MCGIRR DAVID W J

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2025-06-04	2025-06-04	Insmed Inc (INSM)	PS Planned sale	3,000 -3.0% 73.27 USD 219,810	3,000 -3.0%	73.27	USD 219,810
2025-06-05	2025-06-03	Rhythm Pharmaceuticals Inc (RYTM)	PS Planned sale	9,873 -76.7% 65.64 USD 648,090	9,873 -76.7%	65.64	USD 648,090
2025-06-05	2025-06-03	Rhythm Pharmaceuticals Inc (RYTM)	PS Planned sale	55,558 -81.2% 65.15 USD 3,619,404	55,558 -81.2%	65.15	USD 3,619,404
2025-06-04	2025-06-03	Insmed Inc (INSM)	PS Planned sale	3,250 -3.1% 71.30 USD 231,725	3,250 -3.1%	71.30	USD 231,725