|
May 18, 2023 |
May 17, 2023 |
S
Sale
|
Hahn Brian M.
SVP Finance, CFO
Officer
|
3,700
-6.5%
1.95
7,215
USD
|
3,700
-6.5%
|
1.95
|
7,215
USD
|
|
|
May 11, 2023 |
May 10, 2023 |
B
Purchase
|
JUNIUS DANIEL M
Non-Executive Director
|
30,000
+47.4%
1.56
46,800
USD
|
30,000
+47.4%
|
1.56
|
46,800
USD
|
|
|
May 9, 2023 |
May 8, 2023 |
B
Purchase
|
Johnson Bruce S
SVP & Chief Commercial Officer
Officer
|
13,500
+10.8%
1.57
21,195
USD
|
13,500
+10.8%
|
1.57
|
21,195
USD
|
|
|
Feb. 28, 2023 |
Feb. 24, 2023 |
B
Purchase
|
Invus Public Equities, L.P.
Major owner
|
100,000
+1.2%
1.70
170,000
USD
|
100,000
+1.2%
|
1.70
|
170,000
USD
|
|
|
Feb. 23, 2023 |
Feb. 23, 2023 |
B
Purchase
|
Invus Public Equities, L.P.
Major owner
|
200,000
+2.4%
1.75
350,760
USD
|
200,000
+2.4%
|
1.75
|
350,760
USD
|
|
|
Feb. 23, 2023 |
Feb. 22, 2023 |
B
Purchase
|
Invus Public Equities, L.P.
Major owner
|
150,000
+1.8%
1.79
268,995
USD
|
150,000
+1.8%
|
1.79
|
268,995
USD
|
|
|
Feb. 23, 2023 |
Feb. 21, 2023 |
B
Purchase
|
Invus Public Equities, L.P.
Major owner
|
50,000
+0.6%
1.85
92,500
USD
|
50,000
+0.6%
|
1.85
|
92,500
USD
|
|
|
Feb. 17, 2023 |
Feb. 17, 2023 |
B
Purchase
|
Invus Public Equities, L.P.
Major owner
|
200,000
+2.5%
1.71
341,000
USD
|
200,000
+2.5%
|
1.71
|
341,000
USD
|
|
|
Feb. 17, 2023 |
Feb. 16, 2023 |
B
Purchase
|
Invus Public Equities, L.P.
Major owner
|
315,266
+4.2%
1.68
531,129
USD
|
315,266
+4.2%
|
1.68
|
531,129
USD
|
|
|
Feb. 17, 2023 |
Feb. 15, 2023 |
B
Purchase
|
Invus Public Equities, L.P.
Major owner
|
1,000,000
+15.2%
2.16
2,155,800
USD
|
1,000,000
+15.2%
|
2.16
|
2,155,800
USD
|
|
|
Feb. 13, 2023 |
Feb. 9, 2023 |
B
Purchase
|
Invus Public Equities, L.P.
Major owner
|
11,451
+0.2%
3.24
37,123
USD
|
11,451
+0.2%
|
3.24
|
37,123
USD
|
|
|
Jan. 27, 2023 |
Jan. 26, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
1,351,092
-37.7%
3.12
4,213,786
USD
|
1,351,092
-37.7%
|
3.12
|
4,213,786
USD
|
|
|
Jan. 27, 2023 |
Jan. 26, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
1,648,908
-37.7%
3.12
5,142,614
USD
|
1,648,908
-37.7%
|
3.12
|
5,142,614
USD
|
|
|
Jan. 27, 2023 |
Jan. 25, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
293,645
-7.6%
3.26
958,428
USD
|
293,645
-7.6%
|
3.26
|
958,428
USD
|
|
|
Jan. 27, 2023 |
Jan. 25, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
358,371
-7.6%
3.26
1,169,687
USD
|
358,371
-7.6%
|
3.26
|
1,169,687
USD
|
|
|
Jan. 6, 2023 |
Jan. 5, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
32,139
-0.8%
2.76
88,659
USD
|
32,139
-0.8%
|
2.76
|
88,659
USD
|
|
|
Jan. 6, 2023 |
Jan. 5, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
39,223
-0.8%
2.76
108,201
USD
|
39,223
-0.8%
|
2.76
|
108,201
USD
|
|
|
Jan. 4, 2023 |
Jan. 4, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
45,930
-1.2%
2.91
133,643
USD
|
45,930
-1.2%
|
2.91
|
133,643
USD
|
|
|
Jan. 4, 2023 |
Jan. 4, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
56,054
-1.2%
2.91
163,100
USD
|
56,054
-1.2%
|
2.91
|
163,100
USD
|
|
|
Jan. 4, 2023 |
Jan. 3, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
78,730
-1.9%
2.99
235,411
USD
|
78,730
-1.9%
|
2.99
|
235,411
USD
|
|
|
Jan. 4, 2023 |
Jan. 3, 2023 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
96,084
-1.9%
2.99
287,301
USD
|
96,084
-1.9%
|
2.99
|
287,301
USD
|
|
|
Jan. 4, 2023 |
Dec. 30, 2022 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
54,645
-1.3%
3.02
165,028
USD
|
54,645
-1.3%
|
3.02
|
165,028
USD
|
|
|
Jan. 4, 2023 |
Dec. 30, 2022 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
66,690
-1.3%
3.02
201,404
USD
|
66,690
-1.3%
|
3.02
|
201,404
USD
|
|
|
Dec. 27, 2022 |
Dec. 22, 2022 |
B
Purchase
|
Rock Edwin
Chief Medical Officer
Officer
|
110,000
+55.0%
2.25
247,500
USD
|
110,000
+55.0%
|
2.25
|
247,500
USD
|
|
|
Nov. 18, 2022 |
Nov. 17, 2022 |
B
Purchase
|
JUNIUS DANIEL M
Non-Executive Director
|
20,000
+46.2%
1.87
37,400
USD
|
20,000
+46.2%
|
1.87
|
37,400
USD
|
|
|
Nov. 16, 2022 |
Nov. 15, 2022 |
B
Purchase
|
Rock Edwin
Chief Medical Officer
Officer
|
100,000
+100.0%
1.66
166,000
USD
|
100,000
+100.0%
|
1.66
|
166,000
USD
|
|
|
Nov. 16, 2022 |
Nov. 14, 2022 |
B
Purchase
|
Rock Edwin
Chief Medical Officer
Officer
|
100,000
+inf%
1.43
143,000
USD
|
100,000
+inf%
|
1.43
|
143,000
USD
|
|
|
Nov. 14, 2022 |
Nov. 11, 2022 |
B
Purchase
|
PEARSON TIMOTHY R
Non-Executive Director
|
19,400
+369.5%
1.29
25,026
USD
|
19,400
+369.5%
|
1.29
|
25,026
USD
|
|
|
Nov. 14, 2022 |
Nov. 11, 2022 |
B
Purchase
|
Semerjian Harout
Chief Executive Officer
Executive Director
|
25,000
+inf%
1.29
32,250
USD
|
25,000
+inf%
|
1.29
|
32,250
USD
|
|
|
Nov. 14, 2022 |
Nov. 11, 2022 |
B
Purchase
|
Hahn Brian M.
SVP Finance, CFO
Officer
|
20,000
+54.3%
1.06
21,200
USD
|
20,000
+54.3%
|
1.06
|
21,200
USD
|
|
|
Nov. 14, 2022 |
Nov. 11, 2022 |
B
Purchase
|
Girard Armand
SVP, Chief Business Officer
Officer
|
6,500
+28.7%
1.05
6,825
USD
|
6,500
+28.7%
|
1.05
|
6,825
USD
|
|
|
Nov. 14, 2022 |
Nov. 11, 2022 |
B
Purchase
|
Magnani John L.
SVP of Research, CSO
Officer
|
45,045
+14.0%
1.17
52,703
USD
|
45,045
+14.0%
|
1.17
|
52,703
USD
|
|
|
March 10, 2022 |
March 9, 2022 |
S
Sale
|
Hahn Brian M.
SVP Finance, CFO
Officer
|
2,917
-7.3%
1.09
3,180
USD
|
2,917
-7.3%
|
1.09
|
3,180
USD
|
|
|
March 10, 2022 |
March 9, 2022 |
S
Sale
|
Magnani John L.
SVP of Research, CSO
Officer
|
3,227
-1.0%
1.09
3,517
USD
|
3,227
-1.0%
|
1.09
|
3,517
USD
|
|
|
March 10, 2022 |
March 9, 2022 |
S
Sale
|
Girard Armand
SVP, Chief Business Officer
Officer
|
2,339
-9.4%
1.09
2,550
USD
|
2,339
-9.4%
|
1.09
|
2,550
USD
|
|
|
Nov. 18, 2021 |
Nov. 16, 2021 |
B
Purchase
|
Andrews Patricia S
Non-Executive Director
|
40,000
+761.9%
2.05
82,000
USD
|
40,000
+761.9%
|
2.05
|
82,000
USD
|
|
|
Dec. 30, 2020 |
Dec. 28, 2020 |
PS
Planned sale
|
King Rachel K.
President, CEO
Executive Director
|
84,176
-19.1%
3.91
329,128
USD
|
84,176
-19.1%
|
3.91
|
329,128
USD
|
|
|
Nov. 6, 2020 |
Nov. 4, 2020 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
86,090
+15.8%
2.60
223,834
USD
|
86,090
+15.8%
|
2.60
|
223,834
USD
|
|
|
Nov. 6, 2020 |
Nov. 4, 2020 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
506,155
+15.8%
2.60
1,316,003
USD
|
506,155
+15.8%
|
2.60
|
1,316,003
USD
|
|
|
Nov. 6, 2020 |
Nov. 4, 2020 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
674,492
+15.7%
2.60
1,753,679
USD
|
674,492
+15.7%
|
2.60
|
1,753,679
USD
|
|
|
Nov. 3, 2020 |
Oct. 30, 2020 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
15,472
+2.9%
2.75
42,548
USD
|
15,472
+2.9%
|
2.75
|
42,548
USD
|
|
|
Nov. 3, 2020 |
Oct. 30, 2020 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
250,755
+8.5%
2.75
689,576
USD
|
250,755
+8.5%
|
2.75
|
689,576
USD
|
|
|
Nov. 3, 2020 |
Oct. 30, 2020 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
666,385
+18.3%
2.75
1,832,559
USD
|
666,385
+18.3%
|
2.75
|
1,832,559
USD
|
|
|
March 10, 2020 |
March 9, 2020 |
B
Purchase
|
JUNIUS DANIEL M
Non-Executive Director
|
20,000
+111.1%
3.40
68,000
USD
|
20,000
+111.1%
|
3.40
|
68,000
USD
|
|
|
Sept. 9, 2019 |
Sept. 5, 2019 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
124,956
+30.9%
3.18
397,610
USD
|
124,956
+30.9%
|
3.18
|
397,610
USD
|
|
|
Sept. 9, 2019 |
Sept. 5, 2019 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
689,834
+30.4%
3.18
2,195,052
USD
|
689,834
+30.4%
|
3.18
|
2,195,052
USD
|
|
|
Sept. 9, 2019 |
Sept. 5, 2019 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
853,956
+30.7%
3.18
2,717,288
USD
|
853,956
+30.7%
|
3.18
|
2,717,288
USD
|
|
|
Aug. 15, 2019 |
Aug. 13, 2019 |
B
Purchase
|
JUNIUS DANIEL M
Non-Executive Director
|
10,000
+125.0%
3.18
31,800
USD
|
10,000
+125.0%
|
3.18
|
31,800
USD
|
|
|
Oct. 18, 2018 |
Oct. 18, 2018 |
S
Sale
|
Magnani John L.
SVP of Research, CSO
Executive Director
|
3,527
-4.4%
14.02
49,449
USD
|
3,527
-4.4%
|
14.02
|
49,449
USD
|
|
|
Oct. 18, 2018 |
Oct. 17, 2018 |
S
Sale
|
Magnani John L.
SVP of Research, CSO
Executive Director
|
7,273
-8.4%
14.00
101,822
USD
|
7,273
-8.4%
|
14.00
|
101,822
USD
|
|
|
Oct. 18, 2018 |
Oct. 16, 2018 |
S
Sale
|
Magnani John L.
SVP of Research, CSO
Executive Director
|
14,200
-14.1%
14.01
198,942
USD
|
14,200
-14.1%
|
14.01
|
198,942
USD
|
|
|
June 12, 2018 |
June 11, 2018 |
S
Sale
|
Hahn Brian M.
CFO
|
19,345
-100.0%
18.04
348,984
USD
|
19,345
-100.0%
|
18.04
|
348,984
USD
|
|
|
May 11, 2018 |
May 10, 2018 |
S
Sale
|
BARRIS PETER J
Major owner
|
5,533
-0.1%
17.81
98,543
USD
|
5,533
-0.1%
|
17.81
|
98,543
USD
|
|
|
May 11, 2018 |
May 10, 2018 |
S
Sale
|
BARRIS PETER J
Major owner
|
4,006
-0.1%
17.81
71,347
USD
|
4,006
-0.1%
|
17.81
|
71,347
USD
|
|
|
May 11, 2018 |
May 10, 2018 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
5,533
-0.1%
17.81
98,543
USD
|
5,533
-0.1%
|
17.81
|
98,543
USD
|
|
|
May 11, 2018 |
May 10, 2018 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
4,006
-0.1%
17.81
71,347
USD
|
4,006
-0.1%
|
17.81
|
71,347
USD
|
|
|
May 11, 2018 |
May 10, 2018 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
Major owner
|
5,533
-0.1%
17.81
98,543
USD
|
5,533
-0.1%
|
17.81
|
98,543
USD
|
|
|
May 11, 2018 |
May 10, 2018 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
Major owner
|
4,006
-0.1%
17.81
71,347
USD
|
4,006
-0.1%
|
17.81
|
71,347
USD
|
|
|
May 11, 2018 |
May 10, 2018 |
S
Sale
|
NEW ENTERPRISE ASSOCIATES 10 L P
Major owner
|
5,533
-0.1%
17.81
98,543
USD
|
5,533
-0.1%
|
17.81
|
98,543
USD
|
|
|
May 11, 2018 |
May 10, 2018 |
S
Sale
|
NEW ENTERPRISE ASSOCIATES 10 L P
Major owner
|
4,006
-0.1%
17.81
71,347
USD
|
4,006
-0.1%
|
17.81
|
71,347
USD
|
|
|
Dec. 12, 2017 |
Dec. 8, 2017 |
S
Sale
|
Thackray Helen M.
SVP Clinical Development, CMO
|
2,000
-1.3%
15.01
30,020
USD
|
2,000
-1.3%
|
15.01
|
30,020
USD
|
|
|
Sept. 18, 2017 |
Sept. 18, 2017 |
S
Sale
|
Thackray Helen M.
SVP Clinical Development, CMO
|
2,000
-1.3%
13.00
26,000
USD
|
2,000
-1.3%
|
13.00
|
26,000
USD
|
|
|
May 30, 2017 |
May 25, 2017 |
S
Sale
|
Thackray Helen M.
SVP Clinical Development, CMO
Officer
|
2,000
-1.3%
15.57
31,140
USD
|
2,000
-1.3%
|
15.57
|
31,140
USD
|
|
|
May 22, 2017 |
May 19, 2017 |
PS
Planned sale
|
Thackray Helen M.
SVP Clinical Development, CMO
Officer
|
2,000
-1.3%
12.14
24,280
USD
|
2,000
-1.3%
|
12.14
|
24,280
USD
|
|
|
Dec. 21, 2016 |
Dec. 20, 2016 |
B
Purchase
|
JUNIUS DANIEL M
Non-Executive Director
|
5,000
+inf%
6.01
30,050
USD
|
5,000
+inf%
|
6.01
|
30,050
USD
|
|
|
Oct. 4, 2016 |
Oct. 3, 2016 |
PS
Planned sale
|
Thackray Helen M.
VP Clinical Development, CMO
Officer
|
100
-0.1%
7.01
701
USD
|
100
-0.1%
|
7.01
|
701
USD
|
|
|
July 6, 2016 |
July 6, 2016 |
PS
Planned sale
|
Thackray Helen M.
VP Clinical Development, CMO
Officer
|
6,796
-4.0%
6.68
45,397
USD
|
6,796
-4.0%
|
6.68
|
45,397
USD
|
|
|
July 6, 2016 |
July 5, 2016 |
PS
Planned sale
|
Thackray Helen M.
VP Clinical Development, CMO
Officer
|
10,136
-5.6%
7.01
71,053
USD
|
10,136
-5.6%
|
7.01
|
71,053
USD
|
|
|
March 7, 2016 |
March 4, 2016 |
B
Purchase
|
Goldberg Mark Alan
Non-Executive Director
|
10,397
+945.2%
4.77
49,630
USD
|
10,397
+945.2%
|
4.77
|
49,630
USD
|
|
|
Nov. 18, 2015 |
Nov. 16, 2015 |
S
Sale
|
NEW ENTERPRISE ASSOCIATES 10 L P
Major owner
|
452
-0.0%
6.91
3,123
USD
|
452
-0.0%
|
6.91
|
3,123
USD
|
|
|
Nov. 18, 2015 |
Nov. 16, 2015 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
Major owner
|
452
-0.0%
6.91
3,123
USD
|
452
-0.0%
|
6.91
|
3,123
USD
|
|
|
Nov. 18, 2015 |
Nov. 16, 2015 |
S
Sale
|
BARRIS PETER J
Major owner
|
452
-0.0%
6.91
3,123
USD
|
452
-0.0%
|
6.91
|
3,123
USD
|
|
|
Nov. 18, 2015 |
Nov. 16, 2015 |
S
Sale
|
SANDELL SCOTT D
Major owner
|
452
-0.0%
6.91
3,123
USD
|
452
-0.0%
|
6.91
|
3,123
USD
|
|
|
Dec. 23, 2014 |
Dec. 22, 2014 |
S
Sale
|
HENOS MICHAEL A
Non-Executive Director
|
10,659
-2.2%
8.44
89,913
USD
|
10,659
-2.2%
|
8.44
|
89,913
USD
|
|
|
Dec. 23, 2014 |
Dec. 19, 2014 |
S
Sale
|
HENOS MICHAEL A
Non-Executive Director
|
10,598
-2.2%
8.61
91,277
USD
|
10,598
-2.2%
|
8.61
|
91,277
USD
|
|
