2018-08-20 |
2018-08-16 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
3,455
-4.6%
9.94
34,343
USD
|
3,455
-4.6%
|
9.94
|
34,343
USD
|
|
2018-08-20 |
2018-08-16 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
362,765
-4.6%
9.94
3,605,884
USD
|
362,765
-4.6%
|
9.94
|
3,605,884
USD
|
|
2018-08-15 |
2018-08-15 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
736
-1.0%
9.93
7,308
USD
|
736
-1.0%
|
9.93
|
7,308
USD
|
|
2018-08-15 |
2018-08-15 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
77,314
-1.0%
9.93
767,728
USD
|
77,314
-1.0%
|
9.93
|
767,728
USD
|
|
2018-08-15 |
2018-08-14 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
198
-0.3%
9.94
1,968
USD
|
198
-0.3%
|
9.94
|
1,968
USD
|
|
2018-08-15 |
2018-08-14 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
20,777
-0.3%
9.94
206,523
USD
|
20,777
-0.3%
|
9.94
|
206,523
USD
|
|
2018-08-15 |
2018-08-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
820
-1.1%
9.98
8,184
USD
|
820
-1.1%
|
9.98
|
8,184
USD
|
|
2018-08-15 |
2018-08-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
86,103
-1.1%
9.98
859,308
USD
|
86,103
-1.1%
|
9.98
|
859,308
USD
|
|
2018-08-10 |
2018-08-10 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
6,460
-7.9%
9.96
64,342
USD
|
6,460
-7.9%
|
9.96
|
64,342
USD
|
|
2018-08-10 |
2018-08-10 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
678,333
-7.9%
9.96
6,756,197
USD
|
678,333
-7.9%
|
9.96
|
6,756,197
USD
|
|
2018-08-10 |
2018-08-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
249
-0.3%
9.86
2,455
USD
|
249
-0.3%
|
9.86
|
2,455
USD
|
|
2018-08-10 |
2018-08-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
26,139
-0.3%
9.86
257,731
USD
|
26,139
-0.3%
|
9.86
|
257,731
USD
|
|
2018-08-10 |
2018-08-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
615
-0.7%
9.91
6,095
USD
|
615
-0.7%
|
9.91
|
6,095
USD
|
|
2018-08-10 |
2018-08-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
64,575
-0.7%
9.91
639,938
USD
|
64,575
-0.7%
|
9.91
|
639,938
USD
|
|
2018-08-10 |
2018-08-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
1,036
-1.2%
9.95
10,308
USD
|
1,036
-1.2%
|
9.95
|
10,308
USD
|
|
2018-08-10 |
2018-08-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
108,729
-1.2%
9.95
1,081,854
USD
|
108,729
-1.2%
|
9.95
|
1,081,854
USD
|
|
2018-08-10 |
2018-08-08 |
S
Sale
|
FMR LLC
See Remark 1
|
200,000
-24.9%
10.02
2,004,000
USD
|
200,000
-24.9%
|
10.02
|
2,004,000
USD
|
|
2018-08-10 |
2018-08-08 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
4,553
-5.2%
10.00
45,530
USD
|
4,553
-5.2%
|
10.00
|
45,530
USD
|
|
2018-08-10 |
2018-08-08 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
478,107
-5.2%
10.00
4,781,070
USD
|
478,107
-5.2%
|
10.00
|
4,781,070
USD
|
|
2018-08-08 |
2018-08-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
4,200
-0.5%
10.16
42,672
USD
|
4,200
-0.5%
|
10.16
|
42,672
USD
|
|
2018-08-08 |
2018-08-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
11,400
-1.4%
10.12
115,368
USD
|
11,400
-1.4%
|
10.12
|
115,368
USD
|
|
2018-08-08 |
2018-08-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
10,000
-1.2%
10.10
101,000
USD
|
10,000
-1.2%
|
10.10
|
101,000
USD
|
|
2018-08-08 |
2018-08-07 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,000
-0.1%
10.38
10,380
USD
|
1,000
-0.1%
|
10.38
|
10,380
USD
|
|
2018-08-07 |
2018-08-07 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
478
-0.5%
10.01
4,785
USD
|
478
-0.5%
|
10.01
|
4,785
USD
|
|
2018-08-07 |
2018-08-07 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
50,149
-0.5%
10.01
501,991
USD
|
50,149
-0.5%
|
10.01
|
501,991
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
7,200
-0.9%
10.69
76,968
USD
|
7,200
-0.9%
|
10.69
|
76,968
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,980
-0.4%
10.77
32,095
USD
|
2,980
-0.4%
|
10.77
|
32,095
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
6,900
-0.8%
10.68
73,692
USD
|
6,900
-0.8%
|
10.68
|
73,692
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,000
-0.2%
10.48
20,960
USD
|
2,000
-0.2%
|
10.48
|
20,960
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
58,280
-6.4%
10.45
609,026
USD
|
58,280
-6.4%
|
10.45
|
609,026
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,879
-0.3%
10.56
30,402
USD
|
2,879
-0.3%
|
10.56
|
30,402
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
24,367
-2.6%
10.64
259,265
USD
|
24,367
-2.6%
|
10.64
|
259,265
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
10,673
-1.1%
10.47
111,746
USD
|
10,673
-1.1%
|
10.47
|
111,746
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
19,550
-2.0%
10.59
207,035
USD
|
19,550
-2.0%
|
10.59
|
207,035
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
5,700
-0.6%
10.68
60,876
USD
|
5,700
-0.6%
|
10.68
|
60,876
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
400
-0.0%
10.69
4,276
USD
|
400
-0.0%
|
10.69
|
4,276
USD
|
|
2018-08-08 |
2018-08-06 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
6,400
-0.7%
10.48
67,072
USD
|
6,400
-0.7%
|
10.48
|
67,072
USD
|
|
2018-08-07 |
2018-08-03 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
1,125
-1.3%
11.71
13,174
USD
|
1,125
-1.3%
|
11.71
|
13,174
USD
|
|
2018-08-07 |
2018-08-03 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
118,168
-1.3%
11.71
1,383,747
USD
|
118,168
-1.3%
|
11.71
|
1,383,747
USD
|
|
2018-08-06 |
2018-08-03 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
30,000
-3.0%
11.46
343,800
USD
|
30,000
-3.0%
|
11.46
|
343,800
USD
|
|
2018-08-06 |
2018-08-03 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
225,153
-18.2%
11.25
2,532,971
USD
|
225,153
-18.2%
|
11.25
|
2,532,971
USD
|
|
2018-08-06 |
2018-08-02 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,587
-0.2%
12.00
31,044
USD
|
2,587
-0.2%
|
12.00
|
31,044
USD
|
|
2018-08-06 |
2018-08-02 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
12,035
-1.0%
12.16
146,346
USD
|
12,035
-1.0%
|
12.16
|
146,346
USD
|
|
2018-08-06 |
2018-08-02 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
64,900
-4.9%
11.95
775,555
USD
|
64,900
-4.9%
|
11.95
|
775,555
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
7,600
-0.6%
11.91
90,516
USD
|
7,600
-0.6%
|
11.91
|
90,516
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
3,200
-0.2%
11.94
38,208
USD
|
3,200
-0.2%
|
11.94
|
38,208
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
778
-0.1%
11.95
9,297
USD
|
778
-0.1%
|
11.95
|
9,297
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,200
-0.1%
11.95
14,340
USD
|
1,200
-0.1%
|
11.95
|
14,340
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
8,600
-0.6%
11.93
102,598
USD
|
8,600
-0.6%
|
11.93
|
102,598
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,900
-0.2%
12.02
34,858
USD
|
2,900
-0.2%
|
12.02
|
34,858
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,000
-0.1%
12.18
12,180
USD
|
1,000
-0.1%
|
12.18
|
12,180
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
800
-0.1%
12.10
9,680
USD
|
800
-0.1%
|
12.10
|
9,680
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
3,000
-0.2%
12.13
36,390
USD
|
3,000
-0.2%
|
12.13
|
36,390
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,500
-0.1%
11.95
17,925
USD
|
1,500
-0.1%
|
11.95
|
17,925
USD
|
|
2018-08-02 |
2018-08-01 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
35,756
-2.6%
12.11
433,005
USD
|
35,756
-2.6%
|
12.11
|
433,005
USD
|
|
2018-08-02 |
2018-07-31 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,000
-0.1%
12.03
12,030
USD
|
1,000
-0.1%
|
12.03
|
12,030
USD
|
|
2018-08-02 |
2018-07-31 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
500
-0.0%
12.13
6,065
USD
|
500
-0.0%
|
12.13
|
6,065
USD
|
|
2018-08-02 |
2018-07-31 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
6,522
-0.5%
12.11
78,981
USD
|
6,522
-0.5%
|
12.11
|
78,981
USD
|
|
2018-08-02 |
2018-07-31 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
900
-0.1%
12.11
10,899
USD
|
900
-0.1%
|
12.11
|
10,899
USD
|
|
2018-08-02 |
2018-07-31 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
30,000
-2.1%
12.12
363,600
USD
|
30,000
-2.1%
|
12.12
|
363,600
USD
|
|
2018-08-02 |
2018-07-31 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,700
-0.2%
12.13
32,751
USD
|
2,700
-0.2%
|
12.13
|
32,751
USD
|
|
2018-08-02 |
2018-07-31 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
19,250
-1.3%
12.07
232,348
USD
|
19,250
-1.3%
|
12.07
|
232,348
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
10,000
-0.7%
11.44
114,400
USD
|
10,000
-0.7%
|
11.44
|
114,400
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
11,500
-0.8%
11.39
130,985
USD
|
11,500
-0.8%
|
11.39
|
130,985
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
68,092
-4.5%
11.36
773,525
USD
|
68,092
-4.5%
|
11.36
|
773,525
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
253
-0.0%
11.36
2,874
USD
|
253
-0.0%
|
11.36
|
2,874
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
600
-0.0%
11.52
6,912
USD
|
600
-0.0%
|
11.52
|
6,912
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,200
-0.1%
11.54
13,848
USD
|
1,200
-0.1%
|
11.54
|
13,848
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
1,600
-0.1%
11.49
18,384
USD
|
1,600
-0.1%
|
11.49
|
18,384
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
7,800
-0.5%
11.48
89,544
USD
|
7,800
-0.5%
|
11.48
|
89,544
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
400
-0.0%
11.48
4,592
USD
|
400
-0.0%
|
11.48
|
4,592
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
6,000
-0.4%
11.45
68,700
USD
|
6,000
-0.4%
|
11.45
|
68,700
USD
|
|
2018-07-31 |
2018-07-30 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
2,555
-0.2%
11.47
29,306
USD
|
2,555
-0.2%
|
11.47
|
29,306
USD
|
|
2018-07-31 |
2018-07-27 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
18,006
-1.1%
11.56
208,149
USD
|
18,006
-1.1%
|
11.56
|
208,149
USD
|
|
2018-07-31 |
2018-07-27 |
S
Sale
|
FMR LLC
See Remark 1
Major owner
|
130,559
-7.7%
11.60
1,514,484
USD
|
130,559
-7.7%
|
11.60
|
1,514,484
USD
|
|