|
2026-05-28 |
2026-05-26 |
PlS
Vente planifiée
|
Administrateur non-exécutif
|
10 440
+32.2%
430,09
2 022 599 $US
|
10 440
+32.2%
|
430,09
|
2 022 599 $US
|
|
|
2026-05-26 |
2026-05-26 |
PrS
Vente proposée
|
Director
Administrateur non-exécutif
|
96 367
227,14
1 962 193 $US
|
96 367
|
227,14
|
1 962 193 $US
|
|
|
2026-02-24 |
2026-02-20 |
V
Vente
|
Administrateur non-exécutif
|
10 019
-39.7%
120,94
4 664 552 $US
|
10 019
-39.7%
|
120,94
|
4 664 552 $US
|
|
|
2026-02-20 |
2026-02-20 |
PrS
Vente proposée
|
Director
Administrateur non-exécutif
|
4 000
36,36
145 440 $US
|
4 000
|
36,36
|
145 440 $US
|
|
|
2025-02-06 |
2025-02-05 |
V
Vente
|
EVP, Chief Commercial Officer
Dirigeant
|
1 796
-3.4%
21,93
39 379 $US
|
1 796
-3.4%
|
21,93
|
39 379 $US
|
|
|
2025-02-06 |
2025-02-05 |
V
Vente
|
EVP, GC, CCO & Corp Sec
Dirigeant
|
1 339
-3.3%
21,93
29 359 $US
|
1 339
-3.3%
|
21,93
|
29 359 $US
|
|
|
2025-02-06 |
2025-02-05 |
V
Vente
|
CEO, President
Administrateur exécutif
|
4 400
-1.8%
21,93
96 474 $US
|
4 400
-1.8%
|
21,93
|
96 474 $US
|
|
|
2025-02-06 |
2025-02-05 |
V
Vente
|
EVP & Chief Financial Officer
Dirigeant
|
1 734
-2.9%
21,93
38 020 $US
|
1 734
-2.9%
|
21,93
|
38 020 $US
|
|
|
2025-02-05 |
2025-02-05 |
PrS
Vente proposée
|
Officer
Dirigeant
|
1 796
21,93
39 379 $US
|
1 796
|
21,93
|
39 379 $US
|
|
|
2025-02-05 |
2025-02-05 |
PrS
Vente proposée
|
Officer
Dirigeant
|
1 734
21,93
38 020 $US
|
1 734
|
21,93
|
38 020 $US
|
|
|
2025-02-05 |
2025-02-05 |
PrS
Vente proposée
|
Officer
Dirigeant
|
1 339
21,93
29 359 $US
|
1 339
|
21,93
|
29 359 $US
|
|
|
2025-02-05 |
2025-02-05 |
PrS
Vente proposée
|
Officer; Director
Administrateur exécutif
|
4 400
21,93
96 474 $US
|
4 400
|
21,93
|
96 474 $US
|
|
|
2025-02-06 |
2025-02-04 |
V
Vente
|
EVP, Chief Commercial Officer
Dirigeant
|
2 125
-3.8%
20,92
44 457 $US
|
2 125
-3.8%
|
20,92
|
44 457 $US
|
|
|
2025-02-06 |
2025-02-04 |
V
Vente
|
EVP, GC, CCO & Corp Sec
Dirigeant
|
1 448
-3.5%
20,92
30 294 $US
|
1 448
-3.5%
|
20,92
|
30 294 $US
|
|
|
2025-02-06 |
2025-02-04 |
V
Vente
|
CEO, President
Administrateur exécutif
|
4 952
-2.0%
20,92
103 601 $US
|
4 952
-2.0%
|
20,92
|
103 601 $US
|
|
|
2025-02-06 |
2025-02-04 |
V
Vente
|
EVP & Chief Financial Officer
Dirigeant
|
2 036
-3.3%
20,92
42 595 $US
|
2 036
-3.3%
|
20,92
|
42 595 $US
|
|
|
2025-02-04 |
2025-02-04 |
PrS
Vente proposée
|
Officer
Dirigeant
|
2 036
20,92
42 596 $US
|
2 036
|
20,92
|
42 596 $US
|
|
|
2025-02-04 |
2025-02-04 |
PrS
Vente proposée
|
Officer; Director
Administrateur exécutif
|
4 952
20,92
103 602 $US
|
4 952
|
20,92
|
103 602 $US
|
|
|
2025-02-04 |
2025-02-04 |
PrS
Vente proposée
|
Officer
Dirigeant
|
1 448
20,92
30 294 $US
|
1 448
|
20,92
|
30 294 $US
|
|
|
2025-02-04 |
2025-02-04 |
PrS
Vente proposée
|
Officer
Dirigeant
|
2 125
20,92
44 458 $US
|
2 125
|
20,92
|
44 458 $US
|
|
|
2025-01-24 |
2025-01-24 |
PrS
Vente proposée
|
Officer
Dirigeant
|
4 999
22,14
110 678 $US
|
4 999
|
22,14
|
110 678 $US
|
|
|
2024-02-06 |
2024-02-05 |
V
Vente
|
CEO, President
Administrateur exécutif
|
30 545
-1.5%
1,14
34 821 $US
|
30 545
-1.5%
|
1,14
|
34 821 $US
|
|
|
2024-02-06 |
2024-02-05 |
V
Vente
|
EVP & Chief Financial Officer
Dirigeant
|
7 027
-1.7%
1,14
8 011 $US
|
7 027
-1.7%
|
1,14
|
8 011 $US
|
|
|
2024-02-06 |
2024-02-05 |
V
Vente
|
EVP, Chief Commercial Officer
Dirigeant
|
8 918
-2.5%
1,14
10 167 $US
|
8 918
-2.5%
|
1,14
|
10 167 $US
|
|
|
2024-02-06 |
2024-02-02 |
V
Vente
|
CEO, President
Administrateur exécutif
|
22 349
-1.1%
1,13
25 261 $US
|
22 349
-1.1%
|
1,13
|
25 261 $US
|
|
|
2024-02-06 |
2024-02-02 |
V
Vente
|
EVP & Chief Financial Officer
Dirigeant
|
5 601
-1.3%
1,13
6 327 $US
|
5 601
-1.3%
|
1,13
|
6 327 $US
|
|
|
2024-02-06 |
2024-02-02 |
V
Vente
|
EVP, Chief Commercial Officer
Dirigeant
|
5 601
-1.5%
1,13
6 329 $US
|
5 601
-1.5%
|
1,13
|
6 329 $US
|
|
|
2023-02-07 |
2023-02-06 |
V
Vente
|
CEO, President
Administrateur exécutif
|
20 340
-1.2%
1,75
35 595 $US
|
20 340
-1.2%
|
1,75
|
35 595 $US
|
|
|
2023-02-06 |
2023-02-02 |
V
Vente
|
EVP & Chief Financial Officer
Dirigeant
|
5 389
-2.7%
1,66
8 946 $US
|
5 389
-2.7%
|
1,66
|
8 946 $US
|
|
|
2023-02-06 |
2023-02-02 |
V
Vente
|
EVP, Chief Commercial Officer
Dirigeant
|
5 388
-3.6%
1,66
8 945 $US
|
5 388
-3.6%
|
1,66
|
8 945 $US
|
|
|
2023-02-06 |
2023-02-02 |
V
Vente
|
EVP & CMO
Dirigeant
|
5 389
-6.9%
1,66
8 946 $US
|
5 389
-6.9%
|
1,66
|
8 946 $US
|
|
|
2022-06-13 |
2022-06-09 |
A
Achat
|
CEO, President
Administrateur exécutif
|
1 000 000
+255.2%
0,69
688 400 $US
|
1 000 000
+255.2%
|
0,69
|
688 400 $US
|
|
|
2019-05-23 |
2019-05-22 |
A
Achat
|
EVP &Chief Financial Officer
Dirigeant
|
3 274
+7.0%
2,13
6 971 $US
|
3 274
+7.0%
|
2,13
|
6 971 $US
|
|
|
2019-05-23 |
2019-05-22 |
A
Achat
|
EVP &Chief Financial Officer
Dirigeant
|
46 726
+inf%
2,13
99 573 $US
|
46 726
+inf%
|
2,13
|
99 573 $US
|
|
|
2018-10-16 |
2018-10-12 |
PlS
Vente planifiée
|
Cabatuan Nelson
Principal Accounting Officer
Dirigeant
|
10 000
-99.4%
3,12
31 200 $US
|
10 000
-99.4%
|
3,12
|
31 200 $US
|
|
|
2018-09-19 |
2018-09-17 |
PlS
Vente planifiée
|
Duliege Anne-Marie
EVP & Chief Medical Officer
Dirigeant
|
37 500
-100.0%
3,50
131 250 $US
|
37 500
-100.0%
|
3,50
|
131 250 $US
|
|
|
2018-09-19 |
2018-09-17 |
PlS
Vente planifiée
|
Duliege Anne-Marie
EVP & Chief Medical Officer
Dirigeant
|
115 500
-100.0%
3,50
404 250 $US
|
115 500
-100.0%
|
3,50
|
404 250 $US
|
|
|
2018-09-12 |
2018-09-11 |
A
Achat
|
Mayer Eldon C. III
EVP & Chief Commercial Officer
Dirigeant
|
50 000
+30.3%
3,23
161 340 $US
|
50 000
+30.3%
|
3,23
|
161 340 $US
|
|
|
2018-09-12 |
2018-09-10 |
A
Achat
|
Mayer Eldon C. III
EVP & Chief Commercial Officer
Dirigeant
|
50 000
+43.5%
3,28
164 210 $US
|
50 000
+43.5%
|
3,28
|
164 210 $US
|
|
|
2018-09-06 |
2018-09-04 |
PlS
Vente planifiée
|
Duliege Anne-Marie
EVP & Chief Medical Officer
Dirigeant
|
16 500
-100.0%
3,51
57 861 $US
|
16 500
-100.0%
|
3,51
|
57 861 $US
|
|
|
2018-08-27 |
2018-08-23 |
AP
Achat planifié
|
Mayer Eldon C. III
EVP & Chief Commercial Officer
Dirigeant
|
100 000
+666.7%
2,82
282 320 $US
|
100 000
+666.7%
|
2,82
|
282 320 $US
|
|
|
2018-08-21 |
2018-08-17 |
AP
Achat planifié
|
RODRIGUEZ RAUL R
CEO, President
Administrateur exécutif
|
114 000
+191.5%
2,63
300 002 $US
|
114 000
+191.5%
|
2,63
|
300 002 $US
|
|
|
2018-07-05 |
2018-07-02 |
PlS
Vente planifiée
|
Duliege Anne-Marie
EVP & Chief Medical Officer
Dirigeant
|
5 000
-100.0%
2,79
13 932 $US
|
5 000
-100.0%
|
2,79
|
13 932 $US
|
|
|
2018-04-24 |
2018-04-20 |
PlS
Vente planifiée
|
Duliege Anne-Marie
EVP & Chief Medical Officer
|
5 000
-100.0%
4,11
20 550 $US
|
5 000
-100.0%
|
4,11
|
20 550 $US
|
|
|
2017-11-07 |
2017-11-03 |
PlS
Vente planifiée
|
Maynard Ryan D
EVP & CFO
|
100 000
-100.0%
3,90
390 000 $US
|
100 000
-100.0%
|
3,90
|
390 000 $US
|
|
|
2017-07-07 |
2017-07-05 |
PlS
Vente planifiée
|
Duliege Anne-Marie
Chief Medical Officer
Dirigeant
|
5 000
-100.0%
2,69
13 427 $US
|
5 000
-100.0%
|
2,69
|
13 427 $US
|
|
|
2017-01-13 |
2017-01-03 |
PlS
Vente planifiée
|
Duliege Anne-Marie
Chief Medical Officer
Dirigeant
|
5 000
-100.0%
2,41
12 028 $US
|
5 000
-100.0%
|
2,41
|
12 028 $US
|
|
|
2016-09-01 |
2016-08-30 |
PlS
Vente planifiée
|
PAYAN DONALD G
EVP, Pres. Discovery&Research
Administrateur exécutif
|
5 303
-9.1%
4,00
21 214 $US
|
5 303
-9.1%
|
4,00
|
21 214 $US
|
|
|
2015-06-12 |
2015-06-10 |
V
Vente
|
PAYAN DONALD G
EVP, Pres. Discovery&Research
Administrateur exécutif
|
41 666
-41.7%
3,68
153 214 $US
|
41 666
-41.7%
|
3,68
|
153 214 $US
|
|
|
2015-04-03 |
2015-04-01 |
V
Vente
|
PAYAN DONALD G
EVP, Pres. Discovery&Research
Administrateur exécutif
|
10 000
-14.6%
3,75
37 518 $US
|
10 000
-14.6%
|
3,75
|
37 518 $US
|
|
|
2014-09-05 |
2014-09-03 |
V
Vente
|
PAYAN DONALD G
EVP, Pres. Discovery&Research
Administrateur exécutif
|
20 000
-22.6%
2,56
51 200 $US
|
20 000
-22.6%
|
2,56
|
51 200 $US
|
|
|
2014-02-26 |
2014-02-24 |
V
Vente
|
PAYAN DONALD G
EVP, Pres. Discovery&Research
Administrateur exécutif
|
20 000
-18.5%
3,71
74 238 $US
|
20 000
-18.5%
|
3,71
|
74 238 $US
|
|
|
2013-11-20 |
2013-11-19 |
V
Vente
|
BVF PARTNERS L P/IL
See Explanation of Responses
Actionnaire important
|
153 056
-19.1%
2,64
404 343 $US
|
153 056
-19.1%
|
2,64
|
404 343 $US
|
|
|
2013-11-20 |
2013-11-19 |
V
Vente
|
BVF PARTNERS L P/IL
See Explanation of Responses
Actionnaire important
|
331 566
-22.8%
2,64
875 931 $US
|
331 566
-22.8%
|
2,64
|
875 931 $US
|
|
|
2013-06-11 |
2013-06-07 |
A
Achat
|
BVF PARTNERS L P/IL
See Explanation of Responses
Actionnaire important
|
8 102
+1.0%
3,47
28 095 $US
|
8 102
+1.0%
|
3,47
|
28 095 $US
|
|
|
2013-06-11 |
2013-06-07 |
A
Achat
|
BVF PARTNERS L P/IL
See Explanation of Responses
Actionnaire important
|
24 598
+1.7%
3,47
85 298 $US
|
24 598
+1.7%
|
3,47
|
85 298 $US
|
|
|
2012-09-14 |
2012-09-13 |
V
Vente
|
VANCE DOLLY
EVP Corp. Affairs, G.C., Sect.
Dirigeant
|
4 151
-79.0%
10,43
43 284 $US
|
4 151
-79.0%
|
10,43
|
43 284 $US
|
|
|
2012-09-11 |
2012-09-10 |
V
Vente
|
Maynard Ryan D
EVP & CFO
Dirigeant
|
17 586
-100.0%
10,52
184 927 $US
|
17 586
-100.0%
|
10,52
|
184 927 $US
|
|
|
2012-09-14 |
2012-09-07 |
V
Vente
|
Maynard Ryan D
EVP & CFO
Dirigeant
|
23 302
-100.0%
10,67
248 560 $US
|
23 302
-100.0%
|
10,67
|
248 560 $US
|
|
|
2012-09-11 |
2012-09-07 |
V
Vente
|
Maynard Ryan D
EVP & CFO
Dirigeant
|
34 112
-100.0%
10,55
359 960 $US
|
34 112
-100.0%
|
10,55
|
359 960 $US
|
|
|
2012-08-09 |
2012-08-07 |
V
Vente
|
Maynard Ryan D
EVP & CFO
Dirigeant
|
300
-100.0%
10,63
3 188 $US
|
300
-100.0%
|
10,63
|
3 188 $US
|
|
|
2012-08-09 |
2012-08-07 |
V
Vente
|
Maynard Ryan D
EVP & CFO
Dirigeant
|
600
-66.7%
10,62
6 372 $US
|
600
-66.7%
|
10,62
|
6 372 $US
|
|
|
2012-08-09 |
2012-08-07 |
V
Vente
|
Maynard Ryan D
EVP & CFO
Dirigeant
|
100
-10.0%
10,61
1 061 $US
|
100
-10.0%
|
10,61
|
1 061 $US
|
|
|
2012-08-09 |
2012-08-07 |
V
Vente
|
Maynard Ryan D
EVP & CFO
Dirigeant
|
700
-41.2%
10,60
7 420 $US
|
700
-41.2%
|
10,60
|
7 420 $US
|
|
|
2012-06-20 |
2012-06-19 |
V
Vente
|
PAYAN DONALD G
EVP, Pres. Discovery&Research
Administrateur exécutif
|
100
-0.1%
8,71
871 $US
|
100
-0.1%
|
8,71
|
871 $US
|
|
|
2012-06-20 |
2012-06-19 |
V
Vente
|
PAYAN DONALD G
EVP, Pres. Discovery&Research
Administrateur exécutif
|
9 700
-8.2%
8,70
84 390 $US
|
9 700
-8.2%
|
8,70
|
84 390 $US
|
|
|
2012-06-20 |
2012-06-19 |
V
Vente
|
PAYAN DONALD G
EVP, Pres. Discovery&Research
Administrateur exécutif
|
100
-0.1%
8,72
872 $US
|
100
-0.1%
|
8,72
|
872 $US
|
|
|
2012-06-20 |
2012-06-19 |
V
Vente
|
PAYAN DONALD G
EVP, Pres. Discovery&Research
Administrateur exécutif
|
100
-0.1%
8,75
875 $US
|
100
-0.1%
|
8,75
|
875 $US
|
|
|
2011-06-07 |
2011-05-26 |
A
Achat
|
Flynn James E
Actionnaire important
|
301 424
+10.4%
8,00
2 411 392 $US
|
301 424
+10.4%
|
8,00
|
2 411 392 $US
|
|
|
2011-06-07 |
2011-05-26 |
A
Achat
|
Flynn James E
Actionnaire important
|
229 252
+11.2%
8,00
1 834 016 $US
|
229 252
+11.2%
|
8,00
|
1 834 016 $US
|
|
|
2011-06-07 |
2011-05-26 |
A
Achat
|
Flynn James E
Actionnaire important
|
72 800
+10.6%
8,00
582 400 $US
|
72 800
+10.6%
|
8,00
|
582 400 $US
|
|
|
2011-06-07 |
2011-05-26 |
A
Achat
|
Flynn James E
Actionnaire important
|
46 524
+11.0%
8,00
372 192 $US
|
46 524
+11.0%
|
8,00
|
372 192 $US
|
|
|
2010-11-05 |
2010-11-03 |
V
Vente
|
Flynn James E
Actionnaire important
|
3 690
-0.1%
7,55
27 860 $US
|
3 690
-0.1%
|
7,55
|
27 860 $US
|
|
|
2010-11-05 |
2010-11-03 |
V
Vente
|
Flynn James E
Actionnaire important
|
2 605
-0.1%
7,55
19 668 $US
|
2 605
-0.1%
|
7,55
|
19 668 $US
|
|
|
2010-11-05 |
2010-11-03 |
V
Vente
|
Flynn James E
Actionnaire important
|
900
-0.1%
7,55
6 795 $US
|
900
-0.1%
|
7,55
|
6 795 $US
|
|