2018-07-27 |
2018-07-26 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
42 409
-2.4%
12,48
529 264
USD
|
42 409
-2.4%
|
12,48
|
529 264
USD
|
|
2018-07-27 |
2018-07-26 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
7 300
-0.4%
12,55
91 615
USD
|
7 300
-0.4%
|
12,55
|
91 615
USD
|
|
2018-07-27 |
2018-07-26 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
169 102
-8.8%
12,01
2 030 915
USD
|
169 102
-8.8%
|
12,01
|
2 030 915
USD
|
|
2018-07-27 |
2018-07-25 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
13 206
-0.7%
12,00
158 472
USD
|
13 206
-0.7%
|
12,00
|
158 472
USD
|
|
2018-07-27 |
2018-07-25 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
63 833
-3.2%
11,95
762 804
USD
|
63 833
-3.2%
|
11,95
|
762 804
USD
|
|
2018-03-16 |
2018-03-14 |
V
Vente
|
Dempsey James F.
Chief Scientific Officer
Administrateur exécutif
|
75 243
-29.2%
7,57
569 755
USD
|
75 243
-29.2%
|
7,57
|
569 755
USD
|
|
2017-04-27 |
2017-04-25 |
V
Vente
|
FMR LLC
See Remark 1
|
22 661
-0.4%
6,69
151 602
USD
|
22 661
-0.4%
|
6,69
|
151 602
USD
|
|
2017-04-27 |
2017-04-25 |
V
Vente
|
FMR LLC
See Remark 1
|
20
-0.0%
6,79
136
USD
|
20
-0.0%
|
6,79
|
136
USD
|
|
2017-04-27 |
2017-04-25 |
V
Vente
|
FMR LLC
See Remark 1
|
67 900
-1.2%
6,80
461 720
USD
|
67 900
-1.2%
|
6,80
|
461 720
USD
|
|
2017-04-27 |
2017-04-25 |
V
Vente
|
FMR LLC
See Remark 1
|
4 000
-0.1%
6,74
26 960
USD
|
4 000
-0.1%
|
6,74
|
26 960
USD
|
|
2017-04-27 |
2017-04-25 |
V
Vente
|
FMR LLC
See Remark 1
|
6 000
-0.1%
6,69
40 140
USD
|
6 000
-0.1%
|
6,69
|
40 140
USD
|
|
2017-04-27 |
2017-04-25 |
V
Vente
|
FMR LLC
See Remark 1
|
4 900
-0.1%
6,74
33 026
USD
|
4 900
-0.1%
|
6,74
|
33 026
USD
|
|
2017-04-27 |
2017-04-25 |
V
Vente
|
FMR LLC
See Remark 1
|
300
-0.0%
6,76
2 028
USD
|
300
-0.0%
|
6,76
|
2 028
USD
|
|
2017-04-27 |
2017-04-25 |
V
Vente
|
FMR LLC
See Remark 1
|
1 000
-0.0%
6,76
6 760
USD
|
1 000
-0.0%
|
6,76
|
6 760
USD
|
|
2017-04-25 |
2017-04-24 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
300
-0.0%
6,63
1 989
USD
|
300
-0.0%
|
6,63
|
1 989
USD
|
|
2017-04-25 |
2017-04-24 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
6 634
-0.1%
6,60
43 784
USD
|
6 634
-0.1%
|
6,60
|
43 784
USD
|
|
2017-04-25 |
2017-04-24 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
58 200
-1.0%
6,68
388 776
USD
|
58 200
-1.0%
|
6,68
|
388 776
USD
|
|
2017-04-25 |
2017-04-24 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
12 500
-0.2%
6,62
82 750
USD
|
12 500
-0.2%
|
6,62
|
82 750
USD
|
|
2017-04-25 |
2017-04-21 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
6 406
-0.1%
6,86
43 945
USD
|
6 406
-0.1%
|
6,86
|
43 945
USD
|
|
2017-04-25 |
2017-04-21 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
600
-0.0%
6,91
4 146
USD
|
600
-0.0%
|
6,91
|
4 146
USD
|
|
2017-04-25 |
2017-04-21 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
11 399
-0.2%
6,83
77 855
USD
|
11 399
-0.2%
|
6,83
|
77 855
USD
|
|
2017-04-25 |
2017-04-21 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
5 100
-0.1%
6,88
35 088
USD
|
5 100
-0.1%
|
6,88
|
35 088
USD
|
|
2017-04-21 |
2017-04-20 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
700
-0.0%
6,95
4 865
USD
|
700
-0.0%
|
6,95
|
4 865
USD
|
|
2017-04-21 |
2017-04-20 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
800
-0.0%
6,96
5 568
USD
|
800
-0.0%
|
6,96
|
5 568
USD
|
|
2017-04-21 |
2017-04-20 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
1 900
-0.0%
7,02
13 338
USD
|
1 900
-0.0%
|
7,02
|
13 338
USD
|
|
2017-04-21 |
2017-04-20 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
69 472
-1.2%
6,88
477 967
USD
|
69 472
-1.2%
|
6,88
|
477 967
USD
|
|
2017-04-21 |
2017-04-20 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
100
-0.0%
6,95
695
USD
|
100
-0.0%
|
6,95
|
695
USD
|
|
2017-04-21 |
2017-04-19 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
18 864
-0.3%
6,90
130 162
USD
|
18 864
-0.3%
|
6,90
|
130 162
USD
|
|
2017-04-21 |
2017-04-19 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
1 400
-0.0%
6,97
9 758
USD
|
1 400
-0.0%
|
6,97
|
9 758
USD
|
|
2017-04-21 |
2017-04-19 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
8 000
-0.1%
6,97
55 760
USD
|
8 000
-0.1%
|
6,97
|
55 760
USD
|
|
2017-04-19 |
2017-04-18 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
11 000
-0.2%
7,22
79 420
USD
|
11 000
-0.2%
|
7,22
|
79 420
USD
|
|
2017-04-19 |
2017-04-18 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
6 517
-0.1%
6,98
45 489
USD
|
6 517
-0.1%
|
6,98
|
45 489
USD
|
|
2017-04-19 |
2017-04-17 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
1 100
-0.0%
7,81
8 591
USD
|
1 100
-0.0%
|
7,81
|
8 591
USD
|
|
2017-04-19 |
2017-04-17 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
38 400
-0.7%
7,27
279 168
USD
|
38 400
-0.7%
|
7,27
|
279 168
USD
|
|
2017-04-19 |
2017-04-17 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
200
-0.0%
7,79
1 558
USD
|
200
-0.0%
|
7,79
|
1 558
USD
|
|
2017-04-19 |
2017-04-17 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
50 000
-0.8%
7,24
362 000
USD
|
50 000
-0.8%
|
7,24
|
362 000
USD
|
|
2017-04-17 |
2017-04-13 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
13 260
-0.2%
7,68
101 837
USD
|
13 260
-0.2%
|
7,68
|
101 837
USD
|
|
2017-04-17 |
2017-04-13 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
45 400
-0.8%
7,38
335 052
USD
|
45 400
-0.8%
|
7,38
|
335 052
USD
|
|
2017-04-17 |
2017-04-13 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
2 100
-0.0%
7,70
16 170
USD
|
2 100
-0.0%
|
7,70
|
16 170
USD
|
|
2017-04-17 |
2017-04-13 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
16 500
-0.3%
7,49
123 585
USD
|
16 500
-0.3%
|
7,49
|
123 585
USD
|
|
2017-04-17 |
2017-04-13 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
19 200
-0.3%
7,27
139 584
USD
|
19 200
-0.3%
|
7,27
|
139 584
USD
|
|
2017-04-17 |
2017-04-13 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
700
-0.0%
7,54
5 278
USD
|
700
-0.0%
|
7,54
|
5 278
USD
|
|
2017-04-17 |
2017-04-13 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
17 500
-0.3%
7,49
131 075
USD
|
17 500
-0.3%
|
7,49
|
131 075
USD
|
|
2017-04-17 |
2017-04-13 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
300
-0.0%
7,58
2 274
USD
|
300
-0.0%
|
7,58
|
2 274
USD
|
|
2017-04-17 |
2017-04-13 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
900
-0.0%
7,58
6 822
USD
|
900
-0.0%
|
7,58
|
6 822
USD
|
|
2017-04-13 |
2017-04-12 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
96 011
-1.6%
7,41
711 442
USD
|
96 011
-1.6%
|
7,41
|
711 442
USD
|
|
2017-04-13 |
2017-04-12 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
1 669
-0.0%
7,41
12 367
USD
|
1 669
-0.0%
|
7,41
|
12 367
USD
|
|
2017-04-13 |
2017-04-11 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
18 300
-0.3%
7,50
137 250
USD
|
18 300
-0.3%
|
7,50
|
137 250
USD
|
|
2017-04-13 |
2017-04-11 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
1 000
-0.0%
7,50
7 500
USD
|
1 000
-0.0%
|
7,50
|
7 500
USD
|
|
2017-04-13 |
2017-04-11 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
100
-0.0%
7,48
748
USD
|
100
-0.0%
|
7,48
|
748
USD
|
|
2017-04-13 |
2017-04-11 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
56 490
-0.9%
7,34
414 637
USD
|
56 490
-0.9%
|
7,34
|
414 637
USD
|
|
2017-04-13 |
2017-04-11 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
5 824
-0.1%
7,59
44 204
USD
|
5 824
-0.1%
|
7,59
|
44 204
USD
|
|
2017-04-13 |
2017-04-11 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
100
-0.0%
7,53
753
USD
|
100
-0.0%
|
7,53
|
753
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
2 735
-0.0%
7,67
20 977
USD
|
2 735
-0.0%
|
7,67
|
20 977
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
4 888
-0.1%
7,71
37 686
USD
|
4 888
-0.1%
|
7,71
|
37 686
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
13 017
-0.2%
7,70
100 231
USD
|
13 017
-0.2%
|
7,70
|
100 231
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
400
-0.0%
7,71
3 084
USD
|
400
-0.0%
|
7,71
|
3 084
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
700
-0.0%
7,67
5 369
USD
|
700
-0.0%
|
7,67
|
5 369
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
6 222
-0.1%
7,70
47 909
USD
|
6 222
-0.1%
|
7,70
|
47 909
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
94 900
-1.5%
7,81
741 169
USD
|
94 900
-1.5%
|
7,81
|
741 169
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
300
-0.0%
7,71
2 313
USD
|
300
-0.0%
|
7,71
|
2 313
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
100
-0.0%
7,78
778
USD
|
100
-0.0%
|
7,78
|
778
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
11 737
-0.2%
7,70
90 375
USD
|
11 737
-0.2%
|
7,70
|
90 375
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
31 548
-0.5%
7,79
245 759
USD
|
31 548
-0.5%
|
7,79
|
245 759
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
11 709
-0.2%
7,69
90 042
USD
|
11 709
-0.2%
|
7,69
|
90 042
USD
|
|
2017-04-11 |
2017-04-10 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
300
-0.0%
7,68
2 304
USD
|
300
-0.0%
|
7,68
|
2 304
USD
|
|
2017-04-10 |
2017-04-07 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
550
-0.0%
8,08
4 444
USD
|
550
-0.0%
|
8,08
|
4 444
USD
|
|
2017-04-10 |
2017-04-07 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
9 949
-0.2%
8,03
79 890
USD
|
9 949
-0.2%
|
8,03
|
79 890
USD
|
|
2017-04-10 |
2017-04-07 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
500
-0.0%
7,68
3 840
USD
|
500
-0.0%
|
7,68
|
3 840
USD
|
|
2017-04-10 |
2017-04-07 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
6 400
-0.1%
7,99
51 136
USD
|
6 400
-0.1%
|
7,99
|
51 136
USD
|
|
2017-04-10 |
2017-04-07 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
1 400
-0.0%
8,10
11 340
USD
|
1 400
-0.0%
|
8,10
|
11 340
USD
|
|
2017-04-10 |
2017-04-07 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
29 051
-0.5%
7,83
227 469
USD
|
29 051
-0.5%
|
7,83
|
227 469
USD
|
|
2017-04-10 |
2017-04-07 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
600
-0.0%
7,92
4 752
USD
|
600
-0.0%
|
7,92
|
4 752
USD
|
|
2017-04-10 |
2017-04-07 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
500
-0.0%
8,02
4 010
USD
|
500
-0.0%
|
8,02
|
4 010
USD
|
|
2017-04-10 |
2017-04-06 |
V
Vente
|
FMR LLC
See Remark 1
Large shareholder
|
2 900
-0.0%
7,73
22 417
USD
|
2 900
-0.0%
|
7,73
|
22 417
USD
|
|