2018-08-20 |
2018-08-16 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
3 455
-4.6%
9,94
34 343
USD
|
3 455
-4.6%
|
9,94
|
34 343
USD
|
|
2018-08-20 |
2018-08-16 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
362 765
-4.6%
9,94
3 605 884
USD
|
362 765
-4.6%
|
9,94
|
3 605 884
USD
|
|
2018-08-15 |
2018-08-15 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
736
-1.0%
9,93
7 308
USD
|
736
-1.0%
|
9,93
|
7 308
USD
|
|
2018-08-15 |
2018-08-15 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
77 314
-1.0%
9,93
767 728
USD
|
77 314
-1.0%
|
9,93
|
767 728
USD
|
|
2018-08-15 |
2018-08-14 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
198
-0.3%
9,94
1 968
USD
|
198
-0.3%
|
9,94
|
1 968
USD
|
|
2018-08-15 |
2018-08-14 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
20 777
-0.3%
9,94
206 523
USD
|
20 777
-0.3%
|
9,94
|
206 523
USD
|
|
2018-08-15 |
2018-08-13 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
820
-1.1%
9,98
8 184
USD
|
820
-1.1%
|
9,98
|
8 184
USD
|
|
2018-08-15 |
2018-08-13 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
86 103
-1.1%
9,98
859 308
USD
|
86 103
-1.1%
|
9,98
|
859 308
USD
|
|
2018-08-10 |
2018-08-10 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
6 460
-7.9%
9,96
64 342
USD
|
6 460
-7.9%
|
9,96
|
64 342
USD
|
|
2018-08-10 |
2018-08-10 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
678 333
-7.9%
9,96
6 756 197
USD
|
678 333
-7.9%
|
9,96
|
6 756 197
USD
|
|
2018-08-10 |
2018-08-09 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
249
-0.3%
9,86
2 455
USD
|
249
-0.3%
|
9,86
|
2 455
USD
|
|
2018-08-10 |
2018-08-09 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
26 139
-0.3%
9,86
257 731
USD
|
26 139
-0.3%
|
9,86
|
257 731
USD
|
|
2018-08-10 |
2018-08-09 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
615
-0.7%
9,91
6 095
USD
|
615
-0.7%
|
9,91
|
6 095
USD
|
|
2018-08-10 |
2018-08-09 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
64 575
-0.7%
9,91
639 938
USD
|
64 575
-0.7%
|
9,91
|
639 938
USD
|
|
2018-08-10 |
2018-08-09 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
1 036
-1.2%
9,95
10 308
USD
|
1 036
-1.2%
|
9,95
|
10 308
USD
|
|
2018-08-10 |
2018-08-09 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
108 729
-1.2%
9,95
1 081 854
USD
|
108 729
-1.2%
|
9,95
|
1 081 854
USD
|
|
2018-08-10 |
2018-08-08 |
V
Vente
|
FMR LLC
See Remark 1
|
200 000
-24.9%
10,02
2 004 000
USD
|
200 000
-24.9%
|
10,02
|
2 004 000
USD
|
|
2018-08-10 |
2018-08-08 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
4 553
-5.2%
10,00
45 530
USD
|
4 553
-5.2%
|
10,00
|
45 530
USD
|
|
2018-08-10 |
2018-08-08 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
478 107
-5.2%
10,00
4 781 070
USD
|
478 107
-5.2%
|
10,00
|
4 781 070
USD
|
|
2018-08-08 |
2018-08-07 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
4 200
-0.5%
10,16
42 672
USD
|
4 200
-0.5%
|
10,16
|
42 672
USD
|
|
2018-08-08 |
2018-08-07 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
11 400
-1.4%
10,12
115 368
USD
|
11 400
-1.4%
|
10,12
|
115 368
USD
|
|
2018-08-08 |
2018-08-07 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
10 000
-1.2%
10,10
101 000
USD
|
10 000
-1.2%
|
10,10
|
101 000
USD
|
|
2018-08-08 |
2018-08-07 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
1 000
-0.1%
10,38
10 380
USD
|
1 000
-0.1%
|
10,38
|
10 380
USD
|
|
2018-08-07 |
2018-08-07 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
478
-0.5%
10,01
4 785
USD
|
478
-0.5%
|
10,01
|
4 785
USD
|
|
2018-08-07 |
2018-08-07 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
50 149
-0.5%
10,01
501 991
USD
|
50 149
-0.5%
|
10,01
|
501 991
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
7 200
-0.9%
10,69
76 968
USD
|
7 200
-0.9%
|
10,69
|
76 968
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
2 980
-0.4%
10,77
32 095
USD
|
2 980
-0.4%
|
10,77
|
32 095
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
6 900
-0.8%
10,68
73 692
USD
|
6 900
-0.8%
|
10,68
|
73 692
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
2 000
-0.2%
10,48
20 960
USD
|
2 000
-0.2%
|
10,48
|
20 960
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
58 280
-6.4%
10,45
609 026
USD
|
58 280
-6.4%
|
10,45
|
609 026
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
2 879
-0.3%
10,56
30 402
USD
|
2 879
-0.3%
|
10,56
|
30 402
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
24 367
-2.6%
10,64
259 265
USD
|
24 367
-2.6%
|
10,64
|
259 265
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
10 673
-1.1%
10,47
111 746
USD
|
10 673
-1.1%
|
10,47
|
111 746
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
19 550
-2.0%
10,59
207 035
USD
|
19 550
-2.0%
|
10,59
|
207 035
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
5 700
-0.6%
10,68
60 876
USD
|
5 700
-0.6%
|
10,68
|
60 876
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
400
-0.0%
10,69
4 276
USD
|
400
-0.0%
|
10,69
|
4 276
USD
|
|
2018-08-08 |
2018-08-06 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
6 400
-0.7%
10,48
67 072
USD
|
6 400
-0.7%
|
10,48
|
67 072
USD
|
|
2018-08-07 |
2018-08-03 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
1 125
-1.3%
11,71
13 174
USD
|
1 125
-1.3%
|
11,71
|
13 174
USD
|
|
2018-08-07 |
2018-08-03 |
V
Vente
|
ORBIMED ADVISORS LLC
Actionnaire important
|
118 168
-1.3%
11,71
1 383 747
USD
|
118 168
-1.3%
|
11,71
|
1 383 747
USD
|
|
2018-08-06 |
2018-08-03 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
30 000
-3.0%
11,46
343 800
USD
|
30 000
-3.0%
|
11,46
|
343 800
USD
|
|
2018-08-06 |
2018-08-03 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
225 153
-18.2%
11,25
2 532 971
USD
|
225 153
-18.2%
|
11,25
|
2 532 971
USD
|
|
2018-08-06 |
2018-08-02 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
2 587
-0.2%
12,00
31 044
USD
|
2 587
-0.2%
|
12,00
|
31 044
USD
|
|
2018-08-06 |
2018-08-02 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
12 035
-1.0%
12,16
146 346
USD
|
12 035
-1.0%
|
12,16
|
146 346
USD
|
|
2018-08-06 |
2018-08-02 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
64 900
-4.9%
11,95
775 555
USD
|
64 900
-4.9%
|
11,95
|
775 555
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
7 600
-0.6%
11,91
90 516
USD
|
7 600
-0.6%
|
11,91
|
90 516
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
3 200
-0.2%
11,94
38 208
USD
|
3 200
-0.2%
|
11,94
|
38 208
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
778
-0.1%
11,95
9 297
USD
|
778
-0.1%
|
11,95
|
9 297
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
1 200
-0.1%
11,95
14 340
USD
|
1 200
-0.1%
|
11,95
|
14 340
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
8 600
-0.6%
11,93
102 598
USD
|
8 600
-0.6%
|
11,93
|
102 598
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
2 900
-0.2%
12,02
34 858
USD
|
2 900
-0.2%
|
12,02
|
34 858
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
1 000
-0.1%
12,18
12 180
USD
|
1 000
-0.1%
|
12,18
|
12 180
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
800
-0.1%
12,10
9 680
USD
|
800
-0.1%
|
12,10
|
9 680
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
3 000
-0.2%
12,13
36 390
USD
|
3 000
-0.2%
|
12,13
|
36 390
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
1 500
-0.1%
11,95
17 925
USD
|
1 500
-0.1%
|
11,95
|
17 925
USD
|
|
2018-08-02 |
2018-08-01 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
35 756
-2.6%
12,11
433 005
USD
|
35 756
-2.6%
|
12,11
|
433 005
USD
|
|
2018-08-02 |
2018-07-31 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
1 000
-0.1%
12,03
12 030
USD
|
1 000
-0.1%
|
12,03
|
12 030
USD
|
|
2018-08-02 |
2018-07-31 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
500
-0.0%
12,13
6 065
USD
|
500
-0.0%
|
12,13
|
6 065
USD
|
|
2018-08-02 |
2018-07-31 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
6 522
-0.5%
12,11
78 981
USD
|
6 522
-0.5%
|
12,11
|
78 981
USD
|
|
2018-08-02 |
2018-07-31 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
900
-0.1%
12,11
10 899
USD
|
900
-0.1%
|
12,11
|
10 899
USD
|
|
2018-08-02 |
2018-07-31 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
30 000
-2.1%
12,12
363 600
USD
|
30 000
-2.1%
|
12,12
|
363 600
USD
|
|
2018-08-02 |
2018-07-31 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
2 700
-0.2%
12,13
32 751
USD
|
2 700
-0.2%
|
12,13
|
32 751
USD
|
|
2018-08-02 |
2018-07-31 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
19 250
-1.3%
12,07
232 348
USD
|
19 250
-1.3%
|
12,07
|
232 348
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
10 000
-0.7%
11,44
114 400
USD
|
10 000
-0.7%
|
11,44
|
114 400
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
11 500
-0.8%
11,39
130 985
USD
|
11 500
-0.8%
|
11,39
|
130 985
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
68 092
-4.5%
11,36
773 525
USD
|
68 092
-4.5%
|
11,36
|
773 525
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
253
-0.0%
11,36
2 874
USD
|
253
-0.0%
|
11,36
|
2 874
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
600
-0.0%
11,52
6 912
USD
|
600
-0.0%
|
11,52
|
6 912
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
1 200
-0.1%
11,54
13 848
USD
|
1 200
-0.1%
|
11,54
|
13 848
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
1 600
-0.1%
11,49
18 384
USD
|
1 600
-0.1%
|
11,49
|
18 384
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
7 800
-0.5%
11,48
89 544
USD
|
7 800
-0.5%
|
11,48
|
89 544
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
400
-0.0%
11,48
4 592
USD
|
400
-0.0%
|
11,48
|
4 592
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
6 000
-0.4%
11,45
68 700
USD
|
6 000
-0.4%
|
11,45
|
68 700
USD
|
|
2018-07-31 |
2018-07-30 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
2 555
-0.2%
11,47
29 306
USD
|
2 555
-0.2%
|
11,47
|
29 306
USD
|
|
2018-07-31 |
2018-07-27 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
18 006
-1.1%
11,56
208 149
USD
|
18 006
-1.1%
|
11,56
|
208 149
USD
|
|
2018-07-31 |
2018-07-27 |
V
Vente
|
FMR LLC
See Remark 1
Actionnaire important
|
130 559
-7.7%
11,60
1 514 484
USD
|
130 559
-7.7%
|
11,60
|
1 514 484
USD
|
|