2017-12-04 |
2017-11-30 |
PS
Planned sale
|
Sheehy Douglas T.
See Remarks
|
3,750
-100.0%
37.00
138,750
USD
|
3,750
-100.0%
|
37.00
|
138,750
USD
|
|
2017-11-13 |
2017-11-09 |
PS
Planned sale
|
Sheehy Douglas T.
See Remarks
|
1,905
-100.0%
33.00
62,865
USD
|
1,905
-100.0%
|
33.00
|
62,865
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
See Remarks
Executive Director
|
100
-0.0%
36.55
3,655
USD
|
100
-0.0%
|
36.55
|
3,655
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
See Remarks
Executive Director
|
6,960
-2.2%
35.39
246,329
USD
|
6,960
-2.2%
|
35.39
|
246,329
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
See Remarks
Executive Director
|
17,472
-5.1%
34.15
596,685
USD
|
17,472
-5.1%
|
34.15
|
596,685
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
See Remarks
Executive Director
|
75,468
-18.2%
33.23
2,507,870
USD
|
75,468
-18.2%
|
33.23
|
2,507,870
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
Sheehy Douglas T.
See Remarks
|
5,625
-100.0%
37.00
208,125
USD
|
5,625
-100.0%
|
37.00
|
208,125
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
Sheehy Douglas T.
See Remarks
|
7,500
-57.1%
35.63
267,251
USD
|
7,500
-57.1%
|
35.63
|
267,251
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
Sheehy Douglas T.
See Remarks
|
6,333
-100.0%
35.34
223,826
USD
|
6,333
-100.0%
|
35.34
|
223,826
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
Sheehy Douglas T.
See Remarks
|
5,003
-44.1%
34.13
170,739
USD
|
5,003
-44.1%
|
34.13
|
170,739
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
Sheehy Douglas T.
See Remarks
|
22,964
-67.0%
33.25
763,574
USD
|
22,964
-67.0%
|
33.25
|
763,574
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
ADELMAN DANIEL C MD
Chief Medical Officer
|
3,000
-100.0%
35.46
106,375
USD
|
3,000
-100.0%
|
35.46
|
106,375
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
ADELMAN DANIEL C MD
Chief Medical Officer
|
1,470
-32.9%
34.27
50,384
USD
|
1,470
-32.9%
|
34.27
|
50,384
USD
|
|
2017-10-25 |
2017-10-23 |
PS
Planned sale
|
ADELMAN DANIEL C MD
Chief Medical Officer
|
5,530
-55.3%
33.25
183,851
USD
|
5,530
-55.3%
|
33.25
|
183,851
USD
|
|
2017-10-18 |
2017-10-16 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
President and CEO
Executive Director
|
1,154
-0.3%
26.24
30,279
USD
|
1,154
-0.3%
|
26.24
|
30,279
USD
|
|
2017-10-06 |
2017-10-06 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
President and CEO
Executive Director
|
4,047
-1.0%
26.31
106,468
USD
|
4,047
-1.0%
|
26.31
|
106,468
USD
|
|
2017-10-06 |
2017-10-05 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
President and CEO
Executive Director
|
14,689
-3.4%
26.24
385,495
USD
|
14,689
-3.4%
|
26.24
|
385,495
USD
|
|
2017-10-06 |
2017-10-04 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
President and CEO
Executive Director
|
30,110
-6.5%
26.26
790,613
USD
|
30,110
-6.5%
|
26.26
|
790,613
USD
|
|
2017-10-06 |
2017-10-04 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
President and CEO
Executive Director
|
50,000
-9.7%
26.21
1,310,740
USD
|
50,000
-9.7%
|
26.21
|
1,310,740
USD
|
|
2017-09-27 |
2017-09-25 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
President and CEO
Executive Director
|
100,000
-16.3%
25.01
2,500,790
USD
|
100,000
-16.3%
|
25.01
|
2,500,790
USD
|
|
2017-09-27 |
2017-09-25 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
|
20,000
-100.0%
25.00
500,000
USD
|
20,000
-100.0%
|
25.00
|
500,000
USD
|
|
2017-09-27 |
2017-09-25 |
PS
Planned sale
|
ADELMAN DANIEL C MD
Chief Medical Officer
|
10,000
-100.0%
25.00
250,000
USD
|
10,000
-100.0%
|
25.00
|
250,000
USD
|
|
2017-09-11 |
2017-09-07 |
PS
Planned sale
|
Rozenman Mary M.
See Remarks
|
30,000
-99.6%
22.50
675,000
USD
|
30,000
-99.6%
|
22.50
|
675,000
USD
|
|
2017-09-07 |
2017-09-06 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
|
15,167
-100.0%
22.00
333,709
USD
|
15,167
-100.0%
|
22.00
|
333,709
USD
|
|
2017-09-07 |
2017-09-05 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
|
3,223
-100.0%
22.00
70,906
USD
|
3,223
-100.0%
|
22.00
|
70,906
USD
|
|
2017-07-31 |
2017-07-27 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
Officer
|
500
-100.0%
22.00
11,000
USD
|
500
-100.0%
|
22.00
|
11,000
USD
|
|
2017-07-28 |
2017-07-26 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
President and CEO
Executive Director
|
50,000
-7.5%
21.46
1,073,110
USD
|
50,000
-7.5%
|
21.46
|
1,073,110
USD
|
|
2017-07-25 |
2017-07-25 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
Officer
|
4,650
-100.0%
22.00
102,300
USD
|
4,650
-100.0%
|
22.00
|
102,300
USD
|
|
2017-07-25 |
2017-07-24 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
Officer
|
500
-100.0%
22.00
11,000
USD
|
500
-100.0%
|
22.00
|
11,000
USD
|
|
2017-07-25 |
2017-07-21 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
Officer
|
960
-100.0%
22.00
21,120
USD
|
960
-100.0%
|
22.00
|
21,120
USD
|
|
2017-07-21 |
2017-07-21 |
PS
Planned sale
|
Sheehy Douglas T.
See Remarks
Officer
|
7,460
-100.0%
21.66
161,558
USD
|
7,460
-100.0%
|
21.66
|
161,558
USD
|
|
2017-07-17 |
2017-07-17 |
PS
Planned sale
|
Rozenman Mary M.
See Remarks
Officer
|
300
-69.9%
21.38
6,414
USD
|
300
-69.9%
|
21.38
|
6,414
USD
|
|
2017-07-17 |
2017-07-14 |
PS
Planned sale
|
Rozenman Mary M.
See Remarks
Officer
|
5,666
-97.8%
21.39
121,175
USD
|
5,666
-97.8%
|
21.39
|
121,175
USD
|
|
2017-07-17 |
2017-07-13 |
PS
Planned sale
|
Rozenman Mary M.
See Remarks
Officer
|
8,974
-98.6%
21.47
192,658
USD
|
8,974
-98.6%
|
21.47
|
192,658
USD
|
|
2017-07-06 |
2017-07-05 |
PS
Planned sale
|
Rozenman Mary M.
See Remarks
Officer
|
15,060
-99.2%
21.40
322,212
USD
|
15,060
-99.2%
|
21.40
|
322,212
USD
|
|
2017-07-06 |
2017-07-03 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
Officer
|
15,000
-100.0%
20.26
303,911
USD
|
15,000
-100.0%
|
20.26
|
303,911
USD
|
|
2017-07-06 |
2017-07-03 |
PS
Planned sale
|
Rozenman Mary M.
See Remarks
Officer
|
30,000
-99.6%
20.57
617,178
USD
|
30,000
-99.6%
|
20.57
|
617,178
USD
|
|
2017-06-27 |
2017-06-23 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
President and CEO
Executive Director
|
49,400
-6.9%
20.21
998,591
USD
|
49,400
-6.9%
|
20.21
|
998,591
USD
|
|
2017-05-15 |
2017-05-12 |
B
Purchase
|
BJERKHOLT ERIC
Chief Financial Officer
Officer
|
5,000
+inf%
19.84
99,210
USD
|
5,000
+inf%
|
19.84
|
99,210
USD
|
|
2017-05-12 |
2017-05-10 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
See Remarks
Executive Director
|
600
-0.1%
20.15
12,090
USD
|
600
-0.1%
|
20.15
|
12,090
USD
|
|
2017-04-05 |
2017-04-03 |
PS
Planned sale
|
DeSouza Warren L.
Chief Financial Officer
|
15,000
-42.0%
21.58
323,736
USD
|
15,000
-42.0%
|
21.58
|
323,736
USD
|
|
2017-03-23 |
2017-03-21 |
PS
Planned sale
|
DeSouza Warren L.
Chief Financial Officer
|
10,000
-32.6%
22.95
229,500
USD
|
10,000
-32.6%
|
22.95
|
229,500
USD
|
|
2016-11-15 |
2016-11-11 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
See Remarks
Executive Director
|
25,000
-3.4%
25.00
625,000
USD
|
25,000
-3.4%
|
25.00
|
625,000
USD
|
|
2016-11-15 |
2016-11-11 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
See Remarks
Executive Director
|
23,696
-3.1%
25.02
592,990
USD
|
23,696
-3.1%
|
25.02
|
592,990
USD
|
|
2016-11-15 |
2016-11-11 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
Officer
|
20,000
-100.0%
25.00
500,000
USD
|
20,000
-100.0%
|
25.00
|
500,000
USD
|
|
2016-11-15 |
2016-11-10 |
PS
Planned sale
|
DILLY STEPHEN GEORGE
See Remarks
Executive Director
|
1,304
-0.2%
25.00
32,600
USD
|
1,304
-0.2%
|
25.00
|
32,600
USD
|
|
2016-11-10 |
2016-11-08 |
PS
Planned sale
|
Barrowcliffe Susan E.
General Manager, Europe
Officer
|
15,000
-100.0%
20.00
300,000
USD
|
15,000
-100.0%
|
20.00
|
300,000
USD
|
|
2016-11-04 |
2016-11-04 |
PS
Planned sale
|
Rozenman Mary M.
See Remarks
Officer
|
24,096
-100.0%
17.60
424,090
USD
|
24,096
-100.0%
|
17.60
|
424,090
USD
|
|
2016-10-07 |
2016-10-05 |
PS
Planned sale
|
Rozenman Mary M.
See Remarks
Officer
|
25,000
-100.0%
16.80
420,000
USD
|
25,000
-100.0%
|
16.80
|
420,000
USD
|
|
2016-09-09 |
2016-09-08 |
PS
Planned sale
|
Rozenman Mary M.
See Remarks
Officer
|
30,000
-100.0%
16.80
504,000
USD
|
30,000
-100.0%
|
16.80
|
504,000
USD
|
|
2016-06-02 |
2016-05-31 |
S
Sale
|
Foresite Capital Management II, LLC
Major owner
|
120,000
-33.8%
15.23
1,827,360
USD
|
120,000
-33.8%
|
15.23
|
1,827,360
USD
|
|
2016-06-02 |
2016-05-31 |
S
Sale
|
Foresite Capital Management II, LLC
Major owner
|
120,000
-2.9%
15.23
1,827,360
USD
|
120,000
-2.9%
|
15.23
|
1,827,360
USD
|
|
2016-03-31 |
2016-03-29 |
B
Purchase
|
Longitude Capital Partners II, LLC
Major owner
|
45,440
+0.6%
14.15
642,817
USD
|
45,440
+0.6%
|
14.15
|
642,817
USD
|
|
2016-03-31 |
2016-03-29 |
B
Purchase
|
ENRIGHT PATRICK G
Non-Executive Director
Major owner
|
45,440
+0.6%
14.15
642,817
USD
|
45,440
+0.6%
|
14.15
|
642,817
USD
|
|
2016-03-31 |
2016-03-29 |
B
Purchase
|
Longitude Capital Partners II, LLC
Major owner
|
33,064
+0.4%
13.50
446,318
USD
|
33,064
+0.4%
|
13.50
|
446,318
USD
|
|
2016-03-31 |
2016-03-29 |
B
Purchase
|
ENRIGHT PATRICK G
Non-Executive Director
Major owner
|
33,064
+0.4%
13.50
446,318
USD
|
33,064
+0.4%
|
13.50
|
446,318
USD
|
|
2015-08-26 |
2015-08-24 |
B
Purchase
|
Foresite Capital Management II, LLC
Major owner
|
25,485
+7.7%
19.65
500,900
USD
|
25,485
+7.7%
|
19.65
|
500,900
USD
|
|
2015-08-11 |
2015-08-11 |
B
Purchase
|
Foresite Capital Management II, LLC
Major owner
|
17,035
+5.5%
20.50
349,199
USD
|
17,035
+5.5%
|
20.50
|
349,199
USD
|
|
2015-08-11 |
2015-08-11 |
B
Purchase
|
Foresite Capital Management II, LLC
Major owner
|
312,500
+inf%
16.00
5,000,000
USD
|
312,500
+inf%
|
16.00
|
5,000,000
USD
|
|
2015-08-11 |
2015-08-11 |
B
Purchase
|
Foresite Capital Management II, LLC
Major owner
|
312,500
+8.3%
16.00
5,000,000
USD
|
312,500
+8.3%
|
16.00
|
5,000,000
USD
|
|
2015-08-11 |
2015-08-11 |
B
Purchase
|
Longitude Capital Partners II, LLC
Major owner
|
312,500
+4.4%
16.00
5,000,000
USD
|
312,500
+4.4%
|
16.00
|
5,000,000
USD
|
|
2015-08-11 |
2015-08-11 |
B
Purchase
|
ENRIGHT PATRICK G
Non-Executive Director
Major owner
|
312,500
+4.4%
16.00
5,000,000
USD
|
312,500
+4.4%
|
16.00
|
5,000,000
USD
|
|
2015-08-11 |
2015-08-11 |
B
Purchase
|
Iwicki Mark T
Non-Executive Director
|
20,000
+inf%
16.00
320,000
USD
|
20,000
+inf%
|
16.00
|
320,000
USD
|
|
2015-08-11 |
2015-08-11 |
B
Purchase
|
MCDADE MARK
Non-Executive Director
|
16,660
+inf%
16.00
266,560
USD
|
16,660
+inf%
|
16.00
|
266,560
USD
|
|
2015-08-11 |
2015-08-11 |
B
Purchase
|
FALBERG KATHRYN E
Non-Executive Director
|
25,000
+35.8%
16.00
400,000
USD
|
25,000
+35.8%
|
16.00
|
400,000
USD
|
|