United States Biotechnology & Medical Research

Cytokinetics Inc (CYTK)

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Over the last 90 days, Cytokinetics Inc. has seen significant insider selling, with a net value of over $16.9 million. Executives contributed substantially to this net sell-off. Notable transactions include sales by the President & CEO, EVP of Commercial, and EVP of R&D, totaling millions in value. The stock has seen a 14.1% increase in the last 90 days.

Top insider sells (90, 60, 30, 7d)

Top cluster sells (90, 60, 30d)

Top executive sells (90, 60, 30d)

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Stock chart

Ticker: CYTK Exchange: NSM

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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Trades

Malik Fady Ibraham

EVP Research & Development

1 sale — total 100,000 USD

Sale 9 Jun 2026

Value US$4,904,918.41 | Price 259.84 | Shares 94,725

Kaye Edward M. MD

1 sale — total 100,000 USD

Sale 1 Jun 2026

Value US$4,183,071.75 | Price 456.45 | Shares 27,540

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 100,000 USD

Sale 1 Jun 2026

Value US$100,000.00 | Price 74.08 | Shares 1,000

PARSHALL B LYNNE

1 sale — total 100,000 USD

Sale 1 Jun 2026

Value US$100,000.00 | Price 74.08 | Shares 1,000

EDWARD KAYE

Director

1 sale — total 100,000 USD

Proposed sale 1 Jun 2026

Value US$100,000.00 | Price 76.76 | Shares 1,000

Blum Robert I

President & CEO

1 sale — total 100,000 USD

Sale 27 May 2026

Value US$100,000.00 | Price 77.21 | Shares 1,000

Malik Fady Ibraham

EVP Research & Development

1 sale — total 264,915 USD

Sale 19 May 2026

Value US$264,915.00 | Price 75.69 | Shares 3,500

Blum Robert I

President & CEO

1 sale — total 584,400 USD

Sale 14 May 2026

Value US$584,400.00 | Price 77.92 | Shares 7,500

Malik Fady Ibraham

EVP Research & Development

1 sale — total 270,795 USD

Sale 5 May 2026

Value US$270,795.00 | Price 77.37 | Shares 3,500

WENDELL WIERENGA

Director

1 sale — total 266,314 USD

Proposed sale 5 May 2026

Value US$266,313.60 | Price 66.05 | Shares 4,032

JOHN HENDERSON

Director

1 sale — total 1,321,000 USD

Proposed sale 5 May 2026

Value US$1,321,000.00 | Price 66.05 | Shares 20,000

SUNG LEE

Officer

1 sale — total 1,578,991 USD

Proposed sale 5 May 2026

Value US$1,578,991.30 | Price 66.05 | Shares 23,906

WIERENGA WENDELL

1 sale — total 302,400 USD

Sale 5 May 2026

Value US$302,400.00 | Price 75.00 | Shares 4,032

Lee Sung

EVP, Chief Financial Officer

1 sale — total 1,837,654 USD

Sale 5 May 2026

Value US$1,837,654.22 | Price 76.87 | Shares 23,906

HENDERSON JOHN T

1 sale — total 1,519,400 USD

Sale 5 May 2026

Value US$1,519,400.00 | Price 75.97 | Shares 20,000

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 875,474 USD

Sale 5 May 2026

Value US$875,474.25 | Price 77.25 | Shares 11,333

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 1,030,705 USD

Sale 1 May 2026

Value US$1,030,705.00 | Price 65.00 | Shares 15,857

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 948,900 USD

Sale 30 Apr 2026

Value US$948,900.00 | Price 63.26 | Shares 15,000

Blum Robert I

President & CEO

1 sale — total 447,150 USD

Sale 29 Apr 2026

Value US$447,150.00 | Price 59.62 | Shares 7,500

Malik Fady Ibraham

EVP Research & Development

1 sale — total 229,915 USD

Sale 21 Apr 2026

Value US$229,915.00 | Price 65.69 | Shares 3,500

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 491,783 USD

Sale 15 Apr 2026

Value US$491,782.98 | Price 66.02 | Shares 7,449

Blum Robert I

President & CEO

1 sale — total 490,350 USD

Sale 15 Apr 2026

Value US$490,350.00 | Price 65.38 | Shares 7,500

ANDREW CALLOS

Officer

1 sale — total 5,284,048 USD

Proposed sale 15 Apr 2026

Value US$5,284,047.65 | Price 66.35 | Shares 79,639

Malik Fady Ibraham

EVP Research & Development

2 sales — total 292,985 USD

Sale 7 Apr 2026

Value US$64,750.00 | Price 64.75 | Shares 1,000

Sale 7 Apr 2026

Value US$228,235.00 | Price 65.21 | Shares 3,500

FADY MALIK

Officer

1 sale — total 1,428,680 USD

Proposed sale 7 Apr 2026

Value US$1,428,680.00 | Price 64.94 | Shares 22,000

Blum Robert I

President & CEO

1 sale — total 499,725 USD

Sale 1 Apr 2026

Value US$499,725.00 | Price 66.63 | Shares 7,500

ROBERT BLUM

Director; Officer

1 sale — total 2,965,950 USD

Proposed sale 1 Apr 2026

Value US$2,965,950.00 | Price 65.91 | Shares 45,000

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 236,535 USD

Sale 31 Mar 2026

Value US$236,535.00 | Price 65.00 | Shares 3,639

ANDREW CALLOS

Officer

1 sale — total 229,148 USD

Proposed sale 31 Mar 2026

Value US$229,147.83 | Price 62.97 | Shares 3,639

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 119,795 USD

Sale 18 Mar 2026

Value US$119,795.10 | Price 62.07 | Shares 1,930

ANDREW CALLOS

Officer

1 sale — total 119,911 USD

Proposed sale 18 Mar 2026

Value US$119,910.90 | Price 62.13 | Shares 1,930

Lee Sung

EVP, Chief Financial Officer

1 sale — total 306,710 USD

Sale 17 Mar 2026

Value US$306,710.25 | Price 62.15 | Shares 4,935

Callos Andrew

EVP, Chief Commercial Officer

2 sales — total 530,885 USD

Sale 17 Mar 2026

Value US$181,229.40 | Price 62.15 | Shares 2,916

Sale 17 Mar 2026

Value US$349,655.90 | Price 62.15 | Shares 5,626

Malik Fady Ibraham

EVP Research & Development

2 sales — total 747,851 USD

Sale 17 Mar 2026

Value US$273,273.55 | Price 62.15 | Shares 4,397

Sale 17 Mar 2026

Value US$474,577.40 | Price 62.15 | Shares 7,636

Blum Robert I

President & CEO

2 sales — total 2,274,752 USD

Sale 17 Mar 2026

Value US$1,487,125.20 | Price 62.15 | Shares 23,928

Sale 17 Mar 2026

Value US$787,626.95 | Price 62.15 | Shares 12,673

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 104,300 USD

Sale 16 Mar 2026

Value US$104,300.27 | Price 61.03 | Shares 1,709

ANDREW CALLOS

Officer

1 sale — total 102,643 USD

Proposed sale 16 Mar 2026

Value US$102,642.54 | Price 60.06 | Shares 1,709

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 156,779 USD

Sale 9 Mar 2026

Value US$156,779.04 | Price 60.72 | Shares 2,582

Blum Robert I

President & CEO

1 sale — total 481,570 USD

Sale 9 Mar 2026

Value US$481,570.32 | Price 60.72 | Shares 7,931

Malik Fady Ibraham

EVP Research & Development

1 sale — total 176,513 USD

Sale 9 Mar 2026

Value US$176,513.04 | Price 60.72 | Shares 2,907

Callos Andrew

EVP, Chief Commercial Officer

2 sales — total 1,608,730 USD

Sale 5 Mar 2026

Value US$680,680.00 | Price 61.88 | Shares 11,000

Sale 5 Mar 2026

Value US$928,050.00 | Price 61.87 | Shares 15,000

PARSHALL B LYNNE

1 sale — total 306,050 USD

Sale 2 Mar 2026

Value US$306,050.00 | Price 61.21 | Shares 5,000

B LYNNE PARSHALL

Director

1 sale — total 622,200 USD

Proposed sale 2 Mar 2026

Value US$622,200.00 | Price 62.22 | Shares 10,000

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 54,595 USD

Sale 2 Mar 2026

Value US$54,595.32 | Price 61.62 | Shares 886

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 928,950 USD

Sale 5 Feb 2026

Value US$928,950.00 | Price 61.93 | Shares 15,000

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 55,021 USD

Sale 2 Feb 2026

Value US$55,020.60 | Price 62.10 | Shares 886

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 904,200 USD

Sale 5 Jan 2026

Value US$904,200.00 | Price 60.28 | Shares 15,000

ANDREW CALLOS

Officer

1 sale — total 3,785,078 USD

Proposed sale 2 Jan 2026

Value US$3,785,077.80 | Price 63.54 | Shares 59,570

Callos Andrew

EVP, Chief Commercial Officer

2 sales — total 112,585 USD

Sale 2 Jan 2026

Value US$55,896.60 | Price 63.16 | Shares 885

Sale 2 Jan 2026

Value US$56,688.17 | Price 62.09 | Shares 913

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 112,954 USD

Sale 29 Dec 2025

Value US$112,953.96 | Price 62.44 | Shares 1,809

ANDREW CALLOS

Officer

1 sale — total 114,166 USD

Proposed sale 29 Dec 2025

Value US$114,165.99 | Price 63.11 | Shares 1,809

WIERENGA WENDELL

1 sale — total 1,322,800 USD

Sale 22 Dec 2025

Value US$1,322,800.00 | Price 66.14 | Shares 20,000

WENDELL WIERENGA

Director

1 sale — total 1,254,400 USD

Proposed sale 22 Dec 2025

Value US$1,254,400.00 | Price 62.72 | Shares 20,000

Malik Fady Ibraham

EVP Research & Development

1 sale — total 134,728 USD

Sale 16 Dec 2025

Value US$134,728.00 | Price 61.24 | Shares 2,200

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 68,730 USD

Sale 8 Dec 2025

Value US$68,730.32 | Price 65.96 | Shares 1,042

ANDREW CALLOS

Officer

1 sale — total 3,561,753 USD

Proposed sale 5 Dec 2025

Value US$3,561,753.12 | Price 66.54 | Shares 53,528

Callos Andrew

EVP, Chief Commercial Officer

1 sale — total 3,461,452 USD

Sale 5 Dec 2025

Value US$3,461,451.70 | Price 65.95 | Shares 52,486

JOHN T HENDERSON

Director

1 sale — total 577,938 USD

Proposed sale 2 Dec 2025

Value US$577,937.50 | Price 66.05 | Shares 8,750

Malik Fady Ibraham

EVP Research & Development

1 sale — total 140,558 USD

Sale 2 Dec 2025

Value US$140,558.00 | Price 63.89 | Shares 2,200

HENDERSON JOHN T

1 sale — total 559,125 USD

Sale 2 Dec 2025

Value US$559,125.00 | Price 63.90 | Shares 8,750

Harrington Robert Arthur

1 sale — total 143,620 USD

Sale 1 Dec 2025

Value US$143,620.00 | Price 66.80 | Shares 2,150

Kaye Edward M. MD

1 sale — total 1,872,430 USD

Sale 1 Dec 2025

Value US$1,872,430.08 | Price 66.72 | Shares 28,064

EDWARD KAYE

Director

1 sale — total 1,912,000 USD

Proposed sale 1 Dec 2025

Value US$1,912,000.32 | Price 68.13 | Shares 28,064

B LYNNE PARSHALL

Director

1 sale — total 330,800 USD

Proposed sale 19 Nov 2025

Value US$330,800.00 | Price 66.16 | Shares 5,000

PARSHALL B LYNNE

1 sale — total 323,650 USD

Sale 19 Nov 2025

Value US$323,650.00 | Price 64.73 | Shares 5,000

Malik Fady Ibraham

EVP Research & Development

1 sale — total 146,190 USD

Sale 18 Nov 2025

Value US$146,190.00 | Price 66.45 | Shares 2,200

EDWARD KAYE

Director

1 sale — total 321,885 USD

Proposed sale 11 Nov 2025

Value US$321,885.00 | Price 62.20 | Shares 5,175

Kaye Edward M. MD

1 sale — total 336,789 USD

Sale 11 Nov 2025

Value US$336,789.00 | Price 65.08 | Shares 5,175

Malik Fady Ibraham

EVP Research & Development

1 sale — total 136,667 USD

Sale 4 Nov 2025

Value US$136,667.25 | Price 59.55 | Shares 2,295

Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Insider and/or position	Nb. shares Price Value	Number of shares	Price	Value
2026-06-09	2026-06-09	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	94,725 +12.0% 259.84 US$4,904,918	94,725 +12.0%	259.84	US$4,904,918
2026-06-01	2026-06-01	S Sale	2.8 Kaye Edward M. MD Non-Executive Director	27,540 -49.6% 456.45 US$4,183,072	27,540 -49.6%	456.45	US$4,183,072
2026-06-01	2026-06-01	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	10,837 -2.3% 409.21 US$4,640,578	10,837 -2.3%	409.21	US$4,640,578
2026-06-01	2026-06-01	S Sale	3.9 PARSHALL B LYNNE Non-Executive Director	1,000 -24.1% 74.08 US$100,000	1,000 -24.1%	74.08	US$100,000
2026-06-01	2026-06-01	PrS Proposed sale	2.8 EDWARD KAYE Director Non-Executive Director	1,000 76.76 US$100,000	1,000	76.76	US$100,000
2026-05-28	2026-05-27	S Sale	2.7 Blum Robert I President & CEO Executive Director	1,000 -1.9% 77.21 US$100,000	1,000 -1.9%	77.21	US$100,000
2026-05-20	2026-05-19	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	3,500 -2.2% 75.69 US$264,915	3,500 -2.2%	75.69	US$264,915
2026-05-14	2026-05-14	S Sale	2.7 Blum Robert I President & CEO Executive Director	7,500 -1.8% 77.92 US$584,400	7,500 -1.8%	77.92	US$584,400
2026-05-05	2026-05-05	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	3,500 -2.2% 77.37 US$270,795	3,500 -2.2%	77.37	US$270,795
2026-05-05	2026-05-05	PrS Proposed sale	2.8 WENDELL WIERENGA Director Non-Executive Director	4,032 66.05 US$266,314	4,032	66.05	US$266,314
2026-05-05	2026-05-05	PrS Proposed sale	3.7 JOHN HENDERSON Director Non-Executive Director	20,000 66.05 US$1,321,000	20,000	66.05	US$1,321,000
2026-05-05	2026-05-05	PrS Proposed sale	2.4 SUNG LEE Officer Officer	23,906 66.05 US$1,578,991	23,906	66.05	US$1,578,991
2026-05-05	2026-05-05	S Sale	2.8 WIERENGA WENDELL Non-Executive Director	4,032 -11.0% 75.00 US$302,400	4,032 -11.0%	75.00	US$302,400
2026-05-05	2026-05-05	S Sale	2.4 Lee Sung EVP, Chief Financial Officer Officer	23,906 -27.4% 76.87 US$1,837,654	23,906 -27.4%	76.87	US$1,837,654
2026-05-05	2026-05-05	S Sale	3.7 HENDERSON JOHN T Non-Executive Director	20,000 -21.0% 75.97 US$1,519,400	20,000 -21.0%	75.97	US$1,519,400
2026-05-05	2026-05-05	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	11,333 -16.2% 77.25 US$875,474	11,333 -16.2%	77.25	US$875,474
2026-05-04	2026-05-01	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	15,857 -21.3% 65.00 US$1,030,705	15,857 -21.3%	65.00	US$1,030,705
2026-04-30	2026-04-30	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	15,000 -20.4% 63.26 US$948,900	15,000 -20.4%	63.26	US$948,900
2026-04-29	2026-04-29	S Sale	2.7 Blum Robert I President & CEO Executive Director	7,500 -1.8% 59.62 US$447,150	7,500 -1.8%	59.62	US$447,150
2026-04-21	2026-04-21	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	3,500 -2.2% 65.69 US$229,915	3,500 -2.2%	65.69	US$229,915
2026-04-15	2026-04-15	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	7,449 -11.3% 66.02 US$491,783	7,449 -11.3%	66.02	US$491,783
2026-04-15	2026-04-15	S Sale	2.7 Blum Robert I President & CEO Executive Director	7,500 -1.8% 65.38 US$490,350	7,500 -1.8%	65.38	US$490,350
2026-04-15	2026-04-15	PrS Proposed sale	3.1 ANDREW CALLOS Officer Officer	79,639 66.35 US$5,284,048	79,639	66.35	US$5,284,048
2026-04-08	2026-04-07	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	1,000 -0.6% 64.75 US$64,750	1,000 -0.6%	64.75	US$64,750
2026-04-08	2026-04-07	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	3,500 -2.2% 65.21 US$228,235	3,500 -2.2%	65.21	US$228,235
2026-04-07	2026-04-07	PrS Proposed sale	3.8 FADY MALIK Officer Officer	22,000 64.94 US$1,428,680	22,000	64.94	US$1,428,680
2026-04-01	2026-04-01	S Sale	2.7 Blum Robert I President & CEO Executive Director	7,500 -1.7% 66.63 US$499,725	7,500 -1.7%	66.63	US$499,725
2026-04-01	2026-04-01	PrS Proposed sale	2.7 ROBERT BLUM Director; Officer Executive Director	45,000 65.91 US$2,965,950	45,000	65.91	US$2,965,950
2026-03-31	2026-03-31	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	3,639 -5.2% 65.00 US$236,535	3,639 -5.2%	65.00	US$236,535
2026-03-31	2026-03-31	PrS Proposed sale	3.1 ANDREW CALLOS Officer Officer	3,639 62.97 US$229,148	3,639	62.97	US$229,148
2026-03-18	2026-03-18	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	1,930 -2.4% 62.07 US$119,795	1,930 -2.4%	62.07	US$119,795
2026-03-18	2026-03-18	PrS Proposed sale	3.1 ANDREW CALLOS Officer Officer	1,930 62.13 US$119,911	1,930	62.13	US$119,911
2026-03-18	2026-03-17	S Sale	2.4 Lee Sung EVP, Chief Financial Officer Officer	4,935 -5.4% 62.15 US$306,710	4,935 -5.4%	62.15	US$306,710
2026-03-18	2026-03-17	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	2,916 -3.9% 62.15 US$181,229	2,916 -3.9%	62.15	US$181,229
2026-03-18	2026-03-17	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	5,626 -7.0% 62.15 US$349,656	5,626 -7.0%	62.15	US$349,656
2026-03-18	2026-03-17	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	4,397 -2.8% 62.15 US$273,274	4,397 -2.8%	62.15	US$273,274
2026-03-18	2026-03-17	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	7,636 -4.6% 62.15 US$474,577	7,636 -4.6%	62.15	US$474,577
2026-03-18	2026-03-17	S Sale	2.7 Blum Robert I President & CEO Executive Director	23,928 -5.3% 62.15 US$1,487,125	23,928 -5.3%	62.15	US$1,487,125
2026-03-18	2026-03-17	S Sale	2.7 Blum Robert I President & CEO Executive Director	12,673 -2.7% 62.15 US$787,627	12,673 -2.7%	62.15	US$787,627
2026-03-16	2026-03-16	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	1,709 -3.6% 61.03 US$104,300	1,709 -3.6%	61.03	US$104,300
2026-03-16	2026-03-16	PrS Proposed sale	3.1 ANDREW CALLOS Officer Officer	1,709 60.06 US$102,643	1,709	60.06	US$102,643
2026-03-10	2026-03-09	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	2,582 -5.1% 60.72 US$156,779	2,582 -5.1%	60.72	US$156,779
2026-03-10	2026-03-09	S Sale	2.7 Blum Robert I President & CEO Executive Director	7,931 -2.0% 60.72 US$481,570	7,931 -2.0%	60.72	US$481,570
2026-03-10	2026-03-09	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	2,907 -2.1% 60.72 US$176,513	2,907 -2.1%	60.72	US$176,513
2026-03-05	2026-03-05	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	11,000 -17.9% 61.88 US$680,680	11,000 -17.9%	61.88	US$680,680
2026-03-05	2026-03-05	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	15,000 -19.6% 61.87 US$928,050	15,000 -19.6%	61.87	US$928,050
2026-03-02	2026-03-02	S Sale	3.9 PARSHALL B LYNNE Non-Executive Director	5,000 -21.8% 61.21 US$306,050	5,000 -21.8%	61.21	US$306,050
2026-03-02	2026-03-02	PrS Proposed sale	3.9 B LYNNE PARSHALL Director Non-Executive Director	10,000 62.22 US$622,200	10,000	62.22	US$622,200
2026-03-02	2026-03-02	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	886 -1.7% 61.62 US$54,595	886 -1.7%	61.62	US$54,595
2026-02-05	2026-02-05	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	15,000 -22.9% 61.93 US$928,950	15,000 -22.9%	61.93	US$928,950
2026-02-02	2026-02-02	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	886 -1.7% 62.10 US$55,021	886 -1.7%	62.10	US$55,021
2026-01-05	2026-01-05	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	15,000 -22.9% 60.28 US$904,200	15,000 -22.9%	60.28	US$904,200
2026-01-02	2026-01-02	PrS Proposed sale	3.1 ANDREW CALLOS Officer Officer	59,570 63.54 US$3,785,078	59,570	63.54	US$3,785,078
2026-01-02	2026-01-02	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	885 -1.7% 63.16 US$55,897	885 -1.7%	63.16	US$55,897
2026-01-02	2026-01-02	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	913 -1.8% 62.09 US$56,688	913 -1.8%	62.09	US$56,688
2025-12-30	2025-12-29	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	1,809 -3.4% 62.44 US$112,954	1,809 -3.4%	62.44	US$112,954
2025-12-29	2025-12-29	PrS Proposed sale	3.1 ANDREW CALLOS Officer Officer	1,809 63.11 US$114,166	1,809	63.11	US$114,166
2025-12-23	2025-12-22	S Sale	2.8 WIERENGA WENDELL Non-Executive Director	20,000 -38.1% 66.14 US$1,322,800	20,000 -38.1%	66.14	US$1,322,800
2025-12-22	2025-12-22	PrS Proposed sale	2.8 WENDELL WIERENGA Director Non-Executive Director	20,000 62.72 US$1,254,400	20,000	62.72	US$1,254,400
2025-12-16	2025-12-16	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	2,200 -1.6% 61.24 US$134,728	2,200 -1.6%	61.24	US$134,728
2025-12-08	2025-12-08	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	1,042 -2.0% 65.96 US$68,730	1,042 -2.0%	65.96	US$68,730
2025-12-05	2025-12-05	PrS Proposed sale	3.1 ANDREW CALLOS Officer Officer	53,528 66.54 US$3,561,753	53,528	66.54	US$3,561,753
2025-12-05	2025-12-05	S Sale	3.1 Callos Andrew EVP, Chief Commercial Officer Officer	52,486 -50.9% 65.95 US$3,461,452	52,486 -50.9%	65.95	US$3,461,452
2025-12-02	2025-12-02	PrS Proposed sale	3.7 JOHN T HENDERSON Director Non-Executive Director	8,750 66.05 US$577,938	8,750	66.05	US$577,938
2025-12-02	2025-12-02	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	2,200 -1.5% 63.89 US$140,558	2,200 -1.5%	63.89	US$140,558
2025-12-02	2025-12-02	S Sale	3.7 HENDERSON JOHN T Non-Executive Director	8,750 -10.5% 63.90 US$559,125	8,750 -10.5%	63.90	US$559,125
2025-12-02	2025-12-01	S Sale	2.7 Harrington Robert Arthur Non-Executive Director	2,150 -10.4% 66.80 US$143,620	2,150 -10.4%	66.80	US$143,620
2025-12-02	2025-12-01	S Sale	2.8 Kaye Edward M. MD Non-Executive Director	28,064 -73.8% 66.72 US$1,872,430	28,064 -73.8%	66.72	US$1,872,430
2025-12-01	2025-12-01	PrS Proposed sale	2.8 EDWARD KAYE Director Non-Executive Director	28,064 68.13 US$1,912,000	28,064	68.13	US$1,912,000
2025-11-19	2025-11-19	PrS Proposed sale	3.9 B LYNNE PARSHALL Director Non-Executive Director	5,000 66.16 US$330,800	5,000	66.16	US$330,800
2025-11-19	2025-11-19	S Sale	3.9 PARSHALL B LYNNE Non-Executive Director	5,000 -17.9% 64.73 US$323,650	5,000 -17.9%	64.73	US$323,650
2025-11-18	2025-11-18	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	2,200 -1.5% 66.45 US$146,190	2,200 -1.5%	66.45	US$146,190
2025-11-12	2025-11-11	PrS Proposed sale	2.8 EDWARD KAYE Director Non-Executive Director	5,175 62.20 US$321,885	5,175	62.20	US$321,885
2025-11-12	2025-11-11	S Sale	2.8 Kaye Edward M. MD Non-Executive Director	5,175 -34.2% 65.08 US$336,789	5,175 -34.2%	65.08	US$336,789
2025-11-04	2025-11-04	S Sale	3.8 Malik Fady Ibraham EVP Research & Development Officer	2,295 -1.6% 59.55 US$136,667	2,295 -1.6%	59.55	US$136,667