Shanafelt Armen

1.8

1.8

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2021-12-13	2021-12-13	Spyre Therapeutics Inc (SYRE)	B Purchase	79,916 -15.7% 450.42 US$632,925	79,916 -15.7%	450.42	US$632,925
2021-12-13	2021-12-10	Spyre Therapeutics Inc (SYRE)	B Purchase	59,876 -17.7% 281.56 US$2,060,349	59,876 -17.7%	281.56	US$2,060,349
2021-12-13	2021-12-09	Spyre Therapeutics Inc (SYRE)	B Purchase	29,975 -13.3% 379.67 US$2,199,847	29,975 -13.3%	379.67	US$2,199,847