|
2023-10-31 |
2023-10-18 |
B
Compra
|
Gran accionista
|
26 961
433,33
4.208.101 US$
|
26 961
|
433,33
|
4.208.101 US$
|
|
|
2023-10-31 |
2023-10-18 |
B
Compra
|
Gran accionista
|
79 874
328,52
3.768.805 US$
|
79 874
|
328,52
|
3.768.805 US$
|
|
|
2021-02-26 |
2021-02-24 |
Por favor
Venta prevista
|
Chief Medical Officer
Oficial
|
1 855
+42.9%
129,29
4.207.799 US$
|
1 855
+42.9%
|
129,29
|
4.207.799 US$
|
|
|
2021-02-24 |
2021-02-24 |
Por favor
Venta prevista
|
President & CEO
Consejero ejecutivo
|
10 800
-6.9%
17,40
187.919 US$
|
10 800
-6.9%
|
17,40
|
187.919 US$
|
|
|
2021-02-24 |
2021-02-23 |
Por favor
Venta prevista
|
President & CEO
Consejero ejecutivo
|
7 126
-4.4%
17,89
127.483 US$
|
7 126
-4.4%
|
17,89
|
127.483 US$
|
|
|
2021-02-24 |
2021-02-22 |
Por favor
Venta prevista
|
President & CEO
Consejero ejecutivo
|
15 200
-8.5%
19,86
301.813 US$
|
15 200
-8.5%
|
19,86
|
301.813 US$
|
|
|
2021-01-22 |
2021-01-21 |
Por favor
Venta prevista
|
President & CEO
Consejero ejecutivo
|
1 406
-0.8%
15,04
21.147 US$
|
1 406
-0.8%
|
15,04
|
21.147 US$
|
|
|
2021-01-22 |
2021-01-20 |
Por favor
Venta prevista
|
Chief Medical Officer
Oficial
|
3 000
-26.0%
15,03
45.084 US$
|
3 000
-26.0%
|
15,03
|
45.084 US$
|
|
|
2021-01-22 |
2021-01-20 |
Por favor
Venta prevista
|
President & CEO
Consejero ejecutivo
|
19 466
-9.8%
15,03
292.533 US$
|
19 466
-9.8%
|
15,03
|
292.533 US$
|
|
|
2021-03-08 |
2020-12-23 |
B
Compra
|
Consejero no ejecutivo
|
4
+1.6%
11,56
46 US$
|
4
+1.6%
|
11,56
|
46 US$
|
|
|
2021-03-08 |
2020-09-14 |
B
Compra
|
Consejero no ejecutivo
|
1
+0.4%
10,70
11 US$
|
1
+0.4%
|
10,70
|
11 US$
|
|
|
2021-03-08 |
2020-09-11 |
B
Compra
|
Consejero no ejecutivo
|
10
+4.3%
10,07
101 US$
|
10
+4.3%
|
10,07
|
101 US$
|
|
|
2021-03-08 |
2020-08-14 |
B
Compra
|
Consejero no ejecutivo
|
5
+2.2%
11,07
55 US$
|
5
+2.2%
|
11,07
|
55 US$
|
|
|
2021-03-08 |
2020-07-17 |
B
Compra
|
Consejero no ejecutivo
|
4
+1.8%
11,86
47 US$
|
4
+1.8%
|
11,86
|
47 US$
|
|
|
2021-03-08 |
2020-07-07 |
B
Compra
|
Consejero no ejecutivo
|
1
+0.4%
9,60
10 US$
|
1
+0.4%
|
9,60
|
10 US$
|
|
|
2021-03-08 |
2020-05-12 |
B
Compra
|
Consejero no ejecutivo
|
25
+12.5%
15,02
376 US$
|
25
+12.5%
|
15,02
|
376 US$
|
|
|
2020-05-14 |
2020-05-12 |
B
Compra
|
Gran accionista
|
500 000
+30.1%
15,00
7.500.000 US$
|
500 000
+30.1%
|
15,00
|
7.500.000 US$
|
|
|
2020-05-14 |
2020-05-12 |
B
Compra
|
Gran accionista
|
50 000
+3.1%
15,00
750.000 US$
|
50 000
+3.1%
|
15,00
|
750.000 US$
|
|
|
2020-05-14 |
2020-05-12 |
B
Compra
|
Gran accionista
|
225 000
+7.3%
15,00
3.375.000 US$
|
225 000
+7.3%
|
15,00
|
3.375.000 US$
|
|
|
2020-05-14 |
2020-05-12 |
B
Compra
|
Gran accionista
|
800 000
+36.5%
15,00
12.000.000 US$
|
800 000
+36.5%
|
15,00
|
12.000.000 US$
|
|
|
2021-03-08 |
2020-05-08 |
B
Compra
|
Consejero no ejecutivo
|
200
+inf%
15,27
3.054 US$
|
200
+inf%
|
15,27
|
3.054 US$
|
|
|
2020-03-16 |
2020-03-13 |
S
Venta
|
Consejero no ejecutivo
|
2 401
-18.6%
0,55
1.321 US$
|
2 401
-18.6%
|
0,55
|
1.321 US$
|
|
|
2020-03-16 |
2020-03-12 |
S
Venta
|
Consejero no ejecutivo
|
200
-1.5%
0,58
116 US$
|
200
-1.5%
|
0,58
|
116 US$
|
|
|
2020-03-16 |
2020-03-11 |
S
Venta
|
Consejero no ejecutivo
|
399
-3.0%
0,67
267 US$
|
399
-3.0%
|
0,67
|
267 US$
|
|
|
2019-04-11 |
2019-04-10 |
B
Compra
|
|
3 000
+28.6%
3,80
11.391 US$
|
3 000
+28.6%
|
3,80
|
11.391 US$
|
|
|
2018-11-07 |
2018-11-05 |
S
Venta
|
PETIT ROBERT
Chief Scientific Officer
Oficial
|
3 963
-1.7%
0,58
2.299 US$
|
3 963
-1.7%
|
0,58
|
2.299 US$
|
|
|
2018-11-05 |
2018-11-02 |
S
Venta
|
PETIT ROBERT
Chief Scientific Officer
Oficial
|
8 491
-3.5%
0,56
4.755 US$
|
8 491
-3.5%
|
0,56
|
4.755 US$
|
|
|
2018-09-13 |
2018-09-11 |
B
Compra
|
Consejero no ejecutivo
|
33 333
+26.9%
1,20
40.000 US$
|
33 333
+26.9%
|
1,20
|
40.000 US$
|
|
|
2018-04-03 |
2018-04-02 |
S
Venta
|
PETIT ROBERT
Chief Scientific Officer
|
2 193
-1.0%
1,62
3.553 US$
|
2 193
-1.0%
|
1,62
|
3.553 US$
|
|
|
2018-02-02 |
2018-02-02 |
S
Venta
|
Interim CEO
Oficial
|
32
-0.0%
2,93
94 US$
|
32
-0.0%
|
2,93
|
94 US$
|
|
|
2018-01-03 |
2018-01-03 |
S
Venta
|
Bonstein Sara
Chief Financial Officer
Oficial
|
5 224
-2.3%
3,18
16.612 US$
|
5 224
-2.3%
|
3,18
|
16.612 US$
|
|
|
2017-11-06 |
2017-11-06 |
S
Venta
|
Bonstein Sara
Chief Financial Officer
|
3 862
-1.7%
3,30
12.745 US$
|
3 862
-1.7%
|
3,30
|
12.745 US$
|
|
|
2017-11-06 |
2017-11-06 |
S
Venta
|
Chief Scientific Officer
|
3 723
-1.7%
3,30
12.286 US$
|
3 723
-1.7%
|
3,30
|
12.286 US$
|
|
|
2017-11-02 |
2017-11-02 |
S
Venta
|
LOMBARDO ANTHONY A
Interim CEO
|
24
-0.0%
3,19
77 US$
|
24
-0.0%
|
3,19
|
77 US$
|
|
|
2017-11-02 |
2017-11-02 |
S
Venta
|
Chief Scientific Officer
|
12 625
-5.3%
3,19
40.274 US$
|
12 625
-5.3%
|
3,19
|
40.274 US$
|
|
|
2017-11-02 |
2017-11-02 |
S
Venta
|
Chief Financial Officer
|
12 734
-5.2%
3,19
40.621 US$
|
12 734
-5.2%
|
3,19
|
40.621 US$
|
|
|
2017-10-12 |
2017-10-11 |
S
Venta
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Gran accionista
|
600 000
-12.8%
4,30
2.580.000 US$
|
600 000
-12.8%
|
4,30
|
2.580.000 US$
|
|
|
2017-09-26 |
2017-09-26 |
S
Venta
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Gran accionista
|
300 000
-6.0%
4,00
1.200.000 US$
|
300 000
-6.0%
|
4,00
|
1.200.000 US$
|
|
|
2017-09-26 |
2017-09-25 |
S
Venta
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Gran accionista
|
405 323
-7.5%
4,38
1.775.315 US$
|
405 323
-7.5%
|
4,38
|
1.775.315 US$
|
|
|
2017-09-26 |
2017-09-22 |
S
Venta
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Gran accionista
|
534 000
-9.0%
4,68
2.499.120 US$
|
534 000
-9.0%
|
4,68
|
2.499.120 US$
|
|
|
2017-04-03 |
2017-03-31 |
S
Venta
|
PETIT ROBERT
Chief Scientific Officer
|
2 454
-2.0%
8,24
20.221 US$
|
2 454
-2.0%
|
8,24
|
20.221 US$
|
|
|
2017-01-03 |
2016-12-30 |
S
Venta
|
Bonstein Sara
Chief Financial Officer
Oficial
|
5 520
-4.2%
7,37
40.682 US$
|
5 520
-4.2%
|
7,37
|
40.682 US$
|
|
|
2016-12-21 |
2016-12-20 |
S
Venta
|
MCKEARN THOMAS J
Consejero no ejecutivo
|
12 316
-15.0%
8,08
99.513 US$
|
12 316
-15.0%
|
8,08
|
99.513 US$
|
|
|
2016-11-02 |
2016-11-02 |
S
Venta
|
PETIT ROBERT
Chief Scientific Officer
Oficial
|
2 797
-2.3%
8,32
23.271 US$
|
2 797
-2.3%
|
8,32
|
23.271 US$
|
|
|
2016-11-02 |
2016-11-02 |
S
Venta
|
O'Connor Daniel
Chief Executive Officer
Consejero ejecutivo
|
8 240
-2.7%
8,32
68.557 US$
|
8 240
-2.7%
|
8,32
|
68.557 US$
|
|
|
2016-10-26 |
2016-10-25 |
S
Venta
|
Mayes, Gregory T.
Chief Business Officer
Consejero ejecutivo
|
19 162
-15.7%
8,23
157.703 US$
|
19 162
-15.7%
|
8,23
|
157.703 US$
|
|
|
2016-08-10 |
2016-08-09 |
S
Venta
|
Consejero no ejecutivo
|
15 761
-23.7%
15,67
246.975 US$
|
15 761
-23.7%
|
15,67
|
246.975 US$
|
|
|
2016-08-10 |
2016-08-09 |
S
Venta
|
Consejero no ejecutivo
|
11 404
-12.4%
14,85
169.349 US$
|
11 404
-12.4%
|
14,85
|
169.349 US$
|
|
|
2016-08-10 |
2016-08-08 |
S
Venta
|
Consejero no ejecutivo
|
18 000
-21.3%
15,21
273.780 US$
|
18 000
-21.3%
|
15,21
|
273.780 US$
|
|
|
2016-08-10 |
2016-08-08 |
S
Venta
|
Consejero no ejecutivo
|
11 404
-11.1%
15,17
172.999 US$
|
11 404
-11.1%
|
15,17
|
172.999 US$
|
|
|
2016-05-13 |
2016-05-13 |
S
Venta
|
MCKEARN THOMAS J
Consejero no ejecutivo
|
4 100
-4.8%
7,45
30.545 US$
|
4 100
-4.8%
|
7,45
|
30.545 US$
|
|
|
2016-05-02 |
2016-05-02 |
S
Venta
|
PETIT ROBERT
Chief Scientific Officer
Oficial
|
2 785
-2.2%
7,51
20.915 US$
|
2 785
-2.2%
|
7,51
|
20.915 US$
|
|
|
2016-05-02 |
2016-05-02 |
S
Venta
|
O'Connor Daniel
Chief Executive Officer
Oficial
|
8 237
-2.6%
7,51
61.860 US$
|
8 237
-2.6%
|
7,51
|
61.860 US$
|
|
|
2016-04-01 |
2016-03-31 |
S
Venta
|
Chief Scientific Officer
Oficial
|
3 325
-2.5%
9,13
30.357 US$
|
3 325
-2.5%
|
9,13
|
30.357 US$
|
|
|
2016-03-18 |
2016-03-16 |
S
Venta
|
Consejero no ejecutivo
|
14 000
-14.0%
8,25
115.500 US$
|
14 000
-14.0%
|
8,25
|
115.500 US$
|
|
|
2016-02-25 |
2016-02-24 |
S
Venta
|
Chief Financial Officer
Oficial
|
15 037
-15.8%
5,58
83.906 US$
|
15 037
-15.8%
|
5,58
|
83.906 US$
|
|
|
2016-02-01 |
2016-01-29 |
S
Venta
|
Chief Scientific Officer
Oficial
|
3 099
-2.3%
6,88
21.321 US$
|
3 099
-2.3%
|
6,88
|
21.321 US$
|
|
|
2016-02-01 |
2016-01-29 |
S
Venta
|
O'Connor Daniel
Chief Executive Officer
Oficial
|
8 818
-2.7%
6,88
60.668 US$
|
8 818
-2.7%
|
6,88
|
60.668 US$
|
|
|
2015-08-24 |
2015-08-24 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
12 100
+0.2%
14,47
175.087 US$
|
12 100
+0.2%
|
14,47
|
175.087 US$
|
|
|
2015-08-24 |
2015-08-24 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
9 500
+0.2%
13,73
130.435 US$
|
9 500
+0.2%
|
13,73
|
130.435 US$
|
|
|
2015-08-24 |
2015-08-24 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
3 400
+0.1%
14,06
47.804 US$
|
3 400
+0.1%
|
14,06
|
47.804 US$
|
|
|
2015-08-24 |
2015-08-24 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
20 000
+0.3%
12,90
258.000 US$
|
20 000
+0.3%
|
12,90
|
258.000 US$
|
|
|
2015-08-24 |
2015-08-24 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
5 000
+0.1%
13,87
69.350 US$
|
5 000
+0.1%
|
13,87
|
69.350 US$
|
|
|
2015-08-24 |
2015-08-21 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
75 000
+1.3%
14,21
1.065.750 US$
|
75 000
+1.3%
|
14,21
|
1.065.750 US$
|
|
|
2015-08-24 |
2015-08-20 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
12 000
+0.2%
14,17
170.040 US$
|
12 000
+0.2%
|
14,17
|
170.040 US$
|
|
|
2015-08-24 |
2015-08-20 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
13 600
+0.2%
14,31
194.616 US$
|
13 600
+0.2%
|
14,31
|
194.616 US$
|
|
|
2015-08-24 |
2015-08-20 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
45 582
+0.8%
14,32
652.734 US$
|
45 582
+0.8%
|
14,32
|
652.734 US$
|
|
|
2015-08-24 |
2015-08-20 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
103 818
+1.8%
14,28
1.482.521 US$
|
103 818
+1.8%
|
14,28
|
1.482.521 US$
|
|
|
2015-05-04 |
2015-04-30 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
500 000
+9.7%
19,00
9.500.000 US$
|
500 000
+9.7%
|
19,00
|
9.500.000 US$
|
|
|
2015-02-20 |
2015-02-18 |
B
Compra
|
ADAGE CAPITAL PARTNERS GP LLC
Gran accionista
|
684 762
+15.4%
7,50
5.135.715 US$
|
684 762
+15.4%
|
7,50
|
5.135.715 US$
|
|
|
2014-05-09 |
2014-05-09 |
S
Venta
|
Consejero no ejecutivo
|
7 530
-100.0%
2,63
19.823 US$
|
7 530
-100.0%
|
2,63
|
19.823 US$
|
|
|
2014-05-09 |
2014-05-09 |
S
Venta
|
Consejero no ejecutivo
|
7 000
-48.2%
2,63
18.425 US$
|
7 000
-48.2%
|
2,63
|
18.425 US$
|
|
|
2014-04-02 |
2014-03-31 |
B
Compra
|
O'Connor Daniel
Chief Executive Officer
Consejero ejecutivo
|
3 333
+1.1%
3,00
9.999 US$
|
3 333
+1.1%
|
3,00
|
9.999 US$
|
|
|
2013-10-29 |
2013-10-24 |
B
Compra
|
Consejero no ejecutivo
|
25 000
+39.7%
4,00
100.000 US$
|
25 000
+39.7%
|
4,00
|
100.000 US$
|
|
|
2013-10-29 |
2013-10-24 |
B
Compra
|
Consejero no ejecutivo
|
12 500
+28.1%
4,00
50.000 US$
|
12 500
+28.1%
|
4,00
|
50.000 US$
|
|