1.6%
|
5,15
|
13.771 US$
|
|
|
2018-07-30 |
2018-07-30 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
11 513
-1.7%
4,33
49.842 US$
|
11 513
-1.7%
|
4,33
|
49.842 US$
|
|
|
2018-06-27 |
2018-06-25 |
Por favor
Venta prevista
|
Standridge Brent
Chief Operating Officer
Oficial
|
10 000
-9.1%
4,56
45.644 US$
|
10 000
-9.1%
|
4,56
|
45.644 US$
|
|
|
2018-02-01 |
2018-01-30 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
19 367
-2.8%
4,77
92.301 US$
|
19 367
-2.8%
|
4,77
|
92.301 US$
|
|
|
2018-01-12 |
2018-01-11 |
Por favor
Venta prevista
|
TOOMAN CRAIG A
CHIEF FINANCIAL OFFICER
Oficial
|
30 000
-28.6%
5,27
158.040 US$
|
30 000
-28.6%
|
5,27
|
158.040 US$
|
|
|
2017-12-01 |
2017-12-01 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
425 298
-9.0%
5,40
2.296.609 US$
|
425 298
-9.0%
|
5,40
|
2.296.609 US$
|
|
|
2017-12-01 |
2017-12-01 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
1 900
-0.0%
5,44
10.336 US$
|
1 900
-0.0%
|
5,44
|
10.336 US$
|
|
|
2017-12-01 |
2017-12-01 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
50 000
-1.0%
5,45
272.500 US$
|
50 000
-1.0%
|
5,45
|
272.500 US$
|
|
|
2017-12-01 |
2017-12-01 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
100
-0.0%
5,47
547 US$
|
100
-0.0%
|
5,47
|
547 US$
|
|
|
2017-12-01 |
2017-12-01 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
5 110
-0.1%
5,52
28.207 US$
|
5 110
-0.1%
|
5,52
|
28.207 US$
|
|
|
2017-12-01 |
2017-12-01 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
8 020
-0.2%
5,53
44.351 US$
|
8 020
-0.2%
|
5,53
|
44.351 US$
|
|
|
2017-12-01 |
2017-12-01 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
72 000
-1.5%
5,65
406.800 US$
|
72 000
-1.5%
|
5,65
|
406.800 US$
|
|
|
2017-12-01 |
2017-11-30 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
50 000
-1.0%
5,90
295.000 US$
|
50 000
-1.0%
|
5,90
|
295.000 US$
|
|
|
2017-12-01 |
2017-11-30 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
50 000
-1.0%
5,95
297.500 US$
|
50 000
-1.0%
|
5,95
|
297.500 US$
|
|
|
2017-12-01 |
2017-11-30 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
100 000
-2.0%
5,95
595.000 US$
|
100 000
-2.0%
|
5,95
|
595.000 US$
|
|
|
2017-12-01 |
2017-11-30 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
11 472
-0.2%
5,97
68.488 US$
|
11 472
-0.2%
|
5,97
|
68.488 US$
|
|
|
2017-12-01 |
2017-11-30 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
100
-0.0%
6,03
603 US$
|
100
-0.0%
|
6,03
|
603 US$
|
|
|
2017-12-01 |
2017-11-29 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
1 900
-0.0%
6,26
11.894 US$
|
1 900
-0.0%
|
6,26
|
11.894 US$
|
|
|
2017-12-01 |
2017-11-29 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
300
-0.0%
6,28
1.884 US$
|
300
-0.0%
|
6,28
|
1.884 US$
|
|
|
2017-12-01 |
2017-11-29 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
7 700
-0.2%
6,35
48.895 US$
|
7 700
-0.2%
|
6,35
|
48.895 US$
|
|
|
2017-12-01 |
2017-11-29 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
50 000
-1.0%
6,50
325.000 US$
|
50 000
-1.0%
|
6,50
|
325.000 US$
|
|
|
2017-12-01 |
2017-11-29 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
5 751
-0.1%
6,55
37.669 US$
|
5 751
-0.1%
|
6,55
|
37.669 US$
|
|
|
2017-12-01 |
2017-11-29 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
49 865
-1.0%
6,60
329.109 US$
|
49 865
-1.0%
|
6,60
|
329.109 US$
|
|
|
2017-12-01 |
2017-11-29 |
S
Venta
|
Broadfin Healthcare Master Fund Ltd
Gran accionista
|
1 000
-0.0%
6,66
6.660 US$
|
1 000
-0.0%
|
6,66
|
6.660 US$
|
|
|
2017-11-13 |
2017-11-10 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
50 000
-8.6%
7,00
350.000 US$
|
50 000
-8.6%
|
7,00
|
350.000 US$
|
|
|
2017-10-04 |
2017-10-02 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
50 000
-7.9%
6,24
312.115 US$
|
50 000
-7.9%
|
6,24
|
312.115 US$
|
|
|
2017-09-27 |
2017-09-25 |
Por favor
Venta prevista
|
Standridge Brent
Chief Operating Officer
|
10 000
-12.5%
6,11
61.127 US$
|
10 000
-12.5%
|
6,11
|
61.127 US$
|
|
|
2017-09-19 |
2017-09-15 |
Por favor
Venta prevista
|
HEINEN ERNST
Chief Development Officer
|
10 000
-7.1%
6,25
62.500 US$
|
10 000
-7.1%
|
6,25
|
62.500 US$
|
|
|
2017-04-18 |
2017-04-17 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
50 000
-7.9%
5,54
277.150 US$
|
50 000
-7.9%
|
5,54
|
277.150 US$
|
|
|
2017-01-31 |
2017-01-27 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
50 000
-7.3%
7,72
385.875 US$
|
50 000
-7.3%
|
7,72
|
385.875 US$
|
|
|
2016-12-16 |
2016-12-15 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
50 000
-8.4%
7,63
381.380 US$
|
50 000
-8.4%
|
7,63
|
381.380 US$
|
|
|
2016-10-04 |
2016-10-03 |
Por favor
Venta prevista
|
HEINEN ERNST
Chief Development Officer
Oficial
|
10 000
-8.0%
10,00
100.006 US$
|
10 000
-8.0%
|
10,00
|
100.006 US$
|
|
|
2016-09-12 |
2016-09-09 |
Por favor
Venta prevista
|
TOOMAN CRAIG A
CHIEF FINANCIAL OFFICER
Oficial
|
30 000
-29.3%
9,25
277.599 US$
|
30 000
-29.3%
|
9,25
|
277.599 US$
|
|
|
2016-08-10 |
2016-08-09 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
50 000
-7.2%
9,25
462.500 US$
|
50 000
-7.2%
|
9,25
|
462.500 US$
|
|
|
2016-06-28 |
2016-06-28 |
Por favor
Venta prevista
|
STEPHANUS JULIA A
CHIEF COMMERCIAL OFFICER
Oficial
|
30 000
-19.0%
6,25
187.500 US$
|
30 000
-19.0%
|
6,25
|
187.500 US$
|
|
|
2016-06-17 |
2016-06-17 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
25 000
-3.5%
6,32
158.020 US$
|
25 000
-3.5%
|
6,32
|
158.020 US$
|
|
|
2016-06-17 |
2016-06-16 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
75 000
-9.5%
6,24
468.292 US$
|
75 000
-9.5%
|
6,24
|
468.292 US$
|
|
|
2016-06-13 |
2016-06-10 |
Por favor
Venta prevista
|
HEINEN ERNST
Chief Development Officer
Oficial
|
15 000
-10.7%
6,72
100.862 US$
|
15 000
-10.7%
|
6,72
|
100.862 US$
|
|
|
2016-02-02 |
2016-02-01 |
Por favor
Venta prevista
|
TOOMAN CRAIG A
CHIEF FINANCIAL OFFICER
Oficial
|
2 806
-2.7%
3,36
9.436 US$
|
2 806
-2.7%
|
3,36
|
9.436 US$
|
|
|
2015-04-28 |
2015-04-27 |
Por favor
Venta prevista
|
Rhodes Linda
CHIEF SCIENTIFIC OFFICER
Oficial
|
3 300
-0.8%
15,78
52.073 US$
|
3 300
-0.8%
|
15,78
|
52.073 US$
|
|
|
2015-04-28 |
2015-04-27 |
Por favor
Venta prevista
|
Rhodes Linda
CHIEF SCIENTIFIC OFFICER
Oficial
|
11 700
-2.7%
14,78
172.912 US$
|
11 700
-2.7%
|
14,78
|
172.912 US$
|
|
|
2015-01-06 |
2015-01-02 |
Por favor
Venta prevista
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
25 000
-3.5%
17,87
446.648 US$
|
25 000
-3.5%
|
17,87
|
446.648 US$
|
|
|
2014-03-12 |
2014-03-10 |
S
Venta
|
MPM BIOVENTURES V, L.P.
Gran accionista
|
600 000
-17.9%
20,02
12.012.000 US$
|
600 000
-17.9%
|
20,02
|
12.012.000 US$
|
|
|
2014-03-11 |
2014-03-07 |
S
Venta
|
Foley Todd
Gran accionista
|
12 539
-100.0%
19,95
250.153 US$
|
12 539
-100.0%
|
19,95
|
250.153 US$
|
|
|
2014-03-11 |
2014-03-07 |
S
Venta
|
GADICKE ANSBERT
Gran accionista
|
26 713
-100.0%
20,16
538.534 US$
|
26 713
-100.0%
|
20,16
|
538.534 US$
|
|
|
2014-02-05 |
2014-02-03 |
S
Venta
|
MEEUSEN RONALD L
Consejero no ejecutivo
|
45 100
-37.4%
19,00
856.900 US$
|
45 100
-37.4%
|
19,00
|
856.900 US$
|
|
|
2014-02-05 |
2014-02-03 |
S
Venta
|
MEEUSEN RONALD L
Consejero no ejecutivo
|
454 900
-37.4%
19,00
8.643.100 US$
|
454 900
-37.4%
|
19,00
|
8.643.100 US$
|
|
|
2014-02-05 |
2014-02-03 |
S
Venta
|
Avalon Ventures IX, L.P.
Gran accionista
|
825 000
-19.8%
19,00
15.675.000 US$
|
825 000
-19.8%
|
19,00
|
15.675.000 US$
|
|
|
2014-02-05 |
2014-02-03 |
S
Venta
|
Lichter Jay
Consejero no ejecutivo
Gran accionista
|
825 000
-19.8%
19,00
15.675.000 US$
|
825 000
-19.8%
|
19,00
|
15.675.000 US$
|
|
|
2013-07-03 |
2013-07-02 |
B
Compra
|
St Peter Steven
PRESIDENT AND CEO
Consejero ejecutivo
|
8 333
+1.6%
6,00
49.998 US$
|
8 333
+1.6%
|
6,00
|
49.998 US$
|
|
|
2013-07-03 |
2013-07-02 |
B
Compra
|
STEPHANUS JULIA A
CHIEF COMMERCIAL OFFICER
Oficial
|
2 000
+1.5%
6,00
12.000 US$
|
2 000
+1.5%
|
6,00
|
12.000 US$
|
|
|
2013-07-02 |
2013-07-02 |
B
Compra
|
Vander Vort John
Consejero no ejecutivo
Gran accionista
|
500 000
+13.0%
6,00
3.000.000 US$
|
500 000
+13.0%
|
6,00
|
3.000.000 US$
|
|
|
2013-07-02 |
2013-07-02 |
B
Compra
|
MPM BIOVENTURES V, L.P.
Gran accionista
|
500 000
+13.0%
6,00
3.000.000 US$
|
500 000
+13.0%
|
6,00
|
3.000.000 US$
|
|