2018-07-27 |
2018-07-26 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
42,409
-2.4%
12.48
529,264
USD
|
42,409
-2.4%
|
12.48
|
529,264
USD
|
|
2018-07-27 |
2018-07-26 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
7,300
-0.4%
12.55
91,615
USD
|
7,300
-0.4%
|
12.55
|
91,615
USD
|
|
2018-07-27 |
2018-07-26 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
169,102
-8.8%
12.01
2,030,915
USD
|
169,102
-8.8%
|
12.01
|
2,030,915
USD
|
|
2018-07-27 |
2018-07-25 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
13,206
-0.7%
12.00
158,472
USD
|
13,206
-0.7%
|
12.00
|
158,472
USD
|
|
2018-07-27 |
2018-07-25 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
63,833
-3.2%
11.95
762,804
USD
|
63,833
-3.2%
|
11.95
|
762,804
USD
|
|
2018-03-16 |
2018-03-14 |
S
Sale
|
Dempsey James F.
Chief Scientific Officer
Executive Director
|
75,243
-29.2%
7.57
569,755
USD
|
75,243
-29.2%
|
7.57
|
569,755
USD
|
|
2017-04-27 |
2017-04-25 |
S
Sale
|
FMR LLC
See Remark 1
|
22,661
-0.4%
6.69
151,602
USD
|
22,661
-0.4%
|
6.69
|
151,602
USD
|
|
2017-04-27 |
2017-04-25 |
S
Sale
|
FMR LLC
See Remark 1
|
20
-0.0%
6.79
136
USD
|
20
-0.0%
|
6.79
|
136
USD
|
|
2017-04-27 |
2017-04-25 |
S
Sale
|
FMR LLC
See Remark 1
|
67,900
-1.2%
6.80
461,720
USD
|
67,900
-1.2%
|
6.80
|
461,720
USD
|
|
2017-04-27 |
2017-04-25 |
S
Sale
|
FMR LLC
See Remark 1
|
4,000
-0.1%
6.74
26,960
USD
|
4,000
-0.1%
|
6.74
|
26,960
USD
|
|
2017-04-27 |
2017-04-25 |
S
Sale
|
FMR LLC
See Remark 1
|
6,000
-0.1%
6.69
40,140
USD
|
6,000
-0.1%
|
6.69
|
40,140
USD
|
|
2017-04-27 |
2017-04-25 |
S
Sale
|
FMR LLC
See Remark 1
|
4,900
-0.1%
6.74
33,026
USD
|
4,900
-0.1%
|
6.74
|
33,026
USD
|
|
2017-04-27 |
2017-04-25 |
S
Sale
|
FMR LLC
See Remark 1
|
300
-0.0%
6.76
2,028
USD
|
300
-0.0%
|
6.76
|
2,028
USD
|
|
2017-04-27 |
2017-04-25 |
S
Sale
|
FMR LLC
See Remark 1
|
1,000
-0.0%
6.76
6,760
USD
|
1,000
-0.0%
|
6.76
|
6,760
USD
|
|
2017-04-25 |
2017-04-24 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
300
-0.0%
6.63
1,989
USD
|
300
-0.0%
|
6.63
|
1,989
USD
|
|
2017-04-25 |
2017-04-24 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
6,634
-0.1%
6.60
43,784
USD
|
6,634
-0.1%
|
6.60
|
43,784
USD
|
|
2017-04-25 |
2017-04-24 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
58,200
-1.0%
6.68
388,776
USD
|
58,200
-1.0%
|
6.68
|
388,776
USD
|
|
2017-04-25 |
2017-04-24 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
12,500
-0.2%
6.62
82,750
USD
|
12,500
-0.2%
|
6.62
|
82,750
USD
|
|
2017-04-25 |
2017-04-21 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
6,406
-0.1%
6.86
43,945
USD
|
6,406
-0.1%
|
6.86
|
43,945
USD
|
|
2017-04-25 |
2017-04-21 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
600
-0.0%
6.91
4,146
USD
|
600
-0.0%
|
6.91
|
4,146
USD
|
|
2017-04-25 |
2017-04-21 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
11,399
-0.2%
6.83
77,855
USD
|
11,399
-0.2%
|
6.83
|
77,855
USD
|
|
2017-04-25 |
2017-04-21 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
5,100
-0.1%
6.88
35,088
USD
|
5,100
-0.1%
|
6.88
|
35,088
USD
|
|
2017-04-21 |
2017-04-20 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
700
-0.0%
6.95
4,865
USD
|
700
-0.0%
|
6.95
|
4,865
USD
|
|
2017-04-21 |
2017-04-20 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
800
-0.0%
6.96
5,568
USD
|
800
-0.0%
|
6.96
|
5,568
USD
|
|
2017-04-21 |
2017-04-20 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,900
-0.0%
7.02
13,338
USD
|
1,900
-0.0%
|
7.02
|
13,338
USD
|
|
2017-04-21 |
2017-04-20 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
69,472
-1.2%
6.88
477,967
USD
|
69,472
-1.2%
|
6.88
|
477,967
USD
|
|
2017-04-21 |
2017-04-20 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
100
-0.0%
6.95
695
USD
|
100
-0.0%
|
6.95
|
695
USD
|
|
2017-04-21 |
2017-04-19 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
18,864
-0.3%
6.90
130,162
USD
|
18,864
-0.3%
|
6.90
|
130,162
USD
|
|
2017-04-21 |
2017-04-19 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,400
-0.0%
6.97
9,758
USD
|
1,400
-0.0%
|
6.97
|
9,758
USD
|
|
2017-04-21 |
2017-04-19 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
8,000
-0.1%
6.97
55,760
USD
|
8,000
-0.1%
|
6.97
|
55,760
USD
|
|
2017-04-19 |
2017-04-18 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
11,000
-0.2%
7.22
79,420
USD
|
11,000
-0.2%
|
7.22
|
79,420
USD
|
|
2017-04-19 |
2017-04-18 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
6,517
-0.1%
6.98
45,489
USD
|
6,517
-0.1%
|
6.98
|
45,489
USD
|
|
2017-04-19 |
2017-04-17 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,100
-0.0%
7.81
8,591
USD
|
1,100
-0.0%
|
7.81
|
8,591
USD
|
|
2017-04-19 |
2017-04-17 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
38,400
-0.7%
7.27
279,168
USD
|
38,400
-0.7%
|
7.27
|
279,168
USD
|
|
2017-04-19 |
2017-04-17 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
200
-0.0%
7.79
1,558
USD
|
200
-0.0%
|
7.79
|
1,558
USD
|
|
2017-04-19 |
2017-04-17 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
50,000
-0.8%
7.24
362,000
USD
|
50,000
-0.8%
|
7.24
|
362,000
USD
|
|
2017-04-17 |
2017-04-13 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
13,260
-0.2%
7.68
101,837
USD
|
13,260
-0.2%
|
7.68
|
101,837
USD
|
|
2017-04-17 |
2017-04-13 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
45,400
-0.8%
7.38
335,052
USD
|
45,400
-0.8%
|
7.38
|
335,052
USD
|
|
2017-04-17 |
2017-04-13 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,100
-0.0%
7.70
16,170
USD
|
2,100
-0.0%
|
7.70
|
16,170
USD
|
|
2017-04-17 |
2017-04-13 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
16,500
-0.3%
7.49
123,585
USD
|
16,500
-0.3%
|
7.49
|
123,585
USD
|
|
2017-04-17 |
2017-04-13 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
19,200
-0.3%
7.27
139,584
USD
|
19,200
-0.3%
|
7.27
|
139,584
USD
|
|
2017-04-17 |
2017-04-13 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
700
-0.0%
7.54
5,278
USD
|
700
-0.0%
|
7.54
|
5,278
USD
|
|
2017-04-17 |
2017-04-13 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
17,500
-0.3%
7.49
131,075
USD
|
17,500
-0.3%
|
7.49
|
131,075
USD
|
|
2017-04-17 |
2017-04-13 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
300
-0.0%
7.58
2,274
USD
|
300
-0.0%
|
7.58
|
2,274
USD
|
|
2017-04-17 |
2017-04-13 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
900
-0.0%
7.58
6,822
USD
|
900
-0.0%
|
7.58
|
6,822
USD
|
|
2017-04-13 |
2017-04-12 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
96,011
-1.6%
7.41
711,442
USD
|
96,011
-1.6%
|
7.41
|
711,442
USD
|
|
2017-04-13 |
2017-04-12 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,669
-0.0%
7.41
12,367
USD
|
1,669
-0.0%
|
7.41
|
12,367
USD
|
|
2017-04-13 |
2017-04-11 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
18,300
-0.3%
7.50
137,250
USD
|
18,300
-0.3%
|
7.50
|
137,250
USD
|
|
2017-04-13 |
2017-04-11 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,000
-0.0%
7.50
7,500
USD
|
1,000
-0.0%
|
7.50
|
7,500
USD
|
|
2017-04-13 |
2017-04-11 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
100
-0.0%
7.48
748
USD
|
100
-0.0%
|
7.48
|
748
USD
|
|
2017-04-13 |
2017-04-11 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
56,490
-0.9%
7.34
414,637
USD
|
56,490
-0.9%
|
7.34
|
414,637
USD
|
|
2017-04-13 |
2017-04-11 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
5,824
-0.1%
7.59
44,204
USD
|
5,824
-0.1%
|
7.59
|
44,204
USD
|
|
2017-04-13 |
2017-04-11 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
100
-0.0%
7.53
753
USD
|
100
-0.0%
|
7.53
|
753
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,735
-0.0%
7.67
20,977
USD
|
2,735
-0.0%
|
7.67
|
20,977
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
4,888
-0.1%
7.71
37,686
USD
|
4,888
-0.1%
|
7.71
|
37,686
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
13,017
-0.2%
7.70
100,231
USD
|
13,017
-0.2%
|
7.70
|
100,231
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
400
-0.0%
7.71
3,084
USD
|
400
-0.0%
|
7.71
|
3,084
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
700
-0.0%
7.67
5,369
USD
|
700
-0.0%
|
7.67
|
5,369
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
6,222
-0.1%
7.70
47,909
USD
|
6,222
-0.1%
|
7.70
|
47,909
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
94,900
-1.5%
7.81
741,169
USD
|
94,900
-1.5%
|
7.81
|
741,169
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
300
-0.0%
7.71
2,313
USD
|
300
-0.0%
|
7.71
|
2,313
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
100
-0.0%
7.78
778
USD
|
100
-0.0%
|
7.78
|
778
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
11,737
-0.2%
7.70
90,375
USD
|
11,737
-0.2%
|
7.70
|
90,375
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
31,548
-0.5%
7.79
245,759
USD
|
31,548
-0.5%
|
7.79
|
245,759
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
11,709
-0.2%
7.69
90,042
USD
|
11,709
-0.2%
|
7.69
|
90,042
USD
|
|
2017-04-11 |
2017-04-10 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
300
-0.0%
7.68
2,304
USD
|
300
-0.0%
|
7.68
|
2,304
USD
|
|
2017-04-10 |
2017-04-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
550
-0.0%
8.08
4,444
USD
|
550
-0.0%
|
8.08
|
4,444
USD
|
|
2017-04-10 |
2017-04-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
9,949
-0.2%
8.03
79,890
USD
|
9,949
-0.2%
|
8.03
|
79,890
USD
|
|
2017-04-10 |
2017-04-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
500
-0.0%
7.68
3,840
USD
|
500
-0.0%
|
7.68
|
3,840
USD
|
|
2017-04-10 |
2017-04-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
6,400
-0.1%
7.99
51,136
USD
|
6,400
-0.1%
|
7.99
|
51,136
USD
|
|
2017-04-10 |
2017-04-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,400
-0.0%
8.10
11,340
USD
|
1,400
-0.0%
|
8.10
|
11,340
USD
|
|
2017-04-10 |
2017-04-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
29,051
-0.5%
7.83
227,469
USD
|
29,051
-0.5%
|
7.83
|
227,469
USD
|
|
2017-04-10 |
2017-04-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
600
-0.0%
7.92
4,752
USD
|
600
-0.0%
|
7.92
|
4,752
USD
|
|
2017-04-10 |
2017-04-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
500
-0.0%
8.02
4,010
USD
|
500
-0.0%
|
8.02
|
4,010
USD
|
|
2017-04-10 |
2017-04-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,900
-0.0%
7.73
22,417
USD
|
2,900
-0.0%
|
7.73
|
22,417
USD
|
|