|
2018-01-09 |
2018-01-09 |
PS
Planned sale
|
Vaughn Victor
Sr. VP of Sales
Officer
|
15,000
-61.6%
42.04
630,650
USD
|
15,000
-61.6%
|
42.04
|
630,650
USD
|
|
|
2018-01-04 |
2018-01-02 |
PS
Planned sale
|
Vaughn Victor
Sr. VP of Sales
Officer
|
55,000
-85.5%
40.11
2,206,309
USD
|
55,000
-85.5%
|
40.11
|
2,206,309
USD
|
|
|
2017-09-11 |
2017-09-08 |
PS
Planned sale
|
PATRICK GREGORY S
VP, Chief Financial Officer
|
23,481
-59.9%
48.89
1,147,965
USD
|
23,481
-59.9%
|
48.89
|
1,147,965
USD
|
|
|
2017-09-11 |
2017-09-08 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr VP of IP, CSO
|
5,000
-28.6%
49.86
249,303
USD
|
5,000
-28.6%
|
49.86
|
249,303
USD
|
|
|
2017-09-11 |
2017-09-07 |
PS
Planned sale
|
PATRICK GREGORY S
VP, Chief Financial Officer
|
1,519
-68.0%
48.00
72,912
USD
|
1,519
-68.0%
|
48.00
|
72,912
USD
|
|
|
2017-09-11 |
2017-09-07 |
PS
Planned sale
|
PATRICK GREGORY S
VP, Chief Financial Officer
|
25,000
-91.8%
46.36
1,158,903
USD
|
25,000
-91.8%
|
46.36
|
1,158,903
USD
|
|
|
2017-09-11 |
2017-09-07 |
PS
Planned sale
|
Schwabe Stefan K.F.
Executive Vice President R&D
|
95,000
-98.1%
46.59
4,425,575
USD
|
95,000
-98.1%
|
46.59
|
4,425,575
USD
|
|
|
2017-08-16 |
2017-08-16 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr.VP of IP, CSO
|
3,709
-17.5%
45.23
167,755
USD
|
3,709
-17.5%
|
45.23
|
167,755
USD
|
|
|
2017-07-14 |
2017-07-12 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr. VP of IP, CSO
Officer
|
3,735
-15.0%
44.90
167,702
USD
|
3,735
-15.0%
|
44.90
|
167,702
USD
|
|
|
2017-06-27 |
2017-06-23 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr. VP of IP, CSO
|
2,556
-9.3%
44.90
114,774
USD
|
2,556
-9.3%
|
44.90
|
114,774
USD
|
|
|
2017-06-05 |
2017-06-02 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr. VP of IP, CSO
|
10,000
-26.7%
39.86
398,558
USD
|
10,000
-26.7%
|
39.86
|
398,558
USD
|
|
|
2017-05-30 |
2017-05-26 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr. VP of IP, CSO
Officer
|
2,500
-6.2%
35.90
89,758
USD
|
2,500
-6.2%
|
35.90
|
89,758
USD
|
|
|
2017-05-25 |
2017-05-25 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr. VP of IP, CSO
Officer
|
3,887
-8.9%
34.90
135,656
USD
|
3,887
-8.9%
|
34.90
|
135,656
USD
|
|
|
2017-05-25 |
2017-05-24 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr. VP of IP, CSO
Officer
|
1,613
-3.5%
34.90
56,294
USD
|
1,613
-3.5%
|
34.90
|
56,294
USD
|
|
|
2017-04-26 |
2017-04-24 |
PS
Planned sale
|
PATRICK GREGORY S
VP, Chief Financial Officer
|
54,000
-99.6%
32.37
1,747,872
USD
|
54,000
-99.6%
|
32.37
|
1,747,872
USD
|
|
|
2017-04-24 |
2017-04-24 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr. VP of IP, CSO
|
11,806
-20.6%
32.59
384,762
USD
|
11,806
-20.6%
|
32.59
|
384,762
USD
|
|
|
2016-09-16 |
2016-09-16 |
PS
Planned sale
|
PATRICK GREGORY S
VP, Chief Financial Officer
Officer
|
2,000
-35.6%
25.00
50,000
USD
|
2,000
-35.6%
|
25.00
|
50,000
USD
|
|
|
2016-07-15 |
2016-07-14 |
PS
Planned sale
|
PATRICK GREGORY S
VP, Chief Financial Officer
Officer
|
3,395
-37.7%
22.00
74,690
USD
|
3,395
-37.7%
|
22.00
|
74,690
USD
|
|
|
2016-04-12 |
2016-04-11 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr. VP of IP, CSO
Officer
|
30,762
-34.9%
16.49
507,228
USD
|
30,762
-34.9%
|
16.49
|
507,228
USD
|
|
|
2015-12-10 |
2015-12-09 |
PS
Planned sale
|
Bhatt Padmanabh P.
Sr. VP of IP, CSO
Officer
|
4,685
-5.1%
14.90
69,807
USD
|
4,685
-5.1%
|
14.90
|
69,807
USD
|
|
|
2015-12-08 |
2015-12-08 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
|
70,913
-100.0%
14.75
1,045,953
USD
|
70,913
-100.0%
|
14.75
|
1,045,953
USD
|
|
|
2015-12-08 |
2015-12-07 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
|
71,067
-50.1%
14.38
1,022,192
USD
|
71,067
-50.1%
|
14.38
|
1,022,192
USD
|
|
|
2015-12-08 |
2015-12-04 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
|
70,990
-33.3%
14.54
1,032,152
USD
|
70,990
-33.3%
|
14.54
|
1,032,152
USD
|
|
|
2015-11-30 |
2015-11-25 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
|
16,179
-18.0%
16.35
264,494
USD
|
16,179
-18.0%
|
16.35
|
264,494
USD
|
|
|
2015-11-18 |
2015-11-18 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
|
43,000
-100.0%
16.50
709,543
USD
|
43,000
-100.0%
|
16.50
|
709,543
USD
|
|
|
2015-11-18 |
2015-11-17 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
|
50,000
-53.8%
16.71
835,460
USD
|
50,000
-53.8%
|
16.71
|
835,460
USD
|
|
|
2015-11-17 |
2015-11-16 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
|
19,650
-17.4%
16.13
317,035
USD
|
19,650
-17.4%
|
16.13
|
317,035
USD
|
|
|
2015-11-17 |
2015-11-13 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
|
100,000
-47.0%
16.26
1,625,610
USD
|
100,000
-47.0%
|
16.26
|
1,625,610
USD
|
|
|
2015-07-29 |
2015-07-28 |
PS
Planned sale
|
Schwabe Stefan K.F.
Executive Vice President R&D
Officer
|
1,700
-100.0%
21.20
36,040
USD
|
1,700
-100.0%
|
21.20
|
36,040
USD
|
|
|
2015-06-19 |
2015-06-17 |
S
Sale
|
BARRIS PETER J
Large shareholder
|
48,796
-100.0%
16.02
781,800
USD
|
48,796
-100.0%
|
16.02
|
781,800
USD
|
|
|
2015-06-19 |
2015-06-17 |
S
Sale
|
BASKETT FOREST
Large shareholder
|
48,796
-100.0%
16.02
781,800
USD
|
48,796
-100.0%
|
16.02
|
781,800
USD
|
|
|
2015-06-19 |
2015-06-17 |
S
Sale
|
SANDELL SCOTT D
Large shareholder
|
48,796
-100.0%
16.02
781,800
USD
|
48,796
-100.0%
|
16.02
|
781,800
USD
|
|
|
2015-06-19 |
2015-06-17 |
S
Sale
|
SANDELL SCOTT D
Large shareholder
|
63,085
-56.4%
16.67
1,051,804
USD
|
63,085
-56.4%
|
16.67
|
1,051,804
USD
|
|
|
2015-06-19 |
2015-06-17 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
Large shareholder
|
48,796
-100.0%
16.02
781,800
USD
|
48,796
-100.0%
|
16.02
|
781,800
USD
|
|
|
2015-06-19 |
2015-06-17 |
S
Sale
|
BASKETT FOREST
Large shareholder
|
63,085
-56.4%
16.67
1,051,804
USD
|
63,085
-56.4%
|
16.67
|
1,051,804
USD
|
|
|
2015-06-19 |
2015-06-17 |
S
Sale
|
SANDELL SCOTT D
Large shareholder
|
24,716
-100.0%
17.03
420,817
USD
|
24,716
-100.0%
|
17.03
|
420,817
USD
|
|
|
2015-06-19 |
2015-06-17 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
Large shareholder
|
63,085
-56.4%
16.67
1,051,804
USD
|
63,085
-56.4%
|
16.67
|
1,051,804
USD
|
|
|
2015-06-17 |
2015-06-16 |
S
Sale
|
BARRETT M JAMES
Non-Executive Director
Large shareholder
|
55,105
-33.0%
16.85
928,668
USD
|
55,105
-33.0%
|
16.85
|
928,668
USD
|
|
|
2015-06-17 |
2015-06-16 |
S
Sale
|
SANDELL SCOTT D
Large shareholder
|
55,105
-33.0%
16.85
928,668
USD
|
55,105
-33.0%
|
16.85
|
928,668
USD
|
|
|
2015-06-17 |
2015-06-16 |
S
Sale
|
SANDELL SCOTT D
Large shareholder
|
40,332
-62.0%
17.01
685,902
USD
|
40,332
-62.0%
|
17.01
|
685,902
USD
|
|
|
2015-06-17 |
2015-06-16 |
S
Sale
|
BARRIS PETER J
Large shareholder
|
55,105
-33.0%
16.85
928,668
USD
|
55,105
-33.0%
|
16.85
|
928,668
USD
|
|
|
2015-06-17 |
2015-06-16 |
S
Sale
|
BASKETT FOREST
Large shareholder
|
55,105
-33.0%
16.85
928,668
USD
|
55,105
-33.0%
|
16.85
|
928,668
USD
|
|
|
2015-06-17 |
2015-06-16 |
S
Sale
|
BASKETT FOREST
Large shareholder
|
56,359
-100.0%
16.85
949,412
USD
|
56,359
-100.0%
|
16.85
|
949,412
USD
|
|
|
2015-06-12 |
2015-06-11 |
PS
Planned sale
|
Schwabe Stefan K.F.
Executive Vice President R&D
Officer
|
2,286
-32.1%
16.44
37,570
USD
|
2,286
-32.1%
|
16.44
|
37,570
USD
|
|
|
2015-03-31 |
2015-03-30 |
PS
Planned sale
|
Bryan Jones W.
VP of Business Development
Officer
|
6,712
-9.0%
12.02
80,647
USD
|
6,712
-9.0%
|
12.02
|
80,647
USD
|
|
|
2015-03-26 |
2015-03-24 |
PS
Planned sale
|
Bryan Jones W.
VP of Business Development
Officer
|
1,900
-2.7%
12.00
22,800
USD
|
1,900
-2.7%
|
12.00
|
22,800
USD
|
|
|
2013-03-26 |
2013-03-22 |
B
Purchase
|
BIGHAM MICHAEL
Non-Executive Director
|
15,000
+150.0%
5.65
84,795
USD
|
15,000
+150.0%
|
5.65
|
84,795
USD
|
|
|
2013-03-25 |
2013-03-21 |
B
Purchase
|
SIEBERT JOHN M
Non-Executive Director
|
3,000
+24.6%
5.50
16,500
USD
|
3,000
+24.6%
|
5.50
|
16,500
USD
|
|
|
2013-03-26 |
2013-03-20 |
B
Purchase
|
BIGHAM MICHAEL
Non-Executive Director
|
10,000
+inf%
5.26
52,640
USD
|
10,000
+inf%
|
5.26
|
52,640
USD
|
|
|
2013-03-26 |
2013-03-20 |
B
Purchase
|
BIGHAM MICHAEL
Non-Executive Director
|
5,000
+inf%
5.20
25,975
USD
|
5,000
+inf%
|
5.20
|
25,975
USD
|
|
|
2013-03-26 |
2013-03-20 |
B
Purchase
|
BIGHAM MICHAEL
Non-Executive Director
|
5,000
+inf%
5.17
25,860
USD
|
5,000
+inf%
|
5.17
|
25,860
USD
|
|
|
2013-02-14 |
2013-02-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
41,100
-4.8%
7.58
311,361
USD
|
41,100
-4.8%
|
7.58
|
311,361
USD
|
|
|
2013-02-14 |
2013-02-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
108,900
-4.8%
7.58
824,994
USD
|
108,900
-4.8%
|
7.58
|
824,994
USD
|
|
|
2013-02-14 |
2013-02-12 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
41,483
-4.6%
7.52
312,027
USD
|
41,483
-4.6%
|
7.52
|
312,027
USD
|
|
|
2013-02-14 |
2013-02-12 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
110,700
-4.6%
7.52
832,663
USD
|
110,700
-4.6%
|
7.52
|
832,663
USD
|
|
|
2012-12-19 |
2012-12-18 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
100,000
-100.0%
7.08
707,670
USD
|
100,000
-100.0%
|
7.08
|
707,670
USD
|
|
|
2012-12-19 |
2012-12-17 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
197,815
-66.4%
6.85
1,354,617
USD
|
197,815
-66.4%
|
6.85
|
1,354,617
USD
|
|
|
2012-12-05 |
2012-12-04 |
B
Purchase
|
SIEBERT JOHN M
Non-Executive Director
|
7,000
+233.3%
8.14
56,980
USD
|
7,000
+233.3%
|
8.14
|
56,980
USD
|
|
|
2012-05-08 |
2012-05-04 |
B
Purchase
|
NEWHALL CHARLES W III
Non-Executive Director
Large shareholder
|
4,400,000
+70.5%
5.00
22,000,000
USD
|
4,400,000
+70.5%
|
5.00
|
22,000,000
USD
|
|
|
2012-05-08 |
2012-05-04 |
B
Purchase
|
Abingworth Management LTD
Large shareholder
|
1,100,000
+44.0%
5.00
5,500,000
USD
|
1,100,000
+44.0%
|
5.00
|
5,500,000
USD
|
|
|
2012-05-08 |
2012-05-04 |
B
Purchase
|
NEW ENTERPRISE ASSOCIATES 11 LP
Large shareholder
|
4,400,000
+70.5%
5.00
22,000,000
USD
|
4,400,000
+70.5%
|
5.00
|
22,000,000
USD
|
|
|
2012-05-08 |
2012-05-04 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
90,999
+44.0%
5.00
454,995
USD
|
90,999
+44.0%
|
5.00
|
454,995
USD
|
|
|
2012-05-08 |
2012-05-04 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
274,873
+44.0%
5.00
1,374,365
USD
|
274,873
+44.0%
|
5.00
|
1,374,365
USD
|
|
|
2012-05-08 |
2012-05-04 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
734,128
+44.0%
5.00
3,670,640
USD
|
734,128
+44.0%
|
5.00
|
3,670,640
USD
|
|
|
2012-05-08 |
2012-05-04 |
B
Purchase
|
BARRETT M JAMES
Non-Executive Director
Large shareholder
|
4,400,000
+70.5%
5.00
22,000,000
USD
|
4,400,000
+70.5%
|
5.00
|
22,000,000
USD
|
|
|
2012-05-07 |
2012-05-04 |
B
Purchase
|
SHEFFERY MICHAEL B
Non-Executive Director
|
90,999
+44.0%
5.00
454,995
USD
|
90,999
+44.0%
|
5.00
|
454,995
USD
|
|
|
2012-05-07 |
2012-05-04 |
B
Purchase
|
SHEFFERY MICHAEL B
Non-Executive Director
|
274,873
+44.0%
5.00
1,374,365
USD
|
274,873
+44.0%
|
5.00
|
1,374,365
USD
|
|
|
2012-05-07 |
2012-05-04 |
B
Purchase
|
SHEFFERY MICHAEL B
Non-Executive Director
|
734,128
+44.0%
5.00
3,670,640
USD
|
734,128
+44.0%
|
5.00
|
3,670,640
USD
|
|
|
2012-05-07 |
2012-05-04 |
B
Purchase
|
SIEBERT JOHN M
Non-Executive Director
|
3,000
+inf%
5.00
15,000
USD
|
3,000
+inf%
|
5.00
|
15,000
USD
|
|
|
2012-05-07 |
2012-05-04 |
B
Purchase
|
Nuerge William A.
Non-Executive Director
|
15,000
+171.4%
5.00
75,000
USD
|
15,000
+171.4%
|
5.00
|
75,000
USD
|
|
|
2012-05-07 |
2012-05-04 |
B
Purchase
|
Hudson Frederick M.
Non-Executive Director
|
5,000
+inf%
5.00
25,000
USD
|
5,000
+inf%
|
5.00
|
25,000
USD
|
|
|
2012-05-07 |
2012-05-04 |
B
Purchase
|
Khattar Jack A.
President, CEO
Executive Director
|
5,000
+1.3%
5.00
25,000
USD
|
5,000
+1.3%
|
5.00
|
25,000
USD
|
|
|
2012-05-07 |
2012-05-04 |
B
Purchase
|
PATRICK GREGORY S
VP, Chief Financial Officer
Officer
|
3,000
+inf%
5.00
15,000
USD
|
3,000
+inf%
|
5.00
|
15,000
USD
|
|
|
2012-05-07 |
2012-05-04 |
B
Purchase
|
Martin Tami Tillotson
VP of Regulatory Affairs
Officer
|
2,500
+inf%
5.00
12,500
USD
|
2,500
+inf%
|
5.00
|
12,500
USD
|
|
